| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Thornton-Manning, K J Nikula, J A Hotchkiss, K J Avila, K D Rohrbacher, X Ding, A R Dah. Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen. Toxicology and applied pharmacology. vol 142. issue 1. 1997-02-24. PMID:9007030. |
western blot analysis revealed that anti-cyp2a10/11 recognized a sharp band of approximately 50 kda in nasal respiratory and olfactory microsomes, supporting the premise that the antibody is reacting with a cytochrome p450 enzyme. |
1997-02-24 |
2023-08-12 |
human |
| A J Holtmaat, W T Hermens, A B Oestreicher, W H Gispen, M G Kaplitt, J Verhaage. Efficient adenoviral vector-directed expression of a foreign gene to neurons and sustentacular cells in the mouse olfactory neuroepithelium. Brain research. Molecular brain research. vol 41. issue 1-2. 1997-02-20. PMID:8883946. |
the technique to apply the vector to the nasal cavity and the amount of viral vector per mouse are important variables that determine the success of viral vector-mediated gene transfer to the mouse olfactory neuroepithelium. |
1997-02-20 |
2023-08-12 |
mouse |
| R Quinton, W Hasan, W Grant, C Thrasivoulou, R E Quiney, G M Besser, P M Boulou. Gonadotropin-releasing hormone immunoreactivity in the nasal epithelia of adults with Kallmann's syndrome and isolated hypogonadotropic hypogonadism and in the early midtrimester human fetus. The Journal of clinical endocrinology and metabolism. vol 82. issue 1. 1997-01-30. PMID:8989279. |
these findings are consistent with two different interpretations: the nasal gnrh neurons may be vestigial, representing cells that failed to migrate during embryogenesis; alternatively, they may have been generated de novo later in life, a possibility consistent with the recognized plasticity of human postnatal olfactory neuroepithelium. |
1997-01-30 |
2023-08-12 |
human |
| T Su, J J Sheng, T W Lipinskas, X Din. Expression of CYP2A genes in rodent and human nasal mucosa. Drug metabolism and disposition: the biological fate of chemicals. vol 24. issue 8. 1997-01-21. PMID:8869824. |
cyp2a10 and cyp2a11, which are abundant in olfactory microsomes from rabbits, are active in the metabolic activation of a number of nasal toxicants, such as hexamethylphosphoramide and n-nitrosodiethylamine. |
1997-01-21 |
2023-08-12 |
mouse |
| T Su, J J Sheng, T W Lipinskas, X Din. Expression of CYP2A genes in rodent and human nasal mucosa. Drug metabolism and disposition: the biological fate of chemicals. vol 24. issue 8. 1997-01-21. PMID:8869824. |
the identification of cyp2a6 in human nasal tissues may have important implications for risk assessment of potential nasal toxicants, and the abundant expression of the cyp2a genes in rat and mouse olfactory tissue suggests a molecular basis for the known tissue-specific toxicity of numerous inhaled compounds in rodents. |
1997-01-21 |
2023-08-12 |
mouse |
| R Higo, K Ichimura, Y Ota, T Ishizuka, Y Shimazok. [Investigation of "anosmic zones" associated with nasal allergy]. Nihon Jibiinkoka Gakkai kaiho. vol 99. issue 11. 1997-01-14. PMID:8969068. |
twenty-seven nasal allergy patients suffering from olfactory disturbance were evaluated in this study. |
1997-01-14 |
2023-08-12 |
human |
| R Higo, K Ichimura, Y Ota, T Ishizuka, Y Shimazok. [Investigation of "anosmic zones" associated with nasal allergy]. Nihon Jibiinkoka Gakkai kaiho. vol 99. issue 11. 1997-01-14. PMID:8969068. |
these results were inconsistent with the proposed mechanism that nasal obstruction causes olfactory disturbance in patients suffering from nasal allergy. |
1997-01-14 |
2023-08-12 |
human |
| J J Anders, J A Hurloc. Transplanted glial scar impedes olfactory bulb reinnervation. Experimental neurology. vol 142. issue 1. 1997-01-08. PMID:8912905. |
transport of horseradish peroxidase (hrp) from the nasal cavity by the olfactory neurons was used to examine the temporal and spatial pattern of regeneration of the olfactory nerve after axotomy and axotomy followed by glial scar transplantation. |
1997-01-08 |
2023-08-12 |
rat |
| F Weth, W Nadler, S Korschin. Nested expression domains for odorant receptors in zebrafish olfactory epithelium. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 23. 1996-12-30. PMID:8917589. |
the mapping of high-dimensional olfactory stimuli onto the two-dimensional surface of the nasal sensory epithelium constitutes the first step in the neuronal encoding of olfactory input. |
1996-12-30 |
2023-08-12 |
zebrafish |
| N J Slevin, C J Irwin, S S Banerjee, N K Gupta, W T Farringto. Olfactory neural tumours--the role of external beam radiotherapy. The Journal of laryngology and otology. vol 110. issue 11. 1996-12-19. PMID:8944873. |
olfactory neuroblastoma is an uncommon tumour arising in the nasal cavity or paranasal sinuses. |
1996-12-19 |
2023-08-12 |
Not clear |
| M B Genter, D M Owens, H B Carlone, K M Crofto. Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 29. issue 1. 1996-12-11. PMID:8838641. |
whether there is an olfactory deficit associated with the partial loss of the olfactory mucosa (localized around the dorsal medial meatus of the nasal cavity) has yet to be determined. |
1996-12-11 |
2023-08-12 |
rat |
| A C Puche, F Poirier, M Hair, P F Bartlett, B Ke. Role of galectin-1 in the developing mouse olfactory system. Developmental biology. vol 179. issue 1. 1996-12-06. PMID:8873770. |
primary sensory olfactory neurons reside in a neuroepithelium lining the nasal cavity and project topographically onto the surface of the olfactory bulb, a rostral extension of the telencephalon. |
1996-12-06 |
2023-08-12 |
mouse |
| A C Puche, F Poirier, M Hair, P F Bartlett, B Ke. Role of galectin-1 in the developing mouse olfactory system. Developmental biology. vol 179. issue 1. 1996-12-06. PMID:8873770. |
these data indicate that galectin-1 is involved in the growth and/or guidance of primary sensory olfactory axons between the nasal cavity and the olfactory bulb. |
1996-12-06 |
2023-08-12 |
mouse |
| T Ishimaru, M Sakumoto, Y Kimura, M Furukaw. Olfactory evoked potentials produced by electrical stimulation of the olfactory mucosa. Auris, nasus, larynx. vol 23. 1996-12-04. PMID:8809330. |
a bipolar stimulating electrode was placed on the olfactory region of the nasal mucosa via an anterior naris non-invasively. |
1996-12-04 |
2023-08-12 |
Not clear |
| B H Mathison, M L Taylor, M S Bogdanff. Dimethyl sulfate uptake and methylation of DNA in rat respiratory tissues following acute inhalation. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 28. issue 2. 1996-12-04. PMID:8835235. |
following dms exposure, nasal respiratory and olfactory mucosa and lung tissue were removed and dna was isolated for the analysis of methylated purines. |
1996-12-04 |
2023-08-12 |
rat |
| B H Mathison, M L Taylor, M S Bogdanff. Dimethyl sulfate uptake and methylation of DNA in rat respiratory tissues following acute inhalation. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 28. issue 2. 1996-12-04. PMID:8835235. |
repair of n7-methylguanine did not appear to be significantly different between nasal respiratory and olfactory tissues. |
1996-12-04 |
2023-08-12 |
rat |
| H L Eisthen, R G Northcut. Silver lampreys (Ichthyomyzon unicuspis) lack a gonadotropin-releasing hormone- and FMRFamide-immunoreactive terminal nerve. The Journal of comparative neurology. vol 370. issue 2. 1996-12-03. PMID:8808728. |
we conclude that lampreys may lack a terminal nerve, and that the previously described fiber bundle extending from the nasal sac to the ventral forebrain may constitute an extra-bulbar olfactory pathway. |
1996-12-03 |
2023-08-12 |
Not clear |
| P Larsson, H Tjälv. Bioactivation of aflatoxin B1 in the nasal and tracheal mucosa in swine. Journal of animal science. vol 74. issue 7. 1996-12-03. PMID:8818814. |
whole-body autoradiography of 3h-labeled aflatoxin b1 in young pigs showed a localization of bound label in the nasal olfactory and respiratory mucosa, in the tracheo-laryngeal mucosa, and in the conjunctiva, in addition to the liver. |
1996-12-03 |
2023-08-12 |
Not clear |
| P Larsson, H Tjälv. Bioactivation of aflatoxin B1 in the nasal and tracheal mucosa in swine. Journal of animal science. vol 74. issue 7. 1996-12-03. PMID:8818814. |
in vitro experiments with microsomal preparations of various tissues from sows revealed that the nasal respiratory and olfactory mucosa had the highest capacity to form dna-bound aflatoxin b1-metabolites. |
1996-12-03 |
2023-08-12 |
Not clear |
| P Larsson, H Tjälv. Bioactivation of aflatoxin B1 in the nasal and tracheal mucosa in swine. Journal of animal science. vol 74. issue 7. 1996-12-03. PMID:8818814. |
a drastic decrease in the aflatoxin b1-dna binding was observed when microsomal preparations of the nasal respiratory and olfactory mucosa were incubated in the presence of reduced glutathione, but without any addition of cytosolic glutathione-s-transferases. |
1996-12-03 |
2023-08-12 |
Not clear |