| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M V Pino, M G Valerio, G K Miller, J L Larson, D L Rosolia, Z Jayyosi, C N Crouch, J Q Trojanowski, L E Geige. Toxicologic and carcinogenic effects of the type IV phosphodiesterase inhibitor RP 73401 on the nasal olfactory tissue in rats. Toxicologic pathology. vol 27. issue 4. 1999-10-20. PMID:10485818. |
toxicologic and carcinogenic effects of the type iv phosphodiesterase inhibitor rp 73401 on the nasal olfactory tissue in rats. |
1999-10-20 |
2023-08-12 |
mouse |
| M V Pino, M G Valerio, G K Miller, J L Larson, D L Rosolia, Z Jayyosi, C N Crouch, J Q Trojanowski, L E Geige. Toxicologic and carcinogenic effects of the type IV phosphodiesterase inhibitor RP 73401 on the nasal olfactory tissue in rats. Toxicologic pathology. vol 27. issue 4. 1999-10-20. PMID:10485818. |
rp 73401, a type iv phosphodiesterase inhibitor, caused toxic effects in the nasal olfactory region of sprague-dawley rats when administered by either oral or inhalation exposure. |
1999-10-20 |
2023-08-12 |
mouse |
| M V Pino, M G Valerio, G K Miller, J L Larson, D L Rosolia, Z Jayyosi, C N Crouch, J Q Trojanowski, L E Geige. Toxicologic and carcinogenic effects of the type IV phosphodiesterase inhibitor RP 73401 on the nasal olfactory tissue in rats. Toxicologic pathology. vol 27. issue 4. 1999-10-20. PMID:10485818. |
a 2-yr inhalation carcinogenicity study resulted in tumors of the nasal olfactory region in rats treated at 0.5 and 1.0 mg/kg per day. |
1999-10-20 |
2023-08-12 |
mouse |
| M S Bogdanffy, R Sarangapani, D R Plowchalk, A Jarabek, M E Anderse. A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 51. issue 1. 1999-10-15. PMID:10496674. |
vinyl acetate is a nasal carcinogen in rats, but not mice, and induces olfactory degeneration in both species. |
1999-10-15 |
2023-08-12 |
mouse |
| B A Wetmore, A D Mitchell, S A Meyer, M B Gente. Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat. Toxicological sciences : an official journal of the Society of Toxicology. vol 49. issue 2. 1999-10-13. PMID:10416265. |
in contrast, an s9 activation system derived from nasal respiratory mucosa, the tissue physically juxtaposed with the olfactory mucosa but reportedly not susceptible to alachlor-induced tumors, did not produce a mutagenic response for alachlor or the positive control. |
1999-10-13 |
2023-08-12 |
mouse |
| J J Stanek, J B Morri. The effect of inhibition of aldehyde dehydrogenase on nasal uptake of inspired acetaldehyde. Toxicological sciences : an official journal of the Society of Toxicology. vol 49. issue 2. 1999-10-13. PMID:10416267. |
aldh activities (substrate concentration 3 times the k(m)) in anterior (respiratory mucosa) and posterior (olfactory mucosa) nasal tissues averaged 160 and 210 nmol/min), respectively, in control animals (total activity 370 nmol/min), compared to 60 and 80 nmol/min, respectively, in cyanamide-pretreated rats (p < 0.05), indicating that approximately 60% inhibition was obtained. |
1999-10-13 |
2023-08-12 |
rat |
| A J Apter, J F Gent, M E Fran. Fluctuating olfactory sensitivity and distorted odor perception in allergic rhinitis. Archives of otolaryngology--head & neck surgery. vol 125. issue 9. 1999-09-24. PMID:10488987. |
to characterize the relationship between allergic rhinitis, the severity and duration of nasal disease, olfactory function, and self-reported olfactory symptoms, including fluctuations or distortions in odor perception. |
1999-09-24 |
2023-08-12 |
Not clear |
| P Peretto, A Merighi, A Fasolo, L Bonfant. The subependymal layer in rodents: a site of structural plasticity and cell migration in the adult mammalian brain. Brain research bulletin. vol 49. issue 4. 1999-09-09. PMID:10424843. |
nevertheless, it has now been ascertained that these phenomena can occur in the adult mammalian nervous system, at least in three distinct sites: the olfactory neuroepithelium of the nasal mucosa and two brain regions, namely, the hippocampal dentate gyrus and the olfactory bulb. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Tjälve, J Henriksso. Uptake of metals in the brain via olfactory pathways. Neurotoxicology. vol 20. issue 2-3. 1999-09-03. PMID:10385882. |
in the olfactory epithelium the dendrites of the primary olfactory neurons are in contact with the nasal lumen, and via the axons these neurons are also connected to the olfactory bulbs of the brain. |
1999-09-03 |
2023-08-12 |
Not clear |
| T Koujitani, K Yasuhara, H Kobayashi, A Shimada, H Onodera, H Takagi, M Hirose, K Mitsumor. Tumor-promoting activity of 2,6-dimethylaniline in a two-stage nasal carcinogenesis model in N-bis(2-hydroxypropyl)nitrosamine-treated rats. Cancer letters. vol 142. issue 2. 1999-09-02. PMID:10463772. |
these results indicate that dhpn acts as an appropriate initiator for nasal carcinogenesis and that dma exerts a tumor-promoting effect on the olfactory mucosa in the rat nasal cavity. |
1999-09-02 |
2023-08-12 |
rat |
| S Honeybul, G Neil-Dwyer, D A Lang, B T Evans, R O Weller, J Gil. The extended transbasal approach: a quantitative anatomical and histological study. Acta neurochirurgica. vol 141. issue 3. 1999-06-28. PMID:10214481. |
in addition, a histological study was carried out to investigate the level to which identifiable olfactory nerves extended into the nasal mucosa. |
1999-06-28 |
2023-08-12 |
Not clear |
| K H Kim, L Patel, S A Tobet, J C King, B S Rubin, E G Stop. Gonadotropin-releasing hormone immunoreactivity in the adult and fetal human olfactory system. Brain research. vol 826. issue 2. 1999-06-08. PMID:10224299. |
studies in fetal brain tissue of rodents, nonhuman primates and birds have demonstrated that cells containing gonadotropin-releasing hormone (gnrh) migrate from the olfactory placode across the nasal septum into the forebrain. |
1999-06-08 |
2023-08-12 |
human |
| J M Couper Leo, P C Brunje. Developmental analysis of the peripheral olfactory organ of the opossum Monodelphis domestica. Brain research. Developmental brain research. vol 114. issue 1. 1999-05-26. PMID:10209241. |
the present study provides the first detailed morphometric analysis of the development of the olfactory mucosa and the nasal cavity in monodelphis. |
1999-05-26 |
2023-08-12 |
Not clear |
| K Ikeda, K Watanabe, H Suzuki, T Oshima, N Tanno, A Shimomura, H Sunose, T Takasaka, H Ikeda, T Yoshimot. Nasal airway resistance and olfactory acuity following transsphenoidal pituitary surgery. American journal of rhinology. vol 13. issue 1. 1999-05-10. PMID:10088029. |
nasal airway resistance and olfactory acuity following transsphenoidal pituitary surgery. |
1999-05-10 |
2023-08-12 |
Not clear |
| K Ikeda, K Watanabe, H Suzuki, T Oshima, N Tanno, A Shimomura, H Sunose, T Takasaka, H Ikeda, T Yoshimot. Nasal airway resistance and olfactory acuity following transsphenoidal pituitary surgery. American journal of rhinology. vol 13. issue 1. 1999-05-10. PMID:10088029. |
rhinological problems after a transseptal transsphenoidal approach for pituitary tumors were prospectively investigated in 25 patients with special reference to nasal airway resistance and olfactory acuity. |
1999-05-10 |
2023-08-12 |
Not clear |
| V Lun. Allergic rhinitis--making the correct diagnosis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 28 Suppl 6. 1999-04-28. PMID:9988431. |
other useful diagnostic aids are measurements of nasal peak flow, rhinomanometry, acoustic rhinometry, olfactory threshold, and measures of mucociliary function (which may include biopsy for electron microscopy). |
1999-04-28 |
2023-08-12 |
Not clear |
| K M Hau, D W Connell, B J Richardso. Quantitative structure-activity relationships for nasal pungency thresholds of volatile organic compounds. Toxicological sciences : an official journal of the Society of Toxicology. vol 47. issue 1. 1999-04-27. PMID:10048157. |
another advantage of the present model is that it also provides a basis for comparison between the olfactory process and nasal pungency. |
1999-04-27 |
2023-08-12 |
Not clear |
| M Schwanzel-Fukud. Origin and migration of luteinizing hormone-releasing hormone neurons in mammals. Microscopy research and technique. vol 44. issue 1. 1999-04-15. PMID:9915559. |
lhrh-ir cell migration follows a highly ordered course from the initial appearance of the lhrh-ir cells in the epithelium of the medial olfactory pit, to the crossing of these cells in cords on the nasal septum, to their entrance into the forebrain. |
1999-04-15 |
2023-08-12 |
Not clear |
| M Schwanzel-Fukud. Origin and migration of luteinizing hormone-releasing hormone neurons in mammals. Microscopy research and technique. vol 44. issue 1. 1999-04-15. PMID:9915559. |
the n-cam-ir cells migrate into the nasal mesenchyme, trailed by n-cam-ir axons of the olfactory, vomeronasal, and terminal nerves. |
1999-04-15 |
2023-08-12 |
Not clear |
| P Halleux, S Schurmans, S N Schiffman, R Lecocq, J L Conreur, J Dumont, J J Vanderhaeghe. Calcium binding protein calcyphosine in dog central astrocytes and ependymal cells and in peripheral neurons. Journal of chemical neuroanatomy. vol 15. issue 4. 1999-03-15. PMID:9860089. |
both are also present in neurons of nasal olfactory mucosa, enteric auerbach and meissner plexuses, orthosympathic and spinal cord ganglia as well as in endocrine cells of neural crest origin in the adrenal medulla. |
1999-03-15 |
2023-08-12 |
dog |