| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Osamu Nakagawasai, Wataru Nemoto, Hiroshi Onogi, Takahiro Moriya, Jia-Rong Lin, Takayo Odaira, Fukie Yaoita, Takumi Ogawa, Kiminori Ohta, Yasuyuki Endo, Koichi Tan-N. BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice. Behavioural brain research. vol 297. 2016-09-20. PMID:26497104. |
be360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice. |
2016-09-20 |
2023-08-13 |
mouse |
| Zoltán Rusznák, Woojin Scott Kim, Jen-Hsiang T Hsiao, Glenda M Halliday, George Paxinos, YuHong F. Early in vivo Effects of the Human Mutant Amyloid-β Protein Precursor (hAβPPSwInd) on the Mouse Olfactory Bulb. Journal of Alzheimer's disease : JAD. vol 49. issue 2. 2016-09-12. PMID:26484907. |
in conclusion, our results indicate that (1) neurons participating in the mouse olfactory function overexpress aβpp; (2) the cellular composition of the young j20 olfactory bulb is different from that of wild-type littermates; (3) these differences may reflect altered neurogenic activity and/or delayed development of the j20 olfactory system; and (4) aβpp/aβ-associated pathological changes that take place in the j20 hippocampus and olfactory bulb are not identical. |
2016-09-12 |
2023-08-13 |
mouse |
| Bing Wang, Qiang Wang, Hanqing Chen, Xiaoyan Zhou, Hailong Wang, Huiliang Wang, Jing Zhang, Weiyue Fen. Size-Dependent Translocation Pattern, Chemical and Biological Transformation of Nano- and Submicron-Sized Ferric Oxide Particles in the Central Nervous System. Journal of nanoscience and nanotechnology. vol 16. issue 6. 2016-09-08. PMID:27427596. |
the tem images showed particle-like substances of approximately 35-50 nm were located in the axons of olfactory neurons and in the mitochondria and lysosomes of hippocampus cells in the 40 nm-fe2o3 exposed mice. |
2016-09-08 |
2023-08-13 |
mouse |
| Juan Hu, He-Zhou Huang, Xiang Wang, Ao-Ji Xie, Xiong Wang, Dan Liu, Jian-Zhi Wang, Ling-Qiang Zh. Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25367884. |
activation of glycogen synthase kinase-3 mediates the olfactory deficit-induced hippocampal impairments. |
2016-08-30 |
2023-08-13 |
rat |
| Juan Hu, He-Zhou Huang, Xiang Wang, Ao-Ji Xie, Xiong Wang, Dan Liu, Jian-Zhi Wang, Ling-Qiang Zh. Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25367884. |
although it is known that the olfactory information projects to the hippocampus through entorhinal cortex layer ii, the molecular mechanisms linking olfactory deficit to the hippocampus is not understood. |
2016-08-30 |
2023-08-13 |
rat |
| Juan Hu, He-Zhou Huang, Xiang Wang, Ao-Ji Xie, Xiong Wang, Dan Liu, Jian-Zhi Wang, Ling-Qiang Zh. Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25367884. |
using bilateral olfactory bulbectomy (obx) as a model, we found that obx induced memory deficits with activation of several memory-related protein kinases in the hippocampal extracts, including glycogen synthase kinase-3β (gsk-3β), protein kinase a (pka), extracellular-signal-regulated kinase (erk), c-jun n-terminal kinase (jnk), phosphatidylinositol-3-kinase (pi3k), and protein kinase b (pkb). |
2016-08-30 |
2023-08-13 |
rat |
| Juan Hu, He-Zhou Huang, Xiang Wang, Ao-Ji Xie, Xiong Wang, Dan Liu, Jian-Zhi Wang, Ling-Qiang Zh. Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25367884. |
our data indicate that gsk-3 activation mediates the olfactory deficits to the hippocampus, and targeting gsk-3 blocks the pathological connection. |
2016-08-30 |
2023-08-13 |
rat |
| Miwa Kub. [Search of Neurotrophin-mimic Natural Products for Prevention and Treatment of Neurodegenerative Disease]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 135. issue 10. 2016-08-11. PMID:26423871. |
furthermore, chronic treatment with these compounds enhanced hippocampal neurogenesis in dementia model olfactory bulbectomized (obx) mice. |
2016-08-11 |
2023-08-13 |
mouse |
| Mak Adam Daulatza. Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 10. 2016-07-06. PMID:25944089. |
erc is the gateway for olfactory input to the hippocampus, and there is seamless synchronization between sensory function and hippocampal activity. |
2016-07-06 |
2023-08-13 |
Not clear |
| Mak Adam Daulatza. Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 10. 2016-07-06. PMID:25944089. |
transmission of olfactory information to the hippocampus is sequential-it is projected from the olfactory receptors to olfactory bulb to the primary olfactory cortex (comprised the anterior olfactory nucleus, the olfactory tubercle, and the piriform cortex) to the entorhinal cortex (erc). |
2016-07-06 |
2023-08-13 |
Not clear |
| Mak Adam Daulatza. Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 10. 2016-07-06. PMID:25944089. |
through perforant pathway erc enables olfactory inputs to effectively excite hippocampal neurons. |
2016-07-06 |
2023-08-13 |
Not clear |
| Mak Adam Daulatza. Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 10. 2016-07-06. PMID:25944089. |
one of the earliest pathological changes in alzheimer's disease (ad) include the olfactory dysfunction and the atrophy in erc and hippocampus (rate in erc is higher than in the hippocampus). |
2016-07-06 |
2023-08-13 |
Not clear |
| Mak Adam Daulatza. Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 10. 2016-07-06. PMID:25944089. |
olfactory dysfunction negatively impacts the erc and the deafferenting of the hippocampus from olfactory inputs upregulates memory decline. |
2016-07-06 |
2023-08-13 |
Not clear |
| Maria A Tikhonova, Alexander V Romaschenko, Andrey E Akulov, Ying-Jui Ho, Nataliya G Kolosova, Mikhail P Moshkin, Tamara G Amstislavskay. Comparative study of perception and processing of socially or sexually significant odor information in male rats with normal or accelerated senescence using fMRI. Behavioural brain research. vol 294. 2016-06-14. PMID:26248295. |
we compared brain activity of regions involved in the perception (olfactory bulbs) and processing (cerebral cortex, hippocampus, hypothalamus) of sexually or socially significant odor stimulus with 11.7 t mr-scanner and odor perception using behavioral tests in 5-month old males with normal (wistar rats) or accelerated senescence (d-galactose-treated wistar rats (150 mg/kg/day, i.p., 12 weeks) or oxys rats with hereditary defined accelerated aging). |
2016-06-14 |
2023-08-13 |
rat |
| Tingting Sun, Tianpeng Li, Henry Davies, Weiyun Li, Jing Yang, Shanshan Li, Shucai Lin. Altered Morphologies and Functions of the Olfactory Bulb and Hippocampus Induced by miR-30c. Frontiers in neuroscience. vol 10. 2016-05-31. PMID:27242411. |
tests of olfactory sensitivity and associative and spatial memory showed that a certain amount of adult-born neurons are essential for the normal functions of the ob and hippocampus, but there also exist redundant newborn neurons that do not further improve the functioning of these areas. |
2016-05-31 |
2023-08-13 |
Not clear |
| Eleni Siopi, Marie Denizet, Marie-Madeleine Gabellec, Fabrice de Chaumont, Jean-Christophe Olivo-Marin, Jean-Philippe Guilloux, Pierre-Marie Lledo, Françoise Lazarin. Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 2. 2016-05-17. PMID:26758842. |
corticosterone (cort) is known to negatively correlate with hippocampal neurogenesis, yet its effects on olfactory neurogenesis and olfaction remain unknown. |
2016-05-17 |
2023-08-13 |
mouse |
| Orsolya K Penz, Janos Fuzik, Aleksandra B Kurek, Roman Romanov, John Larson, Thomas J Park, Tibor Harkany, Erik Keimpem. Protracted brain development in a rodent model of extreme longevity. Scientific reports. vol 5. 2016-05-16. PMID:26118676. |
instead, we show the prolonged expression of structural plasticity markers, many recognized as being developmentally controlled, and multi-year-long postnatal neuromorphogenesis and spatial synapse refinement in hippocampal and olfactory structures of the naked mole rat brain. |
2016-05-16 |
2023-08-13 |
rat |
| Sarah Sulaiman Ch'ng, Andrew J Lawrenc. Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: A characterisation of OX1R-eGFP mice. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25841630. |
gfp labelling was observed in perikarya and fibres in an extensive range of brain loci encompassing the olfactory and cerebral cortices, dorsal and ventral pallidum, hippocampus, amygdaloid regions, septal areas, thalamic nuclei, hypothalamic nuclei and several brainstem regions, consistent with previous studies of ox1r mrna expression. |
2016-05-05 |
2023-08-13 |
mouse |
| Gabriele C DeLuca, Albert Joseph, Jithin George, Richard L Yates, Marie Hamard, Monika Hofer, Margaret M Esir. Olfactory Pathology in Central Nervous System Demyelinating Diseases. Brain pathology (Zurich, Switzerland). vol 25. issue 5. 2016-05-04. PMID:25230202. |
the extent of olfactory bulb/tract demyelination correlated with that found in the adjacent inferior frontal cortex but not hippocampus. |
2016-05-04 |
2023-08-13 |
human |
| Yuki Kutsuno, Rika Hirashima, Masaya Sakamoto, Hiroko Ushikubo, Hirofumi Michimae, Tomoo Itoh, Robert H Tukey, Ryoichi Fujiwar. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug metabolism and disposition: the biological fate of chemicals. vol 43. issue 7. 2016-02-16. PMID:25953521. |
in addition, we examined the expression of ugt1a1 and 1a6 in the cerebellum, olfactory bulbs, midbrain, hippocampus, and cerebral cortex of hugt1 mice. |
2016-02-16 |
2023-08-13 |
mouse |