| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruth A Singer, Veronika Rajchin, Kwanghoon Park, Nathaniel Heintz, Robert B Darnel. Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation. bioRxiv : the preprint server for biology. 2024-08-26. PMID:39185177. |
electrophysiologic studies of synaptic plasticity, models for learning and memory, are disrupted in fragile x syndrome (fxs). |
2024-08-26 |
2024-08-28 |
Not clear |
| Federico Tesler, Roberta Maria Lorenzi, Adam Ponzi, Claudia Casellato, Fulvia Palesi, Daniela Gandolfi, Claudia A M Gandini Wheeler Kingshott, Jonathan Mapelli, Egidio D'Angelo, Michele Migliore, Alain Destexh. Multiscale modeling of neuronal dynamics in hippocampus CA1. Frontiers in computational neuroscience. vol 18. 2024-08-21. PMID:39165754. |
then, we analyze the implementation of synaptic plasticity within our framework, a key aspect to study the role of hippocampus in learning and memory consolidation, and we demonstrate the capability of our framework to incorporate the variations at synaptic level. |
2024-08-21 |
2024-08-23 |
Not clear |
| Katalin Schlett, Carlos O Oueslati Morales, Norbert Bencsik, Angelika Hausse. Getting smart - Deciphering the neuronal functions of protein kinase D. Biochimica et biophysica acta. Molecular cell research. 2024-08-15. PMID:39147241. |
in the nervous system, pkd has been shown to be involved in learning and memory formation by regulating neurotransmitter release, neurite outgrowth and dendrite development, synapse formation and synaptic plasticity. |
2024-08-15 |
2024-08-18 |
Not clear |
| Lorenzo Morè, Lucia Privitera, Marcia Lopes, J Simon C Arthur, Julie C Lauterborn, Sonia A L Corrêa, Bruno G Frenguell. MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning. Neuropharmacology. 2024-08-11. PMID:39128584. |
we have previously shown that msk1, by virtue of its ability to regulate gene transcription, converts the elevation of bdnf associated with environmental enrichment into molecular, synaptic, cognitive and genomic adaptations that underlie enrichment-induced enhanced synaptic plasticity and learning and memory, a property that msk1 retains across the lifespan. |
2024-08-11 |
2024-08-14 |
mouse |
| Farhad Sanaeifar, Sina Pourranjbar, Mohammad Pourranjbar, Sana Ramezani, Samira Rostami Mehr, Al-Hassan Soliman Wadan, Farnaz Khazeifar. Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration. Experimental gerontology. 2024-08-08. PMID:39116955. |
neurotrophins such as brain-derived neurotrophic factor (bdnf) are critical for neuron survival and synaptic plasticity, which is required for learning and memory. |
2024-08-08 |
2024-08-12 |
Not clear |
| Ashley N Ewens, Alexander Pilski, Shayne D Hastings, Chris Krook-Magnuson, Steven M Graves, Esther Krook-Magnuson, Stanley A Thaye. Levetiracetam prevents neurophysiological changes and preserves cognitive function in the HIV-1 TAT transgenic mouse model of HIV-associated neurocognitive disorder. The Journal of pharmacology and experimental therapeutics. 2024-07-26. PMID:39060163. |
itat mice had an increased frequency of spontaneous excitatory postsynaptic currents in hippocampal slice recordings and impaired long-term potentiation, a form of synaptic plasticity that underlies learning and memory. |
2024-07-26 |
2024-07-29 |
mouse |
| Zeying Lu, Lili Gui, Xiaojuan Sun, Ke Wang, Yueheng Lan, Yin Deng, Shiyang Cao, Kun X. Unveiling the impact of low-frequency electrical stimulation on network synchronization and learning behavior in cultured hippocampal neural networks. Biochemical and biophysical research communications. vol 731. 2024-07-17. PMID:39018969. |
these alterations in network properties indicated enhanced synaptic plasticity and emphasized the positive impact of low-frequency es on hippocampal neural activities, contributing to the brain's capacity for learning and memory. |
2024-07-17 |
2024-07-20 |
Not clear |
| Amol Bhandare, Maisy Haley, Vanessa Torrico Anderson, Luana B Domingos, Marcia Lopes, Sonia A L Corrêa, Mark J Wal. ArcKR expression modifies synaptic plasticity following epileptic activity: Differential effects with in vitro and in vivo seizure-induction protocols. Epilepsia. vol 65. issue 7. 2024-07-16. PMID:38804501. |
one such protein is activity-regulated cytoskeleton-associated protein (arc), which is critically involved in protein-synthesis-dependent synaptic plasticity underlying learning and memory. |
2024-07-16 |
2024-07-18 |
Not clear |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Najah R Hadi, Abdullah A Assiri, Mohammed Alrouji, Nermeen N Welson, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon. Cellular and molecular neurobiology. vol 44. issue 1. 2024-07-08. PMID:38977507. |
glucagon/glp-1 has been shown to promote synaptogenesis, hippocampal synaptic plasticity, and learning and memory, while attenuating amyloid and tau pathologies. |
2024-07-08 |
2024-07-12 |
Not clear |
| Ga-Young Choi, In-Seo Lee, Eunyoung Moon, Hyosung Choi, A Reum Je, Ji-Ho Park, Hee-Seok Kweo. Ameliorative effect of vanillic acid against scopolamine-induced learning and memory impairment in rat via attenuation of oxidative stress and dysfunctional synaptic plasticity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-28. PMID:38941895. |
the study's findings suggest that va has a neuroprotective effect on scop-induced learning and memory impairment linked to the hippocampal cholinergic system, oxidative damage, and synaptic plasticity. |
2024-06-28 |
2024-07-01 |
rat |
| Kuldeep Tripathi, Somoday Hazra, Joyeeta Dutta Hazra, Silvia Mandel, Ruchi Anunu, Martin Kriebel, Hansjurgen Volkmer, Gal Richter-Levi. Selective knockdown of GABAA-α2 subunit in the dorsal dentate gyrus in adulthood induces anxiety, learning and memory deficits and impairs synaptic plasticity. The European journal of neuroscience. 2024-06-10. PMID:38858171. |
selective knockdown of gabaa-α2 subunit in the dorsal dentate gyrus in adulthood induces anxiety, learning and memory deficits and impairs synaptic plasticity. |
2024-06-10 |
2024-06-14 |
rat |
| Gabriel Reichert Blume, Luiz Fernando Freire Roye. Peripheral to brain and hippocampus crosstalk induced by exercise mediates cognitive and structural hippocampal adaptations. Life sciences. 2024-06-09. PMID:38852798. |
both learning and memory as well as other hippocampal functional-related changes such as neurogenesis, cell proliferation, dendrite morphology and synaptic plasticity are controlled by these exercise responsive peripheral proteins. |
2024-06-09 |
2024-06-14 |
Not clear |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Ting Sun, Ya-Ya Du, Yong-Qiang Zhang, Qin-Qin Tian, Xi Li, Jiao-Yan Yu, Yan-Yan Guo, Qing-Qing Liu, Le Yang, Yu-Mei Wu, Qi Yang, Ming-Gao Zha. Activation of GPR55 Ameliorates Maternal Separation-Induced Learning and Memory Deficits by Augmenting 5-HT Synthesis in the Dorsal Raphe Nucleus of Juvenile Mice. ACS omega. vol 9. issue 20. 2024-05-27. PMID:38799363. |
in this study, we sought to discern the repercussions of gpr55 activation on 5-ht synthesis within the drn of adult c57bl/6j mice that experienced ms. concurrently, we analyzed potential alterations in excitatory synaptic transmission, long-term synaptic plasticity, and relevant learning and memory outcomes. |
2024-05-27 |
2024-05-31 |
mouse |
| Sima Gul Ghasemi, Alireza Khoshrou, Samaneh Kakhki, Atefeh Shirinzadeh Feizabadi, Maha Masoudi, Faezeh Bagherifar, Farimah Behesht. Ascorbic Acid Supplementation Improves Adolescent Stress-induced Cognitive Impairment Through Restoration of Behavioral, Biochemical and Electrophysiological Alterations in Male Rats. Neuroscience. 2024-05-17. PMID:38718917. |
the results of our study showed that chronic stress during adolescence could cause learning and memory disorders as well as synaptic plasticity. |
2024-05-17 |
2024-05-27 |
rat |
| Tareq I Jibril, Karem H Alzoubi, Nizar M Mhaidat, Omar F Khabour, Mohammad A Y Alqudah, Abeer M Rababa'h, Nasr Alrabadi, Doaa Al-Udat. Sildenafil prevents chronic psychosocial stress-induced working memory impairment: Role of brain-derived neurotrophic factor. Current research in pharmacology and drug discovery. vol 6. 2024-05-06. PMID:38706525. |
reduced brain-derived neurotrophic factor (bdnf) levels, increased oxidative stress, and alteration of synaptic plasticity biomarkers are also possible contributors to the negative impact of stress on learning and memory. |
2024-05-06 |
2024-05-08 |
rat |
| Jens Stepan, Daniel E Heinz, Frederik Dethloff, Svenja Wiechmann, Silvia Martinelli, Kathrin Hafner, Tim Ebert, Ellen Junglas, Alexander S Häusl, Max L Pöhlmann, Mira Jakovcevski, Julius C Pape, Anthony S Zannas, Thomas Bajaj, Anke Hermann, Xiao Ma, Hermann Pavenstädt, Mathias V Schmidt, Alexandra Philipsen, Christoph W Turck, Jan M Deussing, Gerhard Rammes, Andrew C Robinson, Antony Payton, Michael C Wehr, Valentin Stein, Christopher Murgatroyd, Joachim Kremerskothen, Bernhard Kuster, Carsten T Wotjak, Nils C Gasse. Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice. Science signaling. vol 17. issue 834. 2024-04-30. PMID:38687825. |
the localization, number, and function of postsynaptic ampa-type glutamate receptors (ampars) are crucial for synaptic plasticity, a cellular correlate for learning and memory. |
2024-04-30 |
2024-05-03 |
mouse |
| Wenzhu Wang, Jingyu Zhao, Zihan Li, Xiaoyu Kang, Ting Li, Nickolay K Isaev, Elena A Smirnova, Hui Shen, Lixu Liu, Yan Y. L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-04-28. PMID:38678966. |
our previous researches demonstrated that levodopa (l-dopa) improves learning and memory impairment in gci/r rats by increasing synaptic plasticity of hippocampal neurons. |
2024-04-28 |
2024-05-01 |
rat |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
the activity-regulated cytoskeleton-associated protein (arc), is an immediate early gene that plays a key role in synaptic plasticity, learning and memory. |
2024-03-29 |
2024-04-01 |
mouse |
| Kushagra Nagori, Madhulika Pradhan, Mukesh Sharma, Ajazuddin, Hemant R Badwaik, Kartik T Nakhat. Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease. Current Alzheimer research. 2024-03-26. PMID:38529600. |
by modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ach plays a pivotal role in the regulation of learning and memory. |
2024-03-26 |
2024-03-28 |
Not clear |