| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaaki Miyata, Aki Tozawa, Hijiri Otsuka, Toshifumi Nakamura, Kiyoshi Nagata, Frank J Gonzalez, Yasushi Yamazo. Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity. The Journal of pharmacology and experimental therapeutics. vol 312. issue 2. 2005-03-18. PMID:15466244. |
serum aspartate aminotransferase (ast) activity was elevated 15.7-fold after feeding a 0.25% cholic acid diet, whereas only slight increases in serum ast (1.7- and 2.5-fold) were observed in wild-type mice fed 0.25 and 1% cholic acid diet, respectively. |
2005-03-18 |
2023-08-12 |
mouse |
| Rajagopal Senthilkumar, Namasivayam Nalin. Effect of glycine on tissue fatty acid composition in an experimental model of alcohol-induced hepatotoxicity. Clinical and experimental pharmacology & physiology. vol 31. issue 7. 2005-01-24. PMID:15236634. |
feeding alcohol significantly elevated the activities of serum aspartate transaminase (ast), alanine transaminase (alt), alkaline phosphatases (alp) and gamma-glutamyl transpeptidase (ggt) and altered the liver and brain fatty acid composition compared with control rats. |
2005-01-24 |
2023-08-12 |
rat |
| Jesus A Villanueva, Charles H Halste. Hepatic transmethylation reactions in micropigs with alcoholic liver disease. Hepatology (Baltimore, Md.). vol 39. issue 5. 2004-05-24. PMID:15122759. |
the concept that abnormal methionine metabolism is involved in the pathogenesis of alcoholic liver disease was strengthened by our previous findings in a micropig model where combining dietary folate deficiency with chronic ethanol feeding produced maximal changes in these metabolites together with early onset of microscopic steatohepatitis and an eightfold increase in plasma aspartate aminotransferase. |
2004-05-24 |
2023-08-12 |
Not clear |
| Y Kim, R DiSilvestro, S Clinto. Effects of lycopene-beadlet or tomato-powder feeding on carbon tetrachloride-induced hepatotoxicty in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 11. issue 2-3. 2004-05-13. PMID:15070165. |
feeding with tomato extract (10% tomato powder), but not with lycopene (0.25% lycopene beadlets), partially inhibited ccl4-induced hepatic injury based on the serum activities of sorbitol dehydrogenase and aspartate aminotransferase. |
2004-05-13 |
2023-08-12 |
rat |
| V Thirunavukkarasu, C V Anuradha, P Viswanatha. Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytotherapy research : PTR. vol 17. issue 7. 2003-12-17. PMID:12916070. |
ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. |
2003-12-17 |
2023-08-12 |
rat |
| S A Al-Jishi, B Abuo Hozaif. Effect of Nigella sativa on blood hemostatic function in rats. Journal of ethnopharmacology. vol 85. issue 1. 2003-04-24. PMID:12576196. |
at the end of each feeding period, platelet count, prothrombin time (pt), activated partial thromboplastin time (aptt), thrombin time (tt), levels of fibrinogen, antithrombin iii (at iii), and albumin, and activity levels aspartate aminotransferase (ast) and alanine aminotransferase (alt) were determined. |
2003-04-24 |
2023-08-12 |
rat |
| Naoyuki Nishizawa, Daiki Sato, Yoshiaki Ito, Takashi Nagasawa, Yasuko Hatakeyama, Myeong-Rak Choi, You-Young Choi, Yi Min We. Effects of dietary protein of proso millet on liver injury induced by D-galactosamine in rats. Bioscience, biotechnology, and biochemistry. vol 66. issue 1. 2002-10-04. PMID:11866125. |
d-galactosamine-induced elevations of serum activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase were significantly suppressed by feeding the diet containing 20% protein of proso millet for 14 days as compared with those of rats fed a 20% casein diet, but not in the case of carbon tetrachloride. |
2002-10-04 |
2023-08-12 |
rat |
| N T Thuy, P He, H Takeuch. Comparative effect of dietary olive, safflower, and linseed oils on spontaneous liver tumorigenesis in C3H/He mice. Journal of nutritional science and vitaminology. vol 47. issue 5. 2002-09-10. PMID:11814153. |
in male c3h/he mice, which frequently develop spontaneous liver tumorigenesis, 5 wk of age and weighing about 20 g, the comparative effects on liver tumor incidence from the feeding of olive oil (oli), safflower oil (saf), and linseed oil (lis) diets for 50 wk, the concentrations of total cholesterol (t-chol), triacylglycerol (tg), lipid peroxides in the plasma and liver, and the activities of aspartate aminotransferase (ast) and alanine aminotransferase (alt) in the plasma were examined. |
2002-09-10 |
2023-08-12 |
mouse |
| M Mabuchi, I Kawamura, M Fushimi, T Inoue, S Takeshita, S Takakura, M Matsuo, M Tomoi, T Got. Induction of bone loss by bile duct ligation in rats. In vivo (Athens, Greece). vol 15. issue 4. 2002-04-05. PMID:11695218. |
in these rats, decreases in food intake and plasma igf-i levels plus elevated levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin were also observed. |
2002-04-05 |
2023-08-12 |
rat |
| Anne-Marie Montet, Laurence Oliva, Françoise Beaugé, Jean-Claude Monte. Bile salts modulate chronic ethanol-induced hepatotoxicity. Alcohol and alcoholism (Oxford, Oxfordshire). vol 37. issue 1. 2002-03-28. PMID:11825853. |
the supplementation to chronic ethanol feeding (28 days) with chenodeoxycholate, a hydrophobic bile salt, aggravated steatosis (accumulation of triacylglycerols and cholesterol esters), lipoperoxidation and cytolysis (expressed as elevations of activities of aspartate aminotransferase and glutamate dehydrogenase), while the addition of ursodeoxycholic acid, a hydrophilic bile salt, alleviated ethanol-induced hepatic alterations. |
2002-03-28 |
2023-08-12 |
rat |
| V B Patel, G Sandhu, J M Corbett, M J Dunn, L M Rodrigues, J R Griffiths, W Wassif, R A Sherwood, P J Richardson, V R Preed. A comparative investigation into the effect of chronic alcohol feeding on the myocardium of normotensive and hypertensive rats: an electrophoretic and biochemical study. Electrophoresis. vol 21. issue 12. 2000-12-22. PMID:10939459. |
in wky rats, the only significant change related to increased aspartate aminotransferase activities in response to alcohol feeding. |
2000-12-22 |
2023-08-12 |
rat |
| D F Hwang, J L Hour, H M Chen. Effect of taurine on toxicity of oxidized fish oil in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 38. issue 7. 2000-08-24. PMID:10942319. |
after feeding diet with 3% oxidized fish oil and 5% taurine at the same time, taurine could improve the decrease of body weight and the glutathione (gsh) level in the liver, and the increase of relative ratios of liver and kidney weight to body weight and thiobarbituric acid-reactive substances (tbars) level in the liver of rats caused by oxidized fish oil it also could reduce the activities of aspartate transaminase (ast), alanine transaminase (alt) and alkaline phosphatase (alp) in the plasma of rats caused by oxidized fish oil. |
2000-08-24 |
2023-08-12 |
rat |
| A Ahmad, S G Kahler, P S Kishnani, M Artigas-Lopez, A S Pappu, R Steiner, D S Millington, J L Van Hov. Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate. American journal of medical genetics. vol 87. issue 4. 1999-12-22. PMID:10588840. |
to provide oxaloacetate, she was treated with high-dose citrate (7.5 mol/kg(-1)/day(-1)), aspartate (10 mmol/kg(-1)/day(-1)), and continuous drip feeding. |
1999-12-22 |
2023-08-12 |
Not clear |
| M Yin, K Ikejima, G E Arteel, V Seabra, B U Bradford, H Kono, I Rusyn, R G Thurma. Glycine accelerates recovery from alcohol-induced liver injury. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694963. |
male wistar rats were exposed to ethanol continuously for 6 wk via intragastric feeding that resulted in typical histology of alcoholic liver injury, including steatosis, inflammation, necrosis and increased serum levels of aspartate aminotransferase and alanine aminotransferase. |
1998-09-02 |
2023-08-12 |
rat |
| M Maeno, Y Morimoto, T Hayakawa, Y Suzuki, H Tsug. Feeding experiments of pyridoxine derivatives as vitamin B6. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. vol 67. issue 6. 1998-02-02. PMID:9433679. |
after the feeding experiment, rats were killed and examined in terms of liver kynureninase activity (ec 3.7.1.3) with and without adding exogenous pyridoxal 5'-phosphate (plp), erythrocyte aspartate aminotransferase activity (ec 2.6.1.1), as well as plp concentration in blood. |
1998-02-02 |
2023-08-12 |
rat |
| V Rogiers, Y Vandenberghe, T Vanhaecke, A Geerts, A Callaerts, J Carleer, J Roba, A Vercruyss. Observation of hepatotoxic effects of 2-n-pentylaminoacetamide (Milacemide) in rat liver by a combined in vivo/in vitro approach. Archives of toxicology. vol 71. issue 5. 1997-07-01. PMID:9137805. |
body weight and food intake were recorded and at day 7 of exposure, milacemide concentration, glucose, urea, triglycerides and cholesterol levels and alanine (alt) and aspartate aminotransferase (ast) activities were measured in plasma. |
1997-07-01 |
2023-08-12 |
rat |
| M K Reed, C Barak, C R Malloy, S P Maniscalco, M E Jesse. Effects of glutamate and aspartate on myocardial substrate oxidation during potassium arrest. The Journal of thoracic and cardiovascular surgery. vol 112. issue 6. 1997-01-21. PMID:8975857. |
the purpose of this study was to determine the effects of glutamate and aspartate on metabolic pathways feeding the citric acid cycle during cardioplegic arrest in the presence of physiologic substrates. |
1997-01-21 |
2023-08-12 |
Not clear |
| S Boston, G Wobeser, M Gillespi. Consumption of deoxynivalenol-contaminated wheat by mallard ducks under experimental conditions. Journal of wildlife diseases. vol 32. issue 1. 1996-06-24. PMID:8627931. |
no significant differences were detected in serum protein, calcium, glucose, creatinine kinase, aspartate aminotransferase or uric acid levels, blood packed cell volume, or body or organ weight, between ducks fed contaminated wheat and those fed uncontaminated wheat during a 14-day feeding trial. |
1996-06-24 |
2023-08-12 |
Not clear |
| R G Thurman, W Gao, H D Connor, Y Adachi, R F Stachlewitz, Z Zhong, K T Knecht, B U Bradford, R P Mason, J J Lemaster. Role of Kupffer cells in failure of fatty livers following liver transplantation and alcoholic liver injury. Journal of gastroenterology and hepatology. vol 10 Suppl 1. 1996-03-25. PMID:8589336. |
in rats exposed to ethanol continuously via intragastric feeding for up to 4 weeks, gdcl3 treatment prevented elevation of aspartate aminotransferase (ast) and dramatically reduced the average hepatic pathological score. |
1996-03-25 |
2023-08-12 |
rat |
| K Heiskanen, L Salmenperä, J Perheentupa, M A Siime. Infant vitamin B-6 status changes with age and with formula feeding. The American journal of clinical nutrition. vol 60. issue 6. 1994-12-30. PMID:7985632. |
to study the effect of type of feeding on infant vitamin b-6 status, we determined erythrocyte pyridoxal 5'-phosphate concentration (eplp) and erythrocyte aspartate aminotransferase basal activity (easto) and its activation coefficient (alpha east) in 109 infants at 2, 4, 6, 9, and 12 mo of age. |
1994-12-30 |
2023-08-12 |
Not clear |