| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tadashi Okada, Yuichiro Mita, Hideyuki Sakoda, Masamitsu Nakazat. Impaired adaptation of energy intake induces severe obesity in aged mice on a high-fat diet. Physiological reports. vol 7. issue 3. 2020-04-20. PMID:30706678. |
intraperitoneal administration of glp-1 did not induce expression of genes that regulate feeding in the hypothalamus of aged mice. |
2020-04-20 |
2023-08-13 |
mouse |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
this study evaluated the effects of adx on icv (lateral ventricle) injection of insulin-induced changes on food intake, mrna expression of hypothalamic neuropeptides (insulin receptor (insr), proopiomelanocortin, cocaine and amphetamine-regulated transcript (cart), agouti-related protein, neuropeptide y (npy) in the arcuate nucleus of the hypothalamus (arc), corticotrophin-releasing factor in the paraventricular nucleus of the hypothalamus) and hypothalamic protein content of insulin signaling-related molecules (insulin receptor substrate (irs) 1, protein kinase b (akt), extracellular-signal-regulated kinase (erk1/2), c-jun n-terminal kinase (jnk), protein tyrosine phosphatase-1b (ptp1b) and t cell protein tyrosine phosphatase (tcptp)) compared with sham animals, adx increased the hypothalamic content of pjnk/jnk, ptp1b and tcptp, as well as decreased mrna expression of insr, and corticosterone (b) treatment reversed these effects. |
2020-04-06 |
2023-08-13 |
rat |
| Allison B Reiss, Daniel S Glass, Eric Lam, Amy D Glass, Joshua De Leon, Lora J Kasselma. Oxytocin: Potential to mitigate cardiovascular risk. Peptides. vol 117. 2020-04-02. PMID:31112739. |
the neuropeptide hormone oxytocin, synthesized in the brain hypothalamus, is worthy of consideration as a cvd ancillary treatment because it moderates factors directly linked to atherosclerotic cvd such as inflammation, weight gain, food intake and insulin resistance. |
2020-04-02 |
2023-08-13 |
human |
| Pryscila D S Teixeira, Gisele C Couto, Isadora C Furigo, Edward O List, John J Kopchick, Jose Donat. Central growth hormone action regulates metabolism during pregnancy. American journal of physiology. Endocrinology and metabolism. vol 317. issue 5. 2020-03-30. PMID:31479305. |
however, while brain-specific ghr ablation reduced food intake and body adiposity during gestation, lepr ghr knockout (ko) mice exhibited increased leptin responsiveness in the ventromedial nucleus of the hypothalamus during late pregnancy, although their offspring showed reduced growth rate. |
2020-03-30 |
2023-08-13 |
mouse |
| Haocan Luo, Xu-Fang Liang, Jiao Li, Yanpeng Zhang, Qianqian Xiao, Binbin Peng, Zhilu Zhan. Effect of long-chain saturated and unsaturated fatty acids on hypothalamic fatty acid sensing in Chinese perch (Siniperca chuatsi). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 241. 2020-03-25. PMID:31887407. |
and then, oa, la and ala inhibited food intake, which was consistent with the activation of hypothalamus fa sensing. |
2020-03-25 |
2023-08-13 |
Not clear |
| Jane K Cleal, Kimberley D Bruce, Jasmin L Shearer, Hugh Thomas, Jack Plume, Louise Gregory, James N Shepard, Kerry L Spiers-Fitzgerald, Ravi Mani, Rohan M Lewis, Karen A Lillycrop, Mark A Hanson, Christopher D Byrne, Felino R Cagampan. Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring. International journal of molecular sciences. vol 20. issue 21. 2020-03-23. PMID:31671625. |
we investigated whether an obese pregnancy can alter the molecular clock in the offspring hypothalamus, resulting in changes to their activity and feeding rhythms. |
2020-03-23 |
2023-08-13 |
mouse |
| Yi Zhang, Gang Ji, Guanya Li, Yang Hu, Li Liu, Qingchao Jin, Qianqian Meng, Jizheng Zhao, Kai Yuan, Jixn Liu, Karen M von Deneen, Antao Chen, Guangbin Cui, Huaning Wang, Qingchuan Zhao, Kaichun Wu, Jie Tian, Peter Manza, Dardo Tomasi, Nora D Volkow, Yongzhan Nie, Gene-Jack Wan. Ghrelin reductions following bariatric surgery were associated with decreased resting state activity in the hippocampus. International journal of obesity (2005). vol 43. issue 4. 2020-03-11. PMID:29915363. |
ghrelin stimulates appetite and regulates food intake through its effect on the hypothalamus and hippocampus (hipp). |
2020-03-11 |
2023-08-13 |
Not clear |
| Matthew M Hurley, Mykel R Robble, Grace Callan, SuJean Choi, Robert A Wheele. Pituitary adenylate cyclase-activating polypeptide (PACAP) acts in the nucleus accumbens to reduce hedonic drive. International journal of obesity (2005). vol 43. issue 4. 2020-03-11. PMID:30082747. |
in a separate group of rats, pacap was microinjected into the hypothalamus (a region of the brain in which pacap does not attenuate palatable feeding). |
2020-03-11 |
2023-08-13 |
rat |
| Soo Jin Yang, Hyun Ju Do, Youngae Jung, Geum-Sook Hwang, Min-Jeong Shi. Voglibose-mediated alterations in neurometabolomic profiles in the hypothalamus of high-fat diet-fed mice. Nutritional neuroscience. vol 22. issue 11. 2020-02-26. PMID:29495953. |
we hypothesized that vo prevents weight gain by altering neurometabolome profiles in the hypothalamus to reduce food intake. |
2020-02-26 |
2023-08-13 |
mouse |
| Ji-Yao Li, Xiaoyin Wu, Allen Lee, Shi-Yi Zhou, Chung Owyan. Altered R-spondin 1/CART neurocircuit in the hypothalamus contributes to hyperphagia in diabetes. Journal of neurophysiology. vol 121. issue 3. 2020-02-25. PMID:30649980. |
new & noteworthy this study reports that cocaine and amphetamine-regulated transcript (cart) neurons in the arcuate nucleus (arc) of hypothalamus acted downstream of r-spondin 1 (rspo1) to inhibit food intake. |
2020-02-25 |
2023-08-13 |
rat |
| Kartik T Nakhate, Nishikant K Subhedar, Dadasaheb M Kokar. Involvement of neuropeptide CART in the central effects of insulin on feeding and body weight. Pharmacology, biochemistry, and behavior. vol 181. 2020-02-25. PMID:31054945. |
the present study was undertaken to reveal the functional interaction between cocaine- and amphetamine-regulated transcript (cart), a well-known anorexic peptide, and insulin within the framework of hypothalamus in the regulation of feeding behavior and body weight. |
2020-02-25 |
2023-08-13 |
rat |
| Ke Deng, Lu Yang, Jing Xie, He Tang, Gui-Sheng Wu, Huai-Rong Lu. Whole-brain mapping of projection from mouse lateral septal nucleus. Biology open. vol 8. issue 7. 2020-02-25. PMID:31208998. |
the lateral septal nucleus (ls) plays a critical role in emotionality, social behavior and feeding processes, through neural connections with the hippocampus and hypothalamus. |
2020-02-25 |
2023-08-13 |
mouse |
| Lynda Saber Cherif, Grégory Pourié, Andréa Geoffroy, Amélia Julien, Déborah Helle, Aurélie Robert, Rémy Umoret, Jean-Louis Guéant, Carine Bossenmeyer-Pourié, Jean-Luc Dava. Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus. International journal of molecular sciences. vol 20. issue 20. 2020-02-21. PMID:31615150. |
energy homeostasis and feeding are centrally regulated by the hypothalamus which integrates peripheral signals and acts through several orexigenic and anorexigenic mediators. |
2020-02-21 |
2023-08-13 |
rat |
| Austin P Dreyer, Madison M Martin, Carson V Fulgham, Daniel A Jabr, Lei Bai, Jennifer Beshel, Daniel J Cavanaug. A circadian output center controlling feeding:fasting rhythms in Drosophila. PLoS genetics. vol 15. issue 11. 2020-02-18. PMID:31693685. |
here, building on the conserved components of circadian and metabolic systems in mammals and drosophila melanogaster, we used a recently developed feeding monitor to characterize the contribution to circadian feeding rhythms of two key neuronal populations in the drosophila pars intercerebralis (pi), which is functionally homologous to the mammalian hypothalamus. |
2020-02-18 |
2023-08-13 |
drosophila_melanogaster |
| Qi Li, Jieheng Wu, Wenjin Xi, Xu Chen, Wei Wang, Tianze Zhang, Angang Yang, Tao Wan. Ctrp4, a new adipokine, promotes the differentiation of osteoblasts. Biochemical and biophysical research communications. vol 512. issue 2. 2020-02-07. PMID:30885436. |
studies have shown that ctrp4 is involved in the regulation of tumor cell inflammatory signaling pathways and acts on the hypothalamus to regulate food intake, but its role in osteoblasts is not yet clear. |
2020-02-07 |
2023-08-13 |
mouse |
| Vanessa C D Bobbo, Carlos P Jara, Natália F Mendes, Joseane Morari, Lício A Velloso, Eliana P Araúj. Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review. BioMed research international. vol 2019. 2020-02-06. PMID:31534953. |
specific neurons of the hypothalamus provide important signals to control food intake and energy expenditure. |
2020-02-06 |
2023-08-13 |
Not clear |
| Yoseph Aldras, Sanghamitra Singh, Katrin Bode, Diti Chatterjee Bhowmick, Aleksandar Jeremic, Damien M O'Hallora. An inducible model of human amylin overexpression reveals diverse transcriptional changes. Neuroscience letters. vol 704. 2020-02-05. PMID:30974231. |
amylin has been shown to function within the central nervous system to decrease food intake, and more recently, it has been revealed that amylin is directly transcribed from neurons of the central nervous system, including the hypothalamus, arcuate nucleus, medial preoptic area, and nucleus accumbens. |
2020-02-05 |
2023-08-13 |
human |
| Valentina Vozella, Natalia Realini, Alessandra Misto, Daniele Piomell. Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. International journal of molecular sciences. vol 20. issue 16. 2020-02-04. PMID:31426457. |
feeding stimulates sphingosine-1-phosphate mobilization in mouse hypothalamus. |
2020-02-04 |
2023-08-13 |
mouse |
| Valentina Vozella, Natalia Realini, Alessandra Misto, Daniele Piomell. Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. International journal of molecular sciences. vol 20. issue 16. 2020-02-04. PMID:31426457. |
previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (s1p) reduces food intake by activating g protein-coupled s1p receptor-1 (s1pr1) in the hypothalamus. |
2020-02-04 |
2023-08-13 |
mouse |
| Valentina Vozella, Natalia Realini, Alessandra Misto, Daniele Piomell. Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. International journal of molecular sciences. vol 20. issue 16. 2020-02-04. PMID:31426457. |
we prepared lipid extracts from the hypothalamus of c57bl6/j male mice subjected to one of four conditions: free feeding, 12 h fasting, and 1 h or 6 h refeeding. |
2020-02-04 |
2023-08-13 |
mouse |