| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evelyn Gutierrez, Patricia Joseph, Christos Noutsos, Kinning Poo. Hypothalamic and hippocampal transcriptome changes in App Neuroscience. 2024-07-13. PMID:39002757. |
the hypothalamus is a brain region that exerts homeostatic control on food intake and metabolism and has been noted to be impacted during the active phase of alzheimer's disease. |
2024-07-13 |
2024-07-16 |
Not clear |
| Hui Ye, Xiaohua Yang, Bing Feng, Pei Luo, Valeria C Torres Irizarry, Leslie Carrillo-Sáenz, Meng Yu, Yongjie Yang, Benjamin P Eappen, Marcos David Munoz, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Penghua Lai, Xinyue Qi, Yuliang Zhou, Maya Kota, Devin Dixit, Madeline Mun, Chong Wee Liew, Yuwei Jiang, Chunmei Wang, Yanlin He, Pingwen X. 27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior. Science advances. vol 10. issue 28. 2024-07-12. PMID:38996023. |
supporting this view, we found that delivering 27hc to the brain reduced food intake and activated proopiomelanocortin (pomc) neurons in the arcuate nucleus of the hypothalamus (pomc |
2024-07-12 |
2024-07-15 |
Not clear |
| Li Li, Ciria C Hernandez, Luis E Gimenez, Baijie Xu, Naima S Dahir, Swati, Shari G Birnbaum, Roger D Cone, Chen Li. Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895206. |
our study shows that clozapine boosts food intake by inhibiting melanocortin 4 receptor (mc4r) expressing neurons in the paraventricular nucleus of the hypothalamus. |
2024-06-19 |
2024-06-21 |
mouse |
| Alys Peisley, Ciria C Hernandez, Naima S Dahir, Laura Koepping, Ashleigh Raczkowski, Min Su, Masoud Ghamari-Langroudi, Xinrui Ji, Luis E Gimenez, Roger D Con. Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895219. |
we also demonstrate the structural basis for the blockade of the channel by a small molecule ml418 and demonstrate that channel blockade in vivo activates mc4r neurons in the paraventricular nucleus of the hypothalamus (pvh), inhibiting food intake and inducing weight loss. |
2024-06-19 |
2024-06-21 |
human |
| Feng Rao, Tian Xu. Circadian-independent light regulation of mammalian metabolism. Nature metabolism. 2024-06-03. PMID:38831000. |
such light regulation could involve melanopsin-based, intrinsically photosensitive retinal ganglion cell-initiated brain circuits via the suprachiasmatic nucleus of the hypothalamus and other nuclei, or direct stimulation of opsins expressed in the hypothalamus, adipose tissue, blood vessels and skin to regulate sympathetic tone, lipolysis, glucose uptake, mitochondrial activation, thermogenesis, food intake, blood pressure and melanogenesis. |
2024-06-03 |
2024-06-06 |
Not clear |
| Katharina Voigt, Zane B Andrews, Ian H Harding, Adeel Razi, Antonio Verdejo-Garcí. Hypothalamic effective connectivity at rest is associated with body weight and energy homeostasis. Network neuroscience (Cambridge, Mass.). vol 6. issue 4. 2024-05-27. PMID:38800453. |
the hypothalamus is a central component of the brain networks that regulate food intake. |
2024-05-27 |
2024-05-31 |
human |
| Max Tweedale, Filip Morys, Alexandre Pastor-Bernier, Houman Azizi, Christina Tremblay, Alain Daghe. Obesity and diffusion-weighted imaging of subcortical grey matter in young and older adults. Appetite. 2024-05-26. PMID:38797235. |
internal and external factors mediate patterns of food intake and how it can affect the hypothalamus. |
2024-05-26 |
2024-05-31 |
Not clear |
| Zhenyu Zhang, Hua Zhao, Xiaoling Chen, Gang Tian, Guangmang Liu, Jingyi Cai, Gang Ji. Implications of Jatropha curcas L. cake feed on swine health: A microbiota-gut-brain axis perspective. Animal science journal = Nihon chikusan Gakkaiho. vol 95. issue 1. 2024-05-24. PMID:38783533. |
symptoms included depression, decreased food intake, increased diarrhea, along with hypothalamus and colon lesions. |
2024-05-24 |
2024-05-27 |
Not clear |
| Natalia Marhefkova, Martin Sládek, Alena Sumová, Michal Dubsk. Circadian dysfunction and cardio-metabolic disorders in humans. Frontiers in endocrinology. vol 15. 2024-05-14. PMID:38742195. |
the circadian system comprises the central clock, located in the suprachiasmatic nucleus of the hypothalamus, and the peripheral clocks in various tissues that are interconnected; together they coordinate many daily activities, including sleep and wakefulness, physical activity, food intake, glucose sensitivity and cardiovascular functions. |
2024-05-14 |
2024-05-27 |
human |
| Ying Zhu, Lifeng Yin, Qing Liu, Yaoxing Guan, Shuang Nie, Yongheng Zhu, Fengfeng M. Tryptophan metabolic pathway plays a key role in the stress-induced emotional eating. Current research in food science. vol 8. 2024-05-13. PMID:38736909. |
tryptophan supplementation improved the abnormal expression of appetite regulators (e.g., agrp, ox1r, mc4r), and tryptophan supplementation also increased the tryptophan hydroxylase 2 (tph2) and 5-ht receptors in the hypothalamus of cms mice, which indicates that the 5-ht metabolic pathway influences feeding behavior. |
2024-05-13 |
2024-05-27 |
mouse |
| Russell T Turner, Adam J Branscum, Urszula T Iwanie. Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats. Bone reports. vol 21. 2024-05-06. PMID:38706522. |
however, in contrast to hypothalamus, leptin transgene expression in the dvc had no effect on food intake, circulating insulin, ghrelin and glucose, nor on thermogenic energy expenditure. |
2024-05-06 |
2024-05-08 |
rat |
| Norma Serrano-García, Raúl Pinete-Sánchez, Omar Noel Medina-Campos, Minerva Adriana Ramos-Santander, José Pedraza-Chaverri, Marisol Orozco-Ibarr. Cobalt protoporphyrin modulates antioxidant enzyme activity in the hypothalamus and motor cortex of female rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 4. 2024-04-28. PMID:38678627. |
moreover, it led to an increase in sod activity in the hypothalamus, a pivotal brain region associated with food intake regulation. |
2024-04-28 |
2024-05-01 |
rat |
| G Cutugno, E Kyriakidou, A Nadja. Rethinking the role of microglia in obesity. Neuropharmacology. 2024-04-14. PMID:38615749. |
our literature review focuses on studies conducted in the arcuate nucleus of the hypothalamus, a key structure in the control of food intake. |
2024-04-14 |
2024-04-17 |
Not clear |
| Gisele Castro, Natália Ferreira Mendes, Laís Weissmann, Paula Gabriele Fernandes Quaresma, Mario Jose Abdalla Saad, Patricia Oliveira Prad. Multiple metabolic signals in the CeA regulate feeding: The role of AMPK. Molecular and cellular endocrinology. 2024-04-11. PMID:38604549. |
amp-activated protein kinase (ampk) is a cellular energy sensor, and its thr172 phosphorylation (ampkthr172) in the mediobasal hypothalamus regulates food intake. |
2024-04-11 |
2024-04-14 |
Not clear |
| Veronika Strnadová, Andrea Pačesová, Vilém Charvát, Zuzana Šmotková, Blanka Zelezna, Jaroslav Kunes, Lenka Maletinsk. Anorexigenic neuropeptides as anti-obesity and neuroprotective agents. Bioscience reports. 2024-04-05. PMID:38577975. |
promising candidates for the treatment of obesity are anorexigenic neuropeptides, which are peptides produced by neurons in brain areas implicated in food intake regulation, such as the hypothalamus or the brainstem. |
2024-04-05 |
2024-04-07 |
Not clear |
| Yi Huang, Anyongqi Wang, Wenjiang Zhou, Baoguo Li, Linshan Zhang, Agata M Rudolf, Zengguang Jin, Catherine Hambly, Guanlin Wang, John R Speakma. Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice. Nature communications. vol 15. issue 1. 2024-03-17. PMID:38493217. |
here we combined metabolic trait quantification of mother and offspring mice under low and high fat diet (hfd) feeding during lactation, with single nucleus transcriptomic profiling of their offspring hypothalamus at peak lacation to understand the cellular and molecular alterations in response to maternal dietary pertubation. |
2024-03-17 |
2024-03-19 |
mouse |
| Daniil Grinchii, Viera Kominkova, Eliyahu Dremenco. Putative identification of proopiomelanocortin and neuropeptide-Y neurons of the arcuate nucleus by their response to leptin: in vivo electrophysiology study in male and female rats. General physiology and biophysics. 2024-02-22. PMID:38385362. |
the arcuate nucleus (arn) of the hypothalamus is involved in multiple biological functions, such as feeding, sexual activity, and the regulation of the cardiovascular system. |
2024-02-22 |
2024-02-24 |
rat |
| Shupeng Zhang, Yongpei Lu, Yanling Liu, Mei Wang, Shaoqi Xu, Ya Li, Hongwei Wu, Qaolin Pei, Lei Yang, Lu Lu, Yixiao Xiong, Youlian Liu, Shuhuang Chen, Qin Yao, Qin Kang, Yingzi Li, Defang Chen, Xin Zhang, Ni Tang, Zhiqiong L. Neglected function of gastrin to reduce feeding in Siberian sturgeon (Acipenser baerii) via cholecystokinin receptor B. Fish physiology and biochemistry. 2024-02-21. PMID:38381278. |
in the duodenum, gastrin and cckrb mrnas were reduced at 1 h of fasting, and both were also observed in the stomach and hypothalamus in response to changes in feeding status. |
2024-02-21 |
2024-02-23 |
Not clear |
| Joshua Ortiz-Guzman, Jessica L Swanson, Evelyne K Tantry, Mikhail Kochukov, Kevin Ung, Angela P Addison, Snigdha Srivastava, Benjamin D Belfort, Emily Ji, Sean W Dooling, Sarah A Chen, Qingchun Tong, Benjamin R Arenkie. Cholinergic basal forebrain connectivity to the basolateral amygdala modulates food intake. eNeuro. 2024-02-21. PMID:38383587. |
the hypothalamus has received significant attention for its role in governing feeding behavior and body weight homeostasis. |
2024-02-21 |
2024-02-24 |
mouse |
| Han Jiao, Yongjin Wang, Kang Fu, Xiaoao Xiao, Mo-Qiu Jia, Jia Sun, Jingxiao Wang, Guoqing Zhu, Daying Lyu, Qiulun Lu, Yu Peng, Juan Lv, Li Su, Yuanqing Ga. An orexin-receptor-2-mediated heart-brain axis in cardiac pain. iScience. vol 27. issue 3. 2024-02-16. PMID:38361621. |
orexin is a neuropeptide released from hypothalamus regulating feeding, sleeping, arousal, and cardiovascular activity. |
2024-02-16 |
2024-02-18 |
Not clear |