| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Sells, S L Katyal, S Sell, H Shinozuka, B Lombard. Induction of foci of altered, gamma-glutamyltranspeptidase-positive hepatocytes in carcinogen-treated rats fed a choline-deficient diet. British journal of cancer. vol 40. issue 2. 1979-11-29. PMID:89859. |
a series of experiments was performed to investigate whether, after exposure of rats to a chemical hepatocarcinogen, feeding a choline-deficient (cd) diet would promote the proliferation of initiated liver cells, and their evolution to foci of altered γ-glutamyltranspeptidase (ggt)-positive hepatocytes, without subjecting the animals to further experimental manipulations.diethylnitrosamine (den), in single doses of 15-150 mg/kg body weight, was injected into male, sprague-dawley rats, either intact or 18 h after a partial hepatectomy (ph). |
1979-11-29 |
2023-08-11 |
rat |
| M A Sells, S L Katyal, S Sell, H Shinozuka, B Lombard. Induction of foci of altered, gamma-glutamyltranspeptidase-positive hepatocytes in carcinogen-treated rats fed a choline-deficient diet. British journal of cancer. vol 40. issue 2. 1979-11-29. PMID:89859. |
in all cases, foci of altered, ggt+ hepatocytes were shown to be α-foetoprotein after immunofluorescence staining of liver sections.it is concluded that feeding a cd diet exerts a strong promoting action on the proliferation and further evolution of liver cells initiated by a chemical carcinogen, providing the basis for a new and efficient procedure for the induction of foci of altered hepatocytes in rat liver. |
1979-11-29 |
2023-08-11 |
rat |
| E M Yuhas, T S Miya, R C Schnel. Dose-related alterations in growth and mineral disposition by chronic oral cadmium administration in the male rat. Toxicology. vol 12. issue 1. 1979-10-24. PMID:473222. |
terminal body weight was decreased by 10% in rats ingesting cd at 100 ppm resulting from decreased food intake since weight gain/food consumption ratio was the same for all treatment groups. |
1979-10-24 |
2023-08-11 |
rat |
| B Lombardi, H Shinozuk. Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet. International journal of cancer. vol 23. issue 4. 1979-07-16. PMID:220201. |
the effects of feeding a choline-devoid (cd) or a choline-supplemented (cs) diet on the induction of liver tumors in rats by 2-acetylaminofluorene (aaf) were investigated. |
1979-07-16 |
2023-08-11 |
rat |
| B Lombardi, H Shinozuk. Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet. International journal of cancer. vol 23. issue 4. 1979-07-16. PMID:220201. |
the results extend to aaf those previously obtained with dl-ethionine and azaserine showing that feeding a cd diet greatly potentiates the induction in rats of liver tumors by chemical carcinogens. |
1979-07-16 |
2023-08-11 |
rat |
| M P Verma, R P Sharma, J C Stree. Hepatic and renal metallothionein concentrations in cows, swine, and chickens given cadmium and lead in feed. American journal of veterinary research. vol 39. issue 12. 1979-06-11. PMID:749574. |
the hepatic mt values in pigs and chickens and the renal mt values in all species continued to increase for several weeks after cd feeding was stopped. |
1979-06-11 |
2023-08-11 |
cattle |
| A K Palmer, D D Cozens, E J Spicer, A N Worde. Effects of lindane upon reproductive function in a 3-generation study in rats. Toxicology. vol 10. issue 1. 1978-09-30. PMID:79243. |
a 3-generation study, involving the feeding of lindane at dietary concentrations of 25, 50 or 100 ppm to cd strain rats, did not reveal any adverse effects upon reproductive function as compared with that of control animals. |
1978-09-30 |
2023-08-11 |
rat |
| H Shinozuka, B Lombardi, S Sell, R M Iammarin. Early histological and functional alterations of ethionine liver carcinogenesis in rats fed a choline-deficient diet. Cancer research. vol 38. issue 4. 1978-06-17. PMID:76508. |
the effects of feeding a choline-deficient (cd) or a choline-supplemented diet upon the early stages of dl-ethionine carcinogenesis in rat liver were investigated. |
1978-06-17 |
2023-08-11 |
rat |
| K W Boyer, S G Capa. Fortification variability in rat diets fortified with arsenic, cadmium, and lead. Journal of toxicology and environmental health. vol 3. issue 4. 1978-02-18. PMID:563476. |
eleven rat diets fortified with 200 ppm pb as lead acetate, and/or 50 ppm cd as cadmium chloride, and/or 50 ppm as as sodium arsenate or p-arsanilic acid for use in a feeding study to determine the interactive effects of the three elements in rats were analyzed to confirm the fortification levels. |
1978-02-18 |
2023-08-11 |
rat |
| K R Mahaffey, B A Fowle. Effects of concurrent administration of lead, cadmium, and arsenic in the rat. Environmental health perspectives. vol 19. 1977-11-30. PMID:198203. |
at these concentrations, cd and as reduced weight gain even when differences in food intake were taken into account; administration of both cd and as depressed weight gain more than did either metal alone. |
1977-11-30 |
2023-08-11 |
rat |
| F M Bion, J S Nascimento, N L Antunes, D C Pessoa, E S Lago, L P Freitas, M A Coelho, R B Medeiro. [Nutritive value of sunflower seeds (Helianthus annus) (author's transl)]. Revista brasileira de pesquisas medicas e biologicas. vol 10. issue 4. 1977-11-25. PMID:905604. |
the results indicate that due to its high protein level (52.06%) and coefficient of digestibility (95 cd) sunflower can be used as a feeding formula although its per does not recommend its use as a milk substitute. |
1977-11-25 |
2023-08-11 |
rat |
| P Washko, R J Cousin. Role of dietary calcium and calcium binding protein in cadmium toxicity in rats. The Journal of nutrition. vol 107. issue 5. 1977-06-30. PMID:192863. |
it was concluded, based upon these experiments, that cadmium retention and signs of toxicity are enhanced by feeding low ca diet and that the increased cabp activity due to ca restrictions is responsible for the increased cd uptake observed. |
1977-06-30 |
2023-08-11 |
rat |
| J J Doyle, R A Bernhoft, H H Sandstea. The effects of a low level of dietary cadmium on blood pressure, '24Na, '42K, andwater retention in growing rats. The Journal of laboratory and clinical medicine. vol 86. issue 1. 1975-11-08. PMID:1151143. |
the effects of 5 pg cd per millilter of drinking water on body weight gain, food intake, systolic blood pressure, '24na, '42k; and water retention and freference for nacl solution in male and female rats were studied. |
1975-11-08 |
2023-08-11 |
rat |
| J J Doyle, R A Bernhoft, H H Sandstea. The effects of a low level of dietary cadmium on blood pressure, '24Na, '42K, andwater retention in growing rats. The Journal of laboratory and clinical medicine. vol 86. issue 1. 1975-11-08. PMID:1151143. |
after 205 days, cd had no significant effect on weight gain, food intake, water intake, or feed efficiency. |
1975-11-08 |
2023-08-11 |
rat |