Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Hanfang Xu, Bozhi Li, Ling Li, Zhixin Fan, Xiayu Gong, Lili Wu, Can Ya. Environmental enrichment mitigates PTSD-like behaviors in adult male rats exposed to early life stress by regulating histone acetylation in the hippocampus and amygdala. Journal of psychiatric research. vol 155. 2022-08-27. PMID:36029624. |
we found that adult male rats exposed to els showed behavioral changes, including reduced locomotor activity, increased anxiety-like behaviors, impaired spatial learning and memory, enhanced contextual and cued fear memory, and the hats/hdacs ratio and acetyl h3k9 (ac-h3k9) and acetyl h4k12 (ac-h4k12) were increased in the hippocampus and decreased in the amygdala. |
2022-08-27 |
2023-08-14 |
rat |
Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
furthermore, in the hippocampal microglia, we found that the expression of neurotransmitter release regulators, γ-aminobutyric acid (gaba) receptor gabrb3 and synapsin 1/2, increased under fear memory consolidation and restored (decreased) after extinction. |
2022-08-20 |
2023-08-14 |
mouse |
Bongjun Sur, Bombi Le. Ginsenoside Rg3 modulates spatial memory and fear memory extinction by the HPA axis and BDNF-TrkB pathway in a rat post-traumatic stress disorder. Journal of natural medicines. 2022-08-18. PMID:35982366. |
rg3 administration improved fear memory and spatial memory might be involved in modulating the dysregulation of the hypothalamic-pituitary-adrenal (hpa) axis and monoamine imbalance in the medial prefrontal cortex and hippocampus. |
2022-08-18 |
2023-08-14 |
rat |
Yosif Zaki, William Mau, Christine Cincotta, Amy Monasterio, Emma Odom, Emily Doucette, Stephanie L Grella, Emily Merfeld, Monika Shpokayte, Steve Ramire. Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-08-08. PMID:35941286. |
hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse. |
2022-08-08 |
2023-08-14 |
mouse |
Fernando Midea Cuccovia V Reis, Leonardo Santana Novaes, Nilton Barreto Dos Santos, Kélvia Carolina Ferreira-Rosa, Juliano Genaro Perfetto, Marcus Vinicius C Baldo, Carolina Demarchi Munhoz, Newton Sabino Cantera. Predator fear memory depends on glucocorticoid receptors and protein synthesis in the basolateral amygdala and ventral hippocampus. Psychoneuroendocrinology. vol 141. 2022-04-15. PMID:35427951. |
predator fear memory depends on glucocorticoid receptors and protein synthesis in the basolateral amygdala and ventral hippocampus. |
2022-04-15 |
2023-08-13 |
Not clear |
Fernando Midea Cuccovia V Reis, Leonardo Santana Novaes, Nilton Barreto Dos Santos, Kélvia Carolina Ferreira-Rosa, Juliano Genaro Perfetto, Marcus Vinicius C Baldo, Carolina Demarchi Munhoz, Newton Sabino Cantera. Predator fear memory depends on glucocorticoid receptors and protein synthesis in the basolateral amygdala and ventral hippocampus. Psychoneuroendocrinology. vol 141. 2022-04-15. PMID:35427951. |
previous studies have suggested that the basolateral amygdala (bla) and the ventral hippocampus (vh) are critical sites for predator-related fear memory. |
2022-04-15 |
2023-08-13 |
Not clear |
Hee Ra Park, Mudan Cai, Eun Jin Yan. Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35408943. |
neurogenic interventions for fear memory via modulation of the hippocampal function and neural circuits. |
2022-04-12 |
2023-08-13 |
Not clear |
Abby Basya Finkelstein, Héloïse Leblanc, Rebecca H Cole, Troy Gallerani, Anahita Vieira, Yosif Zaki, Steve Ramire. Social reactivation of fear engrams enhances memory recall. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 12. 2022-03-14. PMID:35286206. |
our work reveals that exposure to a stressed, naïve nonfamiliar conspecific or to the ambient olfactory-auditory cues of a recently stressed familiar conspecific induces reactivation of the cellular ensembles associated with a fear memory in the hippocampus. |
2022-03-14 |
2023-08-13 |
Not clear |
Hiroyuki Miyawaki, Kenji Mizusek. De novo inter-regional coactivations of preconfigured local ensembles support memory. Nature communications. vol 13. issue 1. 2022-03-12. PMID:35277492. |
neuronal ensembles in the amygdala, ventral hippocampus, and prefrontal cortex are involved in fear memory; however, how inter-regional ensemble interactions support memory remains elusive. |
2022-03-12 |
2023-08-13 |
rat |
Dongwook Kim, Hyeji Jung, Yoshinori Shirai, Hyeonho Kim, Jinhu Kim, Dongseok Lim, Takuma Mori, Hyojeong Lee, Dongseok Park, Hee Young Kim, Qi Guo, Bo Pang, Wen Qiu, Xueshan Cao, Emi Kouyama-Suzuki, Takeshi Uemura, Enas Kasem, Yu Fu, Seungjoon Kim, Akinori Tokunaga, Takahiro Yoshizawa, Tatsuo Suzuki, Hiroyuki Sakagami, Kea Joo Lee, Jaewon Ko, Katsuhiko Tabuchi, Ji Won U. IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus. Biological psychiatry. 2022-02-27. PMID:35219498. |
iqsec3 deletion impairs fear memory through upregulation of ribosomal s6k1 signaling in the hippocampus. |
2022-02-27 |
2023-08-13 |
Not clear |
Changsheng Li, Sufang Liu, Yixin Mei, Qingyong Wang, Xihua Lu, Hongle Li, Feng Ta. Differential Effects of Sevoflurane Exposure on Long-Term Fear Memory in Neonatal and Adult Rats. Molecular neurobiology. 2022-02-24. PMID:35201592. |
we observed that early exposure to sevoflurane in neonatal rats impairs hippocampus-dependent fear memory, reduces hippocampal synapse density, and dramatically decreases the expressions of psd-95 and kalirin-7 in the hippocampus of the developing brain. |
2022-02-24 |
2023-08-13 |
rat |
Changsheng Li, Sufang Liu, Yixin Mei, Qingyong Wang, Xihua Lu, Hongle Li, Feng Ta. Differential Effects of Sevoflurane Exposure on Long-Term Fear Memory in Neonatal and Adult Rats. Molecular neurobiology. 2022-02-24. PMID:35201592. |
however, sevoflurane exposure in adult rats has no effects on hippocampus-dependent fear memory and hippocampal synapse density, and the expressions of psd-95 and kalirin-7 in the adult hippocampus are not significantly altered following sevoflurane treatment. |
2022-02-24 |
2023-08-13 |
rat |
Zu-Cheng Shen, Zhi-Xuan Xia, Jian-Min Liu, Jie-Yan Zheng, Yu-Fei Luo, Han Yang, Meng-Die Li, Ting Cao, Hai-Ping Liu, Gui-Lin Jin, Hui-Hui Huang, Chang-Xi Yu, Jun Zho. APT1-mediated de-palmitoylation regulates hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-02-15. PMID:35165175. |
herein, we employed acyl-biotin exchange, co-immunoprecipitation and biotinylation assays, and behavioral and electrophysiological methods, to explore whether palmitoylation is required for hippocampal synaptic transmission and fear memory formation, and involved in functional modification of synaptic proteins such as psd-95 and glutamate receptors, and detected if de-palmitoylation by specific enzymes has influence on glutamatergic synaptic plasticity. |
2022-02-15 |
2023-08-13 |
rat |
Zu-Cheng Shen, Zhi-Xuan Xia, Jian-Min Liu, Jie-Yan Zheng, Yu-Fei Luo, Han Yang, Meng-Die Li, Ting Cao, Hai-Ping Liu, Gui-Lin Jin, Hui-Hui Huang, Chang-Xi Yu, Jun Zho. APT1-mediated de-palmitoylation regulates hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-02-15. PMID:35165175. |
results from hippocampal tissues and fear-conditioned rats showed that palmitoylation is required for synaptic strengthening and fear memory formation. |
2022-02-15 |
2023-08-13 |
rat |
Marta Celorrio, Kirill Shumilov, Camryn Payne, Sangeetha Vadivelu, Stuart H Fries. Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury. Acta neuropathologica communications. vol 10. issue 1. 2022-01-29. PMID:35090569. |
we then conducted a preclinical trial to assess the long-term efficacy of a short course of minocycline finding reductions in hippocampal neurodegeneration and synapse loss, preservation of white matter myelination, and improvements in fear memory performance at 6 months after injury. |
2022-01-29 |
2023-08-13 |
human |
Brett S East, Lauren R Brady, Jennifer J Quin. Differential Effects of Lateral and Medial Entorhinal Cortex Lesions on Trace, Delay and Contextual Fear Memories. Brain sciences. vol 12. issue 1. 2022-01-21. PMID:35053778. |
the entorhinal cortex (ec), with connections to the hippocampus, amygdala, and neocortex, is a critical, yet still underexplored, contributor to fear memory. |
2022-01-21 |
2023-08-13 |
rat |
Juan Wang, Feng Gao, Shuai Cui, Shaojie Yang, Fang Gao, Xuncui Wang, Guoqi Zh. Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD. Pharmacological research. 2022-01-13. PMID:35026406. |
acute or continuous intraperitoneal administration of 7,8-dhf (5mg/kg) after sps&s procedures prevented sps&s-induced fear memory generalization and anxiety-like behaviors as well as abnormalities of hippocampal oscillations. |
2022-01-13 |
2023-08-13 |
mouse |
Yuki Kambe, Thu Nguyen Thi, Kohei Hashiguchi, Yoshimune Sameshima, Akira Yamashita, Takashi Kurihara, Atsuro Miyat. The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice. Journal of pharmacological sciences. vol 148. issue 1. 2021-12-20. PMID:34924114. |
protein targeting to glycogen (ptg) is a crucial molecule for glycogenesis, and its expression level is shown to be increased in the dorsal hippocampus during fear memory acquisition and recall, suggesting that ptg may contribute to the memory process. |
2021-12-20 |
2023-08-13 |
mouse |
Nader Asadian, Houman Parsaie, Abbas Ali Vafaei, Masoumeh Dadkhah, Samira Omoumi, Katayoun Sedagha. Chronic light deprivation induces different effects on spatial and fear memory and hippocampal BDNF/TRKB expression during light and dark phases of rat diurnal rhythm. Behavioural brain research. vol 418. 2021-12-11. PMID:34695541. |
chronic light deprivation induces different effects on spatial and fear memory and hippocampal bdnf/trkb expression during light and dark phases of rat diurnal rhythm. |
2021-12-11 |
2023-08-13 |
human |
Hiroko Ikeda, Shogo Yamamoto, Junzo Kame. Increase in brain l-lactate enhances fear memory in diabetic mice: Involvement of glutamate neurons. Brain research. vol 1767. 2021-12-09. PMID:34129854. |
l-lactate levels in the amygdala and hippocampus, which are known to play important roles in fear memory, were significantly increased in stz-induced diabetic mice. |
2021-12-09 |
2023-08-13 |
mouse |