| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicola Pluchino, Elena Lenzi, Sara Merlini, Andrea Giannini, Alessandra Cubeddu, Elena Casarosa, Silvia Begliuomini, Michele Luisi, Vito Cela, Andrea Riccardo Genazzan. Selective effect of chlormadinone acetate on brain allopregnanolone and opioids content. Contraception. vol 80. issue 1. 2009-09-15. PMID:19501216. |
the purpose of the present study was to evaluate the neuroendocrine effect of chlormadinone acetate (cma) administration, analyzing the brain content of allopregnanolone (allo), an endogenous neurosteroid gamma-aminobutyric acid agonist with anxiolytic properties, and the brain level of beta-endorphin (beta-end), an endogenous opioid implicated in pain mechanism, emotional state and autonomic control. |
2009-09-15 |
2023-08-12 |
Not clear |
| Graziano Pinna, Erminio Costa, Alessandro Guidott. SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Current opinion in pharmacology. vol 9. issue 1. 2009-07-14. PMID:19157982. |
thus, fluoxetine and related congeners facilitate gaba(a) receptor neurotransmission and effectively ameliorate emotional and anxiety disorders and depression by acting as selective brain steroidogenic stimulants (sbsss). |
2009-07-14 |
2023-08-12 |
mouse |
| E Engin, J Stellbrink, D Treit, C T Dickso. Anxiolytic and antidepressant effects of intracerebroventricularly administered somatostatin: behavioral and neurophysiological evidence. Neuroscience. vol 157. issue 3. 2009-04-14. PMID:18940236. |
however, despite its extensive expression in limbic areas, and its co-localization with gaba, a neurotransmitter previously implicated in emotion, the effects of sst on anxiety and depression have not been investigated. |
2009-04-14 |
2023-08-12 |
rat |
| C I Dixon, T W Rosahl, D N Stephen. Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. Pharmacology, biochemistry, and behavior. vol 90. issue 1. 2008-08-28. PMID:18313124. |
targeted deletion of the gabra2 gene encoding alpha2-subunits of gaba(a) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. |
2008-08-28 |
2023-08-12 |
mouse |
| C I Dixon, T W Rosahl, D N Stephen. Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. Pharmacology, biochemistry, and behavior. vol 90. issue 1. 2008-08-28. PMID:18313124. |
mice with point-mutated alpha2 gaba(a) receptor subunits (rendering them diazepam insensitive) are resistant to the anxiolytic-like effects of benzodiazepines (bzs) in the conditioned emotional response (cer) test, but show normal anxiolytic effects of a barbiturate. |
2008-08-28 |
2023-08-12 |
mouse |
| Fabio Pibiri, Marianela Nelson, Alessandro Guidotti, Erminio Costa, Graziano Pinn. Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 14. 2008-06-10. PMID:18391192. |
skf 105,111 (a potent 5alpha-ri inhibitor) decreases corticolimbic allo levels and enhances the contextual fear response in group housed mice, which suggests that social isolation alters emotional responses by reducing the positive allosteric modulation of allo at gaba(a) receptors in corticolimbic circuits. |
2008-06-10 |
2023-08-12 |
mouse |
| Naoki Shigematsu, Kenji Yamamoto, Shun Higuchi, Takaichi Fukud. An immunohistochemical study on a unique colocalization relationship between substance P and GABA in the central nucleus of amygdala. Brain research. vol 1198. 2008-06-02. PMID:18243164. |
these data suggest a unique mode of synaptic transmission at amygdalar sp-containing terminals where slowly-acting sp is concentrated but both gaba and its synthetic enzyme are maintained at low levels, possibly underlying long-lasting responses in emotions. |
2008-06-02 |
2023-08-12 |
Not clear |
| Z Bhagwagar, P J Cowe. 'It's not over when it's over': persistent neurobiological abnormalities in recovered depressed patients. Psychological medicine. vol 38. issue 3. 2008-05-05. PMID:18444278. |
these abnormalities encompass a number of neurochemical and neuropsychological mechanisms that could be relevant to recurrence, including changes in the availability of serotonin (5-hydroxytryptamine, 5-ht) receptor subtypes, decreases in cortical gamma-aminobutyric acid (gaba), increases in cortisol secretion and negative biases in the processing of emotional information. |
2008-05-05 |
2023-08-12 |
Not clear |
| Marcos Tomanik Mercadante, Roberta Monterazzo Cysneiros, José Salomão Schwartzman, Ricardo Mario Arida, Esper Abrão Cavalheiro, Fulvio Alexandre Scorz. Neurogenesis in the amygdala: a new etiologic hypothesis of autism? Medical hypotheses. vol 70. issue 2. 2008-05-02. PMID:17601677. |
interestingly, emotional context cannot be imprinting in mature neurons in the presence of gaba, a neurotransmitter release during new environments experiences. |
2008-05-02 |
2023-08-12 |
Not clear |
| Georg Northoff, Martin Walter, Rolf F Schulte, Johannes Beck, Ulrike Dydak, Anke Henning, Heinz Boeker, Simone Grimm, Peter Boesige. GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI. Nature neuroscience. vol 10. issue 12. 2008-03-17. PMID:17982452. |
our findings show that default-mode network negative bold responses during emotions are mediated by gaba. |
2008-03-17 |
2023-08-12 |
human |
| Gordon Munro, Helle K Erichsen, Naheed R Mirz. Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety. Neuropharmacology. vol 53. issue 5. 2008-01-14. PMID:17714743. |
in the current study, we have compared the antinociceptive actions of diazepam (allosteric gaba(a) receptor modulator), gabapentin (binds to alpha(2)delta ca(2+) channel subunit), lamotrigine, riluzole and phenytoin (na(+) channel blockers), levetiracetam (unknown mechanism), sodium valproate (potentiates gaba-mediated inhibition), ethosuximide (t-type ca(2+) channel blocker) and retigabine (k(v)7 channel opener) in the rat formalin test, with their anxiolytic actions in the rat conditioned emotional response (cer) model of anxiety. |
2008-01-14 |
2023-08-12 |
rat |
| E A Ziablitseva, I V Pavlov. [Effect of GABA receptor agonist phenibut on behavior and respiration of rabbits in the negative emotional situation]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 57. issue 4. 2007-11-30. PMID:17944107. |
[effect of gaba receptor agonist phenibut on behavior and respiration of rabbits in the negative emotional situation]. |
2007-11-30 |
2023-08-12 |
rabbit |
| Maria Giuseppina Pisu, Ivan Floris, Elisabetta Maciocco, Mariangela Serra, Giovanni Biggi. Anticipation and consumption of food each increase the concentration of neuroactive steroids in rat brain and plasma. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16938341. |
the change in emotional state associated with food anticipation may thus result in an increase in the plasma and brain levels of 3alpha,5alpha-th prog and 3alpha,5alpha-th doc in a manner sensitive to the activation of gaba(a) receptor-mediated neurotransmission. |
2007-02-23 |
2023-08-12 |
rat |
| Francesca Biggio, Giorgio Gorini, Stefania Caria, Luca Murru, Maria Cristina Mostallino, Enrico Sanna, Paolo Folles. Plastic neuronal changes in GABA(A) receptor gene expression induced by progesterone metabolites: in vitro molecular and functional studies. Pharmacology, biochemistry, and behavior. vol 84. issue 4. 2006-12-20. PMID:16914187. |
given both the importance of gaba(a) receptors in the regulation of neuronal excitability and the large fluctuations in the plasma and brain concentrations of neuroactive steroids associated with physiological conditions and the response to environmental stimuli, these compounds are likely among the most relevant endogenous modulators that could affect emotional and affective behaviors. |
2006-12-20 |
2023-08-12 |
Not clear |
| Carola Eva, Mariangela Serra, Paolo Mele, GianCarlo Panzica, Alessandra Obert. Physiology and gene regulation of the brain NPY Y1 receptor. Frontiers in neuroendocrinology. vol 27. issue 3. 2006-12-15. PMID:16989896. |
chronic modulation of gaba(a) receptor function by benzodiazepines or neuroactive steroids also affects y(1)r expression in the amygdala, suggesting that a functional interaction between the gaba(a) receptor and y(1)r mediated signalling may contribute to the regulation of emotional behaviour. |
2006-12-15 |
2023-08-12 |
human |
| Fabrício Calvo, Norberto Cysne Coimbr. Interactions between opioid-peptides-containing pathways and GABA(A)-receptors-mediated systems modulate panic-like-induced behaviors elicited by electric and chemical stimulation of the inferior colliculus. Brain research. vol 1104. issue 1. 2006-11-30. PMID:16797498. |
these findings suggest an interaction between endogenous opioid-peptides-containing connections and gaba(a)-receptor-mediated system with direct influence on the organization of the panic-like or fear-induced responses elaborated in the inferior colliculus during critical emotional states. |
2006-11-30 |
2023-08-12 |
Not clear |
| Wolf-Dieter Heiss, Karl Herhol. Brain receptor imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 2. 2006-11-24. PMID:16455637. |
the quantitative imaging for several receptors has gained clinical importance-for example, dopamine (d2)) receptors for differential diagnosis of movement disorders and for assessment of receptor occupancy by neuroleptics drugs; serotonin (5-hydroxytryptamine, 5-ht) receptors and the 5-ht transporter in affective disorders and for assessment of activity of antidepressants; nicotinic receptors and acetylcholinesterase as markers of cognitive and memory impairment; central benzodiazepine-binding sites at the gamma-aminobutyric acid a (gabaa) receptor complex as markers of neuronal integrity in neurodegenerative disorders, epilepsy, and stroke and as the site of action of benzodiazepines; peripheral benzodiazepine receptors as indicators of inflammatory changes; opioid receptors detecting increased cortical excitability in focal epilepsy but also affected in perception of and emotional response to pain; and several receptor systems affected in drug abuse and craving. |
2006-11-24 |
2023-08-12 |
Not clear |
| Jee Hyun Kim, Gavan P McNally, Rick Richardso. Recovery of fear memories in rats: role of gamma-amino butyric acid (GABA) in infantile amnesia. Behavioral neuroscience. vol 120. issue 1. 2006-06-08. PMID:16492115. |
it appears that gaba may be involved in infantile amnesia regardless of the emotional content of the memory. |
2006-06-08 |
2023-08-12 |
rat |
| Irit Akirav, Hagit Raizel, Mouna Marou. Enhancement of conditioned fear extinction by infusion of the GABA(A) agonist muscimol into the rat prefrontal cortex and amygdala. The European journal of neuroscience. vol 23. issue 3. 2006-05-09. PMID:16487156. |
the involvement of gaba(a) receptors in fear extinction in the prefrontal cortex and amygdala is of particular interest, because of the role of these areas in emotional processes, and the role of the gaba(a) receptors in anxiety states. |
2006-05-09 |
2023-08-12 |
rat |
| Kentaro Inagawa, Shinobu Seki, Makoto Bannai, Yukari Takeuchi, Yuji Mori, Michio Takahash. Alleviative effects of gamma-aminobutyric acid (GABA) on behavioral abnormalities in aged dogs. The Journal of veterinary medical science. vol 67. issue 10. 2006-05-05. PMID:16276066. |
dogs administered with gaba tended to exhibit improvement in emotional states and signs may be caused by neurovegetable dysfunction, though effects on cognitive dysfunction syndrome were not always observed. |
2006-05-05 |
2023-08-12 |
Not clear |