| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Wang, Zheyi Wu, Yanyan Wang, Chunchun Chen, Yulong Li, Huiming Dong, Tingjing Yao, Gongsheng Jin, Zhenjie Wan. TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer. Cell biochemistry and biophysics. 2024-07-03. PMID:38961034. |
knockdown of tyms resulted in suppression of cell proliferation and mobility, as well as promotion of apoptosis. |
2024-07-03 |
2024-07-10 |
mouse |
| Yechun Pang, Xingshi Chen, Baiying Xu, Yuanzhou Zhang, Shunshun Liang, Jingying Hu, Rui Liu, Xiaoying Luo, YunFeng Wan. Engineered multitargeting exosomes carrying miR-323a-3p for CRC therapy. International journal of biological macromolecules. 2023-07-13. PMID:37442504. |
mir-exo could effectively induce the crc cell apoptosis by targeting egfr and tyms, and enhance the therapeutic effects of 5-fu on crc. |
2023-07-13 |
2023-08-14 |
mouse |
| Mingxu Fu, Yongyan Pei, Fang Lu, Huici Jiang, Yingying Bi, Jiajing Cheng, Jinlong Qi. Identification of Potential Hub Genes and miRNA-mRNA Pairs Related to the Progression and Prognosis of Cervical Cancer Through Integrated Bioinformatics Analysis. Frontiers in genetics. vol 12. 2022-01-10. PMID:35003215. |
functional experiments showed that tyms knockout could promote the proliferation, migration and invasion of hela cells and reduce apoptosis. |
2022-01-10 |
2023-08-13 |
Not clear |
| Sha Zhang, Liang Yan, Can Cui, Zhen Wang, Jianhui Wu, Min Zhao, Bin Dong, Xiaoya Guan, Xiuyun Tian, Chunyi Ha. Identification of TYMS as a promoting factor of retroperitoneal liposarcoma progression: Bioinformatics analysis and biological evidence. Oncology reports. vol 44. issue 2. 2021-05-03. PMID:32627015. |
the knockdown of tyms reduced proliferation, promoted apoptosis, facilitated cell cycle progression from g1 to s phase, and reduced cell migration and invasion of rlps cells. |
2021-05-03 |
2023-08-13 |
Not clear |
| Sha Zhang, Liang Yan, Can Cui, Zhen Wang, Jianhui Wu, Min Zhao, Bin Dong, Xiaoya Guan, Xiuyun Tian, Chunyi Ha. Identification of TYMS as a promoting factor of retroperitoneal liposarcoma progression: Bioinformatics analysis and biological evidence. Oncology reports. vol 44. issue 2. 2021-05-03. PMID:32627015. |
the effect of tyms downregulation on cell proliferation, apoptosis, cell cycle progression, and cell migration and invasion were evaluated using lentivirus‑mediated short hairpin rna. |
2021-05-03 |
2023-08-13 |
Not clear |
| Xiuwei Wang, Zhen Guan, Yanting Dong, Zhiqiang Zhu, Jianhua Wang, Bo Ni. Inhibition of thymidylate synthase affects neural tube development in mice. Reproductive toxicology (Elmsford, N.Y.). vol 76. 2018-10-31. PMID:29258758. |
these results indicated that inhibition of tyms affected the balance between proliferation and apoptosis in neuroepithelial cells, which might shed some lights on the mechanisms involved in ntds. |
2018-10-31 |
2023-08-13 |
mouse |
| Sze-Kwan Lam, Yuan-Yuan Li, Chun-Yan Zheng, James Chung-Man H. Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25335113. |
arsenic trioxide (ato) has been shown to suppress thymidylate synthase (tyms) in lung adenocarcinoma and colorectal cancer, and induce apoptosis in acute promyelocytic leukemia. |
2015-08-11 |
2023-08-13 |
mouse |