| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Barkovskaya, Kotryna Seip, Bylgja Hilmarsdottir, Gunhild M Maelandsmo, Siver A Moestue, Harri M Itkone. O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:30952976. |
inhibition of ogt as well as the loss of hes1 results in potent cytotoxicity and apoptosis. |
2020-10-13 |
2023-08-13 |
Not clear |
| Abhishek Asthana, Parameswaran Ramakrishnan, Yorleny Vicioso, Keman Zhang, Reshmi Parameswara. Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death. Molecular cancer therapeutics. vol 17. issue 10. 2019-09-09. PMID:30082471. |
inhibition of o-glcnacylation, using ogt inhibitors as well as genetic knockdown of ogt, also led to cell differentiation and apoptosis of aml cells. |
2019-09-09 |
2023-08-13 |
Not clear |
| Longsheng Wang, Shaojun Chen, Ziwei Zhang, Junfeng Zhang, Shiyu Mao, Jiayi Zheng, Yang Xuan, Mengnan Liu, Keke Cai, Wentao Zhang, Yadong Guo, Wei Zhai, Xudong Ya. Suppressed OGT expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer. BMC cancer. vol 18. issue 1. 2019-03-11. PMID:30453909. |
suppressed ogt expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer. |
2019-03-11 |
2023-08-13 |
human |
| Young Ah Lee, Arim Min, Myeong Heon Shi. O-deGlcNAcylation is required for Entamoeba histolytica-induced HepG2 cell death. Microbial pathogenesis. vol 123. 2018-12-28. PMID:30016682. |
o-glcnacylation, similar to phosphorylation, is involved in various cell-signaling processes, including apoptosis and proliferation, with o-glcnac addition and removal regulated by o-glcnac transferase (ogt) and o-glcnacase (oga), respectively. |
2018-12-28 |
2023-08-13 |
Not clear |
| Jung-Lin Wu, Ming-Feng Chiang, Pan-Hung Hsu, Dong-Yen Tsai, Kuo-Hsuan Hung, Ying-Hsiu Wang, Takashi Angata, Kuo-I Li. O-GlcNAcylation is required for B cell homeostasis and antibody responses. Nature communications. vol 8. issue 1. 2018-09-18. PMID:29187734. |
here we show that lack of ogt in b-cell development not only causes severe defects in the activation of bcr signaling, but also perturbs b-cell homeostasis by enhancing apoptosis of mature b cells, partly as a result of impaired response to b-cell activating factor. |
2018-09-18 |
2023-08-13 |
Not clear |
| Jung-Lin Wu, Ming-Feng Chiang, Pan-Hung Hsu, Dong-Yen Tsai, Kuo-Hsuan Hung, Ying-Hsiu Wang, Takashi Angata, Kuo-I Li. O-GlcNAcylation is required for B cell homeostasis and antibody responses. Nature communications. vol 8. issue 1. 2018-09-18. PMID:29187734. |
ogt deficiency in germinal center (gc) b cells also results in enhanced apoptosis of gc b cells and memory b cells in an immune response, consequently causing a reduction of antibody levels. |
2018-09-18 |
2023-08-13 |
Not clear |
| Ti Wen, Kezuo Hou, Zhi Li, Lu Li, Hanjie Yu, Yunpeng Liu, Yangguang Li, Zhinan Yi. Silencing β-linked N-acetylglucosamine transferase induces apoptosis in human gastric cancer cells through PUMA and caspase-3 pathways. Oncology reports. vol 34. issue 6. 2016-08-08. PMID:26397041. |
we used a glycan-binding protein gene microarray to identify potential downstream target genes of ogt, and found that apoptosis-related genes such as galectin and hbegf were decreased after ogt suppression, suggesting that ogt silencing induces apoptosis in gastric cancer tissues. |
2016-08-08 |
2023-08-13 |
mouse |
| Ti Wen, Kezuo Hou, Zhi Li, Lu Li, Hanjie Yu, Yunpeng Liu, Yangguang Li, Zhinan Yi. Silencing β-linked N-acetylglucosamine transferase induces apoptosis in human gastric cancer cells through PUMA and caspase-3 pathways. Oncology reports. vol 34. issue 6. 2016-08-08. PMID:26397041. |
furthermore, in vitro ogt knockdown induced more cell apoptosis through increasing puma and caspase-3 expression. |
2016-08-08 |
2023-08-13 |
mouse |
| Xueling Guo, Jin Shang, Yan Deng, Xiao Yuan, Die Zhu, Huiguo Li. Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling. International journal of molecular medicine. vol 36. issue 1. 2016-03-24. PMID:25936416. |
in parallel, compared with exposure to normoxia, 4 weeks of ih augmented the o-glcnac protein, ogt, phosphorylated erk1/2 and p38 mapk levels, accompanied by a decrease in oga levels and an increase in the levels of myocardial nuclear factor-κb (nf-κb), inflammatory cytokines, caspase-3 and cardiomyocyte apoptosis. |
2016-03-24 |
2023-08-13 |
rat |
| Valerie L Sodi, Sakina Khaku, Raisa Krutilina, Luciana P Schwab, David J Vocadlo, Tiffany N Seagroves, Mauricio J Reginat. mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer. Molecular cancer research : MCR. vol 13. issue 5. 2016-03-10. PMID:25636967. |
finally, mammary tumor epithelial cells derived from mmtv-c-myc transgenic mice contain elevated ogt and o-glcnacylation and ogt inhibition in this model induces apoptosis. |
2016-03-10 |
2023-08-13 |
mouse |
| Peng Luo, Tao He, Rongjian Jiang, Gang L. MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes. Molecular medicine reports. vol 12. issue 1. 2016-01-04. PMID:25776937. |
the expression of mir-423-5p significantly regulated the expression of ogt and its associated downstream targets and induced apoptosis in the cardiomyocytes. |
2016-01-04 |
2023-08-13 |
Not clear |
| Peng Luo, Tao He, Rongjian Jiang, Gang L. MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes. Molecular medicine reports. vol 12. issue 1. 2016-01-04. PMID:25776937. |
therefore, the results of the present study indicated that mir-423-5p was involved in chf via the direct targeting of ogt and the induction of apoptosis in cardiomyocytes. |
2016-01-04 |
2023-08-13 |
Not clear |
| Min-Dian Li, Hai-Bin Ruan, Jay P Singh, Lin Zhao, Tingting Zhao, Sascha Azarhoush, Jing Wu, Ronald M Evans, Xiaoyong Yan. O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression. The Journal of biological chemistry. vol 287. issue 16. 2012-06-19. PMID:22371499. |
functionally, overexpression of ogt enhances glucocorticoid-induced apoptosis in resistant cell lines while knockdown of ogt prevents sensitive cell lines from apoptosis. |
2012-06-19 |
2023-08-12 |
Not clear |
| Howard Goldberg, Catharine Whiteside, I George Fantu. O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells. American journal of physiology. Endocrinology and metabolism. vol 301. issue 4. 2011-11-18. PMID:21712532. |
the high-glucose-stimulated kinase activity of apoptosis signal-regulating kinase 1 (ask1), an upstream mapk kinase kinase for p38 that is negatively regulated by akt, was inhibited by ogt shrna. |
2011-11-18 |
2023-08-12 |
rat |
| Marie Pantaleon, Hwee Y Tan, Georgia R Kafer, Peter L Kay. Toxic effects of hyperglycemia are mediated by the hexosamine signaling pathway and o-linked glycosylation in early mouse embryos. Biology of reproduction. vol 82. issue 4. 2010-07-05. PMID:20032283. |
inhibition of ogt using badgp blocked the negative impact of hyperglycemia on blastocyst formation, cell number, and apoptosis. |
2010-07-05 |
2023-08-12 |
mouse |
| Niall O'Donnell, Natasha E Zachara, Gerald W Hart, Jamey D Mart. Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Molecular and cellular biology. vol 24. issue 4. 2004-03-12. PMID:14749383. |
we show that ogt mutation results in the loss of o-glcnac and causes t-cell apoptosis, neuronal tau hyperphosphorylation, and fibroblast growth arrest with altered expression of c-fos, c-jun, c-myc, sp1, and p27. |
2004-03-12 |
2023-08-12 |
Not clear |