| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ingrid Loison, Adrien Pioger, Sonia Paget, Inès Metatla, Audrey Vincent, Corinne Abbadie, Vanessa Dehennau. O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis. Cell death & disease. vol 15. issue 10. 2024-10-19. PMID:39426963. |
further decreasing this level of o-glcnacylation by knocking-down gfat or ogt redirected the cellular response to subtoxic chemotherapy doses from senescence to apoptosis, in correlation with an enhancement of dna damages. |
2024-10-19 |
2024-10-22 |
Not clear |
| Shunsuke Soma, Koichi Murakami, Yumi Fukuchi, Hiroyoshi Kunimoto, Hideaki Nakajim. OGT ensures survival of mouse fetal liver hematopoietic progenitors partly by regulating Bcl-xL and oxidative phosphorylation. Stem cells (Dayton, Ohio). 2023-10-09. PMID:37813816. |
ogt loss led to profound reduction of differentiating erythroid cells and erythroid progenitors in fls due to massive apoptosis. |
2023-10-09 |
2023-10-15 |
mouse |
| Elina Pokharel, Yam P Aryal, Tae-Young Kim, Anna Kim, Jae-Kwang Jung, Seo-Young An, Tae-Yub Kwon, Bong-Ki Min, Hitoshi Yamamoto, Sung-Won Cho, Wern-Joo Sohn, Chang-Hyeon An, Youngkyun Lee, Do-Yeon Kim, Jung-Hong Ha, Jae-Young Ki. The role of O-GlcNAcylation mediated by OGT during tooth development. Journal of cellular physiology. 2023-04-26. PMID:37098720. |
overall, inhibition of ogt resulted in altered cellular physiology, including proliferation, apoptosis, and epithelial rearrangements, with significant changes in the expression patterns of β-catenin, fibroblast growth factor 4 (fgf4), and sonic hedgehog (shh). |
2023-04-26 |
2023-08-14 |
mouse |
| Mingzhe Li, Fangfang Duan, Zhiqiang Pan, Xiaomei Liu, Wenli Lu, Chao Liang, Zhaoqin Fang, Peike Peng, Dongwei Ji. Astragalus Polysaccharide Promotes Doxorubicin-Induced Apoptosis by Reducing O-GlcNAcylation in Hepatocellular Carcinoma. Cells. vol 12. issue 6. 2023-03-29. PMID:36980207. |
furthermore, ogt lentiviral transfection or pugnac (oga inhibitor) treatment reversed the er stress and apoptosis induced by the combination of dox and aps. |
2023-03-29 |
2023-08-14 |
mouse |
| Francesca Romana Pellegrini, Sara De Martino, Giulia Fianco, Irene Ventura, Davide Valente, Mario Fiore, Daniela Trisciuoglio, Francesca Degrass. Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production. Autophagy. 2023-01-27. PMID:36704963. |
interestingly, autophagic flux blockage, apoptosis induction and ros production were rescued by genetic or pharmacological inhibition of ogt (o-linked n-acetylglucosamine (glcnac) transferase) or by expressing an o-glcnacylation-defective mutant of the snare fusion complex component snap29, pointing to snap29 as the molecular target of sm15 in autophagy. |
2023-01-27 |
2023-08-14 |
Not clear |
| Alicia Wong, Samantha Pritchard, Mackenzie Moore, Brian Akhaphong, Nandini Avula, Megan Beetch, Yoshio Fujitani, Emilyn U Alejandr. Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc Transferase deletion. The Journal of biological chemistry. 2023-01-09. PMID:36623733. |
deletion of o-glcnac transferase (ogt) in pancreatic epithelial progenitor cells results in pancreatic hypoplasia at birth, partly due to increased apoptosis during embryonic development. |
2023-01-09 |
2023-08-14 |
mouse |
| Alicia Wong, Samantha Pritchard, Mackenzie Moore, Brian Akhaphong, Nandini Avula, Megan Beetch, Yoshio Fujitani, Emilyn U Alejandr. Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc Transferase deletion. The Journal of biological chemistry. 2023-01-09. PMID:36623733. |
constitutive loss of ogt in β-cells results in increased er stress and apoptosis, and in the ogt-deficient pancreas, transcriptomic data previously revealed tumor suppressor protein p53 and pancreatic and duodenal homeobox 1 (pdx1), key cell survival proteins in the developing pancreas, as upstream regulators of differentially expressed genes. |
2023-01-09 |
2023-08-14 |
mouse |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
changes in levels of rbm3, akt, glycolysis apoptosis, and ogt were measured. |
2022-09-23 |
2023-08-14 |
mouse |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
compared with wild type (wt) mice, rbm3 and p65 phosphorylation were decreased in specific skeletal muscle ogt (ko) mice, whereas akt phosphorylation, glycolysis, and apoptosis were increased. |
2022-09-23 |
2023-08-14 |
mouse |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
the results show that acute cold exposure upregulated rbm3, ogt, and akt phosphorylation and increased energy consumption, which enhanced glycolysis and prevent apoptosis. |
2022-09-23 |
2023-08-14 |
mouse |
| Constanza Salinas, Gabriel Espinosa, Natalia Morales, Claudio Henríquez, Gabriel Morán, Gonzalo Gajardo, Rafael A Burgos, Benjamin Ubert. Evaluation of peripheral blood polymorphonuclear cell functions after an oral carbohydrate overload in obese and insulin dysregulated horses. Veterinary immunology and immunopathology. vol 250. 2022-06-18. PMID:35716440. |
blood glucose elevation was induced through an infeed-oral glucose test (in-feed ogt), and all assessments of pmn functions (apoptosis, phagocytosis and oxidative burst) were done in vitro after isolation from peripheral blood before and 120 min after carbohydrate overload. |
2022-06-18 |
2023-08-14 |
Not clear |
| Ninon Very, Stéphan Hardivillé, Amélie Decourcelle, Julien Thévenet, Madjid Djouina, Adeline Page, Gérard Vergoten, Céline Schulz, Julie Kerr-Conte, Tony Lefebvre, Vanessa Dehennaut, Ikram El Yazidi-Belkour. Thymidylate synthase O-GlcNAcylation: a molecular mechanism of 5-FU sensitization in colorectal cancer. Oncogene. 2021-11-30. PMID:34845374. |
reciprocally, ogt knockdown decreased 5-fu-induced cancer cell apoptosis by reducing ts protein level and activity. |
2021-11-30 |
2023-08-13 |
Not clear |
| Jingru Zhao, Lipeng Dong, Tiantian Huo, Jinming Cheng, Xiaojuan Li, Xiaojuan Huangfu, Sujuan Sun, Hebo Wang, Litao L. O-GlcNAc Transferase (OGT) Protects Cerebral Neurons from Death During Ischemia/Reperfusion (I/R) Injury by Modulating Drp1 in Mice. Neuromolecular medicine. 2021-10-27. PMID:34705256. |
meanwhile, ogt knockdown significantly enhanced neuronal apoptosis and cleaved caspase-3 level in brain tissues of i/r-induced mice. |
2021-10-27 |
2023-08-13 |
mouse |
| Koichi Murakami, Daisuke Kurotaki, Wataru Kawase, Shunsuke Soma, Yumi Fukuchi, Hiroyoshi Kunimoto, Ryusuke Yoshimi, Shuhei Koide, Motohiko Oshima, Takako Hishiki, Noriyo Hayakawa, Tomomi Matsuura, Mayumi Oda, Kiichi Yanagisawa, Hiroshi Kobayashi, Miho Haraguchi, Yoshitoshi Atobe, Kengo Funakoshi, Atsushi Iwama, Keiyo Takubo, Shinichiro Okamoto, Tomohiko Tamura, Hideaki Nakajim. OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy. Cell reports. vol 34. issue 1. 2021-06-18. PMID:33406421. |
ogt is highly expressed in hspcs, and its disruption induces rapid loss of hspcs with increased reactive oxygen species and apoptosis. |
2021-06-18 |
2023-08-13 |
mouse |
| Hyeon Gyu Seo, Han Byeol Kim, Ji Young Yoon, Tae Hyun Kweon, Yun Soo Park, Jingu Kang, Jinwoo Jung, SeongJin Son, Eugene C Yi, Tae Ho Lee, Won Ho Yang, Jin Won Ch. Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Cell death & disease. vol 11. issue 9. 2021-04-23. PMID:32994395. |
this study shows that ogt is a substrate of the e3 ubiquitin ligase x-linked inhibitor of apoptosis (xiap) which plays an important role in cancer pathogenesis. |
2021-04-23 |
2023-08-13 |
Not clear |
| Juanxian Cheng, Yan Wu, Liping Chen, Ying Li, Fengjiao Liu, Jingyuan Shao, Minghe Huang, Ming Fan, Haitao W. Loss of O-GlcNAc transferase in neural stem cells impairs corticogenesis. Biochemical and biophysical research communications. vol 532. issue 4. 2021-03-11. PMID:32896380. |
the pathology of corticogenesis deficits caused by ogt deletion may largely rely on complicated biological processes, such as proliferation, apoptosis and differentiation. |
2021-03-11 |
2023-08-13 |
mouse |
| Juanxian Cheng, Yan Wu, Liping Chen, Ying Li, Fengjiao Liu, Jingyuan Shao, Minghe Huang, Ming Fan, Haitao W. Loss of O-GlcNAc transferase in neural stem cells impairs corticogenesis. Biochemical and biophysical research communications. vol 532. issue 4. 2021-03-11. PMID:32896380. |
here we report that the selective deletion of o-glcnac transferase (ogt) in neural stem cells (nscs) in mice led to a series of severe brain developmental deficits, including dramatic shrinkage of cortical and hippocampal histoarchitecture, widespread neuronal apoptosis, decrease in cell proliferation, induction of endoplasmic reticulum (er) stress, and inhibition of neuronal dendritic and axonal differentiation. |
2021-03-11 |
2023-08-13 |
mouse |
| Su Jin Lee, Oh-Shin Kwo. O-GlcNAc Transferase Inhibitor Synergistically Enhances Doxorubicin-Induced Apoptosis in HepG2 Cells. Cancers. vol 12. issue 11. 2020-11-28. PMID:33121131. |
herein, we investigated doxorubicin (dox) and o-glcnac transferase (ogt) inhibitor osmi-1 combination treatment, which significantly enhanced apoptosis in hepatocellular carcinoma cells (hepg2) as a result of synergistic drug action in disparate stress signaling pathways. |
2020-11-28 |
2023-08-13 |
mouse |
| Shan-Zhong Yang, Fei Xu, Kaiyu Yuan, Yong Sun, Tong Zhou, Xinyang Zhao, Jay M McDonald, Yabing Che. Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation. Laboratory investigation; a journal of technical methods and pathology. vol 100. issue 5. 2020-10-15. PMID:31896813. |
with gain- and loss-of-function of the o-glcnac-adding enzyme, o-glcnactransferase (ogt), we determined that increasing o-glcnacylation rendered trail-sensitive cells more resistant to tra-8-induced apoptosis, while inhibiting o-glcnacylation promoted tra-8-induced apoptosis in trail-resistance cells. |
2020-10-15 |
2023-08-13 |
mouse |
| Anna Barkovskaya, Kotryna Seip, Bylgja Hilmarsdottir, Gunhild M Maelandsmo, Siver A Moestue, Harri M Itkone. O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:30952976. |
we find a greater dependency on ogt among triple-negative breast cancer (tnbc) cell lines, which respond to ogt inhibition by undergoing cell cycle arrest and apoptosis. |
2020-10-13 |
2023-08-13 |
Not clear |