| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Duncan Stearns, Aneeka Chaudhry, Ty W Abel, Peter C Burger, Chi V Dang, Charles G Eberhar. c-myc overexpression causes anaplasia in medulloblastoma. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16423996. |
indices of proliferation and apoptosis were also significantly higher in myc xenografts. |
2006-02-14 |
2023-08-12 |
mouse |
| Shelly Beer, Anders Zetterberg, Rebecca A Ihrie, Ryan A McTaggart, Qiwei Yang, Nicole Bradon, Constadina Arvanitis, Laura D Attardi, Sandy Feng, Boris Ruebner, Robert D Cardiff, Dean W Felshe. Developmental context determines latency of MYC-induced tumorigenesis. PLoS biology. vol 2. issue 11. 2006-02-03. PMID:15455033. |
surprisingly, apoptosis is not a barrier to myc inducing tumorigenesis. |
2006-02-03 |
2023-08-12 |
mouse |
| Sabine Rottmann, Yan Wang, Marc Nasoff, Quinn L Deveraux, Kim C Quo. A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 42. 2005-12-05. PMID:16210249. |
attenuating the gsk3beta-fbw7 axis results in stabilization of myc, up-regulation of surface levels of the tnf-related apoptosis-inducing ligand death receptor 5, and potentiation of death receptor 5-induced apoptosis in vitro and in vivo. |
2005-12-05 |
2023-08-12 |
human |
| Hui Luo, Qing Li, Julie O'Neal, Friederike Kreisel, Michelle M Le Beau, Michael H Tomasso. c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. Blood. vol 106. issue 7. 2005-11-28. PMID:15972450. |
ectopic expression of c-myc (myc) in most primary cell types results in programmed cell death, and malignant transformation cannot occur without additional mutations that block apoptosis. |
2005-11-28 |
2023-08-12 |
mouse |
| Hui Luo, Qing Li, Julie O'Neal, Friederike Kreisel, Michelle M Le Beau, Michael H Tomasso. c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. Blood. vol 106. issue 7. 2005-11-28. PMID:15972450. |
these data provide the first direct evidence that myc is a critical downstream effector of myeloid leukemogenesis and suggest that myeloid progenitors are intrinsically resistant to myc-induced apoptosis. |
2005-11-28 |
2023-08-12 |
mouse |
| Chi V Dang, Kathryn A O'donnell, Tarja Juopper. The great MYC escape in tumorigenesis. Cancer cell. vol 8. issue 3. 2005-11-14. PMID:16169462. |
acute myc expression increases p53 or arf levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19arf in transgenic myc-induced lymphomas. |
2005-11-14 |
2023-08-12 |
human |
| Chi V Dang, Kathryn A O'donnell, Tarja Juopper. The great MYC escape in tumorigenesis. Cancer cell. vol 8. issue 3. 2005-11-14. PMID:16169462. |
lowe and coworkers (hemann et al., 2005) demonstrate that wild-type myc can also trigger apoptosis by inducing bim, which neutralizes bcl-2. |
2005-11-14 |
2023-08-12 |
human |
| Chi V Dang, Kathryn A O'donnell, Tarja Juopper. The great MYC escape in tumorigenesis. Cancer cell. vol 8. issue 3. 2005-11-14. PMID:16169462. |
in contrast, the myc point mutants failed to induce bim, promoting murine lymphomas that escaped both wild-type p53 and p19arf, and in doing so, evaded apoptosis. |
2005-11-14 |
2023-08-12 |
human |
| Alexey Ushmorov, Klaus-Michael Debatin, Christian Beltinge. Growth inhibition of murine neuroblastoma cells by c-myc with cell cycle arrest in G2/M. Cancer biology & therapy. vol 4. issue 2. 2005-10-20. PMID:15684616. |
c-myc and n-myc belong to the myc family of proteins that plays an important role in cell proliferation, differentiation and apoptosis. |
2005-10-20 |
2023-08-12 |
Not clear |
| Catherine M Shachaf, Dean W Felshe. Rehabilitation of cancer through oncogene inactivation. Trends in molecular medicine. vol 11. issue 7. 2005-10-11. PMID:15955741. |
upon myc inactivation, tumors stereotypically reverse, undergoing proliferative arrest, cellular differentiation and/or apoptosis. |
2005-10-11 |
2023-08-12 |
Not clear |
| Michael T Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A Nilsson, Carlos Cordon-Cardo, John L Cleveland, William P Tansey, Scott W Low. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. vol 436. issue 7052. 2005-09-02. PMID:16094360. |
the c-myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with myc during tumorigenesis. |
2005-09-02 |
2023-08-12 |
mouse |
| Michael T Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A Nilsson, Carlos Cordon-Cardo, John L Cleveland, William P Tansey, Scott W Low. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. vol 436. issue 7052. 2005-09-02. PMID:16094360. |
here we report that two common mutant myc alleles derived from human burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type myc at promoting b cell lymphomagenesis in mice. |
2005-09-02 |
2023-08-12 |
mouse |
| Michael T Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A Nilsson, Carlos Cordon-Cardo, John L Cleveland, William P Tansey, Scott W Low. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. vol 436. issue 7052. 2005-09-02. PMID:16094360. |
mutant myc proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the bh3-only protein bim (a member of the b cell lymphoma 2 (bcl2) family) and effectively inhibit bcl2. |
2005-09-02 |
2023-08-12 |
mouse |
| Michael T Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A Nilsson, Carlos Cordon-Cardo, John L Cleveland, William P Tansey, Scott W Low. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. vol 436. issue 7052. 2005-09-02. PMID:16094360. |
disruption of apoptosis through enforced expression of bcl2, or loss of either bim or p53 function, enables wild-type myc to produce lymphomas as efficiently as mutant myc. |
2005-09-02 |
2023-08-12 |
mouse |
| Jianhong Li, Ekkehard Werner, Manfred Hergenhahn, Rémy Poirey, Zuyu Luo, Jean Rommelaere, Jean-Claude Jauniau. Expression profiling of human hepatoma cells reveals global repression of genes involved in cell proliferation, growth, and apoptosis upon infection with parvovirus H-1. Journal of virology. vol 79. issue 4. 2005-08-09. PMID:15681429. |
these repressed genes clustered mainly into classes involved in transcriptional regulation, signal transduction, immune and stress response, and apoptosis, as exemplified by genes encoding the transcription factors myc, jun, fos, ids, and cebps. |
2005-08-09 |
2023-08-12 |
human |
| Duonan Yu, Michael Dews, Andrea Park, John W Tobias, Andrei Thomas-Tikhonenk. Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies. Cancer research. vol 65. issue 12. 2005-08-08. PMID:15958595. |
importantly, in this system, myc(off)cd20(high) cells were more prone to rituxan-induced apoptosis than myc(on)cd20(med). |
2005-08-08 |
2023-08-12 |
human |
| William R Atchley, Andrew D Fernande. Sequence signatures and the probabilistic identification of proteins in the Myc-Max-Mad network. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 18. 2005-08-01. PMID:15851686. |
myc is a well known oncoprotein, and this family is involved in cell proliferation, apoptosis, and differentiation. |
2005-08-01 |
2023-08-12 |
Not clear |
| Catherine M Shachaf, Dean W Felshe. Tumor dormancy and MYC inactivation: pushing cancer to the brink of normalcy. Cancer research. vol 65. issue 11. 2005-07-28. PMID:15930260. |
upon myc inactivation, tumors variously undergo proliferative arrest, cellular differentiation, and apoptosis and in some cases, apparently permanently revoking tumorigenesis. |
2005-07-28 |
2023-08-12 |
Not clear |
| Andreas Herbst, Michael T Hemann, Kathryn A Tworkowski, Simone E Salghetti, Scott W Lowe, William P Tanse. A conserved element in Myc that negatively regulates its proapoptotic activity. EMBO reports. vol 6. issue 2. 2005-06-27. PMID:15678160. |
myc is an oncoprotein transcription factor that promotes cell proliferation and apoptosis. |
2005-06-27 |
2023-08-12 |
mouse |
| Andreas Herbst, Michael T Hemann, Kathryn A Tworkowski, Simone E Salghetti, Scott W Lowe, William P Tanse. A conserved element in Myc that negatively regulates its proapoptotic activity. EMBO reports. vol 6. issue 2. 2005-06-27. PMID:15678160. |
curiously, disruption of mbiii decreases transformation activity by increasing the efficiency with which myc can induce apoptosis, suggesting that mbiii is a negative regulator of programmed cell death. |
2005-06-27 |
2023-08-12 |
mouse |