| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan-Bin Chen, Xiao-Yu Liao, Jiang-Bo Zhang, Fang Wang, Hai-De Qin, Lanjun Zhang, Yin Yao Shugart, Yi-Xin Zeng, Wei-Hua Ji. ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma. International journal of oncology. vol 50. issue 2. 2017-05-02. PMID:28035363. |
thus, our data indicate that adar2 suppresses tumor growth and induces apoptosis by editing and stabilizing igfbp7 in escc, and this may represent a novel therapeutic target for treating escc. |
2017-05-02 |
2023-08-13 |
Not clear |
| Hongjun Guo, Dongya Zhang, Qingrui F. Inhibition of Cervical Cancer by Promoting IGFBP7 Expression Using Ellagic Acid from Pomegranate Peel. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-03-28. PMID:27941714. |
the apoptosis rate of the igfbp7 group and ellagic acid-treated groups was significantly higher than that of the nc and bl groups in hela cells (p<0.05). |
2017-03-28 |
2023-08-13 |
Not clear |
| Dae-Ho Jang, Youngbo Choi, Yong-Soo Choi, Sun-Mi Kim, Hojung Kwak, Se-Hyun Shin, Surin Hon. Sensitive and selective analysis of a wide concentration range of IGFBP7 using a surface plasmon resonance biosensor. Colloids and surfaces. B, Biointerfaces. vol 123. 2015-08-19. PMID:25466460. |
igfbp7 has been shown to regulate cell proliferation, cell adhesion, cellular senescence, apoptosis, and angiogenesis in several different cancer cell lines. |
2015-08-19 |
2023-08-13 |
Not clear |
| H Jmp Verhagen, D C de Leeuw, M Gm Roemer, F Denkers, W Pouwels, A Rutten, P H Celie, G J Ossenkoppele, G J Schuurhuis, L Smi. IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival. Cell death & disease. vol 5. 2015-02-12. PMID:24967962. |
igfbp7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival. |
2015-02-12 |
2023-08-13 |
human |
| H Jmp Verhagen, D C de Leeuw, M Gm Roemer, F Denkers, W Pouwels, A Rutten, P H Celie, G J Ossenkoppele, G J Schuurhuis, L Smi. IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival. Cell death & disease. vol 5. 2015-02-12. PMID:24967962. |
moreover, overexpression of igfbp7 as well as addition of recombinant human igfbp7 is able to reduce the survival of aml cells by the induction of a g2 cell cycle arrest and apoptosis. |
2015-02-12 |
2023-08-13 |
human |
| Shi-Feng Chen, Lei Yuan, Wen-Juan Fan, Xu-Dong Che. [Overexpression of IGFBP7 induces apoptosis of human colon cancer HT29 cell]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 29. issue 2. 2014-01-23. PMID:23833975. |
[overexpression of igfbp7 induces apoptosis of human colon cancer ht29 cell]. |
2014-01-23 |
2023-08-12 |
human |
| Valentina Evdokimova, Cristina E Tognon, Tania Benatar, Wenyi Yang, Konstantin Krutikov, Michael Pollak, Poul H B Sorensen, Arun Set. IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors. Science signaling. vol 5. issue 255. 2013-05-24. PMID:23250396. |
prolonged exposure to igfbp7 resulted in activation of the translational repressor 4e-binding protein 1 (4e-bp1) and enhanced sensitivity to apoptosis in igf1r-positive cells. |
2013-05-24 |
2023-08-12 |
Not clear |
| Tania Benatar, Wenyi Yang, Yutaka Amemiya, Valentina Evdokimova, Harriette Kahn, Claire Holloway, Arun Set. IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways. Breast cancer research and treatment. vol 133. issue 2. 2012-09-28. PMID:21997538. |
igfbp7 reduces breast tumor growth by induction of senescence and apoptosis pathways. |
2012-09-28 |
2023-08-12 |
mouse |
| Tania Benatar, Wenyi Yang, Yutaka Amemiya, Valentina Evdokimova, Harriette Kahn, Claire Holloway, Arun Set. IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways. Breast cancer research and treatment. vol 133. issue 2. 2012-09-28. PMID:21997538. |
treatment of nod/scid mice harboring xenografts of tnbc cells with igfbp7 systemically every 3-4 days inhibited tumorigenesis, with associated anti-angiogenic effects, together with increased apoptosis. |
2012-09-28 |
2023-08-12 |
mouse |
| Ally Pen, Yves Durocher, Jacqueline Slinn, Marina Rukhlova, Claudie Charlebois, Danica B Stanimirovic, Maria J Moren. Insulin-like growth factor binding protein 7 exhibits tumor suppressive and vessel stabilization properties in U87MG and T98G glioblastoma cell lines. Cancer biology & therapy. vol 12. issue 7. 2012-03-28. PMID:21795858. |
igfbp7 stimulated senescence-associated β-galactosidase in both u87mg and t98g cells without stimulating apoptosis (annexin v and propidium iodide staining, expression of smarcb1 or bnip3l and caspase cleavage) or affecting phosphorylation of p44/42 mapk. |
2012-03-28 |
2023-08-12 |
human |
| Yoshito Tomimaru, Hidetoshi Eguchi, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Masahiro Tanemura, Koji Umeshita, Tonsok Kim, Kenichi Wakasa, Yuichiro Doki, Masaki Mori, Hiroaki Nagan. IGFBP7 downregulation is associated with tumor progression and clinical outcome in hepatocellular carcinoma. International journal of cancer. vol 130. issue 2. 2012-03-16. PMID:21328580. |
insulin-like growth factor-binding protein 7 (igfbp7) functions in several cellular processes including proliferation, senescence and apoptosis. |
2012-03-16 |
2023-08-12 |
Not clear |
| L P Nguyen, A Emley, N Wajapeyee, M R Green, M Mahalinga. BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi. The British journal of dermatology. vol 162. issue 3. 2010-09-20. PMID:19919630. |
we have recently shown that constitutive activation of the braf-mek-erk signalling pathway in oncogenic braf-positive naevi increases expression and secretion of igfbp7, which induces senescence and apoptosis. |
2010-09-20 |
2023-08-12 |
Not clear |
| M G Vizioli, M Sensi, C Miranda, L Cleris, F Formelli, M C Anania, M A Pierotti, A Grec. IGFBP7: an oncosuppressor gene in thyroid carcinogenesis. Oncogene. vol 29. issue 26. 2010-07-19. PMID:20440262. |
insulin-like growth factor-binding protein 7 (igfbp7) is a secreted protein involved in several cellular processes, including proliferation, senescence and apoptosis. |
2010-07-19 |
2023-08-12 |
human |
| M G Vizioli, M Sensi, C Miranda, L Cleris, F Formelli, M C Anania, M A Pierotti, A Grec. IGFBP7: an oncosuppressor gene in thyroid carcinogenesis. Oncogene. vol 29. issue 26. 2010-07-19. PMID:20440262. |
we show that the effects of igfbp7 are related to apoptosis. |
2010-07-19 |
2023-08-12 |
human |
| Rong-Yi Chen, Hong-Xiang Chen, Jia-Xi Lin, Wei-Bing She, Ping Jiang, Li Xu, Ya-Ting T. In-vivo transfection of pcDNA3.1-IGFBP7 inhibits melanoma growth in mice through apoptosis induction and VEGF downexpression. Journal of experimental & clinical cancer research : CR. vol 29. 2010-06-17. PMID:20158915. |
genome-wide rna interference screening study revealed that loss of expression of insulin-like growth factor binding protein 7 (igfbp7) is a critical step in development of a malignant melanoma (mm), and this secreted protein plays a central role in apoptosis of mm. |
2010-06-17 |
2023-08-12 |
mouse |
| Narendra Wajapeyee, Varun Kapoor, Meera Mahalingam, Michael R Gree. Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines. Molecular cancer therapeutics. vol 8. issue 11. 2010-05-27. PMID:19861408. |
we recently identified the secreted protein igfbp7 as a factor required for an activated braf oncogene to induce senescence or apoptosis in primary human cells. |
2010-05-27 |
2023-08-12 |
mouse |
| Narendra Wajapeyee, Varun Kapoor, Meera Mahalingam, Michael R Gree. Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines. Molecular cancer therapeutics. vol 8. issue 11. 2010-05-27. PMID:19861408. |
restoration of igfbp7 function by the addition of recombinant igfbp7 (rigfbp7) induces apoptosis in braf-positive human melanoma cell lines, and systemically administered rigfbp7 markedly suppresses the growth of braf-positive primary tumors in xenografted mice. |
2010-05-27 |
2023-08-12 |
mouse |
| Narendra Wajapeyee, Varun Kapoor, Meera Mahalingam, Michael R Gree. Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines. Molecular cancer therapeutics. vol 8. issue 11. 2010-05-27. PMID:19861408. |
an analysis of the nci60 panel of human cancer cell lines reveals that in addition to melanoma, igfbp7 induces apoptosis in several other cancer types, in particular colorectal cancer cell lines. |
2010-05-27 |
2023-08-12 |
mouse |
| Narendra Wajapeyee, Varun Kapoor, Meera Mahalingam, Michael R Gree. Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines. Molecular cancer therapeutics. vol 8. issue 11. 2010-05-27. PMID:19861408. |
in general, igfbp7 induces apoptosis in human cancer cell lines that have an activating mutation in braf or ras, and that are sensitive to chemical inhibition of braf-mek-erk signaling. |
2010-05-27 |
2023-08-12 |
mouse |
| Toshinori Hinoue, Daniel J Weisenberger, Fei Pan, Mihaela Campan, Myungjin Kim, Joanne Young, Vicki L Whitehall, Barbara A Leggett, Peter W Lair. Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PloS one. vol 4. issue 12. 2010-03-17. PMID:20027224. |
furthermore, we identified cimp-dependent dna hypermethylation of igfbp7, which has been shown to mediate braf(v600e)-induced cellular senescence and apoptosis. |
2010-03-17 |
2023-08-12 |
Not clear |