| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Gugliesi, Valentina Dell'oste, Marco De Andrea, Rossella Baggetta, Michele Mondini, Claudia Zannetti, Benedetta Bussolati, Gianni Camussi, Marisa Gariglio, Santo Landolf. Tumor-derived endothelial cells evade apoptotic activity of the interferon-inducible IFI16 gene. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 31. issue 8. 2011-11-28. PMID:21488755. |
forced ifi16 expression in normal human endothelial cells (ecs) inhibits cell growth and tube morphogenesis of ecs through the triggering of apoptosis by caspase-2 and caspase-3 via nuclear factor-κb (nf-κb) complex activation. |
2011-11-28 |
2023-08-12 |
human |
| Francesca Gugliesi, Marco De Andrea, Michele Mondini, Paola Cappello, Mirella Giovarelli, Yehuda Shoenfeld, PierLuigi Meroni, Marisa Gariglio, Santo Landolf. The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. Journal of autoimmunity. vol 35. issue 2. 2011-03-15. PMID:20488664. |
in this study, we report for the first time that endothelial cells overexpressing ifi16 undergo apoptosis via the activation of caspase 2 and caspase 3, and that a positive feedback loop appears to link these two caspases. |
2011-03-15 |
2023-08-12 |
Not clear |
| Francesca Gugliesi, Marco De Andrea, Michele Mondini, Paola Cappello, Mirella Giovarelli, Yehuda Shoenfeld, PierLuigi Meroni, Marisa Gariglio, Santo Landolf. The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. Journal of autoimmunity. vol 35. issue 2. 2011-03-15. PMID:20488664. |
the relevance of ifi16-mediated apoptosis is highlighted by the observation that ifi16 knock down by rna interference in endothelial cells inhibits the activation of both caspase 2 and caspase 3 by ifn-beta priming and synthetic double-stranded rna treatment. |
2011-03-15 |
2023-08-12 |
Not clear |
| Francesca Gugliesi, Marco De Andrea, Michele Mondini, Paola Cappello, Mirella Giovarelli, Yehuda Shoenfeld, PierLuigi Meroni, Marisa Gariglio, Santo Landolf. The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. Journal of autoimmunity. vol 35. issue 2. 2011-03-15. PMID:20488664. |
collectively, our findings provide new insights into the role of ifi16 in the pathogenesis of autoimmune diseases by demonstrating that in addition to the stimulation of pro-inflammatory molecules, ifi16 also leads to apoptosis in endothelial cells. |
2011-03-15 |
2023-08-12 |
Not clear |
| Rossella Baggetta, Marco De Andrea, Grazia Rosaria Gariano, Michele Mondini, Massimo Rittà, Patrizia Caposio, Paola Cappello, Mirella Giovarelli, Marisa Gariglio, Santo Landolf. The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response. European journal of immunology. vol 40. issue 8. 2010-12-23. PMID:20480502. |
previous gene array analysis of human umbilical vein endothelial cells overexpressing ifi16 has revealed an increased expression of genes involved in inflammation and apoptosis. |
2010-12-23 |
2023-08-12 |
human |
| Jasenka Mazibrada, Marco De Andrea, Massimo Rittà, Cinzia Borgogna, Raffaella Dell'eva, Ulrich Pfeffer, Luigi Chiusa, Marisa Gariglio, Santo Landolf. In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16. Cancer letters. vol 287. issue 1. 2010-02-19. PMID:19553003. |
the interferon-inducible gene, ifi16 has been implicated in the control of cell growth, apoptosis, angiogenesis and immunomodulation. |
2010-02-19 |
2023-08-12 |
Not clear |
| Jasenka Mazibrada, Marco De Andrea, Massimo Rittà, Cinzia Borgogna, Raffaella Dell'eva, Ulrich Pfeffer, Luigi Chiusa, Marisa Gariglio, Santo Landolf. In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16. Cancer letters. vol 287. issue 1. 2010-02-19. PMID:19553003. |
in a previous study we demonstrated that restoring levels of ifi16 in a head and neck squamous cell carcinoma (hnscc)-derived cell line, hno136, reduced its growth in vitro accompanied by a marked increase in doxorubicin-induced apoptosis. |
2010-02-19 |
2023-08-12 |
Not clear |
| Jasenka Mazibrada, Marco De Andrea, Massimo Rittà, Cinzia Borgogna, Raffaella Dell'eva, Ulrich Pfeffer, Luigi Chiusa, Marisa Gariglio, Santo Landolf. In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16. Cancer letters. vol 287. issue 1. 2010-02-19. PMID:19553003. |
further analysis revealed that ifi16 expression triggered apoptosis of tumor cells, as evaluated using tunel assay. |
2010-02-19 |
2023-08-12 |
Not clear |
| Jasenka Mazibrada, Marco De Andrea, Massimo Rittà, Cinzia Borgogna, Raffaella Dell'eva, Ulrich Pfeffer, Luigi Chiusa, Marisa Gariglio, Santo Landolf. In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16. Cancer letters. vol 287. issue 1. 2010-02-19. PMID:19553003. |
in accordance with our previous in vitro experiments, this study demonstrates for the first time that ifi16 exerts in vivo anti-tumoral activity by promoting apoptosis of tumor cells, by inhibiting neo-vascularisation, and by increasing the recruitment of macrophages through the release of chemotactic factors. |
2010-02-19 |
2023-08-12 |
Not clear |
| Lorenza Egistelli, Silvia Chichiarelli, Elisa Gaucci, Margherita Eufemi, M Eugenia Schininà, Alessandra Giorgi, Ioan Lascu, Carlo Turano, Anna Giartosio, Laura Cervon. IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters. Journal of cellular biochemistry. vol 106. issue 4. 2009-06-10. PMID:19170058. |
since p53 stimulates apoptosis and inhibits cellular growth, and cmyc promotes cell growth and, in several instances, also apoptosis, the presence of nm23 and ifi16 on the same dna fragments suggests their common involvement in the reduced development of some tumors. |
2009-06-10 |
2023-08-12 |
human |
| Patrizia Caposio, Francesca Gugliesi, Claudia Zannetti, Simone Sponza, Michele Mondini, Enzo Medico, John Hiscott, Howard A Young, Giorgio Gribaudo, Marisa Gariglio, Santo Landolf. A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. The Journal of biological chemistry. vol 282. issue 46. 2008-01-03. PMID:17699163. |
in this study, gene array analysis of human umbilical vein endothelial cells overexpressing ifi16 revealed an increased expression of genes involved in immunomodulation, cell growth, and apoptosis. |
2008-01-03 |
2023-08-12 |
human |
| Michele Mondini, Matteo Vidali, Paolo Airò, Marco De Andrea, Piersandro Riboldi, Pier Luigi Meroni, Marisa Gariglio, Santo Landolf. Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders. Annals of the New York Academy of Sciences. vol 1110. 2007-12-12. PMID:17911419. |
molecular studies performed in primary endothelial cells overexpressing ifi16 demonstrated that it may be involved in the early steps of inflammation by modulating endothelial cell function, such as expression of adhesion molecules and chemokine production, cell growth, and apoptosis. |
2007-12-12 |
2023-08-12 |
human |
| Mutsuko Ouchi, Toru Ouch. Role of IFI16 in DNA damage and checkpoint. Frontiers in bioscience : a journal and virtual library. vol 13. 2007-12-11. PMID:17981541. |
furthermore, it has been demonstrated that ifi16 is involved in p53-mediated regulation of cell growth and apoptosis. |
2007-12-11 |
2023-08-12 |
Not clear |
| Fatouma Alimirah, Jianming Chen, Francesca J Davis, Divaker Choube. IFI16 in human prostate cancer. Molecular cancer research : MCR. vol 5. issue 3. 2007-05-07. PMID:17339605. |
importantly, increased expression of ifi16 in lncap cells was associated with decreases in the expression of androgen receptor and apoptosis of cells. |
2007-05-07 |
2023-08-12 |
human |
| Fatouma Alimirah, Jianming Chen, Francesca J Davis, Divaker Choube. IFI16 in human prostate cancer. Molecular cancer research : MCR. vol 5. issue 3. 2007-05-07. PMID:17339605. |
conversely, knockdown of ifi16 expression in tsa-treated lncap cells increased androgen receptor protein levels with concomitant decreases in apoptosis. |
2007-05-07 |
2023-08-12 |
human |
| Maria Rosa Bani, Maria Ines Nicoletti, Nawal W Alkharouf, Carmen Ghilardi, David Petersen, Eugenio Erba, Edward A Sausville, Edison T Liu, Raffaella Giavazz. Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts. Molecular cancer therapeutics. vol 3. issue 2. 2004-11-22. PMID:14985451. |
most gene expression alterations were detected 24 h after paclitaxel administration and affected genes involved in various biological functions including cell cycle regulation and cell proliferation (cdc2, cdkn1a, plab, and top2a), apoptosis (bnip3 and pig8), signal transduction and transcriptional regulation (arf1, atf2, fos, gna11, hdac3, madh2, slug, and spry4), fatty acid biosynthesis and sterol metabolism (fdps, idi1, lipa, and sc5d), and ifn-mediated signaling (g1p3, ifi16, ifi27, ifitm1, and isg15). |
2004-11-22 |
2023-08-12 |
mouse |
| Nobuko Fujiuchi, Jason A Aglipay, Takao Ohtsuka, Naoki Maehara, Fikret Sahin, Gloria H Su, Sam W Lee, Toru Ouch. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. The Journal of biological chemistry. vol 279. issue 19. 2004-06-15. PMID:14990579. |
ifi16 is a member of the pyrin superfamily that has been implicated in brca1-mediated apoptosis and inflammation signaling pathways. |
2004-06-15 |
2023-08-12 |
human |
| Nobuko Fujiuchi, Jason A Aglipay, Takao Ohtsuka, Naoki Maehara, Fikret Sahin, Gloria H Su, Sam W Lee, Toru Ouch. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. The Journal of biological chemistry. vol 279. issue 19. 2004-06-15. PMID:14990579. |
adenovirus expression of ifi16 in ifi16-deficient mcf7 induced apoptosis, which was enhanced by radiomimetic neocarcinostatin treatment. |
2004-06-15 |
2023-08-12 |
human |
| Nobuko Fujiuchi, Jason A Aglipay, Takao Ohtsuka, Naoki Maehara, Fikret Sahin, Gloria H Su, Sam W Lee, Toru Ouch. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. The Journal of biological chemistry. vol 279. issue 19. 2004-06-15. PMID:14990579. |
tetracycline-regulated ifi16 also induced apoptosis when coexpressed with p53 in p53-deficient ej cells subjected to ir, suggesting that ifi16 is involved in p53-mediated transmission of apoptosis signaling. |
2004-06-15 |
2023-08-12 |
human |
| Nobuko Fujiuchi, Jason A Aglipay, Takao Ohtsuka, Naoki Maehara, Fikret Sahin, Gloria H Su, Sam W Lee, Toru Ouch. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. The Journal of biological chemistry. vol 279. issue 19. 2004-06-15. PMID:14990579. |
these results suggest that loss of ifi16 results in deregulation of p53-mediated apoptosis, leading to cancer development. |
2004-06-15 |
2023-08-12 |
human |