| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoxu Ding, Xueyan Zhang, Panxia Fang, Weiliang Ba. ETV4/NSUN2 Axis modulates aerobic glycolysis and malignancy in HSCC. Human molecular genetics. 2024-07-30. PMID:39077833. |
through comprehensive experimentation, we demonstrated that etv4 activation promotes hscc cell proliferation and invasion while inhibiting apoptosis. |
2024-07-30 |
2024-08-02 |
Not clear |
| Li Liu, Yong Feng, Xuelian Xiang, Mengtao Xu, Guodu Tan. Biological effect of ETV4 and the underlying mechanism of its regulatory effect on epithelial‑mesenchymal transition in intrahepatic cholangiocarcinoma cells. Oncology letters. vol 28. issue 2. 2024-06-14. PMID:38872859. |
etv4 was identified as a driver of cell growth, invasion, migration and cell cycle progression, while restraining apoptosis in hccc9810 cells. |
2024-06-14 |
2024-06-16 |
Not clear |
| Junxiang Wang, Chengfa Sun, Jian Li, Hua Jiang, Yun Qiu, Mingjie Gon. Knockdown of ETV4 promotes autophagy-dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1. Oncology letters. vol 23. issue 2. 2022-01-03. PMID:34976153. |
the knockdown of etv4 expression inhibited the pi3k/akt/mtor signaling pathway activity to promote autophagy and apoptosis, and this effect could be partially reversed by overexpressing emp1. |
2022-01-03 |
2023-08-13 |
Not clear |
| Junxiang Wang, Chengfa Sun, Jian Li, Hua Jiang, Yun Qiu, Mingjie Gon. Knockdown of ETV4 promotes autophagy-dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1. Oncology letters. vol 23. issue 2. 2022-01-03. PMID:34976153. |
the present study aimed to determine whether etv4 could influence the activation of the pi3k/akt/mtor signaling pathway to affect the autophagy and apoptosis of gbm cells by regulating the transcriptional activity of emp1. |
2022-01-03 |
2023-08-13 |
Not clear |
| Junxiang Wang, Chengfa Sun, Jian Li, Hua Jiang, Yun Qiu, Mingjie Gon. Knockdown of ETV4 promotes autophagy-dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1. Oncology letters. vol 23. issue 2. 2022-01-03. PMID:34976153. |
knockdown of etv4 promotes autophagy-dependent apoptosis in gbm cells by reducing the transcriptional activation of emp1. |
2022-01-03 |
2023-08-13 |
Not clear |
| Junxiang Wang, Chengfa Sun, Jian Li, Hua Jiang, Yun Qiu, Mingjie Gon. Knockdown of ETV4 promotes autophagy-dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1. Oncology letters. vol 23. issue 2. 2022-01-03. PMID:34976153. |
after interfering with the expression of etv4, western blotting was used to detect the expression levels of autophagy- and apoptosis-related proteins, and a tunel assay was used to detect the levels of cell apoptosis. |
2022-01-03 |
2023-08-13 |
Not clear |
| Junxiang Wang, Chengfa Sun, Jian Li, Hua Jiang, Yun Qiu, Mingjie Gon. Knockdown of ETV4 promotes autophagy-dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1. Oncology letters. vol 23. issue 2. 2022-01-03. PMID:34976153. |
in conclusion, these findings indicated that the knockdown of etv4 in gbm cells may reduce the transcriptional activation of emp1 and thereby inhibit pi3k/akt/mtor signaling pathway activity to promote autophagy and apoptosis. |
2022-01-03 |
2023-08-13 |
Not clear |
| Xin Zhang, Yuyan Wang, Xiumei Liu, Anqi Zhao, Zhongheng Yang, Fanshuang Kong, Lili Sun, Yingyu Yu, Lipeng Jian. KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106376. |
in summary, kif2a is upregulated by transcription factor etv4, and its knockdown can effectively inhibit the proliferation and induce the apoptosis of gc cells through the akt signaling pathway in gc cells, implying that the inhibition of kif2a expression is a potential target for gc therapy. |
2021-01-19 |
2023-08-13 |
human |
| Melissa M Keenan, Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D Stevens, Olga Ilkayeva, Zhiqing Huang, Laura A Tollini, Susan K Murphy, Joseph Lucas, Deborah M Muoio, So Young Kim, Jen-Tsan Ch. ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. PLoS genetics. vol 11. issue 10. 2016-04-29. PMID:26452058. |
silencing etv4 also protected cells from hypoxia-induced apoptosis and led to remarkably similar transcriptional responses as with silenced acly or acc1, including an anti-apoptotic program. |
2016-04-29 |
2023-08-13 |
Not clear |
| Melissa M Keenan, Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D Stevens, Olga Ilkayeva, Zhiqing Huang, Laura A Tollini, Susan K Murphy, Joseph Lucas, Deborah M Muoio, So Young Kim, Jen-Tsan Ch. ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. PLoS genetics. vol 11. issue 10. 2016-04-29. PMID:26452058. |
acly and acc1 regulate hypoxia-induced apoptosis by modulating etv4 via α-ketoglutarate. |
2016-04-29 |
2023-08-13 |
Not clear |
| Melissa M Keenan, Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D Stevens, Olga Ilkayeva, Zhiqing Huang, Laura A Tollini, Susan K Murphy, Joseph Lucas, Deborah M Muoio, So Young Kim, Jen-Tsan Ch. ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. PLoS genetics. vol 11. issue 10. 2016-04-29. PMID:26452058. |
supplementation with α-ketoglutarate rescued the hypoxia-induced apoptosis and recapitulated the decreased expression and activity of etv4, likely via an epigenetic mechanism. |
2016-04-29 |
2023-08-13 |
Not clear |