| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher J E Denning, Lauren E Madory, Jessica N Herbert, Ryan A Cabrera, Karen K Szumlinsk. Neuropharmacological Evidence Implicating Drug-Induced Glutamate Receptor Dysfunction in Affective and Cognitive Sequelae of Subchronic Methamphetamine Self-Administration in Mice. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339206. |
neuropharmacological evidence implicating drug-induced glutamate receptor dysfunction in affective and cognitive sequelae of subchronic methamphetamine self-administration in mice. |
2024-02-10 |
2024-02-12 |
mouse |
| Tara L White, Meghan A Gonsalves, Ashley D Harris, Edward G Walsh, Hannah E Joyc. Brain Glutamate Dynamics Predict Positive Agency in Healthy Women: Insights from Combined Application of Pharmacological Challenge, Comprehensive Affective Assessment, and Magnetic Resonance Spectroscopy. ACS chemical neuroscience. 2024-01-18. PMID:38237555. |
brain glutamate dynamics predict positive agency in healthy women: insights from combined application of pharmacological challenge, comprehensive affective assessment, and magnetic resonance spectroscopy. |
2024-01-18 |
2024-01-21 |
human |
| Roni Hogri, Bozhidar Baltov, Ruth Drdla-Schutting, Valeria Mussetto, Holzinger Raphael, Lidia Trofimova, Juergen Sandkuehle. Probing pain aversion in rats with the âHeat Escape Thresholdâ paradigm. Molecular pain. 2023-01-30. PMID:36717755. |
using the het and hargreaves tests, we show that intra-lpbn application of glutamate antagonists reverses the effects of carrageenan on both affective and reflexive pain behaviour, respectively. |
2023-01-30 |
2023-08-14 |
mouse |
| Luca Zangrandi, Claudia Schmuckermair, Hussein Ghareh, Federico Castaldi, Regine Heilbronn, Gerald Zernig, Francesco Ferraguti, Arnau Ramos-Prat. Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping. International journal of molecular sciences. vol 22. issue 15. 2021-08-16. PMID:34360592. |
the metabotropic glutamate receptor type 5 (mglur5) has been proposed to play a crucial role in the selection and regulation of cognitive, affective, and emotional behaviors. |
2021-08-16 |
2023-08-13 |
mouse |
| Dominik Denzel, Lejla Colic, Liliana Ramona Demenescu, Felicia von Düring, Inka Ristow, Hanna Nießen, Luisa Hermann, Jörn Kaufmann, Udo Dannlowski, Jörg Frommer, Matthias Vogel, Meng Li, Anton Lord, Martin Walte. Local glutamate in cingulate cortex subregions differentially correlates with affective network activations during face perception. The European journal of neuroscience. vol 52. issue 3. 2021-06-21. PMID:32239708. |
local glutamate in cingulate cortex subregions differentially correlates with affective network activations during face perception. |
2021-06-21 |
2023-08-13 |
human |
| Margaret D Legarreta, Chandni Sheth, Andrew P Prescot, Perry F Renshaw, Erin C McGlade, Deborah A Yurgelun-Tod. An exploratory proton MRS examination of gamma-aminobutyric acid, glutamate, and glutamine and their relationship to affective aspects of chronic pain. Neuroscience research. vol 163. 2021-05-14. PMID:32171782. |
an exploratory proton mrs examination of gamma-aminobutyric acid, glutamate, and glutamine and their relationship to affective aspects of chronic pain. |
2021-05-14 |
2023-08-13 |
Not clear |
| C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, D Bosch, D Asede, F Malhaire, F Acher, J Giraldo, E Valjent, I Ehrlich, F Ferraguti, J-P Pin, A Llebaria, C Goude. Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4. Molecular psychiatry. vol 23. issue 3. 2019-03-12. PMID:27994221. |
dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4. |
2019-03-12 |
2023-08-13 |
Not clear |
| Rodrigo Noseda, David Borsook, Rami Burstei. Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache. Headache. vol 57 Suppl 2. 2018-03-02. PMID:28485844. |
following the presentation of scientific evidence for monosynaptic connections between thalamic trigeminovascular neurons and axons containing glutamate, gaba, dopamine, noradrenaline, serotonin, histamine, orexin, and melanin-concentrating hormone, this review synthesizes a large body of data to propose that the transmission of headache-related nociceptive signals from the thalamus to the cortex is modulated by potentially opposing forces and that the so-called 'decision' of which system (neuropeptide/neurotransmitter) will dominate the firing of a trigeminovascular thalamic neuron at any given time is determined by the constantly changing physiological (sleep, wakefulness, food intake, body temperature, heart rate, blood pressure), behavioral (addiction, isolation), cognitive (attention, learning, memory use), and affective (stress, anxiety, depression, anger) adjustment needed to keep homeostasis. |
2018-03-02 |
2023-08-13 |
Not clear |
| Michael D Grannan, Catharine A Mielnik, Sean P Moran, Robert W Gould, Jacob Ball, Zhuoyan Lu, Michael Bubser, Amy J Ramsey, Masahito Abe, Hyekyung P Cho, Kellie D Nance, Anna L Blobaum, Colleen M Niswender, P Jeffrey Conn, Craig W Lindsley, Carrie K Jone. Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M ACS chemical neuroscience. vol 7. issue 12. 2017-10-20. PMID:27617634. |
prefrontal cortex-mediated impairments in a genetic model of nmda receptor hypofunction are reversed by the novel m abnormalities in the signaling of the n-methyl-d-aspartate subtype of the glutamate receptor (nmdar) within cortical and limbic brain regions are thought to underlie many of the complex cognitive and affective symptoms observed in individuals with schizophrenia. |
2017-10-20 |
2023-08-13 |
Not clear |
| Anushree N Karkhanis, Thomas J R Beveridge, Bruce E Blough, Sara R Jones, Mark J Ferri. The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug and alcohol dependence. vol 166. 2017-10-11. PMID:27394931. |
the us food and drug administration has not approved a treatment for cocaine addiction, possibly due in part to the fact that repeated cocaine use results in dysregulation of multiple neurotransmitter systems, including glutamate and dopamine, and an emergence of increased negative affective states and heightening motivation to take cocaine despite negative consequences. |
2017-10-11 |
2023-08-13 |
Not clear |
| Robert J Buchanan, Klevest Gjini, Pradeep Modur, Kevin T Meier, Zoltan Nadasdy, Jennifer L Robinso. In vivo measurements of limbic glutamate and GABA concentrations in epileptic patients during affective and cognitive tasks: A microdialysis study. Hippocampus. vol 26. issue 5. 2017-01-06. PMID:26606278. |
in vivo measurements of limbic glutamate and gaba concentrations in epileptic patients during affective and cognitive tasks: a microdialysis study. |
2017-01-06 |
2023-08-13 |
human |
| Enza Palazzo, Rosaria Romano, Livio Luongo, Serena Boccella, Danilo De Gregorio, Maria Elvira Giordano, Francesca Rossi, Ida Marabese, Maria Antonietta Scafuro, Vito de Novellis, Sabatino Maion. MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. Pain. vol 156. issue 6. 2016-02-04. PMID:25760470. |
this study investigated the effects of a single administration of 6-(4-methoxyphenyl)-5-methyl-3-pyridinyl-4-isoxazolo[4,5-c]pyridin-4(5h)-one (mmpip), a negative allosteric modulator (nam) of metabotropic glutamate receptor 7 (mglur7), on pain and on affective and cognitive behavior in neuropathic mice. |
2016-02-04 |
2023-08-13 |
mouse |
| Iriana Galan-Arriero, Gerardo Avila-Martin, Agueda Ferrer-Donato, Julio Gomez-Soriano, Elisabeth Bravo-Esteban, Julian Taylo. Oral administration of the p38α MAPK inhibitor, UR13870, inhibits affective pain behavior after spinal cord injury. Pain. vol 155. issue 10. 2015-11-24. PMID:25180015. |
to conclude, oral treatment with a p38α mapk inhibitor reduces the affective behavioral component of pain after sci in association with a reduction of microglia and specific glutamate receptors within the acc. |
2015-11-24 |
2023-08-13 |
rat |
| Yuan-Yuan Hou, You-Qing Cai, Zhizhong Z Pa. Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced MeCP2 repression of GluA1 in rat central amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716866. |
in the central nucleus of amygdala (cea), a limbic structure critically involved in the affective dimension of pain, proteins of glua1 subunits of glutamate ampa receptors were upregulated during morphine withdrawal, and viral knockdown of cea glua1 eliminated the morphine-seeking behavior in withdrawn rats of the pain group. |
2015-06-29 |
2023-08-13 |
rat |
| Catherine A Spuz, George S Borszc. NMDA or non-NMDA receptor antagonism within the amygdaloid central nucleus suppresses the affective dimension of pain in rats: evidence for hemispheric synergy. The journal of pain. vol 13. issue 4. 2013-01-18. PMID:22424916. |
the present study evaluated the contribution of glutamate receptors in cea to generation of the affective response to acute pain in rats. |
2013-01-18 |
2023-08-12 |
rat |
| Cheryl A Frye, J J Paris, A A Walf, J C Ruscon. Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor. Frontiers in neuroscience. vol 5. 2012-10-02. PMID:22294977. |
in the ventral tegmental area (vta), 3α,5α-thp has actions to facilitate affective, and motivated, social behaviors through non-traditional targets, such as gaba, glutamate, and dopamine receptors. |
2012-10-02 |
2023-08-12 |
rat |
| Brian H Harvey, Mohammed Shahi. Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models. Pharmacology, biochemistry, and behavior. vol 100. issue 4. 2012-05-01. PMID:21708184. |
the glutamate system is an interesting target in this respect, especially given the impact anxiety disorders have on neuroplasticity, cognition and affective function. |
2012-05-01 |
2023-08-12 |
Not clear |
| Jocelyn M Richard, Kent C Berridg. Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust. The European journal of neuroscience. vol 33. issue 4. 2011-05-31. PMID:21198990. |
metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust. |
2011-05-31 |
2023-08-12 |
rat |
| Michael J Glas. The role of functional postsynaptic NMDA receptors in the central nucleus of the amygdala in opioid dependence. Vitamins and hormones. vol 82. 2010-08-20. PMID:20472137. |
activation of ionotropic n-methyl-d-aspartate (nmda)-type glutamate receptors in limbic system nuclei, such as the central nucleus of the amygdala (cea), plays an essential role in autonomic, behavioral, and affective processes that are profoundly impacted by exposure to opioids. |
2010-08-20 |
2023-08-12 |
mouse |
| A Cabral, J De Ross, V M Castilho, M L Brandão, M J Nobr. Glutamate receptor antagonism in inferior colliculus attenuates elevated startle response of high anxiety diazepam-withdrawn rats. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19348870. |
in addition, since bzp withdrawal may function as an unconditioned stressor, the negative affective states observed in ha rats could be a by-product of gaba-glutamate imbalance in brain systems that modulate unconditioned fear and anxiety behaviors, since the blockade of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (ampa) and n-methyl-d-aspartate (nmda) glutamate receptors in the cic clearly reduced the aversion promoted by diazepam withdrawal. |
2009-08-24 |
2023-08-12 |
rat |