| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Gao, Bernadeta Zabielska, Fuyong Jiao, Daoqi Mei, Xiaona Wang, Katarzyna Kotulska, Sergiusz Jozwia. Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex-Current Views on Their Pathogenesis and Management. Journal of clinical medicine. vol 12. issue 3. 2023-02-11. PMID:36769603. |
introduction, tuberous sclerosis complex (tsc) is an autosomal-dominant disorder caused by mutations inactivating tsc1 or tsc2 genes and characterized by the presence of tumors involving many organs, including the brain, heart, kidneys, and skin. |
2023-02-11 |
2023-08-14 |
Not clear |
| Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Iked. Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex. Human genomics. vol 17. issue 1. 2023-02-03. PMID:36732866. |
tsc2 mutation rather than tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex. |
2023-02-03 |
2023-08-14 |
mouse |
| Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Iked. Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex. Human genomics. vol 17. issue 1. 2023-02-03. PMID:36732866. |
tuberous sclerosis complex is caused by pathogenic germline mutations of either the tsc1 or tsc2 gene, but somatic mutations were identified in both genes, and the combined effects of tsc1 and tsc2 mutations have been unknown. |
2023-02-03 |
2023-08-14 |
mouse |
| Meng Liu, Jing-Wen Mai, De-Xing Luo, Guan-Xi Liu, Ting Xu, Wen-Jun Xin, Su-Yan Lin, Zhen-Yu L. NFATc2-dependent Epigenetic Downregulation of the TSC2/Beclin-1 Pathway is Involved in Neuropathic Pain Induced by Oxaliplatin. Molecular pain. 2023-02-03. PMID:36733258. |
utilizing chromatin immunoprecipitation-sequencing (chip-seq) assay combined with bioinformatics analysis, we found that nfatc2 negatively regulated the transcription of tuberous sclerosis complex protein 2 (tsc2), which contributed to the oxaliplatin-induced beclin-1 downregulation. |
2023-02-03 |
2023-08-14 |
rat |
| Chun-Pu Lin, Joleen J H Traets, David W Vredevoogd, Nils L Visser, Daniel S Peepe. TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling. The EMBO journal. 2023-01-30. PMID:36715448. |
here, we use whole-genome crispr-cas9 knockout data to uncover an important role for tuberous sclerosis complex 2 (tsc2) in determining tumor susceptibility to cytotoxic t lymphocyte (ctl) killing in human melanoma cells. |
2023-01-30 |
2023-08-14 |
human |
| Satoru Meguro, Tomoyuki Koguchi, Yusuke Hakozaki, Akifumi Onagi, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa, Yoshiyuki Kojim. Concurrent Reduced Expression of Contiguous Cancer genomics & proteomics. vol 20. issue 1. 2022-12-29. PMID:36581342. |
concurrent reduced expression of contiguous several cases of concurrent reduction of expression of polycystin 1 (pkd1) and tuberous sclerosis complex 2 (tsc2) that are contiguous in chromosome 16p13 have been previously reported. |
2022-12-29 |
2023-08-14 |
Not clear |
| Iya Ghassib, Honghao Zhang, Shuqun Qi, Rawan Moshen, Yuji Mishina, Teresita Bellido, Fei Li. Off-target activity of the 8 kb Dmp1-Cre results in the deletion of Tsc1 gene in mouse intestinal mesenchyme. Transgenic research. 2022-12-22. PMID:36547785. |
histological examination shows the presence of colon polyps in tsc1-deficient mice in association with significantly larger colon and narrower lumen, which recapitulates the common polyps pathology in tuberous sclerosis, an autosomal dominant disorder caused by mutations in either tsc1 or tsc2. |
2022-12-22 |
2023-08-14 |
mouse |
| Fei Li, Yifan Zhang, Zhoujun Lin, Lizhong Yan, Qiao Liu, Yin Li, Xiaolin Pei, Ya Feng, Xiao Han, Juan Yang, Fangxu Zheng, Tianjiao Li, Yupeng Zhang, Zhenkun Fu, Di Shao, Jane Yu, Chenggang L. Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM). Cell death & disease. vol 13. issue 12. 2022-12-21. PMID:36543771. |
lymphangioleiomyomatosis (lam), a progressive pulmonary disease exclusively affecting females, is caused by defects or mutations in the coding gene tuberous sclerosis complex 1 (tsc1) or tsc2, causing the mammalian target of rapamycin complex 1 (mtorc1) activation and autophagy inhibition. |
2022-12-21 |
2023-08-14 |
Not clear |
| Yuanjun Shen, Dmitry A Goncharov, Andressa Pena, Jeffrey Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N Bachman, Baojun Chang, Lifeng Jiang, Paul Dieffenbach, Laura E Fredenburgh, Mauricio Rojas, Horace DeLisser, Ana L Mora, Tatiana V Kudryashova, Elena A Goncharov. Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension. Science signaling. vol 15. issue 763. 2022-12-06. PMID:36473049. |
because cell growth mediated by the mtor-containing mtorc1 complex is inhibited by tuberous sclerosis complex 2 (tsc2), we investigated the role of this gtpase-activating protein in pah pathology. |
2022-12-06 |
2023-08-14 |
mouse |
| Huawen Xu, Yang Zhao, Qingjie Zhao, Mingpu Shi, Zhaoqi Zhang, Wenjun Ding, Yong Zha. Tuberous Sclerosis Complex 1 Deficiency in Macrophages Promotes Unclassical Inflammatory Response to Lipopolysaccharide Aging and disease. vol 13. issue 6. 2022-12-05. PMID:36465179. |
tuberous sclerosis complex 1 deficiency in macrophages promotes unclassical inflammatory response to lipopolysaccharide human tuberous sclerosis (tsc) is mainly caused by genetic mutations of tuberous tsc1or tsc2. |
2022-12-05 |
2023-08-14 |
mouse |
| Canyang Zhan, Lihua Che. [Analysis of TSC2 gene variant in a neonate with tuberous sclerosis complex]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 39. issue 12. 2022-12-01. PMID:36453965. |
[analysis of tsc2 gene variant in a neonate with tuberous sclerosis complex]. |
2022-12-01 |
2023-08-14 |
Not clear |
| Xue Liu, Yan Liu, Rui-Xue Yang, Xiang-Jiu Ding, Er-Shun Lian. Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice. Cell death & disease. vol 13. issue 11. 2022-11-18. PMID:36400753. |
genetic studies have proved the involvement of tuberous sclerosis complex subunit 2 (tsc2) in aortic aneurysm. |
2022-11-18 |
2023-08-14 |
mouse |
| Shengzhao Hu, Yingli Chen, Shipeng Huang, Min Liu, Ying Liu, Shaofang Huan. Sodium Danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome and tuberous sclerosis complex-2 (TSC2)/mammalian target of rapamycin (mTOR) pathways. Annals of translational medicine. vol 10. issue 20. 2022-11-17. PMID:36388798. |
sodium danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating nod-like receptor pyrin domain containing 3 (nlrp3) inflammasome and tuberous sclerosis complex-2 (tsc2)/mammalian target of rapamycin (mtor) pathways. |
2022-11-17 |
2023-08-14 |
Not clear |
| Machiko Kazami, Tomoya Sakamoto, Tsukasa Suzuki, Hirofumi Inoue, Hayato Kato, Ken-Ichi Kobayashi, Tadahiro Tadokoro, Yuji Yamamot. Ca2+/Calmodulin induces translocation of membrane-associated TSC2 to the nucleus where it suppresses CYP24A1 expression. Bioscience, biotechnology, and biochemistry. 2022-11-04. PMID:36331254. |
tuberous sclerosis complex 2 (tsc2) is a tumor-suppressor protein. |
2022-11-04 |
2023-08-14 |
rat |
| Bingying Xu, Zhuqing Li, Shan Li, Hanni Ke, Qian Zhang, Yingying Qin, Ting Gu. Pathogenic variants in TSC2 might cause premature ovarian insufficiency through activated mTOR induced hyperactivation of primordial follicles. Fertility and sterility. 2022-10-13. PMID:36229297. |
to investigate the role of tuberous sclerosis complex (tsc) genes, including tsc1 and tsc2, in the pathogenesis of human premature ovarian insufficiency (poi). |
2022-10-13 |
2023-08-14 |
human |
| Jiahuan Zhang, Song Xu, Kangyan Liang, Xiong Cao, Zhixin Ye, Wenlan Huang, Xiaochun Bai, Yue Zhan. LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions. Cellular signalling. 2022-09-17. PMID:36115548. |
mutations of tsc1 or tsc2 can lead to excessive activation of mtorc1 and cause tuberous sclerosis complex (tsc), which is an autosomal dominant genetic disease prominently characterized by seizures, mental retardation and multiorgan hamartoma. |
2022-09-17 |
2023-08-14 |
mouse |
| Clara Bernardelli, Eloisa Chiaramonte, Silvia Ancona, Silvia M Sirchia, Amilcare Cerri, Elena Lesm. Primary TSC2 International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077111. |
primary tsc2 cutaneous lesions are one of the hallmarks of tuberous sclerosis complex (tsc), a genetic disease in which mtor is hyperactivated due to the lack of hamartin or tuberin. |
2022-09-09 |
2023-08-14 |
Not clear |
| Alfredo Cerisola, Lucía Cibils, María Eugenia Chaibún, Virginia Pedemonte, Melania Rosa. [Tuberous sclerosis complex: diagnosis and current treatment]. Medicina. vol 82 Suppl 3. 2022-09-02. PMID:36054862. |
tuberous sclerosis complex is an autosomal dominant genetic multisystemic disorder caused primarily by mutations in one of the two tumor suppressor genes tsc1 or tsc2, resulting in increased activation of the mtor pathway. |
2022-09-02 |
2023-08-14 |
Not clear |
| Prabhumallikarjun Patil, Bojana Borislavova Pencheva, Vinayak Mahesh Patil, Jason Fangusar. Nervous system (NS) Tumors in Cancer Predisposition Syndromes. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-09-02. PMID:36056180. |
cancer predisposition syndromes that increase risks for ns tumor development in childhood include classic neurocutaneous disorders like neurofibromatosis type 1 and type 2 (nf1, nf2) and tuberous sclerosis complex (tsc) type 1 and 2 (tsc1, tsc2). |
2022-09-02 |
2023-08-14 |
Not clear |
| Paolo Curatolo, Nicola Specchio, Eleonora Aronic. Advances in the genetics and neuropathology of tuberous sclerosis complex: edging closer to targeted therapy. The Lancet. Neurology. vol 21. issue 9. 2022-08-13. PMID:35963265. |
tuberous sclerosis complex is a rare genetic disease associated with mutations in the tsc1 or tsc2 genes, which cause overactivation of the mtor complex. |
2022-08-13 |
2023-08-14 |
Not clear |