| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zha. Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet. Endocrine journal. 2024-03-31. PMID:38556321. |
markedly increased levels of alanine transaminase, aspartate transaminase, alkaline phosphatase albumin, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, elevated values of heart rate, left ventricular end-systolic pressure, left ventricular end-diastolic pressure, systolic pressure, and end diastolic pressure, and decreased value of stroke volume were observed in obese rats, which were sharply reversed by sg. |
2024-03-31 |
2024-04-03 |
rat |
| Shandiz Morega, Andrei Gresita, Smaranda Ioana Mitran, Madalina Iuliana Musat, Ianis Kevyn Stefan Boboc, Victor Gheorman, Ion Udristoiu, Carmen Valeria Albu, Costin Teodor Streba, Bogdan Catalin, Ion Rogovean. Cerebrolysin Use in Patients with Liver Damage-A Translational Study. Life (Basel, Switzerland). vol 12. issue 11. 2022-11-11. PMID:36362945. |
we investigated stroke patients treated with cerebrolysin that presented elevated levels of aspartate aminotransferase (ast) and/or alanine aminotransferase (alt). |
2022-11-11 |
2023-08-14 |
mouse |
| Jiali Xie, Yinmeng Zhu, Chunyang Pang, Lingfei Gao, Huan Yu, Wenjing Lv, Wanli Zhang, Binbin Den. Liver function parameters aspartate aminotransferase and total protein predict functional outcome in stroke patients with non-cardioembolism. Frontiers in nutrition. vol 9. 2022-09-05. PMID:36061892. |
liver function parameters aspartate aminotransferase and total protein predict functional outcome in stroke patients with non-cardioembolism. |
2022-09-05 |
2023-08-14 |
Not clear |
| Rui-Qing Li, Ming-Yue Wan, Jing Shi, Hui-Ling Wang, Fei-Lai Liu, Cheng-Mei Liu, Jin Huang, Ren-Chao Liu, Le Ma, Xiao-Dong Fen. Catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke. Neural regeneration research. vol 13. issue 6. 2020-09-29. PMID:29926828. |
catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke. |
2020-09-29 |
2023-08-13 |
rat |
| Paul Ganguly, Sreyoshi Fatima Ala. Role of homocysteine in the development of cardiovascular disease. Nutrition journal. vol 14. 2015-08-31. PMID:25577237. |
it is well known that neuronal damage following a stroke has been attributed to the over stimulation of excitatory amino acids such as glutamate and aspartate through activation of nmda receptors. |
2015-08-31 |
2023-08-13 |
Not clear |
| Ryan Boschert, Frederick R Adler, David F Blai. Loose coupling in the bacterial flagellar motor. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 15. 2015-07-24. PMID:25825730. |
genetic and biochemical evidence points to a "power stroke" mechanism in which the ions interact with an aspartate residue of motb to drive conformational changes in mota that are transmitted to the rotor protein flig. |
2015-07-24 |
2023-08-13 |
Not clear |
| Esther Shohami, Anat Biego. Novel approach to the role of NMDA receptors in traumatic brain injury. CNS & neurological disorders drug targets. vol 13. issue 4. 2015-02-23. PMID:24168367. |
for more than two decades the intensive research effort on the role of nmda receptors (nmdar) in traumatic brain injury (tbi) and cerebral ischemia (stroke) was led by the observations that extracellular concentrations of glutamate and aspartate are elevated after the insult and play a major role in brain pathologies. |
2015-02-23 |
2023-08-12 |
mouse |
| Alexander A Mongi. Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 14. issue 3-4. 2011-07-14. PMID:17961999. |
the mechanisms of brain tissue damage in stroke are strongly linked to the phenomenon of excitotoxicity, which is defined as damage or death of neural cells due to excessive activation of receptors for the excitatory neurotransmitters glutamate and aspartate. |
2011-07-14 |
2023-08-12 |
Not clear |
| Xiao-Jing Lin, Yi-Lei Li, Gui-Ping Mei, Fei Zou, Dan-Dan He, Xue-Qin Liu, Ya-Jie Li, Ting-Bao Zhao, Mao-Tsun Li. Activated protein C can be used as a prophylactic as well as a therapeutic agent for heat stroke in rodents. Shock (Augusta, Ga.). vol 32. issue 5. 2010-02-22. PMID:19295493. |
biochemical assay also revealed that both renal and hepatic dysfunction (e.g., increased plasma levels of blood urea nitrogen, creatinine, adenine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) were noted during heat stroke. |
2010-02-22 |
2023-08-12 |
human |
| Ing-Kit Lee, Jien-Wei Liu, Kuender D Yan. Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure. The American journal of tropical medicine and hygiene. vol 80. issue 4. 2009-04-28. PMID:19346394. |
compared with the controls, dhf patients with arf were found to be significantly older (p = 0.002) and male predominant (p < 0.001) and to have higher frequency of previous stroke (p = 0.005), chronic renal insufficiency (p = 0.046), dengue shock syndrome (dss; p < 0.001), gastrointestinal bleeding (p < 0.001), and concurrent bacteremia (p = 0.009), lower hemoglobin (p = 0.003) and serum albumin levels (p = 0.003), and higher incidences of prolonged prothrombin time (p < 0.001), elevated aspartate aminotransferase (p < 0.001), and alanine aminotransferase levels (p < 0.001). |
2009-04-28 |
2023-08-12 |
Not clear |
| J M Mount. Nuclear medicine in the rehabilitative treatment evaluation in stroke recovery. Role of diaschisis resolution and cerebral reorganization. Europa medicophysica. vol 43. issue 2. 2007-10-25. PMID:17268387. |
imaging of the stroke recovery process focuses on the physiologic model of stroke characterized by rcbf, metabolism, 1h spectroscopic measures of n-acetyl aspartate (naa), choline (ch) and creatine (cr) in the peri-infarction zone as well as in the extended stroke penumbra including areas of distant ''pure'' diaschisis unencumbered with the confound of cerebral ischemia. |
2007-10-25 |
2023-08-12 |
Not clear |
| P M Walker, D Ben Salem, M Giroud, F Brunott. Is NAA reduction in normal contralateral cerebral tissue in stroke patients dependent on underlying risk factors? Journal of neurology, neurosurgery, and psychiatry. vol 77. issue 5. 2006-05-30. PMID:16614018. |
this retrospective study investigated the dependence of n-acetyl aspartate (naa) ratios on risk factors for cerebral vasculopathy such as sex, age, hypertension, diabetes mellitus, carotid stenosis, and dyslipidaemia, which may have affected brain vessels and induced metabolic brain abnormalities prior to stroke. |
2006-05-30 |
2023-08-12 |
Not clear |
| Païkan Marcaggi, Nashila Hirji, David Attwel. Release of L-aspartate by reversal of glutamate transporters. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16150467. |
we compared the characteristics of aspartate and glutamate release mediated by reversed operation of glast glutamate transporters in salamander retinal glial cells, when high [k(+)](o) solution was applied to mimic the ionic conditions of stroke or glaucoma. |
2006-03-10 |
2023-08-12 |
Not clear |
| Païkan Marcaggi, Nashila Hirji, David Attwel. Release of L-aspartate by reversal of glutamate transporters. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16150467. |
in stroke the extracellular ph shifts acid by around a ph unit: this reduced the release of aspartate and glutamate by reversed uptake by a factor of 8-20. |
2006-03-10 |
2023-08-12 |
Not clear |
| Paul M Walker, Douraïed Ben Salem, Alain Lalande, Maurice Giroud, François Brunott. Time course of NAA T2 and ADC(w) in ischaemic stroke patients: 1H MRS imaging and diffusion-weighted MRI. Journal of the neurological sciences. vol 220. issue 1-2. 2004-07-22. PMID:15140601. |
proton spectroscopy and quantitative diffusion-weighted imaging (dwi) were used to investigate the pertinence of n-acetyl aspartate (naa) as a reliable marker of neuronal density in human stroke. |
2004-07-22 |
2023-08-12 |
human |
| E I Gusev, V I Skvortsov. [Glutamate neurotransmission and calcium metabolism in cerebral ischaemia and under normal conditions]. Uspekhi fiziologicheskikh nauk. vol 33. issue 4. 2003-02-12. PMID:12449809. |
the significant increases in the concentrations of excitatory aminoacidergic neurotransmitters (glutamate and aspartate) in the cerebrospinal fluid were demonstrated in patients with acute ischaemic strokes from the first hours of illness with no dependency on vascular origin of strokes. |
2003-02-12 |
2023-08-12 |
Not clear |
| D E Saunder. MR spectroscopy in stroke. British medical bulletin. vol 56. issue 2. 2000-12-08. PMID:11092084. |
the majority of the stroke studies have been carried out using proton [1h]-mrs which allows the detection of n-acetyl aspartate (naa), a neuronal marker. |
2000-12-08 |
2023-08-12 |
Not clear |
| S T Pendlebury, M A Lee, A M Blamire, P Styles, P M Matthew. Correlating magnetic resonance imaging markers of axonal injury and demyelination in motor impairment secondary to stroke and multiple sclerosis. Magnetic resonance imaging. vol 18. issue 4. 2000-05-18. PMID:10788713. |
we aimed to examine the relationship between motor impairment, magnetisation transfer ratio (mtr) (an index of demyelination), and n-acetyl aspartate (naa) loss (an index of axonal injury) localised to the descending motor pathways in stroke and ms. twelve patients between 1 and 10 months after first ischaemic stroke causing a motor deficit and 12 patients with stable ms with asymmetric motor deficit were examined. |
2000-05-18 |
2023-08-12 |
Not clear |
| E I Gusev, V I Skvortsova, S A Dambinova, K S Raevskiy, A A Alekseev, V G Bashkatova, A V Kovalenko, V S Kudrin, E V Yakovlev. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovascular diseases (Basel, Switzerland). vol 10. issue 1. 2000-05-10. PMID:10629347. |
an early normalization of autoantibody titres to nmda-binding proteins in serum was found (p < 0.01 vs. placebo), a reduction of glutamate and aspartate levels (p < 0.05 vs. placebo), an increase in gaba concentrations (p < 0.01 vs. placebo in severe stroke patients) and also a reduction of tbars levels (p < 0.05 vs. placebo) in csf by day 3. |
2000-05-10 |
2023-08-12 |
Not clear |
| K D Sims, M B Robinso. Expression patterns and regulation of glutamate transporters in the developing and adult nervous system. Critical reviews in neurobiology. vol 13. issue 2. 1999-11-24. PMID:10512489. |
the precise control of extracellular glutamate and aspartate is crucial to the maintenance of normal synaptic transmission and the prevention of excitotoxicity following acute insults to the brain, such as stroke or head trauma, or during the progression of neurodegenerative diseases such as amyotrophic lateral sclerosis. |
1999-11-24 |
2023-08-12 |
Not clear |