| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaodi Tian, Chenglin Liu, Zhang Shu, Gang Che. Review: Therapeutic Targeting of HMGB1 in Stroke. Current drug delivery. vol 14. issue 6. 2018-08-24. PMID:27501713. |
this review discusses the emerging roles of hmgb1 in several stroke models, as well as its potential role as a therapeutic target for stroke patients. |
2018-08-24 |
2023-08-13 |
Not clear |
| Seidu A Richard, Marian Sackey, Zhaoliang Su, Huaxi X. Pivotal neuroinflammatory and therapeutic role of high mobility group box 1 in ischemic stroke. Bioscience reports. vol 37. issue 6. 2018-07-26. PMID:29054968. |
therefore, hmgb1 is new promising therapeutic intervention aimed at promoting neurovascular repair and remodeling after stroke. |
2018-07-26 |
2023-08-13 |
Not clear |
| Jun Young Choi, Yuexian Cui, Samma Tasneem Chowdhury, Byung Gon Ki. High-mobility group box-1 as an autocrine trophic factor in white matter stroke. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 25. 2018-05-04. PMID:28584116. |
we confirmed that cytosolic translocation of hmgb1 and activation of tlr2-mediated signaling pathways occurred in a focal white matter stroke model induced by endothelin-1 injection. |
2018-05-04 |
2023-08-13 |
Not clear |
| Jung Ho Lee, Eun Jang Yoon, Jeho Seo, Adriana Kavoussi, Yong Eun Chung, Sung Phil Chung, Incheol Park, Chul Hoon Kim, Je Sung Yo. Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1. Molecular brain. vol 9. issue 1. 2017-11-06. PMID:27544687. |
in addition to suggesting a potential mechanism for hypothermia's therapeutic effects, our results suggest hmgb1 modulation may lengthen the therapeutic window for stroke treatments. |
2017-11-06 |
2023-08-13 |
Not clear |
| Kazuo Yamagata, Natumi Sone, Sari Suguyama, Toru Nabik. Different effects of arginine vasopressin on high-mobility group box 1 expression in astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats. International journal of experimental pathology. vol 97. issue 2. 2017-07-17. PMID:27126918. |
the purpose of this study was to examine whether avp and/or hypoxia and reoxygenation (h/r) contribute to hmgb1 regulation following ischaemic stroke. |
2017-07-17 |
2023-08-13 |
rat |
| Kazuo Yamagata, Natumi Sone, Sari Suguyama, Toru Nabik. Different effects of arginine vasopressin on high-mobility group box 1 expression in astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats. International journal of experimental pathology. vol 97. issue 2. 2017-07-17. PMID:27126918. |
we hypothesize that regulation of hmgb1 by avp during h/r might be related to induction of inflammation and stroke in shrsp/izm and shrpch1_18 rats. |
2017-07-17 |
2023-08-13 |
rat |
| J Hu, B Liu, Q Zhao, P Jin, F Hua, Z Zhang, Y Liu, K Zan, G Cui, X Y. Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats. Neuroscience. vol 324. 2017-01-10. PMID:26946264. |
type 2 diabetic rats did not show an increased lesion volume, but exhibited significantly increased expression of hmgb1 and rage, bbb leakage, as well as decreased functional outcome after stroke compared with control rats. |
2017-01-10 |
2023-08-13 |
rat |
| J Hu, B Liu, Q Zhao, P Jin, F Hua, Z Zhang, Y Liu, K Zan, G Cui, X Y. Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats. Neuroscience. vol 324. 2017-01-10. PMID:26946264. |
injection of bone marrow stromal cells (bmscs) into type 2 diabetic rats significantly reduced the expression of hmgb1 and rage, attenuated bbb leakage, and improved functional outcome after stroke. |
2017-01-10 |
2023-08-13 |
rat |
| Jue Wang, Dong Han, Miao Sun, Juan Fen. A Combination of Remote Ischemic Perconditioning and Cerebral Ischemic Postconditioning Inhibits Autophagy to Attenuate Plasma HMGB1 and Induce Neuroprotection Against Stroke in Rat. Journal of molecular neuroscience : MN. vol 58. issue 4. 2016-12-26. PMID:26852332. |
a combination of remote ischemic perconditioning and cerebral ischemic postconditioning inhibits autophagy to attenuate plasma hmgb1 and induce neuroprotection against stroke in rat. |
2016-12-26 |
2023-08-13 |
rat |
| Vikramjeet Singh, Stefan Roth, Roland Veltkamp, Arthur Lies. HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke. Antioxidants & redox signaling. vol 24. issue 12. 2016-12-22. PMID:26493086. |
high-mobility group box 1 (hmgb1) has come into the focus of experimental and clinical stroke research because it is released from necrotic brain tissue and its differential redox forms attract and activate immune cells after ischemic brain injury. |
2016-12-22 |
2023-08-13 |
Not clear |
| C F Tsao, W T Huang, T T Liu, P W Wang, C W Liou, T K Lin, C J Hsieh, S W Wen. Expression of high-mobility group box protein 1 in diabetic foot atherogenesis. Genetics and molecular research : GMR. vol 14. issue 2. 2016-02-05. PMID:25966225. |
the role of high mobility group box 1 (hmgb1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (paod). |
2016-02-05 |
2023-08-13 |
human |
| Kazuhide Hayakawa, Nobukazu Miyamoto, Ji Hae Seo, Loc-Duyen D Pham, Kyu-Won Kim, Eng H Lo, Ken Ara. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. Journal of neurochemistry. vol 125. issue 2. 2015-08-18. PMID:23227954. |
high-mobility group box 1 (hmgb1) was initially described as a damage-associated-molecular-pattern (damp) mediator that worsens acute brain injury after stroke. |
2015-08-18 |
2023-08-12 |
mouse |
| Kazuhide Hayakawa, Nobukazu Miyamoto, Ji Hae Seo, Loc-Duyen D Pham, Kyu-Won Kim, Eng H Lo, Ken Ara. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. Journal of neurochemistry. vol 125. issue 2. 2015-08-18. PMID:23227954. |
but, recent findings suggest that hmgb1 can play a surprisingly beneficial role during stroke recovery by promoting endothelial progenitor cell (epc) function and vascular remodeling in cortical gray matter. |
2015-08-18 |
2023-08-12 |
mouse |
| Chao Chen, Xiaojie Lin, Jixian Wang, Guanghui Tang, Zhihao Mu, Xiaoyan Chen, Jin Xu, Yongting Wang, Zhijun Zhang, Guo-Yuan Yan. Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice. Stem cells (Dayton, Ohio). vol 32. issue 10. 2015-05-20. PMID:24888319. |
it was reported that astrocytic-high mobility group box1 (hmgb1) promoted endogenous epc-mediated neurovascular remodeling during stroke recovery. |
2015-05-20 |
2023-08-13 |
mouse |
| Chao Chen, Xiaojie Lin, Jixian Wang, Guanghui Tang, Zhihao Mu, Xiaoyan Chen, Jin Xu, Yongting Wang, Zhijun Zhang, Guo-Yuan Yan. Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice. Stem cells (Dayton, Ohio). vol 32. issue 10. 2015-05-20. PMID:24888319. |
it is unclear whether hmgb1 involves in exogenous epc-mediated stroke recovery. |
2015-05-20 |
2023-08-13 |
mouse |
| Chao Chen, Xiaojie Lin, Jixian Wang, Guanghui Tang, Zhihao Mu, Xiaoyan Chen, Jin Xu, Yongting Wang, Zhijun Zhang, Guo-Yuan Yan. Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice. Stem cells (Dayton, Ohio). vol 32. issue 10. 2015-05-20. PMID:24888319. |
in summary, the result suggested that hmgb1 upregulation in postischemic brain could promote exogenous hpb-epc-mediated stroke recovery by modulating paracrine function of hpb-epcs. |
2015-05-20 |
2023-08-13 |
mouse |
| Arthur Liesz, Alexander Dalpke, Eva Mracsko, Daniel J Antoine, Stefan Roth, Wei Zhou, Huan Yang, Shin-Young Na, Mustafa Akhisaroglu, Thomas Fleming, Tatjana Eigenbrod, Peter P Nawroth, Kevin J Tracey, Roland Veltkam. DAMP signaling is a key pathway inducing immune modulation after brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 2. 2015-04-07. PMID:25589753. |
our results indicate that the cytokine-inducing, fully reduced isoform of hmgb1 was released from the ischemic brain in the hyperacute phase of stroke in mice and patients. |
2015-04-07 |
2023-08-13 |
mouse |
| Nelly Sapojnikova, Tamar Kartvelishvili, Nino Asatiani, Vitaly Zinkevich, Iagor Kalandadze, Darejan Gugutsidze, Roman Shakarishvili, Alexander Tsiskaridz. Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24815357. |
the relations between two main players in the ischemic brain, mmps and hmgb1, were estimated in the plasma of ischemic stroke patients stratified according to the glasgow outcome scale and the oxfordshire community stroke project classification. |
2014-09-25 |
2023-08-13 |
human |
| Teresita Menini, Hisato Ikeda, Satoshi Kimura, Alejandro Gugliucc. Circulating soluble RAGE increase after a cerebrovascular event. Clinical chemistry and laboratory medicine. vol 52. issue 1. 2014-07-31. PMID:23492566. |
based on the evidence from animal studies and the presence of increased high mobility group box 1 protein (hmgb1, a rage ligand) in the serum of stroke patients, we hypothesized that soluble rage (srage) increase in serum after ischemic and hemorrhagic stroke and that the levels decrease with patient improvement. |
2014-07-31 |
2023-08-12 |
Not clear |
| Jingyang Huang, Baoyi Liu, Chenghui Yang, Haili Chen, Dzivor Eunice, Zhongrui Yua. Acute hyperglycemia worsens ischemic stroke-induced brain damage via high mobility group box-1 in rats. Brain research. vol 1535. 2014-05-08. PMID:24012767. |
the aim of this study was to determine whether the extracellular hmgb1 is involved in the worsened ischemic damage during hyperglycemic stroke. |
2014-05-08 |
2023-08-12 |
rat |