| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenbao Liu, Weixia Yang, Jianxin Chen, Qian Wan. Circulating HMGB1 in acute ischemic stroke and its association with post-stroke cognitive impairment. PeerJ. vol 12. 2024-05-06. PMID:38708343. |
high mobility group box 1 (hmgb1) is a protein released by ischemic neurons and implicated in inflammation after stroke. |
2024-05-06 |
2024-05-08 |
Not clear |
| Patrick-Brian Bielawski, Issan Zhang, Clara Correa-Paz, Francisco Campos, Martina Migliavacca, Ester Polo, Pablo Del Pino, Beatriz Pelaz, Denis Vivien, Dusica Maysinge. Modulation of Abundance and Location of High-Mobility Group Box 1 in Human Microglia and Macrophages under Oxygen-Glucose Deprivation. ACS pharmacology & translational science. vol 7. issue 3. 2024-03-14. PMID:38481701. |
this study points out a salient molecular interaction suited for a two-pronged nanotherapeutic intervention in stroke: enhancement of rtpa's thrombolytic activity and modulation of cytosolic interactions between hmgb1 and hsp72 by resveratrol. |
2024-03-14 |
2024-03-16 |
human |
| Lin Qi, Cheng Wang, Lidong Deng, Jia-Ji Pan, Qian Suo, Shengju Wu, Lin Cai, Xudong Shi, Junfeng Sun, Yongting Wang, Yaohui Tang, Weibao Qiu, Guo-Yuan Yang, Jixian Wang, Zhijun Zhan. Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic HMGB1 and CAMK2N1 in mice. Stroke and vascular neurology. 2024-01-08. PMID:38191183. |
low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic hmgb1 and camk2n1 in mice. |
2024-01-08 |
2024-01-10 |
mouse |
| Jie Zhao, Fang Xu, Wanying Xu, Rong Lv, Juan Wang, Xufeng Yan. Higher High-Mobility Group Box-1 Levels are Associated with White Matter Lesions in Ischemic Stroke Patients. Journal of inflammation research. vol 16. 2023-10-16. PMID:37842188. |
we aim to explore whether the circulating hmgb1 concentrations are associated with the white matter lesions (wmls) burden in stroke patients. |
2023-10-16 |
2023-11-08 |
Not clear |
| Yanfang Pei, Wenfeng Ma, Huifang Wang, Fang Chen, Weiwei Xiao, Maiying Fan, Xiaotong Han, Yan Ca. Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke. Genomics. 2023-09-27. PMID:37757977. |
mesenchymal stem cell-derived exosomal mir-548x-3p inhibits pyroptosis of vascular endothelial cells through hmgb1 in heat stroke. |
2023-09-27 |
2023-10-07 |
mouse |
| Frederik Denorme, Irina Portier, John L Rustad, Mark J Cody, Claudia V de Araujo, Chieko Hoki, Matthew D Alexander, Ramesh Grandhi, Mitchell R Dyer, Matthew D Neal, Jennifer J Majersik, Christian C Yost, Robert A Campbel. Neutrophil extracellular traps regulate ischemic stroke brain injury. The Journal of clinical investigation. 2022-03-31. PMID:35358095. |
additionally, we observed increased plasma and platelet surface expressed high mobility group box 1 (hmgb1) in stroke patients. |
2022-03-31 |
2023-08-13 |
mouse |
| Frederik Denorme, Irina Portier, John L Rustad, Mark J Cody, Claudia V de Araujo, Chieko Hoki, Matthew D Alexander, Ramesh Grandhi, Mitchell R Dyer, Matthew D Neal, Jennifer J Majersik, Christian C Yost, Robert A Campbel. Neutrophil extracellular traps regulate ischemic stroke brain injury. The Journal of clinical investigation. 2022-03-31. PMID:35358095. |
mechanistically, platelets were identified as the critical source for hmgb1 causing nets in the acute phase of stroke. |
2022-03-31 |
2023-08-13 |
mouse |
| Frederik Denorme, Irina Portier, John L Rustad, Mark J Cody, Claudia V de Araujo, Chieko Hoki, Matthew D Alexander, Ramesh Grandhi, Mitchell R Dyer, Matthew D Neal, Jennifer J Majersik, Christian C Yost, Robert A Campbel. Neutrophil extracellular traps regulate ischemic stroke brain injury. The Journal of clinical investigation. 2022-03-31. PMID:35358095. |
depleting platelets or platelet-specific knockout of hmgb1 significantly reduced plasma hmgb1 and net levels after stroke, and greatly improved stroke outcomes. |
2022-03-31 |
2023-08-13 |
mouse |
| Mert Seyhan, Kathrin Ungethüm, Michael K Schuhmann, Daniel Mackenrodt, Viktoria Rücker, Felipe A Montellano, Silke Wiedmann, Dominik Rath, Tobias Geisler, Bernhard Nieswandt, Peter Kraft, Christoph Kleinschnitz, Peter U Heuschman. Feasibility of platelet marker analysis in ischemic stroke patients and their association with one-year outcome. A pilot project within a subsample of the Stroke Induced Cardiac Failure in Mice and Men (SICFAIL) cohort study. Platelets. 2021-12-08. PMID:34875957. |
in this pilot study, feasibility of psp analysis by flow cytometry (hmgb1, cd84, cxcr4, cxcr7, cd62p with and without adp-stimulation, cd41, cd61, cd40, gpvi) was investigated in 99 (median 66 years, 67.5% male) acute is patients admitted to stroke unit within a substudy of the stroke-induced cardiac failure in mice and men (sicfail) cohort study. |
2021-12-08 |
2023-08-13 |
mouse |
| Fabian Essig, Lilith Babilon, Christoph Vollmuth, Alexander M Kollikowski, Mirko Pham, László Solymosi, Karl Georg Haeusler, Peter Kraft, Guido Stoll, Michael K Schuhman. High Mobility Group Box 1 Protein in Cerebral Thromboemboli. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681935. |
we here analyzed associated hmgb1 expression in human thromboemboli retrieved via mechanical thrombectomy from 37 stroke patients with large vessel occlusion. |
2021-10-26 |
2023-08-13 |
human |
| Elzbieta Klimiec-Moskal, Paulina Pasinska, Katarzyna Kowalska, Aleksandra Klimkowicz-Mrowiec, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzi. Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium - A pilot study. Journal of neuroimmunology. vol 356. 2021-09-07. PMID:33901789. |
of 571 stroke patients, we compared plasma levels of hmgb1 and gal-3bp in 79 delirious patients with 81 non-delirious patients matched for age and stroke severity. |
2021-09-07 |
2023-08-13 |
Not clear |
| Andrew Vahabzadeh-Hagh, Thomas J McCarthy, Luis De Taboada, Jackson Streeter, Alvaro Pascual-Leone, Eng H Lo, Kazuhide Hayakaw. Near infrared light amplifies endothelial progenitor cell accumulation after stroke. Conditioning medicine. vol 2. issue 4. 2021-07-23. PMID:34291201. |
here, we show that near-infrared (nir) light stimulation of astrocytes increases a calcium-dependent secretion of the prototypical damp, hmgb1, which may then accelerate endothelial progenitor cell (epc) accumulation after stroke. |
2021-07-23 |
2023-08-13 |
mouse |
| Seung-Woo Kim, Ja-Kyeong Le. Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review. Cells. vol 9. issue 8. 2021-03-31. PMID:32731558. |
this review discusses netosis and thrombosis and their crosstalk in various thrombosis-related diseases, focusing on the role of hmgb1 as a mediator in stroke. |
2021-03-31 |
2023-08-13 |
Not clear |
| Yanyan Sun, Mingyan Hei, Zhihui Fang, Zhen Tang, Bo Wang, Na H. High-Mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-Ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31920543. |
recent evidence suggests that high-mobility group box 1 (hmgb1) protein can promote neuroinflammation after stroke in adult rodents, but its role in perinatal hypoxic-ischemic brain damage (hibd) remains largely uninvestigated. |
2020-09-30 |
2023-08-13 |
rat |
| You Li, Jing Zhu, Linfa Chen, Weidong Hu, Mengxu Wang, Shengnan Li, Xuefeng Gu, Hua Tao, Bin Zhao, Guoda Ma, Keshen L. Genetic predisposition to ischaemic stroke by Oncotarget. vol 8. issue 59. 2019-11-20. PMID:29245967. |
genetic predisposition to ischaemic stroke by emerging evidence suggests that the multiligand receptor for advanced glycation end products (rage) and its ligand high mobility group box 1 protein (hmgb1) contribute to the pathophysiology of ischaemic stroke (is). |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiaodi Chen, Jiyong Zhang, Boram Kim, Siddhant Jaitpal, Steven S Meng, Kwame Adjepong, Sayumi Imamura, Hidenori Wake, Masahiro Nishibori, Edward G Stopa, Barbara S Stonestree. High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats. Experimental neurology. vol 311. 2019-04-10. PMID:30217406. |
the high mobility group box-1 (hmgb1) protein is a nuclear protein with pro-inflammatory cytokine properties when it is translocated from the nucleus and released extracellularly after stroke in adult rodents. |
2019-04-10 |
2023-08-13 |
human |
| Kai Le, Sisi Mo, Xiang Lu, Abdoulaye Idriss Ali, Dafan Yu, Yijing Gu. Association of circulating blood HMGB1 levels with ischemic stroke: a systematic review and meta-analysis. Neurological research. vol 40. issue 11. 2018-12-18. PMID:30015578. |
we performed a meta-analysis to assess currently published data pertaining to circulating blood hmgb1 levels in is and the relationship with stroke severity. |
2018-12-18 |
2023-08-13 |
Not clear |
| Miaodan Li, Shumin Chen, Xue Shi, Chenfei Lyu, Yongfang Zhang, Miaoqin Tan, Chen Wang, Nailiang Zang, Xiaoxi Liu, Yafang Hu, Jiangang Shen, Liang Zhou, Yong G. Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke. Journal of neuroinflammation. vol 15. issue 1. 2018-11-23. PMID:30139371. |
this study aimed to investigate the change of hmgb1 after thrombolytic therapy and whether blocking hmgb1 could ameliorate the neurovasculature complications secondary to tpa treatment in stroke rats. |
2018-11-23 |
2023-08-13 |
rat |
| Xiaodi Tian, Chenglin Liu, Zhang Shu, Gang Che. Review: Therapeutic Targeting of HMGB1 in Stroke. Current drug delivery. vol 14. issue 6. 2018-08-24. PMID:27501713. |
review: therapeutic targeting of hmgb1 in stroke. |
2018-08-24 |
2023-08-13 |
Not clear |
| Xiaodi Tian, Chenglin Liu, Zhang Shu, Gang Che. Review: Therapeutic Targeting of HMGB1 in Stroke. Current drug delivery. vol 14. issue 6. 2018-08-24. PMID:27501713. |
however, surprisingly, hmgb1 can mediate beneficial effects during the course of stroke recovery. |
2018-08-24 |
2023-08-13 |
Not clear |