| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kerri M Carlson, Laura Melcher, Shaojuan Lai, Huda Y Zoghbi, H Brent Clark, Harry T Or. Characterization of the zebrafish atxn1/axh gene family. Journal of neurogenetics. vol 23. issue 3. 2011-12-27. PMID:19085187. |
expansion of the polyglutamine tract in atxn1 causes the neurodegenerative disease, spinocerebellar ataxia type 1 (sca1) with prominent cerebellar pathology. |
2011-12-27 |
2023-08-12 |
human |
| Gülin Oz, Manda L Vollmers, Christopher D Nelson, Ryan Shanley, Lynn E Eberly, Harry T Orr, H Brent Clar. In vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21963649. |
here we assessed the sensitivity of high field proton magnetic resonance spectroscopy ((1)h mrs) to monitor reversal of neurodegeneration by taking advantage of a well characterized conditional mouse model of spinocerebellar ataxia type 1 (sca1), where the cerebellar pathology and ataxic phenotype are reversible by doxycycline administration. |
2011-12-20 |
2023-08-12 |
mouse |
| José L Pedroso, Pedro Braga-Neto, André C Felício, Camila C H Aquino, Lucila B Fernandes do Prado, Gilmar Fernandes do Prado, Orlando G P Barsottin. Sleep disorders in cerebellar ataxias. Arquivos de neuro-psiquiatria. vol 69. issue 2A. 2011-12-16. PMID:21537570. |
recently, a large body of evidence has demonstrated a high frequency of non-motor manifestations in cerebellar ataxias, specially in autosomal dominant spinocerebellar ataxias (sca). |
2011-12-16 |
2023-08-12 |
Not clear |
| Federico D'Agata, Paola Caroppo, Andrea Boghi, Mario Coriasco, Marcella Caglio, Bruno Baudino, Katiuscia Sacco, Franco Cauda, Elisabetta Geda, Mauro Bergui, Giuliano Geminiani, Gianni Boris Bradac, Laura Orsi, Paolo Mortar. Linking coordinative and executive dysfunctions to atrophy in spinocerebellar ataxia 2 patients. Brain structure & function. vol 216. issue 3. 2011-12-12. PMID:21461742. |
spinocerebellar ataxias type 2 (sca2) is a rare genetic disorder characterised by the degeneration of the cerebellum, its connections and many brainstem areas. |
2011-12-12 |
2023-08-12 |
Not clear |
| You-Kang Chang, Ming-Hsiang Chen, Yi-Hung Chiang, Yu-Fan Chen, Wei-Hsien Ma, Chian-You Tseng, Bin-Wen Soong, Jennifer H Ho, Oscar K Le. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells. Journal of biomedical science. vol 18. 2011-12-12. PMID:21824437. |
spinocerebellar ataxia (sca) refers to a disease entity in which polyglutamine aggregates are over-produced in purkinje cells (pcs) of the cerebellum as well as other neurons in the central nervous system, and the formation of intracellular polyglutamine aggregates result in the loss of neurons as well as deterioration of motor functions. |
2011-12-12 |
2023-08-12 |
human |
| Takahiro Seki, Naoko Adachi, Nana Abe-Seki, Takayuki Shimahara, Hideyuki Takahashi, Kazuhiro Yamamoto, Naoaki Saito, Norio Saka. Elucidation of the molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant protein kinase Cγ. Journal of pharmacological sciences. vol 116. issue 3. 2011-12-06. PMID:21666345. |
spinocerebellar ataxia (sca) is an inherited neurodegenerative disorder that is characterized by cerebellar atrophy and progressive ataxia and is classified into 31 types by the genetic locus. |
2011-12-06 |
2023-08-12 |
Not clear |
| Ana Solodkin, Christopher M Gome. Spinocerebellar ataxia type 6. Handbook of clinical neurology. vol 103. 2011-12-06. PMID:21827907. |
spinocerebellar ataxia type 6 (sca6) is the prototype of a pure cerebellar ataxia, associated with a severe form of progressive ataxia and cerebellar dysfunction. |
2011-12-06 |
2023-08-12 |
Not clear |
| Giovanni Stevanin, Alexandra Dür. Spinocerebellar ataxia 13 and 25. Handbook of clinical neurology. vol 103. 2011-12-06. PMID:21827913. |
spinocerebellar ataxia (sca) types 13 and 25 are two genetic entities among the autosomal dominant cerebellar ataxias, initially mapped in two french families to chromosomes 19q and 2p, respectively. |
2011-12-06 |
2023-08-12 |
Not clear |
| Sarah Stricker, Timm Oberwahrenbrock, Hanna Zimmermann, Jan Schroeter, Matthias Endres, Alexander U Brandt, Friedemann Pau. Temporal retinal nerve fiber loss in patients with spinocerebellar ataxia type 1. PloS one. vol 6. issue 7. 2011-12-06. PMID:21829579. |
autosomal dominant spinocerebellar ataxia type 1 is an adult onset progressive disorder with well characterized neurodegeneration in the cerebellum and brainstem. |
2011-12-06 |
2023-08-12 |
Not clear |
| Alessandra Rufa, Pamela Federigh. Fast versus slow: different saccadic behavior in cerebellar ataxias. Annals of the New York Academy of Sciences. vol 1233. 2011-11-30. PMID:21950987. |
spinocerebellar ataxia type 2 (sca2) is a genetic neurodegenerative disorder primarily characterized by involvement of the brainstem and cerebellum, basal ganglia, spinal cord, cerebral cortex, but white matter is also involved. |
2011-11-30 |
2023-08-12 |
Not clear |
| Ulf Edener, Veronica Bernard, Yorck Hellenbroich, Gabriele Gillessen-Kaesbach, Christine Zühlk. Two dominantly inherited ataxias linked to chromosome 16q22.1: SCA4 and SCA31 are not allelic. Journal of neurology. vol 258. issue 7. 2011-11-15. PMID:21267591. |
autosomal dominant spinocerebellar ataxias (scas) are heterogeneous neurological disorders characterised by cerebellar dysfunction mostly due to purkinje cell degeneration. |
2011-11-15 |
2023-08-12 |
Not clear |
| Gülin Oz, Isabelle Iltis, Diane Hutter, William Thomas, Khalaf O Bushara, Christopher M Gome. Distinct neurochemical profiles of spinocerebellar ataxias 1, 2, 6, and cerebellar multiple system atrophy. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:20838948. |
distinct neurochemical profiles of spinocerebellar ataxias 1, 2, 6, and cerebellar multiple system atrophy. |
2011-11-10 |
2023-08-12 |
human |
| Gülin Oz, Isabelle Iltis, Diane Hutter, William Thomas, Khalaf O Bushara, Christopher M Gome. Distinct neurochemical profiles of spinocerebellar ataxias 1, 2, 6, and cerebellar multiple system atrophy. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:20838948. |
we compared cerebellar and brainstem neurochemical profiles measured at 4 t from 26 patients with spinocerebellar ataxias (sca1, n = 9; sca2, n = 7; sca6, n = 5) or cerebellar multiple system atrophy (msa-c, n = 5) and 15 age-matched healthy controls. |
2011-11-10 |
2023-08-12 |
human |
| Ana Solodkin, Eitan Peri, E Elinor Chen, Eshel Ben-Jacob, Christopher M Gome. Loss of intrinsic organization of cerebellar networks in spinocerebellar ataxia type 1: correlates with disease severity and duration. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:20886327. |
loss of intrinsic organization of cerebellar networks in spinocerebellar ataxia type 1: correlates with disease severity and duration. |
2011-11-10 |
2023-08-12 |
Not clear |
| Ana Solodkin, Eitan Peri, E Elinor Chen, Eshel Ben-Jacob, Christopher M Gome. Loss of intrinsic organization of cerebellar networks in spinocerebellar ataxia type 1: correlates with disease severity and duration. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:20886327. |
the spinocerebellar ataxias (scas) are a genetically heterogeneous group of cerebellar degenerative disorders, characterized by progressive gait unsteadiness, hand incoordination, and dysarthria. |
2011-11-10 |
2023-08-12 |
Not clear |
| Martin Bares, Ovidiu V Lungu, Tao Liu, Tobias Waechter, Christopher M Gomez, James Ash. The neural substrate of predictive motor timing in spinocerebellar ataxia. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:21110147. |
we examined the role of the cerebellum and striatum in predictive motor timing in a target interception task in healthy (n = 12) individuals and in subjects (n = 9) with spinocerebellar ataxia types 6 and 8. |
2011-11-10 |
2023-08-12 |
human |
| Luis Velázquez-Pérez, Roberto Rodríguez-Labrada, Julio Cesar García-Rodríguez, Luis Enrique Almaguer-Mederos, Tania Cruz-Mariño, José Miguel Laffita-Mes. A comprehensive review of spinocerebellar ataxia type 2 in Cuba. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:21399888. |
spinocerebellar ataxia type 2 (sca2) is an autosomal dominant cerebellar ataxia characterized by a progressive cerebellar syndrome associated to saccadic slowing, peripheral neuropathy, cognitive disorders, and other multisystem features. |
2011-11-10 |
2023-08-12 |
human |
| Vikram G Shakkottai, Maria do Carmo Costa, James M Dell'Orco, Ananthakrishnan Sankaranarayanan, Heike Wulff, Henry L Paulso. Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900579. |
early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. |
2011-10-31 |
2023-08-12 |
mouse |
| Vikram G Shakkottai, Maria do Carmo Costa, James M Dell'Orco, Ananthakrishnan Sankaranarayanan, Heike Wulff, Henry L Paulso. Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900579. |
the relationship between cerebellar dysfunction, motor symptoms, and neuronal loss in the inherited ataxias, including the polyglutamine disease spinocerebellar ataxia type 3 (sca3), remains poorly understood. |
2011-10-31 |
2023-08-12 |
mouse |
| L Eichler, B Bellenberg, H K Hahn, O Köster, L Schöls, C Luka. Quantitative assessment of brain stem and cerebellar atrophy in spinocerebellar ataxia types 3 and 6: impact on clinical status. AJNR. American journal of neuroradiology. vol 32. issue 5. 2011-09-29. PMID:21372168. |
quantitative assessment of brain stem and cerebellar atrophy in spinocerebellar ataxia types 3 and 6: impact on clinical status. |
2011-09-29 |
2023-08-12 |
Not clear |