| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takako Ohno-Shosaku, Yuto Sugawara, Chiho Muranishi, Keisuke Nagasawa, Kozue Kubono, Nami Aoki, Mitsuki Taguchi, Ryousuke Echigo, Naotoshi Sugimoto, Yui Kikuchi, Ryoko Watanabe, Mitsugu Yoned. Effects of clozapine and N-desmethylclozapine on synaptic transmission at hippocampal inhibitory and excitatory synapses. Brain research. vol 1421. 2012-02-07. PMID:21945084. |
clozapine is the first atypical antipsychotic, and improves positive and negative symptoms of many patients with schizophrenia resistant to treatment with other antipsychotic agents. |
2012-02-07 |
2023-08-12 |
rat |
| John Snowdon, Graeme Hallida. A study of the use of clozapine in old age psychiatry. International clinical psychopharmacology. vol 26. issue 4. 2012-02-02. PMID:21278575. |
of the 13 patients who had a history of schizophrenia or schizoaffective disorder, four patients (all female) developed neutropenia and therefore clozapine was stopped. |
2012-02-02 |
2023-08-12 |
Not clear |
| Johann Steiner, Zoltán Sarnyai, Sabine Westphal, Tomasz Gos, Hans-Gert Bernstein, Bernhard Bogerts, Gerburg Keilhof. Protective effects of haloperidol and clozapine on energy-deprived OLN-93 oligodendrocytes. European archives of psychiatry and clinical neuroscience. vol 261. issue 7. 2012-01-30. PMID:21328015. |
the observed protective effects of haloperidol and clozapine on energy-deprived oln-93 oligodendrocytes suggest that previously reported reductions in oligodendrocyte density in schizophrenia are rather disease related than a side effect of medication. |
2012-01-30 |
2023-08-12 |
Not clear |
| Hsiu-Wen Chiu, Yu-Chi Ku, Tien-Chun Li, Hsin-Te Huan. Amisulpride augmentation of clozapine in refractory schizophrenia. The Journal of neuropsychiatry and clinical neurosciences. vol 23. issue 3. 2012-01-25. PMID:21948906. |
amisulpride augmentation of clozapine in refractory schizophrenia. |
2012-01-25 |
2023-08-12 |
Not clear |
| Shunsuke Maehara, Shoki Okuda, Hisashi Oht. Ameliorative effect of N-desmethylclozapine in animal models of social deficits and cognitive functions. Brain research bulletin. vol 86. issue 3-4. 2012-01-23. PMID:21855612. |
these findings suggest that ndmc can improve behavior in animal models of social deficits and cognitive deficits of schizophrenia as well as clozapine. |
2012-01-23 |
2023-08-12 |
rat |
| Kazufumi Hirano, Kirsten L Searle, Shabina Nasir, Chiu-Cheong Aw, Edward R Browne, A Richard Rutte. In vivo 5-HT(6) receptor occupancy by antipsychotic drugs in the rat brain. Neuroscience letters. vol 503. issue 3. 2012-01-20. PMID:21896308. |
patients with schizophrenia show cognitive impairment as a fundamental symptom, and it is proposed that the procognitive properties of some antipsychotics such as olanzapine and clozapine would be, in part, due to the central blockade of 5-ht(6) receptors. |
2012-01-20 |
2023-08-12 |
rat |
| Taku Nagai, Yuko Kitahara, Daisuke Ibi, Toshitaka Nabeshima, Akira Sawa, Kiyofumi Yamad. Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment. Behavioural brain research. vol 225. issue 1. 2012-01-18. PMID:21835207. |
furthermore, this mouse model may be useful for the screening of potential antipsychotic compounds that could be more effective than clozapine in ameliorating negative symptoms and cognitive impairment in schizophrenia. |
2012-01-18 |
2023-08-12 |
mouse |
| Xiaofeng Guo, Jinguo Zhai, Qinling Wei, Elizabeth W Twamley, Hua Jin, Maosheng Fang, Maorong Hu, Jingping Zha. Neurocognitive effects of first- and second-generation antipsychotic drugs in early-stage schizophrenia: a naturalistic 12-month follow-up study. Neuroscience letters. vol 503. issue 2. 2012-01-13. PMID:21888948. |
in a 12-month, open-label, multicenter study, 698 patients with early-stage schizophrenia (duration of illness ≤5 years) were prescribed chlorpromazine, sulpiride, clozapine, risperidone, olanzapine, quetiapine, or aripiprazole monotherapy. |
2012-01-13 |
2023-08-12 |
Not clear |
| Ragy R Girgis, Michael R Phillips, Xiaodong Li, Kejin Li, Huiping Jiang, Chengjing Wu, Naihua Duan, Yajuan Niu, Jeffrey A Lieberma. Clozapine v. chlorpromazine in treatment-naive, first-episode schizophrenia: 9-year outcomes of a randomised clinical trial. The British journal of psychiatry : the journal of mental science. vol 199. issue 4. 2012-01-12. PMID:21292928. |
clozapine v. chlorpromazine in treatment-naive, first-episode schizophrenia: 9-year outcomes of a randomised clinical trial. |
2012-01-12 |
2023-08-12 |
Not clear |
| Johann Guillemot, Marie-Amélie Lukaszewski, Valérie Montel, Fabien Delahaye, Sylvain Mayeur, Christine Laborie, Anne Dickes-Coopman, Isabelle Dutriez-Casteloot, Jean Lesage, Christophe Breton, Didier Viea. Influence of prenatal undernutrition on the effects of clozapine and aripiprazole in the adult male rats: relevance to a neurodevelopmental origin of schizophrenia? European journal of pharmacology. vol 667. issue 1-3. 2011-12-27. PMID:21514291. |
influence of prenatal undernutrition on the effects of clozapine and aripiprazole in the adult male rats: relevance to a neurodevelopmental origin of schizophrenia? |
2011-12-27 |
2023-08-12 |
rat |
| Johann Guillemot, Marie-Amélie Lukaszewski, Valérie Montel, Fabien Delahaye, Sylvain Mayeur, Christine Laborie, Anne Dickes-Coopman, Isabelle Dutriez-Casteloot, Jean Lesage, Christophe Breton, Didier Viea. Influence of prenatal undernutrition on the effects of clozapine and aripiprazole in the adult male rats: relevance to a neurodevelopmental origin of schizophrenia? European journal of pharmacology. vol 667. issue 1-3. 2011-12-27. PMID:21514291. |
our results do not rule out a putative developmental origin of schizophrenia and may help to understand the way by which atypical neuroleptics, such as clozapine, sensitize schizophrenic patients to the development of metabolic disorders. |
2011-12-27 |
2023-08-12 |
rat |
| Johann Guillemot, Christine Laborie, Isabelle Dutriez-Casteloot, Michel Maron, Sylvie Deloof, Jean Lesage, Christophe Breton, Didier Viea. Could maternal perinatal atypical antipsychotic treatments program later metabolic diseases in the offspring? European journal of pharmacology. vol 667. issue 1-3. 2011-12-27. PMID:21664905. |
we have recently reported that rat offspring from prenatally undernourished mothers exhibit a low birth weight associated with modified sensitivity to clozapine and aripiprazole in adulthood reinforcing the idea that some forms of schizophrenia may be acquired during early development. |
2011-12-27 |
2023-08-12 |
rat |
| W Wolfgang Fleischhacker, Martti E Heikkinen, Jean-Pierre Olié, Wally Landsberg, Patricia Dewaele, Robert D McQuade, Jean-Yves Loze, Delphine Hennicken, Wendy Kerselaer. Effects of adjunctive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial. The international journal of neuropsychopharmacology. vol 13. issue 8. 2011-12-19. PMID:20459883. |
effects of adjunctive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial. |
2011-12-19 |
2023-08-12 |
Not clear |
| Maximiliano Bergman, Inés Bignone, Agustina Bisio, Viviana Bologna, Analía Sabatin. [Risk minimization evolution of agranulocytosis caused by the administration of pharmaceutical products containing Clozapine in Argentina]. Vertex (Buenos Aires, Argentina). vol 22. issue 96. 2011-12-15. PMID:21977603. |
clozapine is an antipsychotic medication used in the treatment of schizophrenia. |
2011-12-15 |
2023-08-12 |
Not clear |
| Oguz Mutlu, Güner Ulak, Ipek Komsuoglu Celikyurt, Füruzan Yildiz Akar, Faruk Erden, Pelin Tanyer. Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21693127. |
the results of the present study demonstrated that olanzapine, sertindole and clozapine improved cognition in mk-801 treated mice, and indicate that these drugs have a potential to improve cognition in schizophrenia. |
2011-12-09 |
2023-08-12 |
mouse |
| A W de Raad, N C Siegersma, P C Clahsen, C Hagestein-de Bruij. [Eosinophilic colitis caused by clozapine]. Nederlands tijdschrift voor geneeskunde. vol 155. issue 36. 2011-12-01. PMID:21914234. |
clozapine is an antipsychotic agent used when patients experience excessive extrapyramidal side effects from other antipsychotic agents or for therapy resistant schizophrenia. |
2011-12-01 |
2023-08-12 |
Not clear |
| Adriana Galistu, Cristina Modde, Maria Cristina Pireddu, Flavia Franconi, Gino Serra, Paolo S D'Aquil. Clozapine increases reward evaluation but not overall ingestive behaviour in rats licking for sucrose. Psychopharmacology. vol 216. issue 3. 2011-11-29. PMID:21360098. |
clozapine and the "atypical" antipsychotics are less prone than neuroleptics to induce extrapyramidal motor effects, worsening of the negative symptoms of schizophrenia and dysphoria. |
2011-11-29 |
2023-08-12 |
rat |
| Menahem Krakowski, Pal Czobo. Cholesterol and cognition in schizophrenia: a double-blind study of patients randomized to clozapine, olanzapine and haloperidol. Schizophrenia research. vol 130. issue 1-3. 2011-11-23. PMID:21549568. |
cholesterol and cognition in schizophrenia: a double-blind study of patients randomized to clozapine, olanzapine and haloperidol. |
2011-11-23 |
2023-08-12 |
human |
| David C Henderson, Oliver Freudenreich, Christina P C Borba, Xingyue Wang, Paul M Copeland, Eric Macklin, Xiaoduo Fan, Corinne Cather, Donald C Gof. Effects of modafinil on weight, glucose and lipid metabolism in clozapine-treated patients with schizophrenia. Schizophrenia research. vol 130. issue 1-3. 2011-11-23. PMID:21565464. |
sedation is a common side effect of clozapine treatment and may exacerbate metabolic consequences of poor diet and exercise habits that are common in patients with schizophrenia. |
2011-11-23 |
2023-08-12 |
Not clear |
| Chien-Chih Chen, Tiao-Lai Huan. Effects of antipsychotics on the serum BDNF levels in schizophrenia. Psychiatry research. vol 189. issue 3. 2011-11-15. PMID:21320726. |
specifically, this study measured serum bdnf levels in 53 patients with paranoid schizophrenia during a relapse and again 4 weeks following the administration of antipsychotic treatment (with risperidone in 32 cases, and clozapine in 21 cases). |
2011-11-15 |
2023-08-12 |
human |