| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhishekh H Ashok, Jim Myers, Tiago Reis Marques, Eugenii A Rabiner, Oliver D Howe. Reduced mu opioid receptor availability in schizophrenia revealed with [ Nature communications. vol 10. issue 1. 2020-02-17. PMID:31582737. |
mu-opioid receptors (mor) in the striatum play a key role in hedonic processing and reward function and are reduced post-mortem in schizophrenia. |
2020-02-17 |
2023-08-13 |
Not clear |
| Nurith Amitai, Susan B Powell, Jared W Youn. Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia. Behavioural brain research. vol 364. 2020-02-13. PMID:29175446. |
animal models of schizophrenia are required to test targeted treatments and since patients exhibit reduced effort (breakpoints) for reward in a progressive ratio (pr) task, we examined the pr breakpoints of rats treated with the nmda receptor antagonist phencyclidine or those reared in isolation - two common manipulations used to induce schizophrenia-relevant behaviors in rodents. |
2020-02-13 |
2023-08-13 |
rat |
| Andràs Tikàsz, Alexandre Dumais, Olivier Lipp, Emmanuel Stip, Pierre Lalonde, Mélanie Laurelli, Ovidiu Lungu, Stéphane Potvi. Reward-related decision-making in schizophrenia: A multimodal neuroimaging study. Psychiatry research. Neuroimaging. vol 286. 2020-02-10. PMID:30897449. |
during the reward outcomes, increased activations were observed in schizophrenia in the left anterior insula, the putamen, and frontal sub-regions. |
2020-02-10 |
2023-08-13 |
human |
| Andràs Tikàsz, Alexandre Dumais, Olivier Lipp, Emmanuel Stip, Pierre Lalonde, Mélanie Laurelli, Ovidiu Lungu, Stéphane Potvi. Reward-related decision-making in schizophrenia: A multimodal neuroimaging study. Psychiatry research. Neuroimaging. vol 286. 2020-02-10. PMID:30897449. |
the fact that schizophrenia patients had increased activations in sub-cortical regions such as the striatum and insula in response to reward events suggests that the impaired decision-making abilities of these patients are mostly driven by an overvaluation of outcome stimuli. |
2020-02-10 |
2023-08-13 |
human |
| Peter E Clayson, Jonathan K Wynn, Zachary P Infantolino, Greg Hajcak, Michael F Green, William P Hora. Reward processing in certain versus uncertain contexts in schizophrenia: An event-related potential (ERP) study. Journal of abnormal psychology. vol 128. issue 8. 2020-02-03. PMID:31657597. |
reward processing in certain versus uncertain contexts in schizophrenia: an event-related potential (erp) study. |
2020-02-03 |
2023-08-13 |
Not clear |
| Peter E Clayson, Jonathan K Wynn, Zachary P Infantolino, Greg Hajcak, Michael F Green, William P Hora. Reward processing in certain versus uncertain contexts in schizophrenia: An event-related potential (ERP) study. Journal of abnormal psychology. vol 128. issue 8. 2020-02-03. PMID:31657597. |
disturbances in motivation are prominent in the clinical presentation of people with schizophrenia and might reflect a disturbance in reward processing. |
2020-02-03 |
2023-08-13 |
Not clear |
| Peter E Clayson, Jonathan K Wynn, Zachary P Infantolino, Greg Hajcak, Michael F Green, William P Hora. Reward processing in certain versus uncertain contexts in schizophrenia: An event-related potential (ERP) study. Journal of abnormal psychology. vol 128. issue 8. 2020-02-03. PMID:31657597. |
recent advances in affective neuroscience have subdivided reward processing into distinct components, but there are two limitations of the prior work in schizophrenia. |
2020-02-03 |
2023-08-13 |
Not clear |
| Peter E Clayson, Jonathan K Wynn, Zachary P Infantolino, Greg Hajcak, Michael F Green, William P Hora. Reward processing in certain versus uncertain contexts in schizophrenia: An event-related potential (ERP) study. Journal of abnormal psychology. vol 128. issue 8. 2020-02-03. PMID:31657597. |
we examined whether individuals with schizophrenia show the typical certainty effects across three phases of reward processing: cue evaluation, feedback anticipation, and feedback receipt. |
2020-02-03 |
2023-08-13 |
Not clear |
| Peter E Clayson, Jonathan K Wynn, Zachary P Infantolino, Greg Hajcak, Michael F Green, William P Hora. Reward processing in certain versus uncertain contexts in schizophrenia: An event-related potential (ERP) study. Journal of abnormal psychology. vol 128. issue 8. 2020-02-03. PMID:31657597. |
electroencephalography from 74 healthy controls and 92 people with schizophrenia was recorded during a cued gambling task under conditions in which cues indicated forthcoming reward outcomes that were certain or uncertain. |
2020-02-03 |
2023-08-13 |
Not clear |
| Peter E Clayson, Jonathan K Wynn, Zachary P Infantolino, Greg Hajcak, Michael F Green, William P Hora. Reward processing in certain versus uncertain contexts in schizophrenia: An event-related potential (ERP) study. Journal of abnormal psychology. vol 128. issue 8. 2020-02-03. PMID:31657597. |
initial cue evaluation (cue p300) was intact in the schizophrenia group, but people with schizophrenia showed diminished certainty effects during feedback anticipation (stimulus-preceding negativity [spn]) and receipt (feedback reward positivity [frewp] and feedback p300). |
2020-02-03 |
2023-08-13 |
Not clear |
| Philipp Sterzer, Martin Voss, Florian Schlagenhauf, Andreas Hein. Decision-making in schizophrenia: A predictive-coding perspective. NeuroImage. vol 190. 2020-01-27. PMID:29860087. |
there is also extensive evidence relating the symptoms of schizophrenia to aberrant signaling of prediction errors, especially in the domain of reward and value-based decision-making. |
2020-01-27 |
2023-08-13 |
Not clear |
| Dennis Hernaus, Michael J Frank, Elliot C Brown, Jaime K Brown, James M Gold, James A Walt. Impaired Expected Value Computations in Schizophrenia Are Associated With a Reduced Ability to Integrate Reward Probability and Magnitude of Recent Outcomes. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 4. issue 3. 2020-01-06. PMID:30683607. |
impaired expected value computations in schizophrenia are associated with a reduced ability to integrate reward probability and magnitude of recent outcomes. |
2020-01-06 |
2023-08-13 |
Not clear |
| Jessica A Cooper, Deanna M Barch, L Felice Reddy, William P Horan, Michael F Green, Michael T Treadwa. Effortful goal-directed behavior in schizophrenia: Computational subtypes and associations with cognition. Journal of abnormal psychology. vol 128. issue 7. 2020-01-02. PMID:31282687. |
half of the participants with schizophrenia failed to incorporate information about reward and probability when making effort-expenditure decisions. |
2020-01-02 |
2023-08-13 |
human |
| Erin K Moran, Adam J Culbreth, Sridhar Kandala, Deanna M Barc. From neuroimaging to daily functioning: A multimethod analysis of reward anticipation in people with schizophrenia. Journal of abnormal psychology. vol 128. issue 7. 2020-01-02. PMID:31464449. |
recent work suggests that deficits in reinforcement learning and anticipatory responses to reward may be two mechanisms that help explain impairments in motivation in those with schizophrenia. |
2020-01-02 |
2023-08-13 |
human |
| Erin K Moran, Adam J Culbreth, Sridhar Kandala, Deanna M Barc. From neuroimaging to daily functioning: A multimethod analysis of reward anticipation in people with schizophrenia. Journal of abnormal psychology. vol 128. issue 7. 2020-01-02. PMID:31464449. |
in regards to anticipatory responses, we found that people with schizophrenia showed blunted activation in the anterior cingulate, insula, caudate, and putamen while anticipating reward. |
2020-01-02 |
2023-08-13 |
human |
| Erin C Dowd, Michael J Frank, Anne Collins, James M Gold, Deanna M Barc. Probabilistic Reinforcement Learning in Patients With Schizophrenia: Relationships to Anhedonia and Avolition. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 1. issue 5. 2019-11-20. PMID:27833939. |
here, we examined whether alterations in reinforcement learning may contribute to these symptoms in schizophrenia by impairing the translation of reward information into goal-directed action. |
2019-11-20 |
2023-08-13 |
Not clear |
| Faith Borgan, Owen O'Daly, Karen Hoang, Mattia Veronese, Dominic Withers, Rachel Batterham, Oliver Howe. Neural Responsivity to Food Cues in Patients With Unmedicated First-Episode Psychosis. JAMA network open. vol 2. issue 1. 2019-11-20. PMID:30646204. |
although obesity is linked to the altered reward processing of food cues, no studies have investigated this link in schizophrenia without the confounds of antipsychotics and illness chronicity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Byung-Hoon Kim, Yu-Bin Shin, Sunghyon Kyeong, Seon-Koo Lee, Jae-Jin Ki. Disrupted salience processing involved in motivational deficits for real-life activities in patients with schizophrenia. Schizophrenia research. vol 197. 2019-11-12. PMID:29395610. |
during the functional magnetic resonance imaging scan, 20 patients with schizophrenia and 20 normal controls performed a task mimicking real-life situations, in which an avatar proposed participation in a daily activity with either an intrinsic or extrinsic reward. |
2019-11-12 |
2023-08-13 |
Not clear |
| Byung-Hoon Kim, Yu-Bin Shin, Sunghyon Kyeong, Seon-Koo Lee, Jae-Jin Ki. Disrupted salience processing involved in motivational deficits for real-life activities in patients with schizophrenia. Schizophrenia research. vol 197. 2019-11-12. PMID:29395610. |
disrupted salience processing in schizophrenia including aberrant salience network and a disconnection of the salience and reward networks may account for the lack of motivation for daily activities. |
2019-11-12 |
2023-08-13 |
Not clear |
| Naoki Hashimoto, Atsuhito Toyomaki, Tamaki Miyamoto, Akane Miyazaki, Ichiro Kuksum. Olanzapine, blonanserin, and aripiprazole associated with different frontostriatal reward system activation in patients with schizophrenia. Schizophrenia research. vol 197. 2019-11-11. PMID:29223323. |
olanzapine, blonanserin, and aripiprazole associated with different frontostriatal reward system activation in patients with schizophrenia. |
2019-11-11 |
2023-08-13 |
Not clear |