| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinxiu Shi, Akane Shibayama, Qiang Liu, Vu Q Nguyen, Jinong Feng, Mónica Santos, Teresa Temudo, Patricia Maciel, Steve S Somme. Detection of heterozygous deletions and duplications in the MECP2 gene in Rett syndrome by Robust Dosage PCR (RD-PCR). Human mutation. vol 25. issue 5. 2006-06-05. PMID:15841480. |
fifty to eighty percent of rett syndrome (rtt) cases have point mutations in the gene encoding methyl-cpg-binding protein-2 (mecp2). |
2006-06-05 |
2023-08-12 |
Not clear |
| Jonathan D Picker, Rebecca Yang, Laura Ricceri, Joanne Berger-Sweene. An altered neonatal behavioral phenotype in Mecp2 mutant mice. Neuroreport. vol 17. issue 5. 2006-05-17. PMID:16543822. |
we examined somatic growth, somatosensory reflexes, and ultrasonic calls from postnatal day 3 to day 18 in mecp2 mutant mice, a mouse model of rett syndrome. |
2006-05-17 |
2023-08-12 |
mouse |
| Kirstine Ravn, Jytte Bieber Nielsen, Ola Husbeth Skjeldal, Alison Kerr, Maj Hulten, Marianne Schwart. Large genomic rearrangements in MECP2. Human mutation. vol 25. issue 3. 2006-05-16. PMID:15712379. |
in 1999, mutations in the x-linked gene methyl-cpg-binding protein 2 (mecp2) were first reported in patients with rett syndrome (rtt). |
2006-05-16 |
2023-08-12 |
Not clear |
| Terry Gemelli, Olivier Berton, Erika D Nelson, Linda I Perrotti, Rudolf Jaenisch, Lisa M Monteggi. Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice. Biological psychiatry. vol 59. issue 5. 2006-05-11. PMID:16199017. |
mutations in the methyl-cpg binding protein 2 (mecp2) gene cause rett syndrome (rtt), a neurodevelopmental disorder that is accompanied by a broad array of behavioral phenotypes, mainly affecting females. |
2006-05-11 |
2023-08-12 |
mouse |
| Jean-Charles Viemari, Jean-Christophe Roux, Andrew K Tryba, Véronique Saywell, Henri Burnet, Fernando Peña, Sébastien Zanella, Michelle Bévengut, Magali Barthelemy-Requin, Laura B K Herzing, Anne Moncla, Josette Mancini, Jan-Marino Ramirez, Laurent Villard, Gérard Hilair. Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 50. 2006-05-11. PMID:16354910. |
rett syndrome is a severe x-linked neurological disorder in which most patients have mutations in the methyl-cpg binding protein 2 (mecp2) gene and suffer from bioaminergic deficiencies and life-threatening breathing disturbances. |
2006-05-11 |
2023-08-12 |
mouse |
| C Philippe, L Villard, N De Roux, M Raynaud, J P Bonnefond, L Pasquier, G Lesca, J Mancini, P Jonveaux, A Moncla, J Chelly, T Bienven. Spectrum and distribution of MECP2 mutations in 424 Rett syndrome patients: a molecular update. European journal of medical genetics. vol 49. issue 1. 2006-04-26. PMID:16473305. |
spectrum and distribution of mecp2 mutations in 424 rett syndrome patients: a molecular update. |
2006-04-26 |
2023-08-12 |
Not clear |
| C Philippe, L Villard, N De Roux, M Raynaud, J P Bonnefond, L Pasquier, G Lesca, J Mancini, P Jonveaux, A Moncla, J Chelly, T Bienven. Spectrum and distribution of MECP2 mutations in 424 Rett syndrome patients: a molecular update. European journal of medical genetics. vol 49. issue 1. 2006-04-26. PMID:16473305. |
mutations in the mecp2 (methyl-cpg-binding protein) gene have been reported to cause rett syndrome (rtt), an x-linked progressive encephalopathy. |
2006-04-26 |
2023-08-12 |
Not clear |
| M Meins, J Lehmann, F Gerresheim, J Herchenbach, M Hagedorn, K Hameister, J T Epple. Submicroscopic duplication in Xq28 causes increased expression of the MECP2 gene in a boy with severe mental retardation and features of Rett syndrome. Journal of medical genetics. vol 42. issue 2. 2006-04-20. PMID:15689435. |
submicroscopic duplication in xq28 causes increased expression of the mecp2 gene in a boy with severe mental retardation and features of rett syndrome. |
2006-04-20 |
2023-08-12 |
Not clear |
| R E Amir, P Fang, Z Yu, D G Glaze, A K Percy, H Y Zoghbi, B B Roa, I B Van den Veyve. Mutations in exon 1 of MECP2 are a rare cause of Rett syndrome. Journal of medical genetics. vol 42. issue 2. 2006-04-20. PMID:15689438. |
mutations in exon 1 of mecp2 are a rare cause of rett syndrome. |
2006-04-20 |
2023-08-12 |
Not clear |
| E Scala, F Ariani, F Mari, R Caselli, C Pescucci, I Longo, I Meloni, D Giachino, M Bruttini, G Hayek, M Zappella, A Renier. CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms. Journal of medical genetics. vol 42. issue 2. 2006-04-20. PMID:15689447. |
both the classic form and preserved speech variant of rett syndrome are due to mutations in the mecp2 gene. |
2006-04-20 |
2023-08-12 |
Not clear |
| Gregory J Pelka, Catherine M Watson, Tania Radziewic, Melinda Hayward, Hooshang Lahooti, John Christodoulou, Patrick P L Ta. Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain : a journal of neurology. vol 129. issue Pt 4. 2006-04-17. PMID:16467389. |
rett syndrome (rtt) is a debilitating neurological condition associated with mutations in the x-linked mecp2 gene, where apparently normal development is seen prior to the onset of cognitive and motor deterioration at 6-18 months of life. |
2006-04-17 |
2023-08-12 |
mouse |
| Véronique Saywell, Angèle Viola, Sylviane Confort-Gouny, Yann Le Fur, Laurent Villard, Patrick J Cozzon. Brain magnetic resonance study of Mecp2 deletion effects on anatomy and metabolism. Biochemical and biophysical research communications. vol 340. issue 3. 2006-04-06. PMID:16380085. |
rett syndrome, a neurodevelopmental x-linked disorder, represents the most important genetic cause of severe mental retardation in the female population and results from a mutation in the gene encoding methyl-cpg-binding protein 2 (mecp2). |
2006-04-06 |
2023-08-12 |
mouse |
| Paolo Moretti, Jonathan M Levenson, Fortunato Battaglia, Richard Atkinson, Ryan Teague, Barbara Antalffy, Dawna Armstrong, Ottavio Arancio, J David Sweatt, Huda Y Zoghb. Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 1. 2006-03-31. PMID:16399702. |
loss-of-function mutations or abnormal expression of the x-linked gene encoding methyl cpg binding protein 2 (mecp2) cause a spectrum of postnatal neurodevelopmental disorders including rett syndrome (rtt), nonsyndromic mental retardation, learning disability, and autism. |
2006-03-31 |
2023-08-12 |
mouse |
| Yi E Sun, Hao W. The ups and downs of BDNF in Rett syndrome. Neuron. vol 49. issue 3. 2006-03-30. PMID:16446133. |
rett syndrome (rtt) is an x-linked postnatal neurodevelopmental disorder, which is primarily caused by mutations in the gene encoding methyl-cpg binding protein 2 (mecp2). |
2006-03-30 |
2023-08-12 |
Not clear |
| Qiang Chang, Gargi Khare, Vardhan Dani, Sacha Nelson, Rudolf Jaenisc. The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron. vol 49. issue 3. 2006-03-30. PMID:16446138. |
mutations in the mecp2 gene cause rett syndrome (rtt). |
2006-03-30 |
2023-08-12 |
mouse |
| Stanley M Gartler, Kartik R Varadarajan, Ping Luo, Theresa K Canfield, Jeff Traynor, Uta Francke, R Scott Hanse. Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins. BMC biology. vol 2. 2006-03-09. PMID:15377381. |
in addition, we determined whether a specific methyl-cpg binding protein, mecp2, is necessary for the inactive x histone modification pattern by studying rett syndrome cells which are deficient in mecp2 function. |
2006-03-09 |
2023-08-12 |
human |
| Yukiko Asaka, Denis G M Jugloff, Liang Zhang, James H Eubanks, Reiko Maki Fitzsimond. Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome. Neurobiology of disease. vol 21. issue 1. 2006-03-09. PMID:16087343. |
rett syndrome is an x-linked neurodevelopmental disorder caused by mutations in the gene encoding the transcriptional repressor methyl-cpg-binding protein 2 (mecp2). |
2006-03-09 |
2023-08-12 |
mouse |
| Yukiko Asaka, Denis G M Jugloff, Liang Zhang, James H Eubanks, Reiko Maki Fitzsimond. Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome. Neurobiology of disease. vol 21. issue 1. 2006-03-09. PMID:16087343. |
together, these data provide the first evidence that the loss of mecp2 expression is accompanied by age-dependent alterations in excitatory synaptic plasticity that are likely to contribute to the cognitive and functional deficits underlying rett syndrome. |
2006-03-09 |
2023-08-12 |
mouse |
| Megumi Adachi, Edward W Keefer, Frederick S Jone. A segment of the Mecp2 promoter is sufficient to drive expression in neurons. Human molecular genetics. vol 14. issue 23. 2006-03-07. PMID:16251199. |
rett syndrome (rtt) is caused by mutations in the gene encoding methyl cpg-binding protein 2 (mecp2). |
2006-03-07 |
2023-08-12 |
mouse |
| Sarojini S Budden, Heather C Dorsey, Robert D Steine. Clinical profile of a male with Rett syndrome. Brain & development. vol 27 Suppl 1. 2006-02-21. PMID:16182490. |
after his older sister was diagnosed with atypical rett syndrome; mecp2 mutation studies on him revealed a pathogenic mutation. |
2006-02-21 |
2023-08-12 |
Not clear |