| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wan Y Leong, Zhi H Lim, Vladimir Korzh, Thomas Pietri, Eyleen L K Go. Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2. Frontiers in cellular neuroscience. vol 9. 2016-01-06. PMID:26733807. |
the sensory deficits caused by mecp2 deficiency mirror the diminished sensory response observed in rett syndrome patients. |
2016-01-06 |
2023-08-13 |
mouse |
| Keerthi Krishnan, Bor-Shuen Wang, Jiangteng Lu, Lang Wang, Arianna Maffei, Jianhua Cang, Z Josh Huan. MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 34. 2015-12-30. PMID:26261347. |
mutations in methyl-cpg-binding protein 2 (mecp2) cause rett syndrome, an autism spectrum-associated disorder with a host of neurological and sensory symptoms, but the pathogenic mechanisms remain elusive. |
2015-12-30 |
2023-08-13 |
mouse |
| Meagan R Pitcher, José A Herrera, Shelly A Buffington, Mikhail Y Kochukov, Jonathan K Merritt, Amanda R Fisher, N Carolyn Schanen, Mauro Costa-Mattioli, Jeffrey L Neu. Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene. Human molecular genetics. vol 24. issue 9. 2015-12-22. PMID:25634563. |
rett syndrome like phenotypes in the r255x mecp2 mutant mouse are rescued by mecp2 transgene. |
2015-12-22 |
2023-08-13 |
mouse |
| Meagan R Pitcher, José A Herrera, Shelly A Buffington, Mikhail Y Kochukov, Jonathan K Merritt, Amanda R Fisher, N Carolyn Schanen, Mauro Costa-Mattioli, Jeffrey L Neu. Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene. Human molecular genetics. vol 24. issue 9. 2015-12-22. PMID:25634563. |
rett syndrome (rtt) is a severe neurodevelopmental disorder that is usually caused by mutations in methyl-cpg-binding protein 2 (mecp2). |
2015-12-22 |
2023-08-13 |
mouse |
| Min Jung Park, Susan Aja, Qun Li, Alicia L Degano, Judith Penati, Justin Zhuo, Charles R Roe, Gabriele V Ronnet. Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice. PloS one. vol 9. issue 10. 2015-12-21. PMID:25299635. |
rett syndrome (rtt) is an autism spectrum disorder (asd) caused by mutations in the x-linked mecp2 gene that encodes methyl-cpg binding protein 2 (mecp2). |
2015-12-21 |
2023-08-13 |
mouse |
| Kamal K E Gadalla, Paul D Ross, John S Riddell, Mark E S Bailey, Stuart R Cob. Gait analysis in a Mecp2 knockout mouse model of Rett syndrome reveals early-onset and progressive motor deficits. PloS one. vol 9. issue 11. 2015-12-15. PMID:25392929. |
gait analysis in a mecp2 knockout mouse model of rett syndrome reveals early-onset and progressive motor deficits. |
2015-12-15 |
2023-08-13 |
mouse |
| Ugljesa Djuric, Aaron Y L Cheung, Wenbo Zhang, Rebecca S Mok, Wesley Lai, Alina Piekna, Jason A Hendry, P Joel Ross, Peter Pasceri, Dae-Sung Kim, Michael W Salter, James Elli. MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells. Neurobiology of disease. vol 76. 2015-12-14. PMID:25644311. |
mecp2 mutations cause the x-linked neurodevelopmental disorder rett syndrome (rtt) by consistently altering the protein encoded by the mecp2e1 alternative transcript. |
2015-12-14 |
2023-08-13 |
human |
| Steven Andrew Baker, Laura Marie Lombardi, Huda Yahya Zoghb. Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2. The Journal of biological chemistry. vol 290. issue 37. 2015-12-04. PMID:26245896. |
methyl-cpg binding protein 2 (mecp2) is a nuclear protein with important roles in regulating chromatin structure and gene expression, and mutations in mecp2 cause rett syndrome (rtt). |
2015-12-04 |
2023-08-13 |
Not clear |
| Somnath Pandey, Glenn E Simmons, Svitlana Malyarchuk, Tara N Calhoun, Kevin Pruit. A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1. Genes & cancer. vol 6. issue 9-10. 2015-12-01. PMID:26622943. |
as mecp2 contributes to tumor suppressor gene silencing and its mutation causes rett syndrome, we investigated how novel post-translational-modification contributes to its function. |
2015-12-01 |
2023-08-13 |
Not clear |
| Aleksandra Djukic, Susan A Rose, Jeffery J Jankowski, Judith F Feldma. Rett syndrome: recognition of facial expression and its relation to scanning patterns. Pediatric neurology. vol 51. issue 5. 2015-11-04. PMID:25217338. |
rett syndrome is a severely disabling neurodevelopmental disorder caused by mutations in the x-linked mecp2 gene. |
2015-11-04 |
2023-08-13 |
Not clear |
| Heather McGowan, Zhiping P Pan. Regulatory functions and pathological relevance of the MECP2 3'UTR in the central nervous system. Cell regeneration (London, England). vol 4. 2015-10-30. PMID:26516454. |
loss-of-function mutations in mecp2 cause rett syndrome (rtt), a debilitating neurodevelopmental disorder characterized by a phase of normal development, followed by the progressive loss of milestones and cognitive disability. |
2015-10-30 |
2023-08-13 |
Not clear |
| Wooje Lee, Jung-Mi Yun, Rima Woods, Keith Dunaway, Dag H Yasui, Janine M Lasalle, Qizhi Gon. MeCP2 regulates activity-dependent transcriptional responses in olfactory sensory neurons. Human molecular genetics. vol 23. issue 23. 2015-10-29. PMID:25008110. |
mecp2 binds to methylated dna and modulates gene expression during neuronal development and mecp2 mutation causes the autistic disorder rett syndrome. |
2015-10-29 |
2023-08-13 |
mouse |
| Navasona Krishnan, Keerthi Krishnan, Christopher R Connors, Meng S Choy, Rebecca Page, Wolfgang Peti, Linda Van Aelst, Stephen D Shea, Nicholas K Tonk. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. The Journal of clinical investigation. vol 125. issue 8. 2015-10-23. PMID:26214522. |
the x-linked neurological disorder rett syndrome (rtt) presents with autistic features and is caused primarily by mutations in a transcriptional regulator, methyl cpg-binding protein 2 (mecp2). |
2015-10-23 |
2023-08-13 |
mouse |
| Laura Marie Lombardi, Steven Andrew Baker, Huda Yahya Zoghb. MECP2 disorders: from the clinic to mice and back. The Journal of clinical investigation. vol 125. issue 8. 2015-10-23. PMID:26237041. |
two severe, progressive neurological disorders characterized by intellectual disability, autism, and developmental regression, rett syndrome and mecp2 duplication syndrome, result from loss and gain of function, respectively, of the same critical gene, methyl-cpg-binding protein 2 (mecp2). |
2015-10-23 |
2023-08-13 |
mouse |
| Laura Marie Lombardi, Steven Andrew Baker, Huda Yahya Zoghb. MECP2 disorders: from the clinic to mice and back. The Journal of clinical investigation. vol 125. issue 8. 2015-10-23. PMID:26237041. |
instead, neuronal dysfunction can be reversed in a rett syndrome mouse model if mecp2 function is restored. |
2015-10-23 |
2023-08-13 |
mouse |
| Sinisa Colic, Min Lang, Robert G Wither, Zhang Liang, James H Eubanks, Berj L Bardakjia. Characterization of HFOs in short and long duration discharges recorded from in-vivo MeCP2-deficient mice. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2014. 2015-10-20. PMID:25571017. |
mutations in the x-linked gene encoding methyl cpg-binding protein 2 (mecp2) have been linked to a neurodevelopmental disorder known as rett syndrome. |
2015-10-20 |
2023-08-13 |
mouse |
| Benyam Kinde, Harrison W Gabel, Caitlin S Gilbert, Eric C Griffith, Michael E Greenber. Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 22. 2015-10-13. PMID:25739960. |
we review studies of one critical reader of dna methylation in the brain, the rett syndrome protein methyl cpg-binding protein 2 (mecp2), and discuss how differential binding affinity of mecp2 for non-cpg and hydroxymethylation may affect the function of this methyl-binding protein in the nervous system. |
2015-10-13 |
2023-08-13 |
Not clear |
| Melissa T Manners, Yuzhen Tian, Zhaolan Zhou, Seena K Aji. MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity. FEBS open bio. vol 5. 2015-10-09. PMID:26448907. |
mecp2 mutations cause rett syndrome and these patients report decreased pain perception. |
2015-10-09 |
2023-08-13 |
mouse |
| Correction for Chen et al., MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 22. 2015-10-01. PMID:25918409. |
correction for chen et al., mecp2 binds to non-cg methylated dna as neurons mature, influencing transcription and the timing of onset for rett syndrome. |
2015-10-01 |
2023-08-13 |
Not clear |
| Gabriella Livide, Tommaso Patriarchi, Mariangela Amenduni, Sonia Amabile, Dag Yasui, Eleonora Calcagno, Caterina Lo Rizzo, Giulia De Falco, Cristina Ulivieri, Francesca Ariani, Francesca Mari, Maria Antonietta Mencarelli, Johannes Wilhelm Hell, Alessandra Renieri, Ilaria Melon. GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells. European journal of human genetics : EJHG. vol 23. issue 2. 2015-09-29. PMID:24916645. |
rett syndrome is a monogenic disease due to de novo mutations in either mecp2 or cdkl5 genes. |
2015-09-29 |
2023-08-13 |
Not clear |