| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weihong Ji, Yan Li, Ruiyuan Liu, Zhiguo Lu, Linying Liu, Zhuyan Shi, Jie Shen, Xin Zhan. Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard" for synergistic treatment of synucleinopathies. Materials horizons. vol 8. issue 4. 2021-11-26. PMID:34821912. |
this study indicates that the synaptic vesicle-inspired nps may have the potential to open up a new avenue for the treatment of synucleinopathies, as well as other neurodegenerative diseases. |
2021-11-26 |
2023-08-13 |
Not clear |
| Nathalia Barth de Oliveira, Ana Carolina Irioda, Priscila Elias Ferreira Stricker, Bassam Felipe Mogharbel, Nádia Nascimento da Rosa, Dilcele Silva Moreira Dziedzic, Katherine Athayde Teixeira de Carvalh. Natural Membrane Differentiates Human Adipose-Derived Mesenchymal Stem Cells to Neurospheres by Mechanotransduction Related to YAP and AMOT Proteins. Membranes. vol 11. issue 9. 2021-09-30. PMID:34564504. |
when induced to the neuronal differentiation, they form neurospheres composed of neural precursors (nps) that can be an alternative in treating neurodegenerative diseases. |
2021-09-30 |
2023-08-13 |
human |
| Tina Wahle, Adriana Sofranko, Susan Dekkers, Mark R Miller, Harm J Heusinkveld, Catrin Albrecht, Flemming R Cassee, Roel P F Schin. Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease. Neurochemistry international. vol 138. 2021-07-30. PMID:32422323. |
whether and how engineered nanoparticles (nps) may cause neurotoxicity and promote neurodegenerative diseases such as alzheimer's disease (ad) is largely unstudied. |
2021-07-30 |
2023-08-13 |
mouse |
| Feng-Dan Zhu, Yu-Jiao Hu, Lu Yu, Xiao-Gang Zhou, Jian-Ming Wu, Yong Tang, Da-Lian Qin, Qing-Ze Fan, An-Guo W. Nanoparticles: A Hope for the Treatment of Inflammation in CNS. Frontiers in pharmacology. vol 12. 2021-06-15. PMID:34122112. |
therefore, nps with good biodegradability and biocompatibility have the potential to be developed as an effective and minimally invasive carrier to help other drugs cross the bbb or as a therapeutic agent for the treatment of neuroinflammation-mediated neurodegenerative diseases. |
2021-06-15 |
2023-08-13 |
Not clear |
| Feng-Dan Zhu, Yu-Jiao Hu, Lu Yu, Xiao-Gang Zhou, Jian-Ming Wu, Yong Tang, Da-Lian Qin, Qing-Ze Fan, An-Guo W. Nanoparticles: A Hope for the Treatment of Inflammation in CNS. Frontiers in pharmacology. vol 12. 2021-06-15. PMID:34122112. |
in this review, we summarized various nanoparticles applied in cns, and their mechanisms and effects in the modulation of inflammation responses in neurodegenerative diseases, providing insights and suggestions for the use of nps in the treatment of neuroinflammation-related neurodegenerative diseases. |
2021-06-15 |
2023-08-13 |
Not clear |
| Qinghua Zhang, Dawei Lu, Dingyi Wang, Xuezhi Yang, Peijie Zuo, Hang Yang, Qiang Fu, Qian Liu, Guibin Jian. Separation and Tracing of Anthropogenic Magnetite Nanoparticles in the Urban Atmosphere. Environmental science & technology. vol 54. issue 15. 2020-11-27. PMID:32644802. |
nanosized magnetite is a highly toxic material due to its strong ability to generate reactive oxygen species in vivo, and the presence of magnetite nps in the brain has been linked with aging and neurodegenerative diseases such as alzheimer's disease. |
2020-11-27 |
2023-08-13 |
human |
| Cristina de la Torre, Valentín Ceñ. The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer's Disease Therapeutics and Diagnostics. Pharmaceutics. vol 10. issue 4. 2020-09-29. PMID:30336640. |
a global view of the ad pathophysiology is described in order to understand the need for an effective treatment and why nanoparticles (nps) could be an important weapon against neurodegenerative diseases by solving the general problem of poor delivery into the central nervous system (cns) for many drugs. |
2020-09-29 |
2023-08-13 |
Not clear |
| Sonali S Bharate, Serge Mignani, Ram A Vishwakarm. Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis. Journal of medicinal chemistry. vol 61. issue 23. 2019-09-30. PMID:29989814. |
we have discussed unique physicochemical properties of nps and np-inspired vis-à-vis synthetic drugs, isoform selectivity, and evolutionary relationship, providing a rationale for increasing focus on natural product driven discovery for next-generation drugs for neurodegenerative diseases. |
2019-09-30 |
2023-08-13 |
Not clear |
| Matthew O Goodman, Lori Chibnik, Tianxi Ca. Variance components genetic association test for zero-inflated count outcomes. Genetic epidemiology. vol 43. issue 1. 2019-02-18. PMID:30353568. |
commonly in biomedical research, studies collect data in which an outcome measure contains informative excess zeros; for example, when observing the burden of neuritic plaques (nps) in brain pathology studies, those who show none contribute to our understanding of neurodegenerative disease. |
2019-02-18 |
2023-08-13 |
Not clear |
| Alicja Cieslak, Eric E Smith, John Lysack, Zahinoor Ismai. Case series of mild behavioral impairment: toward an understanding of the early stages of neurodegenerative diseases affecting behavior and cognition. International psychogeriatrics. vol 30. issue 2. 2018-11-26. PMID:29017626. |
these early nps can be characterized within the domains outlined in the istaart-aa mbi criteria, and detected with the mbi-c, which may help clinicians consider neurodegenerative disease in the differential diagnosis of later life onset psychiatric symptomatology. |
2018-11-26 |
2023-08-13 |
Not clear |
| Mohammad Javad Hajipour, Forough Ghasemi, Haniyeh Aghaverdi, Mohammad Raoufi, Uwe Linne, Fatemeh Atyabi, Iraj Nabipour, Morteza Azhdarzadeh, Hossein Derakhshankhah, Alireza Lotfabadi, Afshar Bargahi, Zahra Alekhamis, Afsaneh Aghaie, Ehsan Hashemi, Abbas Tafakhori, Vajiheh Aghamollaii, Marzie Maserat Mashhadi, Sara Sheibani, Hojatollah Vali, Morteza Mahmoud. Sensing of Alzheimer's Disease and Multiple Sclerosis Using Nano-Bio Interfaces. Journal of Alzheimer's disease : JAD. vol 59. issue 4. 2018-04-12. PMID:28759965. |
using gold (au) nps with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, alzheimer's disease (ad) and multiple sclerosis (ms). |
2018-04-12 |
2023-08-13 |
human |
| Miaoyi Wang, Aleksandr Kakinen, Emily H Pilkington, Thomas P Davis, Pu Chun K. Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation. Biomaterials science. vol 5. issue 3. 2018-03-13. PMID:28078343. |
recent studies have shown promise on the use of small molecules and nanoparticles (nps) for the inhibition of protein aggregation, a hallmark of neurodegenerative diseases and type 2 diabetes (t2d). |
2018-03-13 |
2023-08-13 |
human |
| Marco Canevelli, Alessandro Blasimme, Nicola Vanacore, Giuseppe Bruno, Matteo Cesar. Mild behavioral impairment: Ethical, methodological and clinical reflections. Neuroscience and biobehavioral reviews. vol 69. 2017-10-20. PMID:27570153. |
the rationale supporting the need of such novel construct is that neuropsychiatric symptoms (nps), even when they do not configure major psychiatric disorders, may still constitute early manifestations of neurodegenerative diseases, potentially anticipating the onset of dementia. |
2017-10-20 |
2023-08-13 |
Not clear |
| Kentaro Hirao, Gregory M Pontone, Gwenn S Smit. Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease. Neuroscience and biobehavioral reviews. vol 49. 2015-09-16. PMID:25446948. |
neuropsychiatric symptoms (nps) are very common in neurodegenerative diseases and are a major contributor to disability and caregiver burden. |
2015-09-16 |
2023-08-13 |
human |
| Kentaro Hirao, Gregory M Pontone, Gwenn S Smit. Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease. Neuroscience and biobehavioral reviews. vol 49. 2015-09-16. PMID:25446948. |
there is accumulating evidence that nps may be a prodrome and/or a "risk factor" of neurodegenerative diseases. |
2015-09-16 |
2023-08-13 |
human |
| Antonietta Vilella, Giovanni Tosi, Andreas M Grabrucker, Barbara Ruozi, Daniela Belletti, Maria Angela Vandelli, Tobias M Boeckers, Flavio Forni, Michele Zol. Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution. Journal of controlled release : official journal of the Controlled Release Society. vol 174. 2014-09-12. PMID:24316476. |
these findings show that g7-nps can cross the bbb and target specific brain cell populations, suggesting that these nps can be promising carriers for the treatment of neuropsychiatric and neurodegenerative diseases. |
2014-09-12 |
2023-08-12 |
Not clear |
| Oksana Forostyak, Nataliya Romanyuk, Alexei Verkhratsky, Eva Sykova, Govindan Dayanith. Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors. Stem cells and development. vol 22. issue 10. 2014-02-20. PMID:23294113. |
human embryonic stem cell-derived neural precursors (hesc nps) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. |
2014-02-20 |
2023-08-12 |
human |
| Sushil Sharma, Afsha Rais, Ranbir Sandhu, Wynand Nel, Manuchair Ebad. Clinical significance of metallothioneins in cell therapy and nanomedicine. International journal of nanomedicine. vol 8. 2014-01-30. PMID:23620664. |
mts are induced as a defensive mechanism in chronic inflammatory conditions including neurodegenerative diseases, cardiovascular diseases, cancer, and infections, hence can serve as early and sensitive biomarkers of environmental safety and effectiveness of newly developed nps for clinical applications. |
2014-01-30 |
2023-08-12 |
human |
| Eleonore Fröhlich, Claudia Meindl, Eva Roblegg, Birgit Ebner, Markus Absenger, Thomas R Piebe. Action of polystyrene nanoparticles of different sizes on lysosomal function and integrity. Particle and fibre toxicology. vol 9. 2012-11-29. PMID:22789069. |
data from environmental exposure to nanoparticles (nps) suggest that chronic exposure may increase the incidence of lung, cardiovascular and neurodegenerative diseases. |
2012-11-29 |
2023-08-12 |
Not clear |
| Giovanni Tosi, Rita Adriana Fano, Lucia Bondioli, Luca Badiali, Rois Benassi, Francesco Rivasi, Barbara Ruozi, Flavio Forni, Maria Angela Vandell. Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood-brain barrier. Nanomedicine (London, England). vol 6. issue 3. 2011-08-26. PMID:21542682. |
nanoneuroscience, based on the use polymeric nanoparticles (nps), represents an emerging field of research for achieving an effective therapy for neurodegenerative diseases. |
2011-08-26 |
2023-08-12 |
Not clear |