| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Furuya, N Imai, K Shiokawa, J Kir. [Effect on gene expression of the expanded CTG repeat on 3'-untranslated region of myotonic dystrophy (DM) protein kinase]. Nihon rinsho. Japanese journal of clinical medicine. vol 57. issue 4. 1999-06-01. PMID:10222793. |
although the mechanism of myotonic dystrophy remains controversial, some evidence suggests that cug repeats in the dmpk mrna may have pathological effects. |
1999-06-01 |
2023-08-12 |
Not clear |
| H Ueda, M Shimokawa, M Yamamoto, N Kameda, H Mizusawa, T Baba, N Terada, Y Fujii, S Ohno, S Ishiura, T Kobayash. Decreased expression of myotonic dystrophy protein kinase and disorganization of sarcoplasmic reticulum in skeletal muscle of myotonic dystrophy. Journal of the neurological sciences. vol 162. issue 1. 1999-05-17. PMID:10064167. |
pathological expression of myotonic'dystrophy protein kinase (dmpk) in skeletal muscle of myotonic dystrophy (dm) was studied by western blot analysis, immunohistochemistry, and immunoelectron microscopy of dmpk. |
1999-05-17 |
2023-08-12 |
Not clear |
| C L Winchester, R K Ferrier, A Sermoni, B J Clark, K J Johnso. Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy. Human molecular genetics. vol 8. issue 3. 1999-05-03. PMID:9949207. |
characterization of the expression of dmpk and six5 in the human eye and implications for pathogenesis in myotonic dystrophy. |
1999-05-03 |
2023-08-12 |
human |
| C L Winchester, R K Ferrier, A Sermoni, B J Clark, K J Johnso. Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy. Human molecular genetics. vol 8. issue 3. 1999-05-03. PMID:9949207. |
the pathogenic mechanisms underlying myotonic dystrophy (dm), which results from a (ctg) n repeat expansion mutation in the 3'-untranslated region (3'-utr) of the myotonic dystrophy protein kinase gene ( dmpk ), remain obscure. |
1999-05-03 |
2023-08-12 |
human |
| C I Berul, C T Maguire, M J Aronovitz, J Greenwood, C Miller, J Gehrmann, D Housman, M E Mendelsohn, S Redd. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. The Journal of clinical investigation. vol 103. issue 4. 1999-04-13. PMID:10021468. |
dmpk dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. |
1999-04-13 |
2023-08-12 |
mouse |
| C I Berul, C T Maguire, M J Aronovitz, J Greenwood, C Miller, J Gehrmann, D Housman, M E Mendelsohn, S Redd. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. The Journal of clinical investigation. vol 103. issue 4. 1999-04-13. PMID:10021468. |
haploinsufficiency of myotonic dystrophy protein kinase (dmpk), dm locus-associated homeodomain protein (dmahp) and/or titration of rna-binding proteins by expanded cug sequences have been hypothesized to underlie the multi-system defects observed in dm. |
1999-04-13 |
2023-08-12 |
mouse |
| C I Berul, C T Maguire, M J Aronovitz, J Greenwood, C Miller, J Gehrmann, D Housman, M E Mendelsohn, S Redd. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. The Journal of clinical investigation. vol 103. issue 4. 1999-04-13. PMID:10021468. |
these results demonstrate that dmpk dosage is a critical element modulating cardiac conduction integrity and conclusively link haploinsufficiency of dmpk with cardiac disease in myotonic dystrophy. |
1999-04-13 |
2023-08-12 |
mouse |
| K Ogata, A Takahashi, N Oguchi, J Ishitoya, S Fuse, T Shimp. [Somatic mosaicism of p(CTG)n expansion in a case of myotonic dystrophy with parotid tumor]. Rinsho shinkeigaku = Clinical neurology. vol 38. issue 8. 1999-03-24. PMID:9916519. |
myotonic dystrophy (md) is an autosomal dominant systemic disorder with an unstable expansion of the ctg triplet repeat in the 3'-untranslated region of the gene encoding myotonine protein kinase (dmpk) which maps to chromosome 19q13.3. |
1999-03-24 |
2023-08-12 |
Not clear |
| X Lu, N A Timchenko, L T Timchenk. Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy. Human molecular genetics. vol 8. issue 1. 1999-03-18. PMID:9887331. |
myotonic dystrophy (dm) is a neuromuscular disorder associated with ctg triplet repeat expansion in the myotonin protein kinase gene ( dmpk ). |
1999-03-18 |
2023-08-12 |
mouse |
| M F Phillips, M T Rogers, R Barnetson, C Braun, H G Harley, J Myring, D Stevens, C M Wiles, P S Harpe. PROMM: the expanding phenotype. A family with proximal myopathy, myotonia and deafness. Neuromuscular disorders : NMD. vol 8. issue 7. 1999-02-04. PMID:9829272. |
there was no abnormal expansion of the ctg triplet repeat in the last exon of the dystrophia myotonica protein kinase (dmpk) gene associated with myotonic dystrophy. |
1999-02-04 |
2023-08-12 |
Not clear |
| M Gennarelli, M Pavoni, P Amicucci, G Novelli, B Dallapiccol. A single polymerase chain reaction-based protocol for detecting normal and expanded alleles in myotonic dystrophy. Diagnostic molecular pathology : the American journal of surgical pathology, part B. vol 7. issue 3. 1999-02-04. PMID:9836067. |
the myotonic dystrophy (dm) expansion varies from 50 to 4000 ctg repeats in the 3' untranslated region of the dmpk gene. |
1999-02-04 |
2023-08-12 |
Not clear |
| E Rajcan-Separovic, J M Barcelo, R G Kornelu. Fluorescence in situ hybridization analysis of the replication properties of the myotonic dystrophy protein kinase (DMPK) gene region. Cytogenetics and cell genetics. vol 82. issue 3-4. 1999-02-01. PMID:9858828. |
fluorescence in situ hybridization analysis of the replication properties of the myotonic dystrophy protein kinase (dmpk) gene region. |
1999-02-01 |
2023-08-12 |
Not clear |
| E Rajcan-Separovic, J M Barcelo, R G Kornelu. Fluorescence in situ hybridization analysis of the replication properties of the myotonic dystrophy protein kinase (DMPK) gene region. Cytogenetics and cell genetics. vol 82. issue 3-4. 1999-02-01. PMID:9858828. |
myotonic dystrophy (dm) is caused by an expansion of a ctg repeat sequence in the 3' noncoding region of a protein kinase gene (dmpk) at 19q13.3. |
1999-02-01 |
2023-08-12 |
Not clear |
| E Rajcan-Separovic, J M Barcelo, R G Kornelu. Fluorescence in situ hybridization analysis of the replication properties of the myotonic dystrophy protein kinase (DMPK) gene region. Cytogenetics and cell genetics. vol 82. issue 3-4. 1999-02-01. PMID:9858828. |
we used in situ hybridization to analyse the replication timing of the genomic region containing dmpk in fibroblasts and myoblasts from controls and myotonic dystrophy patients. |
1999-02-01 |
2023-08-12 |
Not clear |
| P Groenen, B Wiering. Expanding complexity in myotonic dystrophy. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 20. issue 11. 1999-01-21. PMID:9872056. |
there is now circumstantial evidence that long (ctg)n repeats may affect the expression of any of at least three genes, myotonic dystrophy protein kinase (dmpk), dmr-n9 (gene 59), and a dm-associated homeodomain protein (dmahp). |
1999-01-21 |
2023-08-12 |
Not clear |
| Y C Pham, N Man, L T Lam, G E Morri. Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies. Human molecular genetics. vol 7. issue 12. 1998-12-15. PMID:9811941. |
there is considerable confusion in the literature about the size of the myotonic dystrophy protein kinase (dmpk) and its localization within tissues. |
1998-12-15 |
2023-08-12 |
mouse |
| Y C Pham, N Man, L T Lam, G E Morri. Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies. Human molecular genetics. vol 7. issue 12. 1998-12-15. PMID:9811941. |
we have used a new panel of monoclonal antibodies (mabs) to begin to resolve these issues, which are important for understanding the possible role of dmpk in myotonic dystrophy. |
1998-12-15 |
2023-08-12 |
mouse |
| Y C Pham, N Man, L T Lam, G E Morri. Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies. Human molecular genetics. vol 7. issue 12. 1998-12-15. PMID:9811941. |
nine out of 10 mabs located dmpk to intercalated discs in human heart, an affected tissue in myotonic dystrophy. |
1998-12-15 |
2023-08-12 |
mouse |
| A S Lia, H Seznec, H Hofmann-Radvanyi, F Radvanyi, C Duros, C Saquet, M Blanche, C Junien, G Gourdo. Somatic instability of the CTG repeat in mice transgenic for the myotonic dystrophy region is age dependent but not correlated to the relative intertissue transcription levels and proliferative capacities. Human molecular genetics. vol 7. issue 8. 1998-09-09. PMID:9668171. |
a (ctg)nexpansion in the 3'-untranslated region (utr) of the dm protein kinase gene ( dmpk ) is responsible for causing myotonic dystrophy (dm). |
1998-09-09 |
2023-08-12 |
mouse |
| K S Koch, H L Leffer. Giant hairpins formed by CUG repeats in myotonic dystrophy messenger RNAs might sterically block RNA export through nuclear pores. Journal of theoretical biology. vol 192. issue 4. 1998-08-17. PMID:9680723. |
energy minimization calculations were used to generate secondary structures of partial and full-length myotonic dystrophy messenger rnas (dmpk mrnas) carrying variable numbers of cug triplet repeats (n = 0 to 500). |
1998-08-17 |
2023-08-12 |
Not clear |