| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Gunji, C Skolnick, T Bednarczuk, S Benes, B A Ackrell, B Cochran, J S Kennerdell, J R Wal. Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine-receptor antibody-negative patients. Clinical immunology and immunopathology. vol 87. issue 3. 1998-07-20. PMID:9646837. |
extraocular muscle weakness and double vision are present in about 90% of patients with myasthenia gravis and are the predominant complaints in about 20% of patients, when the condition is called ocular myasthenia gravis (omg). |
1998-07-20 |
2023-08-12 |
Not clear |
| K Gunji, C Skolnick, T Bednarczuk, S Benes, B A Ackrell, B Cochran, J S Kennerdell, J R Wal. Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine-receptor antibody-negative patients. Clinical immunology and immunopathology. vol 87. issue 3. 1998-07-20. PMID:9646837. |
while serum antibodies against the achr are detected in most patients with generalized myasthenia gravis (gmg), they are not found in about one-third of patients with the ocular variety, and epidemiological, clinical, and serological studies suggest that omg and gmg are two separate diseases. |
1998-07-20 |
2023-08-12 |
Not clear |
| K Gunji, C Skolnick, T Bednarczuk, S Benes, B A Ackrell, B Cochran, J S Kennerdell, J R Wal. Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine-receptor antibody-negative patients. Clinical immunology and immunopathology. vol 87. issue 3. 1998-07-20. PMID:9646837. |
antibodies recognizing purified succinate dehydrogenase (67 kda) were found in 42% of patients with omg, in 100% (5 of 5) of patients with gmg, and in 48% of all patients with myasthenia gravis not associated with graves' hyperthyroidism. |
1998-07-20 |
2023-08-12 |
Not clear |
| K Gunji, C Skolnick, T Bednarczuk, S Benes, B A Ackrell, B Cochran, J S Kennerdell, J R Wal. Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine-receptor antibody-negative patients. Clinical immunology and immunopathology. vol 87. issue 3. 1998-07-20. PMID:9646837. |
similarly, while the demonstration of antibodies reactive with eye muscle antigens associated with tao in patients with omg raises the possibility that the link between the ocular lesions of myasthenia gravis and graves' disease may be autoimmunity against a common antigen(s), it is more likely that both disorders are mediated by cytotoxic t cells recognizing another cell membrane antigen, such as the novel thyroid and eye muscle shared protein g2s, and that serum antibodies reactive with succinate dehydrogenase fp subunit and calsequestrin are markers of an immune-mediated eye muscle reaction. |
1998-07-20 |
2023-08-12 |
Not clear |
| Z Y Wang, D K Okita, J Howard, B M Conti-Fin. T-cell recognition of muscle acetylcholine receptor subunits in generalized and ocular myasthenia gravis. Neurology. vol 50. issue 4. 1998-05-07. PMID:9566393. |
our purpose was to identify the muscle acetylcholine receptor (achr) subunits recognized by autoimmune cd4+ t cells in myasthenia gravis (mg) and determine whether they differ in generalized (gmg) and ocular mg (omg), and as gmg progresses. |
1998-05-07 |
2023-08-12 |
Not clear |
| C MacLennan, D Beeson, A M Buijs, A Vincent, J Newsom-Davi. Acetylcholine receptor expression in human extraocular muscles and their susceptibility to myasthenia gravis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124798. |
we have (1) studied mrna expression for each of the achr subunits (alpha, beta, gamma, delta, and epsilon) in human muscle, including eom, and (2) compared the binding of sera from ocular myasthenia gravis (omg) patients with fetal (alpha2 beta gamma delta) and adult (alpha2 beta epsilon delta) human achrs. |
1997-04-24 |
2023-08-12 |
human |
| C W Zimmermann, F Eble. Repertoires of autoantibodies against homologous eye muscle in ocular and generalized myasthenia gravis differ. The Clinical investigator. vol 71. issue 6. 1993-09-23. PMID:8353403. |
if weakness of the eye muscles remains the only symptom of myasthenia gravis (mg) for more than 2 years, the condition is operationally defined as ocular mg (omg). |
1993-09-23 |
2023-08-12 |
Not clear |
| F T Christiansen, M S Pollack, M J Garlepp, R L Dawkin. Myasthenia gravis and HLA antigens in American blacks and other races. Journal of neuroimmunology. vol 7. issue 2-3. 1985-01-31. PMID:6334696. |
in this study hla a, b, c and dr typing on 28 american blacks with either gmg or ocular myasthenia gravis (omg) is reported. |
1985-01-31 |
2023-08-12 |
Not clear |
| M J Garlepp, R L Dawkins, F T Christiansen, J Lawton, G Luciani, J McLeod, J Bradley, G Genkins, C S Ten. Autoimmunity in ocular and generalised myasthenia gravis. Journal of neuroimmunology. vol 1. issue 3. 1982-05-27. PMID:7334085. |
restricted ocular myasthenia gravis (omg) and generalised myasthenia gravis (gmg) have been shown to differ in a number of respects. |
1982-05-27 |
2023-08-12 |
Not clear |