| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claire E Wells, Michael I Polkey, Emma H Bake. Insulin resistance is associated with skeletal muscle weakness in COPD. Respirology (Carlton, Vic.). vol 21. issue 4. 2016-12-13. PMID:26678022. |
we tested the hypothesis that insulin resistance contributes to skeletal muscle weakness in people with stable copd. |
2016-12-13 |
2023-08-13 |
Not clear |
| Reena Thakrar, Rob Shulman, Geoff Bellingan, Mervyn Singe. Management of a mixed overdose of calcium channel blockers, β-blockers and statins. BMJ case reports. vol 2014. 2015-01-21. PMID:24907219. |
the patient was successfully treated with aggressive resuscitation including cardiac pacing and multiorgan support, glucagon and high-dose insulin for toxicity related to calcium channel blockade and β-blockade, and ubiquinone for treating severe presumed statin-induced rhabdomyolysis and muscle weakness. |
2015-01-21 |
2023-08-13 |
Not clear |
| Sabine Hübner, Jan Tuckerman. Molecular mechanisms of the glucocorticoid receptor in steroid therapy - lessons from transgenic mice. Biomolecular concepts. vol 3. issue 3. 2014-12-03. PMID:25436536. |
however, their therapeutic effects are hampered by severe side effects, such as muscle weakness, insulin resistance, fat redistribution, and osteoporosis. |
2014-12-03 |
2023-08-13 |
mouse |
| Fenfen Wu, Wentao Mi, Stephen C Canno. Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis. Brain : a journal of neurology. vol 136. issue Pt 12. 2014-02-10. PMID:24142145. |
we developed a cav1.1-r528h knock-in mouse model of hypokalaemic periodic paralysis and show herein that bumetanide protects against both muscle weakness from low k+ challenge in vitro and loss of muscle excitability in vivo from a glucose plus insulin infusion. |
2014-02-10 |
2023-08-12 |
mouse |
| Alan G Wasserstei. L-carnitine supplementation in dialysis: treatment in quest of disease. Seminars in dialysis. vol 26. issue 1. 2013-07-16. PMID:23173999. |
l-carnitine (lc) administration has been recommended for specific indications in dialysis patients, including epoetin-resistant anemia, intradialytic hypotension, cardiomyopathy, fatigue, muscle weakness, and exercise performance; it may ameliorate insulin resistance, inflammation, and protein wasting. |
2013-07-16 |
2023-08-12 |
Not clear |
| Kay Ohlendiec. Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics. Journal of nutrition and metabolism. vol 2012. 2012-08-23. PMID:22523676. |
insulin resistance in skeletal muscle tissues and diabetes-related muscle weakness are serious pathophysiological problems of increasing medical importance. |
2012-08-23 |
2023-08-12 |
Not clear |
| Jorge Rojas-Rodríguez, Luis E Escobar-Linares, Mario Garcia-Carrasco, Ricardo O Escárcega, Salvador Fuentes-Alexandro, Alfonso Zamora-Ustara. The relationship between the metabolic syndrome and energy-utilization deficit in the pathogenesis of obesity-induced osteoarthritis. Medical hypotheses. vol 69. issue 4. 2007-10-24. PMID:17368954. |
the fatigue and muscle weakness induced by insulin resistance and inflammation in obese patients with metabolic syndrome increase the frequency and the intensity of traumatic events of peripheral or axial joints that result in stretch and breaking of tenoperiosteal junction and abrasive damage of cartilage and therefore in these patients with metabolic syndrome and pro-inflammatory state the reparative process of cartilage and periarticular tissues would be severely modified by the growth factor activity in presence of high levels of insulin. |
2007-10-24 |
2023-08-12 |
Not clear |
| H Degens, M Soop, P Höök, O Ljungqvist, L Larsso. Post-operative effects on insulin resistance and specific tension of single human skeletal muscle fibres. Clinical science (London, England : 1979). vol 97. issue 4. 2000-01-11. PMID:10491345. |
in conclusion, the muscle weakness associated with post-operative insulin resistance is not related to a decreased specific tension or a loss of myofibrillar proteins. |
2000-01-11 |
2023-08-12 |
human |
| H Degens, M Soop, P Höök, O Ljungqvist, L Larsso. Post-operative effects on insulin resistance and specific tension of single human skeletal muscle fibres. Clinical science (London, England : 1979). vol 97. issue 4. 2000-01-11. PMID:10491345. |
surgery and accidental trauma are associated with a transient period of insulin resistance, substrate catabolism and muscle weakness. |
2000-01-11 |
2023-08-12 |
human |
| R Lazarus, D Sparrow, S T Weis. Handgrip strength and insulin levels: cross-sectional and prospective associations in the Normative Aging Study. Metabolism: clinical and experimental. vol 46. issue 11. 1997-12-02. PMID:9361683. |
the findings suggest that skeletal muscle weakness may precede and predict the development of insulin resistance, and raise the intriguing possibility of some common cause in skeletal muscle pathophysiology. |
1997-12-02 |
2023-08-12 |
human |
| E Vlachopapadopoulou, J J Zachwieja, J M Gertner, D Manzione, D M Bier, D E Matthews, A E Sloni. Metabolic and clinical response to recombinant human insulin-like growth factor I in myotonic dystrophy--a clinical research center study. The Journal of clinical endocrinology and metabolism. vol 80. issue 12. 1996-01-31. PMID:8530624. |
muscle weakness and wasting in myotonic dystrophy (myd) are believed to be due to a decrease in muscle protein synthesis, secondary to insulin resistance. |
1996-01-31 |
2023-08-12 |
human |
| T Yoshimura, M Kaneuji, T Okuno, M Yoshioka, T Ueda, H Mikawa, T Kowata, T Kamiy. Periodic paralysis with cardiac arrhythmia. European journal of pediatrics. vol 140. issue 4. 1983-12-20. PMID:6628456. |
muscle weakness was not provoked by intravenous administration of 45 g glucose or of 72 g glucose followed by 10 units of regular insulin. |
1983-12-20 |
2023-08-12 |
Not clear |
| T Johnsen, M E Houston, B Salti. Skeletal muscle characteristics and carbohydrate metabolism after glucose loading in hypokalaemic periodic paralysis. Scandinavian journal of clinical and laboratory investigation. vol 38. issue 6. 1978-12-20. PMID:705237. |
these data suggest that patients with hypokalaemic periodic paralysis have an enhanced metabolism of carbohydrates and that insulin seems to be an important factor leading to the onset of muscle weakness. |
1978-12-20 |
2023-08-11 |
human |