| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jason T Connor, Kristine R Broglio, Valerie Durkalski, William J Meurer, Karen C Johnsto. The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study. Trials. vol 16. 2016-05-27. PMID:25885963. |
the stroke hyperglycemia insulin network effort (shine) trial was selected for funding by the nih-ninds at the start of adapt-it and is currently an ongoing phase iii trial of tight glucose control in hyperglycemic acute ischemic stroke patients. |
2016-05-27 |
2023-08-13 |
Not clear |
| Vasileios-Arsenios Lioutas, Vera Nova. Intranasal insulin neuroprotection in ischemic stroke. Neural regeneration research. vol 11. issue 3. 2016-04-29. PMID:27127468. |
intranasal insulin neuroprotection in ischemic stroke. |
2016-04-29 |
2023-08-13 |
Not clear |
| Vasileios-Arsenios Lioutas, Freddy Alfaro-Martinez, Francisco Bedoya, Chen-Chih Chung, Daniela A Pimentel, Vera Nova. Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke. Translational stroke research. vol 6. issue 4. 2016-03-21. PMID:26040423. |
intranasal insulin and insulin-like growth factor 1 as neuroprotectants in acute ischemic stroke. |
2016-03-21 |
2023-08-13 |
human |
| Vasileios-Arsenios Lioutas, Freddy Alfaro-Martinez, Francisco Bedoya, Chen-Chih Chung, Daniela A Pimentel, Vera Nova. Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke. Translational stroke research. vol 6. issue 4. 2016-03-21. PMID:26040423. |
intranasally administered insulin has demonstrated a benefit for prevention of cognitive decline in older people, and igf-1 has shown potential benefit to improve functional outcomes in animal models of acute ischemic stroke. |
2016-03-21 |
2023-08-13 |
human |
| Aleksandra Jotic, Tanja Milicic, Nadezda Covickovic Sternic, Vladimir S Kostic, Katarina Lalic, Veljko Jeremic, Milija Mijajlovic, Ljiljana Lukic, Natasa Rajkovic, Milorad Civcic, Marija Macesic, Jelena P Seferovic, Jelena Stanarcic, Sandra Aleksic, Nebojsa M Lali. Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke. International journal of endocrinology. vol 2015. 2015-06-19. PMID:26089903. |
decreased insulin sensitivity and impaired fibrinolytic activity in type 2 diabetes patients and nondiabetics with ischemic stroke. |
2015-06-19 |
2023-08-13 |
Not clear |
| Aleksandra Jotic, Tanja Milicic, Nadezda Covickovic Sternic, Vladimir S Kostic, Katarina Lalic, Veljko Jeremic, Milija Mijajlovic, Ljiljana Lukic, Natasa Rajkovic, Milorad Civcic, Marija Macesic, Jelena P Seferovic, Jelena Stanarcic, Sandra Aleksic, Nebojsa M Lali. Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke. International journal of endocrinology. vol 2015. 2015-06-19. PMID:26089903. |
we analyzed (a) insulin sensitivity (is), (b) plasma insulin (pi), and (c) plasminogen activator inhibitor-1 (pai-1) in type 2 diabetes (t2d) patients with (group a) and without (group b) atherothrombotic ischemic stroke (atis), nondiabetics with atis (group c), and healthy controls (group d). |
2015-06-19 |
2023-08-13 |
Not clear |
| Duo L. Omega-3 polyunsaturated fatty acids and non-communicable diseases: meta-analysis based systematic review. Asia Pacific journal of clinical nutrition. vol 24. issue 1. 2015-04-24. PMID:25740737. |
n-3 pufas have the following beneficial effects; cardio-protective effects, reduce ischemic stroke risk in both men and women and total stroke risk in women, increase insulin sensitivity in asians, decrease risk of breast cancer and colorectal cancer in men. |
2015-04-24 |
2023-08-13 |
human |
| Li-Man Hung, Jiung-Pang Huang, Jiuan-Miaw Liao, Meng-Hsuan Yang, Dai-Er Li, Yuan-Ji Day, Shiang-Suo Huan. Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite. Journal of biomedical science. vol 21. 2015-03-30. PMID:25223305. |
insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite. |
2015-03-30 |
2023-08-13 |
rat |
| Catherine M Viscoli, Lawrence M Brass, Antonio Carolei, Robin Conwit, Gary A Ford, Karen L Furie, Mark Gorman, Peter D Guarino, Silvio E Inzucchi, Anne M Lovejoy, Mark W Parsons, Peter N Peduzzi, Peter A Ringleb, Gregory G Schwartz, J David Spence, David Tanne, Lawrence H Young, Walter N Kerna. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial. American heart journal. vol 168. issue 6. 2015-02-09. PMID:25458644. |
pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the insulin resistance intervention after stroke trial. |
2015-02-09 |
2023-08-13 |
Not clear |
| Catherine M Viscoli, Lawrence M Brass, Antonio Carolei, Robin Conwit, Gary A Ford, Karen L Furie, Mark Gorman, Peter D Guarino, Silvio E Inzucchi, Anne M Lovejoy, Mark W Parsons, Peter N Peduzzi, Peter A Ringleb, Gregory G Schwartz, J David Spence, David Tanne, Lawrence H Young, Walter N Kerna. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial. American heart journal. vol 168. issue 6. 2015-02-09. PMID:25458644. |
specifically, iris will test the effectiveness of pioglitazone, an insulin-sensitizing drug of the thiazolidinedione class, for reducing the risk for stroke and myocardial infarction (mi) among insulin resistant, nondiabetic patients with a recent ischemic stroke or tia. |
2015-02-09 |
2023-08-13 |
Not clear |
| Annika Lundström, Ann-Charlotte Laska, Magnus Von Arbin, Gun Jörneskog, Håkan Wallé. Glucose intolerance and insulin resistance as predictors of low platelet response to clopidogrel in patients with minor ischemic stroke or TIA. Platelets. vol 25. issue 2. 2014-10-28. PMID:23527528. |
glucose intolerance and insulin resistance as predictors of low platelet response to clopidogrel in patients with minor ischemic stroke or tia. |
2014-10-28 |
2023-08-12 |
Not clear |
| Annika Lundström, Ann-Charlotte Laska, Magnus Von Arbin, Gun Jörneskog, Håkan Wallé. Glucose intolerance and insulin resistance as predictors of low platelet response to clopidogrel in patients with minor ischemic stroke or TIA. Platelets. vol 25. issue 2. 2014-10-28. PMID:23527528. |
the relation between high on-treatment platelet reactivity (hpr), and the level of glucose intolerance and insulin resistance (ir) was studied in clopidogrel-treated patients with minor ischemic stroke or tia. |
2014-10-28 |
2023-08-12 |
Not clear |
| Adam Lemanowicz, Zbigniew Serafi. Imaging of patients treated with bariatric surgery. Polish journal of radiology. vol 79. 2014-06-24. PMID:24497896. |
obesity leads to significant systemic disorders, such as hypertension, hypercholesterolemia, hypertriglyceridemia and insulin resistance, and also increases the risk of developing cardiovascular diseases (ischemic heart disease, ischemic stroke), metabolic diseases (type 2 diabetes), certain types of cancer, and degenerative bone disorders (osteoarthritis). |
2014-06-24 |
2023-08-12 |
Not clear |
| Ya-Yu Wang, Shih-Yi Lin, Yu-Han Chuang, Wayne Huey-Herng Sheu, Kwong-Chung Tung, Chun-Jung Che. Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats. Endocrinology. vol 155. issue 4. 2014-05-19. PMID:24437486. |
activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats. |
2014-05-19 |
2023-08-12 |
rat |
| Ya-Yu Wang, Shih-Yi Lin, Yu-Han Chuang, Wayne Huey-Herng Sheu, Kwong-Chung Tung, Chun-Jung Che. Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats. Endocrinology. vol 155. issue 4. 2014-05-19. PMID:24437486. |
these results suggest that acute ischemic stroke can activate proinflammatory pathways in the liver by the catecholamines and is associated with the development of hepatic insulin resistance. |
2014-05-19 |
2023-08-12 |
rat |
| Shiang-Suo Huang, Yi-Jhu Lu, Jiung-Pang Huang, Yang-Tzu Wu, Yuan-Ji Day, Li-Man Hun. The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes. Journal of vascular surgery. vol 59. issue 2. 2014-03-20. PMID:23663869. |
therefore, the present study was aimed to identify the key factor involved in the neuroprotective action of insulin beyond its hypoglycemic effects in streptozotocin-diabetic rats with ischemic stroke. |
2014-03-20 |
2023-08-12 |
rat |
| Hebbani Nagarajappa Shivaprasad, Sushma Gopalakrishna, Bhanumathy Mariyanna, Midhun Thekkoot, Roopa Reddy, Boreddy Shivanandappa Tippeswam. Effect of Coleus forskohlii extract on cafeteria diet-induced obesity in rats. Pharmacognosy research. vol 6. issue 1. 2014-02-05. PMID:24497741. |
obesity is a metabolic disorder that can lead to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance and also increases the risk of coronary heart disease, ischemic stroke and type 2 diabetes mellitus. |
2014-02-05 |
2023-08-12 |
rat |
| Kelly A Tennant, Craig E Brow. Diabetes augments in vivo microvascular blood flow dynamics after stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 49. 2014-01-31. PMID:24305815. |
these results indicate that chronic hyperglycemia significantly affects the vascular response to ischemic stroke and that insulin only partially mitigates these changes. |
2014-01-31 |
2023-08-12 |
mouse |
| Monik C Jiménez, Qi Sun, Markus Schürks, Stephanie Chiuve, Frank B Hu, Joann E Manson, Kathryn M Rexrod. Low dehydroepiandrosterone sulfate is associated with increased risk of ischemic stroke among women. Stroke. vol 44. issue 7. 2013-09-05. PMID:23704104. |
dheas may influence ischemic stroke risk through atherosclerotic-related mechanisms (endothelial function and smooth muscle cell proliferation) or insulin resistance. |
2013-09-05 |
2023-08-12 |
Not clear |
| Aleksandra Jotic, Nadezda Covickovic Sternic, Vladimir S Kostic, Katarina Lalic, Tanja Milicic, Milija Mijajlovic, Ljiljana Lukic, Milorad Civcic, Emina Colak, Marija Macesic, Jelena P Seferovic, Sandra Aleksic, Nebojsa M Lali. Type 2 diabetic patients with ischemic stroke: decreased insulin sensitivity and decreases in antioxidant enzyme activity are related to different stroke subtypes. International journal of endocrinology. vol 2013. 2013-07-11. PMID:23843789. |
type 2 diabetic patients with ischemic stroke: decreased insulin sensitivity and decreases in antioxidant enzyme activity are related to different stroke subtypes. |
2013-07-11 |
2023-08-12 |
Not clear |