| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Wang, Yu Jiang, Dan Zeng, Wensheng Zhou, Xiuqin Hon. Prognostic value of plasma HMGB1 in ischemic stroke patients with cerebral ischemia-reperfusion injury after intravenous thrombolysis. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 29. issue 9. 2020-11-02. PMID:32807461. |
prognostic value of plasma hmgb1 in ischemic stroke patients with cerebral ischemia-reperfusion injury after intravenous thrombolysis. |
2020-11-02 |
2023-08-13 |
Not clear |
| Yingze Ye, Zhi Zeng, Tong Jin, Hongfei Zhang, Xiaoxing Xiong, Lijuan G. The Role of High Mobility Group Box 1 in Ischemic Stroke. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31001089. |
acting as an endogenous danger-associated molecular pattern (damp) protein, hmgb1 mediates cerebral inflammation and brain injury and participates in the pathogenesis of ischemic stroke. |
2020-09-29 |
2023-08-13 |
Not clear |
| Kai Le, Sisi Mo, Xiang Lu, Abdoulaye Idriss Ali, Dafan Yu, Yijing Gu. Association of circulating blood HMGB1 levels with ischemic stroke: a systematic review and meta-analysis. Neurological research. vol 40. issue 11. 2018-12-18. PMID:30015578. |
association of circulating blood hmgb1 levels with ischemic stroke: a systematic review and meta-analysis. |
2018-12-18 |
2023-08-13 |
Not clear |
| Seidu A Richard, Marian Sackey, Zhaoliang Su, Huaxi X. Pivotal neuroinflammatory and therapeutic role of high mobility group box 1 in ischemic stroke. Bioscience reports. vol 37. issue 6. 2018-07-26. PMID:29054968. |
high mobility group box 1 (hmgb1) is non-histone nuclear protein that is currently one of the crucial proinflammatory alarmins in ischemic stroke (is). |
2018-07-26 |
2023-08-13 |
Not clear |
| Toshiyuki Tsukagawa, Ryu Katsumata, Mitsugu Fujita, Keizo Yasui, Cassim Akhoon, Kenjiro Ono, Kenji Dohi, Toru Arug. Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 26. issue 10. 2018-05-21. PMID:28645523. |
in experimental models, inhibition of high-mobility group box-1 (hmgb1) signaling has been reported to protect against the sequelae of ischemic stroke. |
2018-05-21 |
2023-08-13 |
Not clear |
| Toshiyuki Tsukagawa, Ryu Katsumata, Mitsugu Fujita, Keizo Yasui, Cassim Akhoon, Kenjiro Ono, Kenji Dohi, Toru Arug. Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 26. issue 10. 2018-05-21. PMID:28645523. |
here, we determined the clinical significance of serum hmgb1 levels in patients with acute ischemic stroke. |
2018-05-21 |
2023-08-13 |
Not clear |
| Leila Sadat-Hatamnezhad, Asghar Tanomand, Javad Mahmoudi, Siamak Sandoghchian Shotorban. Activation of Toll-Like Receptors 2 by High-Mobility Group Box 1 in Monocytes from Patients with Ischemic Stroke. Iranian biomedical journal. vol 20. issue 4. 2017-04-07. PMID:27040385. |
in this regard, the purpose of this study was to assess the expression level of tlr2 on monocytes in patients with ischemic stroke and to evaluate the expression change profile following high-mobility group box 1 (hmgb1) stimulation. |
2017-04-07 |
2023-08-13 |
Not clear |
| Chong Wang, Jie Jiang, Xiuping Zhang, Linjie Song, Kai Sun, Ruxiang X. Inhibiting HMGB1 Reduces Cerebral Ischemia Reperfusion Injury in Diabetic Mice. Inflammation. vol 39. issue 6. 2017-04-04. PMID:27596007. |
blocking hmgb1 function by intraperitoneal injection of anti-hmgb1 neutralizing antibodies reversed the inflammatory response and the extent of brain damage, suggesting that hmgb1 plays an important role in cerebral ischemic stroke in diabetic mice. |
2017-04-04 |
2023-08-13 |
mouse |
| Vikramjeet Singh, Stefan Roth, Roland Veltkamp, Arthur Lies. HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke. Antioxidants & redox signaling. vol 24. issue 12. 2016-12-22. PMID:26493086. |
hmgb1 as a key mediator of immune mechanisms in ischemic stroke. |
2016-12-22 |
2023-08-13 |
Not clear |
| Yoshihiko Nakamura, Takafumi Nakano, Keiichi Irie, Kazunori Sano, Junichi Tanaka, Yuta Yamashita, Tomomitsu Satho, Koichi Matsuo, Masayuki Fujioka, Hiroyasu Ishikura, Kenichi Mishim. Recombinant human soluble thrombomodulin ameliorates cerebral ischemic injury through a high-mobility group box 1 inhibitory mechanism without hemorrhagic complications in mice. Journal of the neurological sciences. vol 362. 2016-12-13. PMID:26944163. |
some investigators reported that hmgb1 is associated with ischemic stroke. |
2016-12-13 |
2023-08-13 |
mouse |
| Yoshihiko Nakamura, Takafumi Nakano, Keiichi Irie, Kazunori Sano, Junichi Tanaka, Yuta Yamashita, Tomomitsu Satho, Koichi Matsuo, Masayuki Fujioka, Hiroyasu Ishikura, Kenichi Mishim. Recombinant human soluble thrombomodulin ameliorates cerebral ischemic injury through a high-mobility group box 1 inhibitory mechanism without hemorrhagic complications in mice. Journal of the neurological sciences. vol 362. 2016-12-13. PMID:26944163. |
however, there have been no previous studies to determine whether rhstm can ameliorate cerebral ischemic injury through its hmgb1 inhibitory mechanism in ischemic stroke. |
2016-12-13 |
2023-08-13 |
mouse |
| Ker Zhing Lok, Milan Basta, Silvia Manzanero, Thiruma V Arumuga. Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia. Journal of neuroinflammation. vol 12. 2016-08-10. PMID:25886362. |
ischemic stroke triggers the release of damage-associated molecular patterns (damps) such as high-mobility group box 1 (hmgb1), which activate toll-like receptors (tlrs) and receptor for advanced glycation endproducts (rage) in the affected area, leading to an exaggerated inflammatory response and cell death. |
2016-08-10 |
2023-08-13 |
human |
| Nelly Sapojnikova, Tamar Kartvelishvili, Nino Asatiani, Vitaly Zinkevich, Iagor Kalandadze, Darejan Gugutsidze, Roman Shakarishvili, Alexander Tsiskaridz. Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24815357. |
the relations between two main players in the ischemic brain, mmps and hmgb1, were estimated in the plasma of ischemic stroke patients stratified according to the glasgow outcome scale and the oxfordshire community stroke project classification. |
2014-09-25 |
2023-08-13 |
human |
| Nelly Sapojnikova, Tamar Kartvelishvili, Nino Asatiani, Vitaly Zinkevich, Iagor Kalandadze, Darejan Gugutsidze, Roman Shakarishvili, Alexander Tsiskaridz. Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24815357. |
correlation between mmp-9 and extracellular cytokine hmgb1 in prediction of human ischemic stroke outcome. |
2014-09-25 |
2023-08-13 |
human |
| Nelly Sapojnikova, Tamar Kartvelishvili, Nino Asatiani, Vitaly Zinkevich, Iagor Kalandadze, Darejan Gugutsidze, Roman Shakarishvili, Alexander Tsiskaridz. Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24815357. |
in patients with ischemic stroke increased plasma levels of mmp-9 and hmgb1 are associated with a poor functional outcome and are significantly correlated with each other (p=0.0054). |
2014-09-25 |
2023-08-13 |
human |
| Ju-Ming Huang, Jin Hu, Ning Chen, Min-Lei H. Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke. Journal of critical care. vol 28. issue 5. 2014-05-27. PMID:23137435. |
this study aimed to investigate impact of plasma hmgb1 level on 1-year clinical outcomes of ischemic stroke. |
2014-05-27 |
2023-08-12 |
Not clear |
| Sung-Chun Tang, Yu-Chi Wang, Yu-I Li, Hsiao-Ching Lin, Silvia Manzanero, Yu-Hsuan Hsieh, Simon Phipps, Chaur-Jong Hu, Hung-Yi Chiou, Yi-Shuian Huang, Wei-Shiung Yang, Mark P Mattson, Thiruma V Arumugam, Jiann-Shing Jen. Functional role of soluble receptor for advanced glycation end products in stroke. Arteriosclerosis, thrombosis, and vascular biology. vol 33. issue 3. 2013-04-10. PMID:23288172. |
here, we aim to identify the role of plasma srage and high mobility group box 1 (hmgb1) in imaging-confirmed is patients, as well as mice subjected to focal ischemic stroke. |
2013-04-10 |
2023-08-12 |
mouse |
| Jianhua Qiu, Jian Xu, Yi Zheng, Ying Wei, Xiaoxia Zhu, Eng H Lo, Michael A Moskowitz, John R Sim. High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia. Stroke. vol 41. issue 9. 2010-09-22. PMID:20671243. |
this study was intended to investigate the role of extracellular hmgb1 in ischemic stroke by examining the response of the zymogen matrix metalloproteinase-9 (mmp-9) to hmgb1 in vivo and in vitro. |
2010-09-22 |
2023-08-12 |
Not clear |
| Shuji Mori, Keyue Liu, Hideo K Takahashi, Masahiro Nishibor. [Therapeutic effect of anti-nucleokine monoclonal antibody on ischemic brain infarction]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 129. issue 1. 2009-04-13. PMID:19122433. |
these findings indicate the usefulness of hmgb1 as a novel therapeutic to target ischemic stroke. |
2009-04-13 |
2023-08-12 |
rat |