| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R H Chowdhury, M N Hasa. Pembrolizumab Induced Hypophysitis in a Patient Allergic to Triamcinolone: An Increasingly Recognized Endocrinopathy Related to Immunotherapy. Mymensingh medical journal : MMJ. vol 29. issue 4. 2020-10-30. PMID:33116112. |
subsequent endocrine work ups revealed features consistent with hypophysitis that lead to hypopituitarism in the form of secondary adrenal insufficiency and hypothyroidism. |
2020-10-30 |
2023-08-13 |
Not clear |
| Keitaro Kanie, Genzo Iguchi, Hironori Bando, Yasunori Fujita, Yukiko Odake, Kenichi Yoshida, Ryusaku Matsumoto, Hidenori Fukuoka, Wataru Ogawa, Yutaka Takahash. Two Cases of Atezolizumab-Induced Hypophysitis. Journal of the Endocrine Society. vol 2. issue 1. 2020-09-30. PMID:29362727. |
these results suggest a caution for the late-onset central adrenal insufficiency associated with hypophysitis in patients treated with anti-pd-l1 antibodies. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shivani Patel, Venessa Chin, Jerry R Greenfiel. Durvalumab-induced diabetic ketoacidosis followed by hypothyroidism. Endocrinology, diabetes & metabolism case reports. vol 2019. 2020-09-28. PMID:31829972. |
treatment with levothyroxine was commenced after excluding adrenal insufficiency (early morning cortisol: 339 nmol/l) and hypophysitis (normal pituitary on mri). |
2020-09-28 |
2023-08-13 |
Not clear |
| Maitreyee Rai, Mylene G. Nivolumab Induced Adrenal Insufficiency: Rare Side-effect of a New Anti-cancer Therapy - Immune-checkpoint Inhibitors. Cureus. vol 12. issue 4. 2020-09-28. PMID:32399358. |
adrenocorticotrophic hormone (acth) was checked that came out to be low <5pg/ml, favoring a diagnosis of secondary adrenal insufficiency likely due to hypophysitis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Salem Gaballa, Kyaw M Hlaing, Nathan Mahler, Safa Moursy, Ameenjamal Ahme. A Rare Case of Immune-Mediated Primary Adrenal Insufficiency With Cytotoxic T-Lymphocyte Antigen-4 Inhibitor Ipilimumab in Metastatic Melanoma of Lung and Neck of Unknown Primary. Cureus. vol 12. issue 6. 2020-09-28. PMID:32676241. |
the immune-related endocrinopathies of these treatments have been well documented, such as hypothyroidism, hyperthyroidism, primary adrenal insufficiency (pai), insulin-dependent diabetes, and hypophysitis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Nayson L Fernandes, Soujanya Sodavarapu, Sukhmine Nedopil, Nikita Mohapatra, Dinesh Vya. Checkpoint Inhibitor in a Melanoma Patient With Polyendocrinopathy and Gangrenous Gallbladder With a Mass. Cureus. vol 12. issue 6. 2020-09-28. PMID:32724737. |
incidentally, the patient was diagnosed two years ago with hypothyroidism, hypophysitis, secondary adrenal insufficiency, and pneumonitis, each suspected to be secondary to treatment with pembrolizumab (keytruda), a monoclonal anti-programmed cell death-1 antibody. |
2020-09-28 |
2023-08-13 |
Not clear |
| Marta Dudzińska, Michał Szczyrek, Kamila Wojas-Krawczyk, Joanna Świrska, Izabela Chmielewska, Agnieszka Zwola. Endocrine Adverse Events of Nivolumab in Non-Small Cell Lung Cancer Patients-Literature Review. Cancers. vol 12. issue 8. 2020-09-28. PMID:32824462. |
hypophysitis, adrenal insufficiency and diabetes are possible complications which require immediate treatment. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jingli Lu, Lulu Li, Yan Lan, Yan Liang, Haiyang Men. Immune checkpoint inhibitor-associated pituitary-adrenal dysfunction: A systematic review and meta-analysis. Cancer medicine. vol 8. issue 18. 2020-09-16. PMID:31679184. |
the rate was 2.43% (95% ci, 1.73%-3.22%) for all-grade adrenal insufficiency and 3.25% (95% ci, 2.15%-4.51%) for hypophysitis. |
2020-09-16 |
2023-08-13 |
human |
| Jingli Lu, Lulu Li, Yan Lan, Yan Liang, Haiyang Men. Immune checkpoint inhibitor-associated pituitary-adrenal dysfunction: A systematic review and meta-analysis. Cancer medicine. vol 8. issue 18. 2020-09-16. PMID:31679184. |
compared with the placebo or other therapeutic regimens, ici agents were associated with a higher incidence of serious-grade adrenal insufficiency (or 3.19, 95% ci, 1.84 to 5.54) and hypophysitis (or 4.77, 95% ci, 2.60 to 8.78). |
2020-09-16 |
2023-08-13 |
human |
| Sahityasri Thapi, Amanda Leiter, Matthew Galsky, Emily J Gallaghe. Recovery from secondary adrenal insufficiency in a patient with immune checkpoint inhibitor therapy induced hypophysitis. Journal for immunotherapy of cancer. vol 7. issue 1. 2020-08-13. PMID:31511065. |
recovery from secondary adrenal insufficiency in a patient with immune checkpoint inhibitor therapy induced hypophysitis. |
2020-08-13 |
2023-08-13 |
Not clear |
| F Castinetti, F Albarel, F Archambeaud, J Bertherat, B Bouillet, P Buffier, C Briet, B Cariou, Ph Caron, O Chabre, Ph Chanson, C Cortet, C Do Cao, D Drui, M Haissaguerre, S Hescot, F Illouz, E Kuhn, N Lahlou, E Merlen, V Raverot, S Smati, B Verges, F Borson-Chazo. French Endocrine Society Guidance on endocrine side effects of immunotherapy. Endocrine-related cancer. vol 26. issue 2. 2020-07-13. PMID:30400055. |
we will then look in turn at endocrinopathies that are induced by icpi including dysthyroidism, hypophysitis, primary adrenal insufficiency and fulminant diabetes. |
2020-07-13 |
2023-08-13 |
Not clear |
| L Agrawal, A Bacal, S Jain, V Singh, N Emanuele, Ma Emanuele, F Mea. Immune checkpoint inhibitors and endocrine side effects, a narrative review. Postgraduate medicine. vol 132. issue 2. 2020-04-27. PMID:31876444. |
a unique underrecognized side effect of the autoimmune response is hypophysitis leading to central adrenal insufficiency which can be fatal. |
2020-04-27 |
2023-08-13 |
Not clear |
| Tomonori Sekizaki, Hiraku Kameda, Chiho Oba, Kyu Yong Cho, Akinobu Nakamura, Hideaki Miyoshi, Takahiro Osawa, Nobuo Shinohara, Tatsuya Atsum. Nivolumab-induced hypophysitis causing secondary adrenal insufficiency after transient ACTH elevation. Endocrine journal. vol 66. issue 10. 2020-03-23. PMID:31217401. |
nivolumab-induced hypophysitis causing secondary adrenal insufficiency after transient acth elevation. |
2020-03-23 |
2023-08-13 |
Not clear |
| Tomonori Sekizaki, Hiraku Kameda, Chiho Oba, Kyu Yong Cho, Akinobu Nakamura, Hideaki Miyoshi, Takahiro Osawa, Nobuo Shinohara, Tatsuya Atsum. Nivolumab-induced hypophysitis causing secondary adrenal insufficiency after transient ACTH elevation. Endocrine journal. vol 66. issue 10. 2020-03-23. PMID:31217401. |
these findings and his clinical course suggested secondary adrenal insufficiency arising from nivolumab-induced hypophysitis. |
2020-03-23 |
2023-08-13 |
Not clear |
| Tomonori Sekizaki, Hiraku Kameda, Chiho Oba, Kyu Yong Cho, Akinobu Nakamura, Hideaki Miyoshi, Takahiro Osawa, Nobuo Shinohara, Tatsuya Atsum. Nivolumab-induced hypophysitis causing secondary adrenal insufficiency after transient ACTH elevation. Endocrine journal. vol 66. issue 10. 2020-03-23. PMID:31217401. |
in previous reports, most cases of immune checkpoint inhibitor (ici)-induced hypophysitis were diagnosed based on adrenal insufficiency symptoms or hyponatremia with low acth and cortisol. |
2020-03-23 |
2023-08-13 |
Not clear |
| Yoshiaki Tsukizawa, Keisuke Kondo, Toshihisa Ichiba, Hiroshi Naito, Kazuhito Mizuki, Ken Masud. Refractory hypotension due to Nivolumab-induced adrenal insufficiency. Nagoya journal of medical science. vol 80. issue 2. 2019-11-20. PMID:29915446. |
immune checkpoint inhibitors can cause immune-related adverse events, including dermatitis, enterocolitis, hepatitis and hypophysitis, but adrenal insufficiency rarely occurs. |
2019-11-20 |
2023-08-13 |
Not clear |
| Silvia Martina Ferrari, Poupak Fallahi, Giusy Elia, Francesca Ragusa, Ilaria Ruffilli, Armando Patrizio, Maria Rosaria Galdiero, Enke Baldini, Salvatore Ulisse, Gianni Marone, Alessandro Antonell. Autoimmune Endocrine Dysfunctions Associated with Cancer Immunotherapies. International journal of molecular sciences. vol 20. issue 10. 2019-11-13. PMID:31137683. |
immune-related endocrine toxicities are usually irreversible in 50% of cases, and include hypophysitis, thyroid dysfunctions, type 1 diabetes mellitus, and adrenal insufficiency. |
2019-11-13 |
2023-08-13 |
Not clear |
| Alberto Romano, Donato Rigante, Clelia Cipoll. Autoimmune phenomena involving the pituitary gland in children: New developing data about diagnosis and treatment. Autoimmunity reviews. vol 18. issue 10. 2019-11-08. PMID:31401342. |
antidiuretic hormone deficiency with central diabetes insipidus and growth retardation are the most significant presenting symptoms in children with hypophysitis, requiring a careful differential diagnosis with other causes of hypopituitarism, including tumors of the sellar region, differently from adults in whom adrenal insufficiency, hypogonadism, headache or diplopia might be the leading manifestations. |
2019-11-08 |
2023-08-13 |
human |
| Jeremy Chang, Jeffrey Tran, Dina Kamel, Arnab Bas. Nivolumab-induced hypophysitis leading to hypopituitarism and secondary empty sella syndrome in a patient with non-small cell lung cancer. BMJ case reports. vol 12. issue 3. 2019-06-24. PMID:30850565. |
a comprehensive workup revealed multiple endocrinological abnormalities consistent with hypophysitis leading to hypopituitarism in the form of central adrenal insufficiency and hypogonadism as well as a partially empty sella on imaging. |
2019-06-24 |
2023-08-13 |
Not clear |
| Jeroen de Filette, Corina Emilia Andreescu, Filip Cools, Bert Bravenboer, Brigitte Velkenier. A Systematic Review and Meta-Analysis of Endocrine-Related Adverse Events Associated with Immune Checkpoint Inhibitors. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 51. issue 3. 2019-06-17. PMID:30861560. |
the weighted incidence and risk ratio were estimated for hypophysitis, primary thyroid disease, primary adrenal insufficiency, and diabetes mellitus. |
2019-06-17 |
2023-08-13 |
Not clear |