All Relations between Frontotemporal Dementia and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Lianna D'Brant, Natasha Rugenstein, Su Kyoung Na, Michael J Miller, Timothy F Czajka, Nicole Trudeau, Emily Fitz, Lindsay Tomaszek, Elizabeth S Fisher, Ethan Mash, Shona Joy, Steven Lotz, Susan Borden, Katherine Stevens, Susan K Goderie, Yue Wang, Taylor Bertucci, Celeste M Karch, Sally Temple, David C Butle. Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of bioRxiv : the preprint server for biology. 2024-06-10. PMID:38854137. fully human bifunctional intrabodies achieve graded reduction of intracellular tau and rescue survival of tau protein aggregation is a hallmark of several neurodegenerative diseases, including alzheimer's disease, frontotemporal dementia (ftd) and progressive supranuclear palsy (psp), spurring development of tau-lowering therapeutic strategies. 2024-06-10 2024-06-14 human
Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. g272v and p301l mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3r and 4r tau frontotemporal dementia. 2024-06-10 2024-06-14 rat
Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. tau pathologies are detected in the brains of some of the most common neurodegenerative diseases including alzheimer's disease (ad), lewy body dementia (lbd), chronic traumatic encephalopathy (cte), and frontotemporal dementia (ftd). 2024-06-10 2024-06-14 rat
b' Elka Stefanova, Ana Marjanovi\\xc4\\x87, Valerija Dobri\\xc4\\x8di\\xc4\\x87, Gorana Mandi\\xc4\\x87-Stojmenovi\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Marija Brankovi\\xc4\\x87, Maksim \\xc5\\xa0ar\\xc4\\x8devi\\xc4\\x87, Ivana Novakovi\\xc4\\x87, Vladimir S Kosti\\xc4\\x8. Frequency of C9orf72, GRN, and MAPT pathogenic variants in patients recruited at the Belgrade Memory Center. Neurogenetics. 2024-06-07. PMID:38847891.' most of the heritability in frontotemporal dementia (ftd) is accounted for by autosomal dominant hexanucleotide expansion in the chromosome 9 open reading frame 72 (c9orf72), pathogenic/likely pathogenic variants in progranulin (grn), and microtubule-associated protein tau (mapt) genes. 2024-06-07 2024-06-10 human
Chao Qi, Sofia Lövestam, Alexey G Murzin, Sew Peak-Chew, Catarina Franco, Marika Bogdani, Caitlin Latimer, Jill R Murrell, Patrick W Cullinane, Zane Jaunmuktane, Thomas D Bird, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments with the Alzheimer fold in cases with bioRxiv : the preprint server for biology. 2024-05-24. PMID:38746388. tau filaments with the alzheimer fold in cases with frontotemporal dementia (ftd) and alzheimer's disease are the most common forms of early-onset dementia. 2024-05-24 2024-05-27 Not clear
Chao Qi, Ryota Kobayashi, Shinobu Kawakatsu, Fuyuki Kametani, Sjors H W Scheres, Michel Goedert, Masato Hasegaw. Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G. Acta neuropathologica. vol 147. issue 1. 2024-05-17. PMID:38758288. dominantly inherited mutation d395g in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of behavioural-variant frontotemporal dementia, with marked vacuolation and abundant filamentous tau inclusions made of all six brain isoforms. 2024-05-17 2024-05-27 Not clear
Grigorii Sultanakhmetov, Sophia Jobien M Limlingan, Aoi Fukuchi, Keisuke Tsuda, Hirokazu Suzuki, Iori Kato, Taro Saito, Adam Z Weitemier, Kanae And. Brain communications. vol 6. issue 3. 2024-05-08. PMID:38712317. accumulation of abnormally phosphorylated tau proteins is linked to various neurodegenerative diseases, including alzheimer's disease and frontotemporal dementia. 2024-05-08 2024-05-27 Not clear
Daniel T Ohm, Sharon X Xie, Noah Capp, Sanaz Arezoumandan, Katheryn A Q Cousins, Katya Rascovsky, David A Wolk, Vivianna M Van Deerlin, Edward B Lee, Corey T McMillan, David J Irwi. Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644997. behavioral variant frontotemporal dementia (bvftd) is a clinical syndrome primarily caused by either tau (bvftd-tau) or tdp-43 (bvftd-tdp) proteinopathies. 2024-04-22 2024-04-24 Not clear
Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaska. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644999. tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. 2024-04-22 2024-04-24 mouse
Osama Al-Dalahmah, Matti Lam, Julie J McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A Jakubiak, Rebekka Kühn, Yoon A Kim, Maria Caterina De Rosa, Claudia A Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Angeliki Mela, Hong Lu, Michael A DeTure, Jean Paul Vonsattel, Zbigniew K Wszolek, Dennis W Dickson, Tanja Kuhlmann, Holm Zaehres, Hans R Schöler, Andrew A Sproul, Markus D Siegelin, Philip L De Jager, James E Goldman, Vilas Menon, Peter Canoll, Gunnar Hargu. Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons. Cell stem cell. 2024-04-16. PMID:38626772. frontotemporal dementia (ftd) is an incurable group of early-onset dementias that can be caused by the deposition of hyperphosphorylated tau in patient brains. 2024-04-16 2024-04-19 mouse
Hassan Bukhari, Vanitha Nithianadam, Rachel A Battaglia, Anthony Cicalo, Souvarish Sarkar, Aram Comjean, Yanhui Hu, Matthew J Leventhal, Xianjun Dong, Mel B Fean. Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Genome research. 2024-04-10. PMID:38599684. transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a missense mutations in the gene encoding the microtubule-associated protein tau cause autosomal dominant forms of frontotemporal dementia. 2024-04-10 2024-04-13 human
Hassan Bukhari, Vanitha Nithianadam, Rachel A Battaglia, Anthony Cicalo, Souvarish Sarkar, Aram Comjean, Yanhui Hu, Matthew J Leventhal, Xianjun Dong, Mel B Fean. Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Genome research. 2024-04-10. PMID:38599684. multiple models of frontotemporal dementia based on transgenic expression of human tau in experimental model organisms, including 2024-04-10 2024-04-13 human
Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. mapt-associated frontotemporal dementia (ftd), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and alzheimer's disease (ad)) tau is recognized as a significant pathogenic driver of the disease. 2024-03-30 2024-04-02 Not clear
Koping Chang, Alexander Barrett, Khoa Pham, Juan C Troncos. Lateral geniculate body is spared of tau pathology in Pick disease. Journal of neuropathology and experimental neurology. 2024-02-27. PMID:38412343. the pathobiology of tau is of great importance for understanding the mechanisms of neurodegeneration in aging and age-associated disorders such as alzheimer disease (ad) and frontotemporal dementias. 2024-02-27 2024-03-01 Not clear
Hassan Bukhari, Vanitha Nithianandam, Rachel A Battaglia, Anthony Cicalo, Souvarish Sarkar, Aram Comjean, Yanhui Hu, Matthew J Leventhal, Xianjun Dong, Mel B Fean. Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352559. transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a missense mutations in the gene encoding the microtubule-associated protein tau cause autosomal dominant forms of frontotemporal dementia. 2024-02-14 2024-02-16 human
Hassan Bukhari, Vanitha Nithianandam, Rachel A Battaglia, Anthony Cicalo, Souvarish Sarkar, Aram Comjean, Yanhui Hu, Matthew J Leventhal, Xianjun Dong, Mel B Fean. Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352559. multiple models of frontotemporal dementia based on transgenic expression of human tau in experimental model organisms, including 2024-02-14 2024-02-16 human
Lukasz Joachimiak, Sofia Bali, Ruhar Singh, Pawel Wydorski, Aleksandra Wosztyl, Valerie Perez, Dailu Chen, Josep Riz. Ensemble-based design of tau to inhibit aggregation while preserving biological activity. Research square. 2024-02-05. PMID:38313287. mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. 2024-02-05 2024-02-07 Not clear
Giorgi Margvelani, Justin R Welden, Andrea Arizaca Maquera, Jennifer E Van Eyk, Christopher Murray, Sandra C Miranda Sardon, Stefan Stam. Influence of FTDP-17 mutants on circular tau RNAs. Biochimica et biophysica acta. Molecular basis of disease. 2024-01-29. PMID:38286213. at least 53 mutations in the microtubule associated protein tau gene (mapt) have been identified that cause frontotemporal dementia. 2024-01-29 2024-02-01 human
Christy Hung, Rickie Patan. 4R tau drives endolysosomal and autophagy dysfunction in frontotemporal dementia. Autophagy. 2024-01-09. PMID:38174587. 4r tau drives endolysosomal and autophagy dysfunction in frontotemporal dementia. 2024-01-09 2024-01-10 Not clear
Sofia Bali, Ruhar Singh, Pawel M Wydorski, Aleksandra Wosztyl, Valerie A Perez, Dailu Chen, Josep Rizo, Lukasz A Joachimia. Ensemble-based design of tau to inhibit aggregation while preserving biological activity. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168322. mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. 2024-01-03 2024-01-06 Not clear