| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qijun Li, Hang Li, Zhaoxia Huang, Yanfeng Li, Ruixue Cu. A Peculiar Tau Accumulation Pattern Identified Via 18F-Florzolotau PET Imaging in a Patient With Frontotemporal Dementia Caused by a Mutation in the MAPT Gene. Clinical nuclear medicine. 2024-07-16. PMID:39010313. |
a peculiar tau accumulation pattern identified via 18f-florzolotau pet imaging in a patient with frontotemporal dementia caused by a mutation in the mapt gene. |
2024-07-16 |
2024-07-18 |
Not clear |
| Qijun Li, Hang Li, Zhaoxia Huang, Yanfeng Li, Ruixue Cu. A Peculiar Tau Accumulation Pattern Identified Via 18F-Florzolotau PET Imaging in a Patient With Frontotemporal Dementia Caused by a Mutation in the MAPT Gene. Clinical nuclear medicine. 2024-07-16. PMID:39010313. |
we reported imaging findings with a peculiar tau accumulation pattern in a 56 year-old woman with frontotemporal dementia caused by q351r mutation in the microtubule-associated protein tau (mapt) gene. |
2024-07-16 |
2024-07-18 |
Not clear |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as seen, for example, in conditions such as frontotemporal dementia and alzheimer disease. |
2024-07-16 |
2024-07-19 |
human |
| Yang Sun, Sadequl Islam, Yuan Gao, Tomohisa Nakamura, Taisuke Tomita, Makoto Michikawa, Kun Zo. Presenilin deficiency enhances tau phosphorylation and its secretion. Journal of neurochemistry. 2024-07-01. PMID:38946496. |
psen mutations are associated with tau aggregation in frontotemporal dementia, regardless of the presence or absence of aβ pathology. |
2024-07-01 |
2024-07-03 |
Not clear |
| Kiran Bhaskar, Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackeria. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. Research square. 2024-07-01. PMID:38946961. |
tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. |
2024-07-01 |
2024-07-03 |
mouse |
| . Editorial Note: Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau. PloS one. vol 19. issue 6. 2024-06-27. PMID:38935762. |
editorial note: genotype-specific differences between mouse cns stem cell lines expressing frontotemporal dementia mutant or wild type human tau. |
2024-06-27 |
2024-06-30 |
mouse |
| Gregory A Mohl, Gary Dixon, Emily Marzette, Justin McKetney, Avi J Samelson, Carlota Pereda Serras, Julianne Jin, Andrew Li, Steven C Boggess, Danielle L Swaney, Martin Kampman. The disease-causing tau V337M mutation induces tau hypophosphorylation and perturbs axon morphology pathways. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895329. |
tau aggregation is a hallmark of several neurodegenerative diseases, including alzheimer's disease and frontotemporal dementia. |
2024-06-19 |
2024-06-21 |
Not clear |
| Lianna D'Brant, Natasha Rugenstein, Su Kyoung Na, Michael J Miller, Timothy F Czajka, Nicole Trudeau, Emily Fitz, Lindsay Tomaszek, Elizabeth S Fisher, Ethan Mash, Shona Joy, Steven Lotz, Susan Borden, Katherine Stevens, Susan K Goderie, Yue Wang, Taylor Bertucci, Celeste M Karch, Sally Temple, David C Butle. Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of bioRxiv : the preprint server for biology. 2024-06-10. PMID:38854137. |
fully human bifunctional intrabodies achieve graded reduction of intracellular tau and rescue survival of tau protein aggregation is a hallmark of several neurodegenerative diseases, including alzheimer's disease, frontotemporal dementia (ftd) and progressive supranuclear palsy (psp), spurring development of tau-lowering therapeutic strategies. |
2024-06-10 |
2024-06-14 |
human |
| Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. |
g272v and p301l mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3r and 4r tau frontotemporal dementia. |
2024-06-10 |
2024-06-14 |
rat |
| Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. |
tau pathologies are detected in the brains of some of the most common neurodegenerative diseases including alzheimer's disease (ad), lewy body dementia (lbd), chronic traumatic encephalopathy (cte), and frontotemporal dementia (ftd). |
2024-06-10 |
2024-06-14 |
rat |
| b' Elka Stefanova, Ana Marjanovi\\xc4\\x87, Valerija Dobri\\xc4\\x8di\\xc4\\x87, Gorana Mandi\\xc4\\x87-Stojmenovi\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Marija Brankovi\\xc4\\x87, Maksim \\xc5\\xa0ar\\xc4\\x8devi\\xc4\\x87, Ivana Novakovi\\xc4\\x87, Vladimir S Kosti\\xc4\\x8. Frequency of C9orf72, GRN, and MAPT pathogenic variants in patients recruited at the Belgrade Memory Center. Neurogenetics. 2024-06-07. PMID:38847891.' |
most of the heritability in frontotemporal dementia (ftd) is accounted for by autosomal dominant hexanucleotide expansion in the chromosome 9 open reading frame 72 (c9orf72), pathogenic/likely pathogenic variants in progranulin (grn), and microtubule-associated protein tau (mapt) genes. |
2024-06-07 |
2024-06-10 |
human |
| Chao Qi, Sofia Lövestam, Alexey G Murzin, Sew Peak-Chew, Catarina Franco, Marika Bogdani, Caitlin Latimer, Jill R Murrell, Patrick W Cullinane, Zane Jaunmuktane, Thomas D Bird, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments with the Alzheimer fold in cases with bioRxiv : the preprint server for biology. 2024-05-24. PMID:38746388. |
tau filaments with the alzheimer fold in cases with frontotemporal dementia (ftd) and alzheimer's disease are the most common forms of early-onset dementia. |
2024-05-24 |
2024-05-27 |
Not clear |
| Chao Qi, Ryota Kobayashi, Shinobu Kawakatsu, Fuyuki Kametani, Sjors H W Scheres, Michel Goedert, Masato Hasegaw. Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G. Acta neuropathologica. vol 147. issue 1. 2024-05-17. PMID:38758288. |
dominantly inherited mutation d395g in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of behavioural-variant frontotemporal dementia, with marked vacuolation and abundant filamentous tau inclusions made of all six brain isoforms. |
2024-05-17 |
2024-05-27 |
Not clear |
| Grigorii Sultanakhmetov, Sophia Jobien M Limlingan, Aoi Fukuchi, Keisuke Tsuda, Hirokazu Suzuki, Iori Kato, Taro Saito, Adam Z Weitemier, Kanae And. Brain communications. vol 6. issue 3. 2024-05-08. PMID:38712317. |
accumulation of abnormally phosphorylated tau proteins is linked to various neurodegenerative diseases, including alzheimer's disease and frontotemporal dementia. |
2024-05-08 |
2024-05-27 |
Not clear |
| Daniel T Ohm, Sharon X Xie, Noah Capp, Sanaz Arezoumandan, Katheryn A Q Cousins, Katya Rascovsky, David A Wolk, Vivianna M Van Deerlin, Edward B Lee, Corey T McMillan, David J Irwi. Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644997. |
behavioral variant frontotemporal dementia (bvftd) is a clinical syndrome primarily caused by either tau (bvftd-tau) or tdp-43 (bvftd-tdp) proteinopathies. |
2024-04-22 |
2024-04-24 |
Not clear |
| Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaska. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644999. |
tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. |
2024-04-22 |
2024-04-24 |
mouse |
| Osama Al-Dalahmah, Matti Lam, Julie J McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A Jakubiak, Rebekka Kühn, Yoon A Kim, Maria Caterina De Rosa, Claudia A Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Angeliki Mela, Hong Lu, Michael A DeTure, Jean Paul Vonsattel, Zbigniew K Wszolek, Dennis W Dickson, Tanja Kuhlmann, Holm Zaehres, Hans R Schöler, Andrew A Sproul, Markus D Siegelin, Philip L De Jager, James E Goldman, Vilas Menon, Peter Canoll, Gunnar Hargu. Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons. Cell stem cell. 2024-04-16. PMID:38626772. |
frontotemporal dementia (ftd) is an incurable group of early-onset dementias that can be caused by the deposition of hyperphosphorylated tau in patient brains. |
2024-04-16 |
2024-04-19 |
mouse |
| Hassan Bukhari, Vanitha Nithianadam, Rachel A Battaglia, Anthony Cicalo, Souvarish Sarkar, Aram Comjean, Yanhui Hu, Matthew J Leventhal, Xianjun Dong, Mel B Fean. Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Genome research. 2024-04-10. PMID:38599684. |
transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a missense mutations in the gene encoding the microtubule-associated protein tau cause autosomal dominant forms of frontotemporal dementia. |
2024-04-10 |
2024-04-13 |
human |
| Hassan Bukhari, Vanitha Nithianadam, Rachel A Battaglia, Anthony Cicalo, Souvarish Sarkar, Aram Comjean, Yanhui Hu, Matthew J Leventhal, Xianjun Dong, Mel B Fean. Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Genome research. 2024-04-10. PMID:38599684. |
multiple models of frontotemporal dementia based on transgenic expression of human tau in experimental model organisms, including |
2024-04-10 |
2024-04-13 |
human |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
mapt-associated frontotemporal dementia (ftd), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and alzheimer's disease (ad)) tau is recognized as a significant pathogenic driver of the disease. |
2024-03-30 |
2024-04-02 |
Not clear |