| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ian R Mackenzie, Matthew Baker, Gemma West, John Woulfe, Najeeb Qadi, Jennifer Gass, Ashley Cannon, Jennifer Adamson, Howard Feldman, Caroline Lindholm, Stacey Melquist, Rachel Pettman, A Dessa Sadovnick, Emily Dwosh, Sidney W Whiteheart, Michael Hutton, Stuart M Pickering-Brow. A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain : a journal of neurology. vol 129. issue Pt 4. 2006-04-17. PMID:16401619. |
over 30 different mutations have now been identified in mapt that cause frontotemporal dementia (ftd). |
2006-04-17 |
2023-08-12 |
Not clear |
| Minoru Yasuda, Yoshitsugu Nakamura, Toshio Kawamata, Hiroshi Kaneyuki, Kiyoshi Maeda, Osamu Komur. Phenotypic heterogeneity within a new family with the MAPT p301s mutation. Annals of neurology. vol 58. issue 6. 2006-01-31. PMID:16240366. |
mutations in the gene encoding the microtubule-associated protein tau (mapt) cause frontotemporal dementia and parkinsonism linked to chromosome 17. |
2006-01-31 |
2023-08-12 |
Not clear |
| J J Zarranz, I Ferrer, E Lezcano, M I Forcadas, B Eizaguirre, B Atarés, B Puig, J C Gómez-Esteban, C Fernández-Maiztegui, I Rouco, T Pérez-Concha, M Fernández, O Rodríguez, A B Rodríguez-Martínez, M Martínez de Pancorbo, P Pastor, J Pérez-Tu. A novel mutation (K317M) in the MAPT gene causes FTDP and motor neuron disease. Neurology. vol 64. issue 9. 2006-01-06. PMID:15883319. |
frontotemporal dementia with parkinsonism is often linked to chromosome 17 and is related to mutations in the mapt gene. |
2006-01-06 |
2023-08-12 |
Not clear |
| I F Bronner, B C ter Meulen, A Azmani, L A Severijnen, R Willemsen, W Kamphorst, R Ravid, P Heutink, J C van Swiete. Hereditary Pick's disease with the G272V tau mutation shows predominant three-repeat tau pathology. Brain : a journal of neurology. vol 128. issue Pt 11. 2005-11-28. PMID:16014652. |
frontotemporal dementia and parkinsonism linked to chromosome 17 have been associated with mutations in the microtubule associated protein tau (mapt or tau) gene. |
2005-11-28 |
2023-08-12 |
Not clear |
| Marc Cruts, Rosa Rademakers, Ilse Gijselinck, Julie van der Zee, Bart Dermaut, Tim de Pooter, Peter de Rijk, Jurgen Del-Favero, Christine van Broeckhove. Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region. Human molecular genetics. vol 14. issue 13. 2005-10-11. PMID:15888485. |
familial frontotemporal dementia (ftd), characterized by tau-negative, ubiquitin-positive inclusions at autopsy, is linked to a chromosomal region at 17q21 (ftdu-17), encompassing the gene encoding the microtubule associated protein tau, mapt. |
2005-10-11 |
2023-08-12 |
human |
| S Signorini, R Ghidoni, L Barbiero, L Benussi, G Binett. Prevalence of pathogenic mutations in an Italian clinical series of patients with familial dementia. Current Alzheimer research. vol 1. issue 3. 2005-09-07. PMID:15975068. |
instead, mutations in the mapt gene were associated with familial frontotemporal dementia (fftd) linked to chromosome 17 (ftdp-17). |
2005-09-07 |
2023-08-12 |
Not clear |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
the role of tau (mapt) in frontotemporal dementia and related tauopathies. |
2005-03-31 |
2023-08-12 |
mouse |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
in patients diagnosed with frontotemporal dementia and parkinsonism linked to chromosome 17, mutations in the gene encoding tau (mapt) have been identified that disrupt the normal binding of tau to tubulin resulting in pathological deposits of hyperphosphorylated tau. |
2005-03-31 |
2023-08-12 |
mouse |
| Stuart Pickering-Brown, Matt Baker, Thomas Bird, John Trojanowski, Virginia Lee, Huw Morris, Martin Rossor, John C Janssen, David Neary, David Craufurd, Anna Richardson, Julie Snowden, John Hardy, David Mann, Mike Hutto. Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 125B. issue 1. 2005-03-21. PMID:14755449. |
the +16 exon 10 splice mutation of the tau gene (microtubule-associated protein tau, mapt) has been reported in numerous families with frontotemporal dementia (ftd). |
2005-03-21 |
2023-08-12 |
Not clear |
| Alan M Pittman, Amanda J Myers, Jaime Duckworth, Leslie Bryden, Melissa Hanson, Patrick Abou-Sleiman, Nicholas W Wood, John Hardy, Andrew Lees, Rohan de Silv. The structure of the tau haplotype in controls and in progressive supranuclear palsy. Human molecular genetics. vol 13. issue 12. 2004-12-22. PMID:15115761. |
mutations of the tau gene (mapt) are the cause of frontotemporal dementia with parkinsonism linked to chromosome 17, giving tau a central role in the pathogenic process. |
2004-12-22 |
2023-08-12 |
Not clear |
| Bart Dermaut, Samir Kumar-Singh, Sebastian Engelborghs, Jessie Theuns, Rosa Rademakers, Jos Saerens, Barbara A Pickut, Karin Peeters, Marleen van den Broeck, Krist'l Vennekens, Stephen Claes, Marc Cruts, Patrick Cras, Jean-Jacques Martin, Christine Van Broeckhoven, Peter Paul De Dey. A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques. Annals of neurology. vol 55. issue 5. 2004-06-15. PMID:15122701. |
familial forms of frontotemporal dementia (ftd) with tauopathy are mostly caused by mutations in the gene encoding the microtubule-associated protein tau (mapt). |
2004-06-15 |
2023-08-12 |
Not clear |
| Cezary Zekanowski, Beata Pepłońska, Maria Styczyńska, Katarzyna Gustaw, Jacek Kuźnicki, Maria Barcikowsk. Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia. Dementia and geriatric cognitive disorders. vol 16. issue 3. 2003-11-05. PMID:12826737. |
mutation screening of the mapt and sth genes in polish patients with clinically diagnosed frontotemporal dementia. |
2003-11-05 |
2023-08-12 |
Not clear |
| Brian C Kraemer, Bin Zhang, James B Leverenz, James H Thomas, John Q Trojanowski, Gerard D Schellenber. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 17. 2003-10-29. PMID:12872001. |
frontotemporal dementia with parkinsonism chromosome 17 type (ftdp-17) is caused by mutations in mapt, the gene encoding tau. |
2003-10-29 |
2023-08-12 |
human |
| P Poorkaj, A Kas, I D'Souza, Y Zhou, Q Pham, M Stone, M V Olson, G D Schellenber. A genomic sequence analysis of the mouse and human microtubule-associated protein tau. Mammalian genome : official journal of the International Mammalian Genome Society. vol 12. issue 9. 2001-12-07. PMID:11641718. |
mutations in the coding and intronic sequences of mapt cause autosomal dominant frontotemporal dementia (ftdp-17). |
2001-12-07 |
2023-08-12 |
mouse |
| G Roks, B Dermaut, P Heutink, A Julliams, H Backhovens, M Van de Broeck, S Serneels, A Hofman, C Van Broeckhoven, C M van Duijn, M Crut. Mutation screening of the tau gene in patients with early-onset Alzheimer's disease. Neuroscience letters. vol 277. issue 2. 2000-02-08. PMID:10624829. |
the gene encoding tau (mapt) was recently found mutated in frontotemporal dementia (ftd) and other tauopathies. |
2000-02-08 |
2023-08-12 |
Not clear |