| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriella Marcon, Giacomina Rossi, Giorgio Giaccone, Anna Rita Giovagnoli, Elena Piccoli, Sergio Zanini, Onelio Geatti, Vito Toso, Marina Grisoli, Fabrizio Tagliavin. Variability of the clinical phenotype in an Italian family with dementia associated with an intronic deletion in the GRN gene. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21677378. |
mutations in the progranulin gene (grn) were recently identified as an important cause of familial frontotemporal dementia (ftd). |
2012-01-11 |
2023-08-12 |
Not clear |
| Ezra Y Rosen, Eric M Wexler, Revital Versano, Giovanni Coppola, Fuying Gao, Kellen D Winden, Michael C Oldham, Lauren Herl Martens, Ping Zhou, Robert V Farese, Daniel H Geschwin. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron. vol 71. issue 6. 2011-11-14. PMID:21943601. |
progranulin (grn) mutations cause frontotemporal dementia (ftd), but grn's function in the cns remains largely unknown. |
2011-11-14 |
2023-08-12 |
mouse |
| Lucia Tapia, Austen Milnerwood, Aobo Guo, Fergil Mills, Eileen Yoshida, Cristina Vasuta, Ian R Mackenzie, Lynn Raymond, Max Cynader, William Jia, Shernaz X Bamj. Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 31. 2011-10-11. PMID:21813674. |
frontotemporal dementia (ftd) has been linked to mutations in the progranulin gene (grn) that lead to progranulin (pgrn) haploinsufficiency. |
2011-10-11 |
2023-08-12 |
rat |
| J L Whitwell, S D Weigand, J L Gunter, B F Boeve, R Rademakers, M Baker, D S Knopman, Z K Wszolek, R C Petersen, C R Jack, K A Joseph. Trajectories of brain and hippocampal atrophy in FTD with mutations in MAPT or GRN. Neurology. vol 77. issue 4. 2011-09-27. PMID:21753165. |
to use multiple serial mri to assess rates and trajectories of brain and hippocampal atrophy in subjects with frontotemporal dementia (ftd) with progranulin (grn) or microtubule-associated protein tau (mapt) gene mutations. |
2011-09-27 |
2023-08-12 |
human |
| Anna M Pietroboni, Giorgio G Fumagalli, Laura Ghezzi, Chiara Fenoglio, Francesca Cortini, Maria Serpente, Claudia Cantoni, Emanuela Rotondo, Priscilla Corti, Miryam Carecchio, Mariateresa Bassi, Nereo Bresolin, Domenico Galbiati, Daniela Galimberti, Elio Scarpin. Phenotypic heterogeneity of the GRN Asp22fs mutation in a large Italian kindred. Journal of Alzheimer's disease : JAD. vol 24. issue 2. 2011-08-04. PMID:21258152. |
the asp22fs(g.63_64insc) mutation in progranulin gene (grn) has been so far reported in one patient who developed frontotemporal dementia (ftd) at the age of 65. |
2011-08-04 |
2023-08-12 |
Not clear |
| Basar Cenik, Chantelle F Sephton, Colleen M Dewey, Xunde Xian, Shuguang Wei, Kimberley Yu, Wenze Niu, Giovanni Coppola, Sarah E Coughlin, Suzee E Lee, Daniel R Dries, Sandra Almeida, Daniel H Geschwind, Fen-Biao Gao, Bruce L Miller, Robert V Farese, Bruce A Posner, Gang Yu, Joachim Her. Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. The Journal of biological chemistry. vol 286. issue 18. 2011-07-01. PMID:21454553. |
progranulin (grn) haploinsufficiency is a frequent cause of familial frontotemporal dementia, a currently untreatable progressive neurodegenerative disease. |
2011-07-01 |
2023-08-12 |
human |
| Wang-Xia Wang, Bernard R Wilfred, Sindhu K Madathil, Guiliang Tang, Yanling Hu, James Dimayuga, Arnold J Stromberg, Qingwei Huang, Kathryn E Saatman, Peter T Nelso. miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. The American journal of pathology. vol 177. issue 1. 2010-12-06. PMID:20489155. |
grn has also been directly implicated in frontotemporal dementia and may contribute to alzheimer's disease pathogenesis. |
2010-12-06 |
2023-08-12 |
mouse |
| Parastoo Momeni, Karen DeTucci, Richard E Straub, Daniel R Weinberger, Peter Davies, Jordan Grafman, John Hardy, Edward D Hue. Progranulin (GRN) in two siblings of a Latino family and in other patients with schizophrenia. Neurocase. vol 16. issue 3. 2010-08-18. PMID:20087814. |
mutations of a gene at this location (grn) are associated with frontotemporal dementia. |
2010-08-18 |
2023-08-12 |
Not clear |
| Parastoo Momeni, Karen DeTucci, Richard E Straub, Daniel R Weinberger, Peter Davies, Jordan Grafman, John Hardy, Edward D Hue. Progranulin (GRN) in two siblings of a Latino family and in other patients with schizophrenia. Neurocase. vol 16. issue 3. 2010-08-18. PMID:20087814. |
a recent study demonstrated that patients with frontotemporal dementia who presented with symptoms of schizophrenia show neuropathological findings consistent with grn mutations, but were not tested for grn mutations (velakoulis, walterfang, mocellin, pantelis, & mclean, 2009). |
2010-08-18 |
2023-08-12 |
Not clear |
| Parastoo Momeni, Karen DeTucci, Richard E Straub, Daniel R Weinberger, Peter Davies, Jordan Grafman, John Hardy, Edward D Hue. Progranulin (GRN) in two siblings of a Latino family and in other patients with schizophrenia. Neurocase. vol 16. issue 3. 2010-08-18. PMID:20087814. |
we sequenced grn in one of the siblings with frontotemporal dementia and one of the siblings with schizophrenia. |
2010-08-18 |
2023-08-12 |
Not clear |
| Parastoo Momeni, Karen DeTucci, Richard E Straub, Daniel R Weinberger, Peter Davies, Jordan Grafman, John Hardy, Edward D Hue. Progranulin (GRN) in two siblings of a Latino family and in other patients with schizophrenia. Neurocase. vol 16. issue 3. 2010-08-18. PMID:20087814. |
this finding, in conjunction with other studies (escamilla et al., 2009; velakoulis et al., 2009), suggests that there may be an association between schizophrenia, frontotemporal dementia, and grn mutations in latino populations that should be investigated further. |
2010-08-18 |
2023-08-12 |
Not clear |
| Hiroshige Fujishiro, Masato Hasegawa, Tetsuaki Ara. [The molecular pathology of frontotemporal lobar degeneration]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 112. issue 4. 2010-06-22. PMID:20496755. |
familial ftld has been linked to mutations in several genes: the microtubule-associated protein tau (mapt), progranulin (grn), valosin-containing protein (vcp) and charged multivescicular body protein 2b (chmp2b), and genetic locus on chromosome 9p linked to familial amyotrophic lateral sclerosis (als) and frontotemporal dementia. |
2010-06-22 |
2023-08-12 |
Not clear |
| Jun Wang, Philip Van Damme, Carlos Cruchaga, Michael A Gitcho, Jose Manuel Vidal, Manuel Seijo-Martínez, Lei Wang, Jane Y Wu, Wim Robberecht, Alison Goat. Pathogenic cysteine mutations affect progranulin function and production of mature granulins. Journal of neurochemistry. vol 112. issue 5. 2010-03-15. PMID:20028451. |
frontotemporal dementia with ubiquitin-positive inclusions (ftld-u) can be caused by mutations in the progranulin gene (grn). |
2010-03-15 |
2023-08-12 |
Not clear |
| Chang-En Yu, Thomas D Bird, Lynn M Bekris, Thomas J Montine, James B Leverenz, Ellen Steinbart, Nichole M Galloway, Howard Feldman, Randall Woltjer, Carol A Miller, Elisabeth McCarty Wood, Murray Grossman, Leo McCluskey, Christopher M Clark, Manuela Neumann, Adrian Danek, Douglas R Galasko, Steven E Arnold, Alice Chen-Plotkin, Anna Karydas, Bruce L Miller, John Q Trojanowski, Virginia M-Y Lee, Gerard D Schellenberg, Vivianna M Van Deerli. The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. Archives of neurology. vol 67. issue 2. 2010-03-05. PMID:20142524. |
mutation in the progranulin gene (grn) can cause frontotemporal dementia (ftd). |
2010-03-05 |
2023-08-12 |
Not clear |
| Sandra Pereson, Hans Wils, Gernot Kleinberger, Eileen McGowan, Mado Vandewoestyne, Bianca Van Broeck, Geert Joris, Ivy Cuijt, Dieter Deforce, Michael Hutton, Christine Van Broeckhoven, Samir Kumar-Sing. Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. The Journal of pathology. vol 219. issue 2. 2009-12-14. PMID:19557827. |
because loss of grn has recently been shown to cause frontotemporal dementia and serves as a risk factor for ad, the strong grn reactivity around dense-core plaques is consistent with an important role of this factor in ad pathogenesis. |
2009-12-14 |
2023-08-12 |
mouse |
| Jayashree Viswanathan, Petra Mäkinen, Seppo Helisalmi, Annakaisa Haapasalo, Hilkka Soininen, Mikko Hiltune. An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 5. 2009-09-16. PMID:19016491. |
recently, it was shown that mutations in granulin (grn) gene cause tau-negative frontotemporal dementia supporting the idea that granulin is involved in neurodegeneration. |
2009-09-16 |
2023-08-12 |
human |
| Rosa Rademakers, Jason L Eriksen, Matt Baker, Todd Robinson, Zeshan Ahmed, Sarah J Lincoln, Nicole Finch, Nicola J Rutherford, Richard J Crook, Keith A Josephs, Bradley F Boeve, David S Knopman, Ronald C Petersen, Joseph E Parisi, Richard J Caselli, Zbigniew K Wszolek, Ryan J Uitti, Howard Feldman, Michael L Hutton, Ian R Mackenzie, Neill R Graff-Radford, Dennis W Dickso. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Human molecular genetics. vol 17. issue 23. 2008-12-29. PMID:18723524. |
common variation in the mir-659 binding-site of grn is a major risk factor for tdp43-positive frontotemporal dementia. |
2008-12-29 |
2023-08-12 |
Not clear |
| Rosa Rademakers, Jason L Eriksen, Matt Baker, Todd Robinson, Zeshan Ahmed, Sarah J Lincoln, Nicole Finch, Nicola J Rutherford, Richard J Crook, Keith A Josephs, Bradley F Boeve, David S Knopman, Ronald C Petersen, Joseph E Parisi, Richard J Caselli, Zbigniew K Wszolek, Ryan J Uitti, Howard Feldman, Michael L Hutton, Ian R Mackenzie, Neill R Graff-Radford, Dennis W Dickso. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Human molecular genetics. vol 17. issue 23. 2008-12-29. PMID:18723524. |
loss-of-function mutations in progranulin (grn) cause ubiquitin- and tar dna-binding protein 43 (tdp-43)-positive frontotemporal dementia (ftld-u), a progressive neurodegenerative disease affecting approximately 10% of early-onset dementia patients. |
2008-12-29 |
2023-08-12 |
Not clear |
| John C van Swieten, Peter Heutin. Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia. The Lancet. Neurology. vol 7. issue 10. 2008-12-18. PMID:18771956. |
mutations in progranulin (grn) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia. |
2008-12-18 |
2023-08-12 |
Not clear |
| Odity Mukherjee, Jun Wang, Michael Gitcho, Sumi Chakraverty, Lisa Taylor-Reinwald, Shantia Shears, John S K Kauwe, Joanne Norton, Denise Levitch, Eileen H Bigio, Kimmo J Hatanpaa, Charles L White, John C Morris, Nigel J Cairns, Alison Goat. Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. Human mutation. vol 29. issue 4. 2008-04-16. PMID:18183624. |
molecular characterization of novel progranulin (grn) mutations in frontotemporal dementia. |
2008-04-16 |
2023-08-12 |
Not clear |