| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sang-Hun Lee, Young-Jin Kang, Bret N Smit. Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645248. |
most dentate pv+ interneurons survive status epilepticus, but surviving pv+ interneuron mediated inhibition is compromised in the dentate gyrus shortly after status epilepticus, contributing to epileptogenesis in temporal lobe epilepsy. |
2024-04-22 |
2024-04-24 |
mouse |
| Sang-Hun Lee, Young-Jin Kang, Bret N Smit. Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645248. |
our results suggest not only that the compensatory changes in pv+ interneuron circuits develop after ihk treatment, but also that increased pv+ interneuron mediated inhibition in the dentate gyrus may compensate for cell loss and reduced intrinsic excitability of dentate pv+ interneurons to stop seizures in temporal lobe epilepsy. |
2024-04-22 |
2024-04-24 |
mouse |
| Erik H Middlebrooks, Vivek Gupta, Amit K Agarwal, Brin E Freund, Steven A Messina, William O Tatum, David S Sabsevitz, Anteneh M Feyissa, Seyed M Mirsattari, Fernando N Galan, Alfredo Quinones-Hinojosa, Sanjeet S Grewal, John V Murra. Radiologic Classification of Hippocampal Sclerosis in Epilepsy. AJNR. American journal of neuroradiology. 2024-02-21. PMID:38383054. |
this framework will not only benefit current clinical evaluations, but also enhance future studies involving high-resolution mri in temporal lobe epilepsy.abbreviations: ca = cornu ammonis; dg = dentate gyrus; hs = hippocampal sclerosis; ilae = international league against epilepsy; srlm = strata radiatum, lacunosum, and moleculare layers; tle = temporal lobe epilepsy. |
2024-02-21 |
2024-02-24 |
Not clear |
| Veronica Diaz-Villegas, Luz Adriana Pichardo-Macías, Sergio Juárez-Méndez, Iván Ignacio-Mejía, Noemí Cárdenas-Rodríguez, Marco Antonio Vargas-Hernández, Julieta Griselda Mendoza-Torreblanca, Sergio R Zamudi. Changes in the Dentate Gyrus Gene Expression Profile Induced by Levetiracetam Treatment in Rats with Mesial Temporal Lobe Epilepsy. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338984. |
changes in the dentate gyrus gene expression profile induced by levetiracetam treatment in rats with mesial temporal lobe epilepsy. |
2024-02-10 |
2024-02-12 |
rat |
| Marijke Vergaelen, Simona Manzella, Kristl Vonck, Erine Craey, Jeroen Spanoghe, Mathieu Sprengers, Evelien Carrette, Wytse Jan Wadman, Jean Delbeke, Paul Boon, Lars Emil Larsen, Robrecht Raed. Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203829. |
increased dentate gyrus excitability in the intrahippocampal kainic acid mouse model for temporal lobe epilepsy. |
2024-01-11 |
2024-01-13 |
mouse |
| Yu Chen, Xiao-Lin Wu, Hai-Bo Hu, Shu-Nan Yang, Zi-Yi Zhang, Guan-Ling Fu, Chu-Tong Zhang, Zi-Meng Li, Feng Wu, Kai-Wei Si, Yan-Bing Ma, Sheng-Feng Ji, Jin-Song Zhou, Xiao-Yong Ren, Xin-Li Xiao, Jian-Xin Li. Neuronal MeCP2 in the dentate gyrus regulates mossy fiber sprouting of mice with temporal lobe epilepsy. Neurobiology of disease. 2023-11-06. PMID:37931884. |
neuronal mecp2 in the dentate gyrus regulates mossy fiber sprouting of mice with temporal lobe epilepsy. |
2023-11-06 |
2023-11-08 |
mouse |
| Jiandong Yu, Vijayalakshmi Santhakuma. Electrical Coupling between Parvalbumin Basket Cells is Reduced after Experimental Status Epilepticus. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808695. |
using a pilocarpine induced status epilepticus (se) model of acquired temporal lobe epilepsy in rat, this study examined changes in electrical coupling between pv-ins in the hippocampal dentate gyrus one week after se. |
2023-10-09 |
2023-10-15 |
human |
| Laura Mundrucz, Angéla Kecskés, Nóra Henn-Mike, Péter Kóbor, Péter Buzás, Rudi Vennekens, Miklós Kecské. TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy. BMC biology. vol 21. issue 1. 2023-04-26. PMID:37101159. |
mossy cells comprise a large fraction of excitatory neurons in the hippocampal dentate gyrus, and their loss is one of the major hallmarks of temporal lobe epilepsy (tle). |
2023-04-26 |
2023-08-14 |
Not clear |
| Heming Cheng, Qiuwen Lou, Yi Wang, Zhong Che. Double-Edged Mossy Cells in Temporal Lobe Epilepsy: Evil in the Early Stage Through a BDNF-Dependent Strengthening Dentate Gyrus Circuit. Neuroscience bulletin. 2023-01-31. PMID:36719591. |
double-edged mossy cells in temporal lobe epilepsy: evil in the early stage through a bdnf-dependent strengthening dentate gyrus circuit. |
2023-01-31 |
2023-08-14 |
Not clear |
| Robyn M Busch, Lamis Yehia, Ingmar Blümcke, Bo Hu, Richard Prayson, Bruce P Hermann, Imad M Najm, Charis En. Molecular and subregion mechanisms of episodic memory phenotypes in temporal lobe epilepsy. Brain communications. vol 4. issue 6. 2022-11-24. PMID:36419965. |
here, we use spatial quantitation to examine differential expression of targeted proteins and transcripts in four brain regions essential for episodic memory (dentate gyrus, ca3, ca1, neocortex) between temporal lobe epilepsy patients with and without episodic memory impairment. |
2022-11-24 |
2023-08-14 |
Not clear |
| Amanda Seelman, Kristina Vu, Paul Buckmaster, Ken Mackie, Cara Field, Shawn Johnson, Megan Wyet. Cannabinoid receptor 1-labeled boutons in the sclerotic dentate gyrus of epileptic sea lions. Epilepsy research. vol 184. 2022-06-20. PMID:35724601. |
pathology in the dentate gyrus, including sclerosis, is a hallmark of temporal lobe epilepsy, and reduced inhibition to dentate granule cells may contribute to epileptogenesis. |
2022-06-20 |
2023-08-14 |
Not clear |
| Yi Cao, Chongyang Sun, Jianyu Huang, Peng Sun, Lulu Wang, Shuyu He, Jianxiang Liao, Zhonghua Lu, Yi Lu, Cheng Zhon. Dysfunction of the Hippocampal-Lateral Septal Circuit Impairs Risk Assessment in Epileptic Mice. Frontiers in molecular neuroscience. vol 15. 2022-05-16. PMID:35571372. |
notably, during the impaired approach-risk assessment, the favorably activated dorsal dentate gyrus and ca3 glutamatergic neurons increased (∼9%) and dorsal dentate gyrus and ca3 gabaergic neurons decreased (∼7%) in the temporal lobe epilepsy mice. |
2022-05-16 |
2023-08-13 |
mouse |
| Yi Cao, Chongyang Sun, Jianyu Huang, Peng Sun, Lulu Wang, Shuyu He, Jianxiang Liao, Zhonghua Lu, Yi Lu, Cheng Zhon. Dysfunction of the Hippocampal-Lateral Septal Circuit Impairs Risk Assessment in Epileptic Mice. Frontiers in molecular neuroscience. vol 15. 2022-05-16. PMID:35571372. |
in particular, the dorsal dentate gyrus and ca3 somatostatin-positive neurons and dorsal lateral septum cholecystokinin-positive neurons are selectively vulnerable to damage after temporal lobe epilepsy. |
2022-05-16 |
2023-08-13 |
mouse |
| Angéla Kecskés, Boldizsár Czéh, Miklós Kecské. Mossy cells of the dentate gyrus: Drivers or inhibitors of epileptic seizures? Biochimica et biophysica acta. Molecular cell research. 2022-05-08. PMID:35526721. |
mossy cells (mcs) are glutamatergic cells of the dentate gyrus with an important role in temporal lobe epilepsy. |
2022-05-08 |
2023-08-13 |
Not clear |
| James K Chambers, Shinya Iwasaki, Shigeki Imamoto, Yuya Nakamoto, Kazuyuki Uchid. A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation. The Journal of veterinary medical science. 2022-03-28. PMID:35342145. |
a case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation. |
2022-03-28 |
2023-08-13 |
cat |
| James K Chambers, Shinya Iwasaki, Shigeki Imamoto, Yuya Nakamoto, Kazuyuki Uchid. A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation. The Journal of veterinary medical science. 2022-03-28. PMID:35342145. |
this report describes a case of feline temporal lobe epilepsy and hippocampal sclerosis associated with dentate gyrus malformation. |
2022-03-28 |
2023-08-13 |
cat |
| Antoine D Madar, Jesse A Pfammatter, Jessica Bordenave, Erin I Plumley, Swetha Ravi, Michael Cowie, Eli P Wallace, Bruce P Hermann, Rama K Maganti, Mathew V Jone. Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 46. 2021-11-28. PMID:34620720. |
in temporal lobe epilepsy, the ability of the dentate gyrus to limit excitatory cortical input to the hippocampus breaks down, leading to seizures. |
2021-11-28 |
2023-08-13 |
mouse |
| Catarina Orcinha, Antje Kilias, Enya Paschen, Marie Follo, Carola A Haa. Reelin Is Required for Maintenance of Granule Cell Lamination in the Healthy and Epileptic Hippocampus. Frontiers in molecular neuroscience. vol 14. 2021-09-07. PMID:34483838. |
one characteristic feature of mesial temporal lobe epilepsy is granule cell dispersion (gcd), a pathological widening of the granule cell layer in the dentate gyrus. |
2021-09-07 |
2023-08-13 |
mouse |
| Xin-Li Xiao, Xiao-Lin Wu, Peng-Bo Yang, Hai-Bo Hu, Yu Chen, Min-Li, Kai-Wei Si, Feng Wu, Jian-Xin Li. Status epilepticus induced Gadd45b is required for augmented dentate neurogenesis. Stem cell research. vol 49. 2021-06-21. PMID:33279798. |
in animal models with temporal lobe epilepsy (tle), the status epilepticus (se) leads to a dramatic increase in number of newly born neuron in the subgranular zone (sgz) of dentate gyrus. |
2021-06-21 |
2023-08-13 |
mouse |
| Hajnalka Ábrahám, Judit E Molnár, Noémi Sóki, Csilla Gyimesi, Zsolt Horváth, József Janszky, Tamás Dóczi, László Seres. Etiology-related Degree of Sprouting of Parvalbumin-immunoreactive Axons in the Human Dentate Gyrus in Temporal Lobe Epilepsy. Neuroscience. vol 448. 2021-05-14. PMID:32931846. |
etiology-related degree of sprouting of parvalbumin-immunoreactive axons in the human dentate gyrus in temporal lobe epilepsy. |
2021-05-14 |
2023-08-13 |
human |