| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Wang, Linshan Sun, Jingjing You, Honghai Peng, Haijing Yan, Jiangong Wang, Fengjiao Sun, Minghu Cui, Sanwang Wang, Zheng Zhang, Xueli Fan, Dunjiang Liu, Cuilan Liu, Changyun Qiu, Chao Chen, Zhicheng Xu, Jinbo Chen, Wei Li, Bin Li. Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress. EMBO reports. 2023-10-23. PMID:37870400. |
chronic stress induces depression and insulin resistance, between which there is a bidirectional relationship. |
2023-10-23 |
2023-11-08 |
Not clear |
| Jing Wang, Linshan Sun, Jingjing You, Honghai Peng, Haijing Yan, Jiangong Wang, Fengjiao Sun, Minghu Cui, Sanwang Wang, Zheng Zhang, Xueli Fan, Dunjiang Liu, Cuilan Liu, Changyun Qiu, Chao Chen, Zhicheng Xu, Jinbo Chen, Wei Li, Bin Li. Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress. EMBO reports. 2023-10-23. PMID:37870400. |
we describe here a brain-sympathetic nerve-adipose circuit originating in the hypothalamic paraventricular nucleus (pvn) with a role in depression and insulin resistance induced by chronic stress. |
2023-10-23 |
2023-11-08 |
Not clear |
| Jing Wang, Linshan Sun, Jingjing You, Honghai Peng, Haijing Yan, Jiangong Wang, Fengjiao Sun, Minghu Cui, Sanwang Wang, Zheng Zhang, Xueli Fan, Dunjiang Liu, Cuilan Liu, Changyun Qiu, Chao Chen, Zhicheng Xu, Jinbo Chen, Wei Li, Bin Li. Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress. EMBO reports. 2023-10-23. PMID:37870400. |
chemogenetic manipulations suggest a role for the pvn in depression and insulin resistance. |
2023-10-23 |
2023-11-08 |
Not clear |
| Sang Jin Rhee, Sooyeon Min, Minseok Hong, Hyunju Lee, Han-Sung Lee, Dae Hun Kang, Yong Min Ah. The association between insulin resistance and depressive symptoms - A national representative cross-sectional study. Journal of psychosomatic research. vol 175. 2023-10-09. PMID:37812941. |
increasing evidence suggests a positive association between insulin resistance (ir) and depression. |
2023-10-09 |
2023-10-15 |
Not clear |
| M Luciano, G Sampogna, E D'Ambrosio, A Rampino, M Amore, P Calcagno, A Rossi, R Rossi, C Carmassi, L Dell'Osso, E Bianciardi, A Siracusano, Bianca Della Rocca, M Di Vincenzo, A Fiorill. One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial. European archives of psychiatry and clinical neuroscience. 2023-09-04. PMID:37665401. |
this multicentric randomized controlled trial (rct), carried out in six italian university mental health sites, aims to test the efficacy of a six-month psychosocial intervention (lyfestyle) on body mass index (bmi), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, framingham and homeostasis model assessment of insulin resistance (homa-ir) indexes in patients with schizophrenia, bipolar disorder, and major depression. |
2023-09-04 |
2023-09-07 |
Not clear |
| Nahi Sabih Alruwaili, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Amany E Ragab, Ahmad Awad Alenazi, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Antidepressants and type 2 diabetes: highways to knowns and unknowns. Diabetology & metabolic syndrome. vol 15. issue 1. 2023-08-31. PMID:37653558. |
therefore, management of depression by antidepressant agents improves glucose homeostasis and insulin sensitivity. |
2023-08-31 |
2023-09-07 |
Not clear |
| Xiaofeng Ruan, Xiaoming Zhang, Liming Liu, Jianjun Zhan. Mechanism of Xiaoyao San in treating non-alcoholic fatty liver disease with liver depression and spleen deficiency: based on bioinformatics, metabolomics and Journal of biomolecular structure & dynamics. 2023-07-13. PMID:37440274. |
in conclusion, xys might treat nafld with liver depression and spleen deficiency by down-regulating ptgs2, up-regulating pparg, reducing aa content, increasing camp, improving insulin resistance, affecting glucose and lipid metabolism, inhibiting oxidative stress and inflammatory response.communicated by ramaswamy h. sarma. |
2023-07-13 |
2023-08-14 |
rat |
| Yuka Nakaya, Satoshi Kosukegawa, Satomi Kobayashi, Kensuke Hirose, Kouhei Kitano, Kotoe Mayahara, Hiroki Takei, Mitsuru Motoyoshi, Masayuki Kobayash. Insulin potentiates inhibitory synaptic currents between fast-spiking and pyramidal neurons in the rat insular cortex. Neuropharmacology. 2023-07-02. PMID:37393988. |
insulin plays roles in brain functions such as neural development and plasticity and is reported to be involved in dementia and depression. |
2023-07-02 |
2023-08-14 |
rat |
| Suet-Kei Wu, Wei-Jen Chen, Jane Pei-Chen Chang, Ta-Wei Guu, Ming-Che Hsin, Chih-Kun Huang, David Mischoulon, Lucile Capuron, Kuan-Pin S. Personalized Medicine of Omega-3 Fatty Acids in Depression Treatment in Obese and Metabolically Dysregulated Patients. Journal of personalized medicine. vol 13. issue 6. 2023-06-28. PMID:37373992. |
recent studies have shown that metabolic dysfunction, which is commonly observed in obese individuals and is characterized by inflammation, insulin resistance, leptin resistance, and hypertension, is a critical risk factor for depression. |
2023-06-28 |
2023-08-14 |
Not clear |
| M M Lackovic, M T Macvanin, M M Obradovic, Z M Gluvic, E M Sudar-Milovanovic, S B Sipetic Grujicic, E R Isenovi. Impact of treatment modalities on quality of life and depression in type 2 diabetes. European review for medical and pharmacological sciences. vol 27. issue 11. 2023-06-15. PMID:37318472. |
the current study compares qol in t2dm patients treated with insulin to those treated with oral antihyperglycemics (oahs), as well as the frequency and severity of depression in patients. |
2023-06-15 |
2023-08-14 |
Not clear |
| Sarah D Bauermeister, Michael Ben Yehuda, Graham Reid, Gregory Howgego, Karen Ritchie, Tam Watermeyer, Sarah Gregory, Graciela Muniz Terrera, Ivan Koyche. Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort. BMJ mental health. vol 26. issue 1. 2023-05-26. PMID:37236657. |
insulin resistance, age and depression's impact on cognition in middle-aged adults from the prevent cohort. |
2023-05-26 |
2023-08-14 |
Not clear |
| Sarah D Bauermeister, Michael Ben Yehuda, Graham Reid, Gregory Howgego, Karen Ritchie, Tam Watermeyer, Sarah Gregory, Graciela Muniz Terrera, Ivan Koyche. Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort. BMJ mental health. vol 26. issue 1. 2023-05-26. PMID:37236657. |
alzheimer's disease (ad), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health. |
2023-05-26 |
2023-08-14 |
Not clear |
| Rafiatu Azumah, Katja Hummitzsch, Richard A Anderson, Raymond J Rodger. Genes in loci genetically associated with polycystic ovary syndrome are dynamically expressed in human fetal gonadal, metabolic and brain tissues. Frontiers in endocrinology. vol 14. 2023-05-24. PMID:37223019. |
polycystic ovary syndrome (pcos) is a heterogeneous disorder, affecting around 10% of women of reproductive age, with infertility, depression or anxiety, obesity, insulin resistance and type 2 diabetes as risk factors. |
2023-05-24 |
2023-08-14 |
human |
| Josef Finsterer, Carla Scorz. Is insulin resistance truly responsible for post-COVID depression? Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2023-05-01. PMID:37127358. |
is insulin resistance truly responsible for post-covid depression? |
2023-05-01 |
2023-08-14 |
Not clear |
| Judith Gruber, Ruth Hanssen, Mishal Qubad, Aicha Bouzouina, Vivi Schack, Hannah Sochor, Carmen Schiweck, Mareike Aichholzer, Silke Matura, David A Slattery, Yurdaguel Zopf, Stephanie L Borgland, Andreas Reif, Sharmili Edwin Thanaraja. Impact of insulin and insulin resistance on brain dopamine signalling and reward processing- an underexplored mechanism in the pathophysiology of depression? Neuroscience and biobehavioral reviews. 2023-04-14. PMID:37059404. |
impact of insulin and insulin resistance on brain dopamine signalling and reward processing- an underexplored mechanism in the pathophysiology of depression? |
2023-04-14 |
2023-08-14 |
human |
| Ling Luo, Jie Hu, Ruixian Huang, Danli Kong, Wei Hu, Yuanlin Ding, Haibing Y. The association between dietary inflammation index and depression. Frontiers in psychiatry. vol 14. 2023-04-10. PMID:37032915. |
we aimed to evaluate whether depression is associated with increased risk of dietary inflammatory index (dii) or energy-adjusted dii (e-dii) and whether the association is partly explained by insulin resistance (ir). |
2023-04-10 |
2023-08-14 |
Not clear |
| Hiroshi Kunug. Depression and lifestyle: focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Psychiatry and clinical neurosciences. 2023-03-30. PMID:36992617. |
main biological mechanisms of the link between the lifestyle factors and depression include monoamine imbalance, inflammation, altered stress response, oxidative stress, and dysfunction of brain-derived neurotrophic factor, although other players such as insulin, leptin, and orexin also play a role. |
2023-03-30 |
2023-08-14 |
Not clear |
| Hussein Kadhem Al-Hakeim, Tabarek Hadi Al-Naqeeb, Abbas F Almulla, Michael Mae. The physio-affective phenome of major depression is strongly associated with biomarkers of astroglial and neuronal projection toxicity which in turn are associated with peripheral inflammation, insulin resistance and lowered calcium. Journal of affective disorders. vol 331. 2023-03-30. PMID:36996718. |
the physio-affective phenome of major depression is strongly associated with biomarkers of astroglial and neuronal projection toxicity which in turn are associated with peripheral inflammation, insulin resistance and lowered calcium. |
2023-03-30 |
2023-08-14 |
Not clear |
| Ana M Gutierrez-Colina, Madison Bristol, Emma L M Clark, Natalia Sanchez, Lauren D Gulley, Elizabeth Ruzicka, Elizabeth P Handing, Elizabeth Kinsella, Eve Kutchman, Michael Witten, Michelle A Clementi, Talia Thompson, Laura Pyle, Stephen Aichele, Andrea B Goldschmidt, Britni Belcher, Kristen J Nadeau, Megan M Kelsey, Lauren B Shomake. Cognitive-behavioral therapy and exercise training in adolescent females with elevated depression symptoms and at-risk for type 2 diabetes: Protocol for a randomized controlled trial. Contemporary clinical trials. 2023-03-14. PMID:36918091. |
depression symptoms are associated with both poorer physical fitness and greater insulin resistance, the key risk factor in adolescent-onset t2d. |
2023-03-14 |
2023-08-14 |
Not clear |
| David R Hillman, Melissa Carlucci, Jean G Charchaflieh, Tom V Cloward, Bhargavi Gali, Peter C Gay, M Melanie Lyons, Margaret M McNeill, Mandeep Singh, Meltem Yilmaz, Dennis H Auckle. Society of Anesthesia and Sleep Medicine Position Paper on Patient Sleep During Hospitalization. Anesthesia and analgesia. 2023-02-06. PMID:36745563. |
these include cardiovascular dysfunction, impaired ventilatory function, cognitive impairment, increased pain perception, psychomotor disturbance (including increased fall risk), psychological disturbance (including anxiety and depression), metabolic dysfunction (including increased insulin resistance and catabolic propensity), and immune dysfunction and proinflammatory effects (increasing infection risk and pain generation). |
2023-02-06 |
2023-08-14 |
Not clear |