| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder, Margit Burmeiste. Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. Biological psychiatry. vol 55. issue 3. 2004-04-01. PMID:14744464. |
a gaba(a) receptor alpha6 subunit variant (pro385ser) has been associated with alcohol-related traits but has not been studied in neuroticism or depression. |
2004-04-01 |
2023-08-12 |
Not clear |
| Alfredo Brancucci, Nicola Berretta, Nicola B Mercuri, Walter Francescon. Gamma-hydroxybutyrate and ethanol depress spontaneous excitatory postsynaptic currents in dopaminergic neurons of the substantia nigra. Brain research. vol 997. issue 1. 2004-03-29. PMID:14715150. |
these effects were gaba(b)-independent and the ghb-induced depression was blocked by the ghb receptor antagonist 6,7,8,9-tetrahydro-5[h]benzocyclohepte-5-ol-4-ylidene acetic acid (ncs-382), pointing to a specific effect of this drug. |
2004-03-29 |
2023-08-12 |
rat |
| Torbjörn Bäckström, Agneta Andersson, Lotta Andreé, Vita Birzniece, Marie Bixo, Inger Björn, David Haage, Monica Isaksson, Inga-Maj Johansson, Charlott Lindblad, Per Lundgren, Sigrid Nyberg, Inga-Stina Odmark, Jessica Strömberg, Inger Sundström-Poromaa, Sahruh Turkmen, Göran Wahlström, Mingde Wang, Anna-Carin Wihlbäck, Di Zhu, Elisabeth Zingmar. Pathogenesis in menstrual cycle-linked CNS disorders. Annals of the New York Academy of Sciences. vol 1007. 2004-03-25. PMID:14993039. |
examples of symptoms and disorders caused by the direct action of gaba steroids are sedation, memory and learning disturbance, clumsiness, increased appetite, worsening of petit mal epilepsy, negative mood as tension, irritability and depression during hormone treatments, and the premenstrual dysphoric disorder (pmdd). |
2004-03-25 |
2023-08-12 |
human |
| Vibhakar C Kotak, Dan H Sane. Gain adjustment of inhibitory synapses in the auditory system. Biological cybernetics. vol 89. issue 5. 2004-03-10. PMID:14669016. |
while either glycine or gaba(a) receptors could independently display inhibitory ltd, focal delivery of gaba, but not glycine, at the postsynaptic-locus induces depression. |
2004-03-10 |
2023-08-12 |
Not clear |
| Vibhakar C Kotak, Dan H Sane. Gain adjustment of inhibitory synapses in the auditory system. Biological cybernetics. vol 89. issue 5. 2004-03-10. PMID:14669016. |
furthermore, the gaba(b) receptor antagonist, sch-50911, prevents gaba or synaptically induced depression. |
2004-03-10 |
2023-08-12 |
Not clear |
| Kate E Chandler, Alessandra P Princivalle, Ruth Fabian-Fine, Norman G Bowery, Dimitri M Kullmann, Matthew C Walke. Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 36. 2004-01-16. PMID:14673002. |
here we report that status epilepticus, triggered by either perforant path stimulation or pilocarpine administration, was followed 24 hr later by a loss of gaba(b) receptor-mediated heterosynaptic depression among populations of mossy fibers. |
2004-01-16 |
2023-08-12 |
Not clear |
| J Victor Nadle. The recurrent mossy fiber pathway of the epileptic brain. Neurochemical research. vol 28. issue 11. 2004-01-14. PMID:14584819. |
factors that diminish activity include short-term, frequency-dependent depression (frequencies < 1 hz); feedback activation of type ii metabotropic glutamate receptors; and the potential release of gaba, neuropeptide y, adenosine, and dynorphin from recurrent mossy fiber boutons. |
2004-01-14 |
2023-08-12 |
Not clear |
| Eric H Chang, Vibhakar C Kotak, Dan H Sane. Long-term depression of synaptic inhibition is expressed postsynaptically in the developing auditory system. Journal of neurophysiology. vol 90. issue 3. 2003-11-19. PMID:12761279. |
focal application of gaba, but not glycine, on the postsynaptic lso neuron was sufficient to induce depression of the amino acid-evoked response, or mntb-evoked inhibitory postsynaptic potentials. |
2003-11-19 |
2023-08-12 |
Not clear |
| Roger G Drake, Lori L Davis, Marshall E Cates, Michele E Jewell, Sandra M Ambrose, Joette S Low. Baclofen treatment for chronic posttraumatic stress disorder. The Annals of pharmacotherapy. vol 37. issue 9. 2003-11-06. PMID:12921495. |
previous studies have shown the efficacy of gamma-aminobutyric acid b (gaba(b)) receptor agonists in treating anxiety in patients with panic disorder and in treating depression and anxiety in alcoholic patients. |
2003-11-06 |
2023-08-12 |
Not clear |
| Sergei Kirischuk, Jan Akyeli, Radu Iosub, Rosemarie Granty. Pre- and postsynaptic contribution of GABAC receptors to GABAergic synaptic transmission in rat collicular slices and cultures. The European journal of neuroscience. vol 18. issue 4. 2003-10-14. PMID:12925001. |
we conclude that presynaptic gabacrs are activated by endogenous gaba and can alleviate the short-term depression resulting from a preceding episode of gaba release. |
2003-10-14 |
2023-08-12 |
rat |
| Hui Li, Le Wu, Yun-Qing L. Opioid peptides modulate the response of neurons of the superficial laminae of the rat spinal dorsal horn to GABA. Biochemical and biophysical research communications. vol 307. issue 3. 2003-09-04. PMID:12893284. |
the antagonists of mu-, kappa-, and delta-opioid receptors-beta-funaltrexamine (beta-fna), nor-binaltorphimine (nor-bni), and naltrindole (nti) prevented the damgo-, dyn-a-, and dpdpe-induced depression of i(gaba). |
2003-09-04 |
2023-08-12 |
rat |
| Masanori Yamauchi, Steven G Shimada, Hiroshi Sekiyama, J G Collin. Neither spinal gamma-aminobutyric acid-A nor strychnine-sensitive glycine receptor systems are the sole mediators of halothane depression of spinal dorsal horn sensory neurons. Anesthesia and analgesia. vol 97. issue 2. 2003-08-22. PMID:12873928. |
part of that depression may be mediated by anesthetic interactions with gamma-aminobutyric acid type a (gaba(a)) and strychnine-sensitive glycine inhibitory neurotransmitter systems. |
2003-08-22 |
2023-08-12 |
rat |
| Masanori Yamauchi, Steven G Shimada, Hiroshi Sekiyama, J G Collin. Neither spinal gamma-aminobutyric acid-A nor strychnine-sensitive glycine receptor systems are the sole mediators of halothane depression of spinal dorsal horn sensory neurons. Anesthesia and analgesia. vol 97. issue 2. 2003-08-22. PMID:12873928. |
in this electrophysiological study, we attempted to antagonize halothane depression of lt neurons by administering bicuculline (a competitive gaba(a) antagonist) and/or strychnine (a competitive glycine antagonist) systemically, alone or in combination, to decerebrate, spinal cord-transected rats. |
2003-08-22 |
2023-08-12 |
rat |
| Masanori Yamauchi, Steven G Shimada, Hiroshi Sekiyama, J G Collin. Neither spinal gamma-aminobutyric acid-A nor strychnine-sensitive glycine receptor systems are the sole mediators of halothane depression of spinal dorsal horn sensory neurons. Anesthesia and analgesia. vol 97. issue 2. 2003-08-22. PMID:12873928. |
the inability of bicuculline and strychnine, alone or in combination, to completely reverse halothane depression suggests that although gaba(a) and glycine systems are involved in the observed halothane depression, additional mechanisms of action are also required for halothane depression of lt spinal sensory neurons. |
2003-08-22 |
2023-08-12 |
rat |
| Takeshi Sakaba, Erwin Nehe. Direct modulation of synaptic vesicle priming by GABA(B) receptor activation at a glutamatergic synapse. Nature. vol 424. issue 6950. 2003-08-21. PMID:12917685. |
here we show that g-protein-mediated signalling, such as through gaba (gamma-amino butyric acid) subtype b (gaba(b)) receptors, retards the recruitment of synaptic vesicles during sustained activity and after short-term depression. |
2003-08-21 |
2023-08-12 |
Not clear |
| D Wang, L-N Cui, L P Renau. Pre- and postsynaptic GABA(B) receptors modulate rapid neurotransmission from suprachiasmatic nucleus to parvocellular hypothalamic paraventricular nucleus neurons. Neuroscience. vol 118. issue 1. 2003-08-13. PMID:12676136. |
at 1 microm where baclofen had no significant postsynaptic effect, evidence of activation of presynaptic gaba(b) receptors included reduction in scn-evoked ipscs and epscs with no change in their kinetics, and paired-pulse depression that was sensitive to both baclofen and saclofen. |
2003-08-13 |
2023-08-12 |
Not clear |
| Jitendra N Singh, Shripad B Deshpand. Involvement of the GABAergic system for Ptychodiscus brevis toxin-induced depression of synaptic transmission elicited in isolated spinal cord from neonatal rats. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742643. |
the pbtx depressed the reflexes in a concentration-dependent manner and the depression was blocked by gaba(a) antagonist, bicuculline (1 microm). |
2003-07-22 |
2023-08-12 |
rat |
| Jitendra N Singh, Shripad B Deshpand. Involvement of the GABAergic system for Ptychodiscus brevis toxin-induced depression of synaptic transmission elicited in isolated spinal cord from neonatal rats. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742643. |
gaba also produced depression of the reflexes in a concentration-dependent manner. |
2003-07-22 |
2023-08-12 |
rat |
| Jitendra N Singh, Shripad B Deshpand. Involvement of the GABAergic system for Ptychodiscus brevis toxin-induced depression of synaptic transmission elicited in isolated spinal cord from neonatal rats. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742643. |
simultaneous application of submaximal concentrations of pbtx (28 microm) and gaba (30 microm) enhanced the depression (>75%). |
2003-07-22 |
2023-08-12 |
rat |
| Jitendra N Singh, Shripad B Deshpand. Involvement of the GABAergic system for Ptychodiscus brevis toxin-induced depression of synaptic transmission elicited in isolated spinal cord from neonatal rats. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742643. |
the n-methyl-d-aspartate receptor antagonist, dl-2-amino-5-phosphono-pentanoic acid (10 microm), blocked the pbtx-induced depression of msr and also the enhancement of gaba response by pbtx. |
2003-07-22 |
2023-08-12 |
rat |