| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joel S Goldber. Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions. Perspectives in medicinal chemistry. vol 4. 2011-07-14. PMID:20703328. |
it is proposed that treatment of central pain, a localized process, may be treated by gaba supplementation, like parkinson's disease and depression. |
2011-07-14 |
2023-08-12 |
Not clear |
| Lisa M Del Valle-Mojica, Yoshira M Ayala-Marín, Carmen M Ortiz-Sanchez, Bianca A Torres-Hernández, Safa Abdalla-Mukhaimer, José G Orti. Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:21584239. |
although gaba neurotransmission has been suggested as a mechanism for valeriana officinalis effects, cns depression can also be evoked by inhibition of ionotropic (iglur) and metabotropic glutamate receptors (mglur). |
2011-07-14 |
2023-08-12 |
rat |
| Jon T Brown, Clair A Booth, Andrew D Randal. Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons. The European journal of neuroscience. vol 33. issue 5. 2011-07-01. PMID:21269340. |
in contrast, the depression was resistant to the mglur5 antagonist 2-methyl-6-(phenylethynyl)pyridine hydrochloride (mpep) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa)/kainate, n-methyl-d-aspartate (nmda) and γ-aminobutyric acid (gaba)(a) antagonists. |
2011-07-01 |
2023-08-12 |
rat |
| Shang-Feng Gao, Ai-Min Ba. Corticotropin-releasing hormone, glutamate, and γ-aminobutyric acid in depression. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 17. issue 1. 2011-06-15. PMID:20236945. |
in addition, an increasing body of clinical and postmortem evidence is pointing to a role played by γ-aminobutyric acid (gaba) and glutamate in the etiology of depression. |
2011-06-15 |
2023-08-12 |
Not clear |
| Joana Lourenço, Isabel Matias, Giovanni Marsicano, Christophe Mull. Pharmacological activation of kainate receptors drives endocannabinoid mobilization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 9. 2011-05-13. PMID:21368036. |
we show that the depression of gabaergic synaptic transmission induced by ka (3 μm) is strongly inhibited by the simultaneous blockade of cb(1) and gaba(b) receptors with sr141716a (5 μm) and cgp55845 (5 μm), respectively. |
2011-05-13 |
2023-08-12 |
mouse |
| Subroto Ghose, Michelle K Winter, Kenneth E McCarson, Carol A Tamminga, Salvatore J Enn. The GABAβ receptor as a target for antidepressant drug action. British journal of pharmacology. vol 162. issue 1. 2011-04-05. PMID:20735410. |
preclinical and clinical data suggest that a modification in gaba(b) receptor expression and function may contribute to the symptoms of major depression and the response to antidepressants. |
2011-04-05 |
2023-08-12 |
human |
| Subroto Ghose, Michelle K Winter, Kenneth E McCarson, Carol A Tamminga, Salvatore J Enn. The GABAβ receptor as a target for antidepressant drug action. British journal of pharmacology. vol 162. issue 1. 2011-04-05. PMID:20735410. |
clinical and post-mortem studies reveal changes in gabaergic transmission associated with depression as well as depression-related changes in gaba(b) subunit expression that are localized to the cortical depression network. |
2011-04-05 |
2023-08-12 |
human |
| Subroto Ghose, Michelle K Winter, Kenneth E McCarson, Carol A Tamminga, Salvatore J Enn. The GABAβ receptor as a target for antidepressant drug action. British journal of pharmacology. vol 162. issue 1. 2011-04-05. PMID:20735410. |
together with the earlier preclinical studies, these new data point to a role for the gaba(b) system in major depression and support the antidepressant potential of gaba(b) receptor antagonists. |
2011-04-05 |
2023-08-12 |
human |
| Yan-Cai Xiong, Xue-Mei Li, Xue-Jing Wang, Yu-Qiang Liu, Fang Qiu, Dan Wu, Yun-Bo Gan, Bang-Hua Wang, Wang-Ping H. Prokineticin 2 suppresses GABA-activated current in rat primary sensory neurons. Neuropharmacology. vol 59. issue 7-8. 2011-02-07. PMID:20800074. |
these results suggest that pk2 down-regulates the function of the gaba(a) receptor via g-protein and protein kinase c dependent signal pathways in primary sensory neurons and this depression might underlie the hyperalgesia induced by pk2. |
2011-02-07 |
2023-08-12 |
rat |
| Fulvia Bongianni, Donatella Mutolo, Elenia Cinelli, Tito Pantale. Respiratory responses induced by blockades of GABA and glycine receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit. Brain research. vol 1344. 2011-01-10. PMID:20483350. |
gaba(a) receptor blockade by bicuculline (5mm) or gabazine (2mm) within the bötc induced strong depression of respiratory activity up to apnea. |
2011-01-10 |
2023-08-12 |
rabbit |
| John F Cryan, David A Slatter. GABAB receptors and depression. Current status. Advances in pharmacology (San Diego, Calif.). vol 58. 2010-11-01. PMID:20655491. |
dysfunction of the gamma amino butyric acid (gaba)-ergic system has been purported to play a role in psychiatric disorders, including anxiety and major depression. |
2010-11-01 |
2023-08-12 |
mouse |
| Daniel A Zlott, Mary Byrn. Mechanisms by which pharmacologic agents may contribute to fatigue. PM & R : the journal of injury, function, and rehabilitation. vol 2. issue 5. 2010-09-02. PMID:20656627. |
cns depression can also result from increased inhibitory activity within the cns, as is seen with benzodiazepines and barbiturates, which augment the effects of the inhibitory neurotransmitter, gamma-aminobutyric acid. |
2010-09-02 |
2023-08-12 |
Not clear |
| Sang-Hun Lee, Csaba Földy, Ivan Soltes. Distinct endocannabinoid control of GABA release at perisomatic and dendritic synapses in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534847. |
although several key elements of the currently known molecular machinery for endocannabinoid synthesis are thought be primarily localized in dendrites, our results revealed that the depolarization-induced suppression of inhibition, the endocannabinoid-mediated tonic inhibition of gaba release, and the metabotropic glutamate receptor activation-induced, cb(1)r-mediated depression of gaba release were all significantly less effective at dendritic compared with perisomatic synapses. |
2010-08-24 |
2023-08-12 |
Not clear |
| Benjamin Hassfurth, Benedikt Grothe, Ursula Koc. The mammalian interaural time difference detection circuit is differentially controlled by GABAB receptors during development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 29. 2010-08-13. PMID:20660254. |
here, we show that, before hearing onset, gaba(b)r-mediated depression of transmitter release is much stronger for excitation than inhibition, whereas in mature animals gaba(b)rs mainly control the inhibition. |
2010-08-13 |
2023-08-12 |
Not clear |
| Beata Karolewicz, Dorota Maciag, Gillian O'Dwyer, Craig A Stockmeier, Anteneh M Feyissa, Grazyna Rajkowsk. Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression. The international journal of neuropsychopharmacology. vol 13. issue 4. 2010-07-14. PMID:20236554. |
reduced levels of gad-67, which is localized to somata of gaba neurons, further support our observation of a decreased density of gabaergic neurons in the pfc in depression. |
2010-07-14 |
2023-08-12 |
human |
| Beata Karolewicz, Dorota Maciag, Gillian O'Dwyer, Craig A Stockmeier, Anteneh M Feyissa, Grazyna Rajkowsk. Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression. The international journal of neuropsychopharmacology. vol 13. issue 4. 2010-07-14. PMID:20236554. |
moreover, our data support previous neuroimaging observations that antidepressant medication normalizes gaba deficits in depression. |
2010-07-14 |
2023-08-12 |
human |
| M F Weine. Treatment of behavioral/psychological symptoms in Alzheimer's disease. Expert review of neurotherapeutics. vol 1. issue 1. 2010-06-25. PMID:19811048. |
selective (for brain region) gaba agonists seem to offer the greatest theoretical promise for reducing agitated behaviors not driven by depression or psychosis. |
2010-06-25 |
2023-08-12 |
Not clear |
| Inbar Brosh, Edi Barka. Learning-induced enhancement of feedback inhibitory synaptic transmission. Learning & memory (Cold Spring Harbor, N.Y.). vol 16. issue 7. 2010-06-23. PMID:19546230. |
moreover, paired-pulse depression of these ipsps, indicating enhanced gaba release, is also apparent after learning. |
2010-06-23 |
2023-08-12 |
Not clear |
| Tim S Heistek, Johannes C Lodder, Arjen B Brussaard, Laurens W J Bosman, Huibert D Mansvelde. GABAergic inhibition shapes frequency adaptation of cortical activity in a frequency-dependent manner. Brain research. vol 1321. 2010-06-09. PMID:20114035. |
in contrast, in mice lacking the gaba(a) receptor alpha1 subunit facilitation was reduced and depression enhanced. |
2010-06-09 |
2023-08-12 |
mouse |
| Naoki Goto, Reiji Yoshimura, Junji Moriya, Shingo Kakeda, Kenji Hayashi, Nobuhisa Ueda, Atsuko Ikenouchi-Sugita, Wakako Umene-Nakano, Norihiro Oonari, Yukunori Korogi, Jun Nakamur. Critical examination of a correlation between brain gamma-aminobutyric acid (GABA) concentrations and a personality trait of extroversion in healthy volunteers as measured by a 3 Tesla proton magnetic resonance spectroscopy study. Psychiatry research. vol 182. issue 1. 2010-05-27. PMID:20227251. |
we hypothesized that brain gamma-aminobutyric acid (gaba) levels are associated with neuroticism, a trait associated with depression and anxiety disorders. |
2010-05-27 |
2023-08-12 |
human |