| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongmei Chi, Kun Zhang, Jianxing Zhang, Zhaoli He, Hongxia Zhou, Wan Huang, Yang Liu, Jingxiu Huang, Weian Zeng, Xiaohui Bai, Chaopeng Ou, Handong Ouyan. Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice. Nature communications. vol 16. issue 1. 2025-03-15. PMID:40087317. |
we find reduced astrocytes and ptn in the dorsomedial pfc of male mice with depression induced by chronic restraint and social defeat stress. |
2025-03-15 |
2025-03-18 |
mouse |
| Wei Gao, Bharat Biswal, Xinqin Zhou, Jintao Xing, Jiemin Yang, JiaJin Yua. The neural mechanisms subserving the adaptiveness of emotion regulation flexibility and its link to depression. Journal of affective disorders. 2025-03-13. PMID:40081594. |
furthermore, the functional coupling between the dlpfc and the ventromedial prefrontal cortex (vmpfc) mediated the relationship between erf adaptiveness and depression during changing-goals, but not during changing-situations. |
2025-03-13 |
2025-03-16 |
human |
| Yvette I Sheline, Michael E Thase, Elizabeth A Hembree, Nicholas L Balderston, Frederick J Nitchie, Alexandra S Batzdorf, Walid Makhoul, Kevin G Lync. Neuroimaging changes in major depression with brief computer-assisted cognitive behavioral therapy compared to waitlist. Molecular psychiatry. 2025-03-12. PMID:40069356. |
a shortened cbt schedule coupled with home computer exercises was associated with decreased depression symptoms and augmented pfc connectivity with multiple subcortical regions. |
2025-03-12 |
2025-03-14 |
human |
| Leanne M Williams, Jerome Yesavag. Cognitive control circuit function predicts antidepressant outcomes: A signal detection approach to actionable clinical decisions. Personalized medicine in psychiatry. vol 45-46. 2025-03-11. PMID:40066316. |
we previously identified a cognitive biotype of depression characterized by dysfunction of the brain's cognitive control circuit, comprising the dorsolateral prefrontal cortex (dlpfc) and dorsal anterior cingulate cortex (dacc), derived from functional magnetic resonance imaging (fmri). |
2025-03-11 |
2025-03-13 |
Not clear |
| Brandi Quintanilla, Dede Greenstein, Ashutosh Tripathi, Alona Bartosh, Peixiong Yuan, Carlos A Zarate, Anilkumar Pilla. Assessment of complement cascade components in patients with major depressive disorder. Brain, behavior, and immunity. 2025-03-10. PMID:40064429. |
an increase in complement component 3 (c3) expression was previously found in the prefrontal cortex of individuals with depression. |
2025-03-10 |
2025-03-13 |
human |
| Unai Sarriés-Serrano, Lluis Miquel-Rio, Noemí Santana, Verónica Paz, María Sancho-Alonso, Luis F Callado, J Javier Meana, Analia Bortolozz. Impaired unfolded protein response, BDNF and synuclein markers in postmortem dorsolateral prefrontal cortex and caudate nucleus of patients with depression and Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. 2025-02-27. PMID:40015617. |
impaired unfolded protein response, bdnf and synuclein markers in postmortem dorsolateral prefrontal cortex and caudate nucleus of patients with depression and parkinson's disease. |
2025-02-27 |
2025-03-02 |
Not clear |
| David Plevin, Elizabeth H X Thomas, Lisa Hahn, Scott Clark, Leo Che. Clinical predictors of standard and accelerated theta burst rTMS treatment response in depression: an analysis from a multicentre RCT. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2025-02-26. PMID:40001284. |
our group conducted a single-blind, controlled, multi-site trial, wherein participants with treatment-resistant depression were randomised to standard 10 hz rtms, applied to the left dorsolateral prefrontal cortex (dlpfc), or accelerated bilateral tbs (abltbs), applied sequentially to the right then left dlpfc. |
2025-02-26 |
2025-02-28 |
human |
| Jithin Thekkelkuthiyathottil Joseph, Ashok Jammigumpula, Sivapriya Vaidyanathan, Samir Kumar Prahara. Sequential bilateral repetitive transcranial magnetic stimulation in depression: Targeting right orbitofrontal cortex and left dorsolateral prefrontal cortex in nonresponders. Asian journal of psychiatry. vol 105. 2025-02-13. PMID:39947103. |
sequential bilateral repetitive transcranial magnetic stimulation in depression: targeting right orbitofrontal cortex and left dorsolateral prefrontal cortex in nonresponders. |
2025-02-13 |
2025-02-16 |
Not clear |
| Feng Yan, Siyan Zan, Jiahua Xu, Shaokun Zhao, Zhiren Wang, Fude Yan. Cognitive and Clinical Dimensions of Structural and Functional Insula Alterations in Patients with Depression: A Resting-State fMRI Study. The International journal of neuroscience. 2025-02-06. PMID:39915081. |
furthermore, functional connectivity analyses identified disrupted insula-medial prefrontal cortex circuits, highlighting their contribution to the pathophysiology of depression. |
2025-02-06 |
2025-02-09 |
Not clear |
| Leonardo Tozzi, Claire Bertrand, Laura Michele Hack, Timothy Lyons, Alisa Marie Olmsted, Divya Rajasekharan, TeChieh Chen, Yosef A Berlow, Jerome A Yesavage, Kelvin Lim, Michelle R Madore, Noah S Philip, Paul Holtzheimer, Leanne Maree William. A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trial. Nature. Mental health. vol 2. issue 8. 2025-02-06. PMID:39911692. |
we previously identified a cognitive biotype of depression characterized by treatment resistance, impaired cognitive control behavioral performance and dysfunction in the cognitive control circuit, comprising the dorsolateral prefrontal cortex (dlpfc) and dorsal anterior cingulate cortex (dacc). |
2025-02-06 |
2025-02-08 |
Not clear |
| Angela Michela De Stasi, Javier Zorrilla de San Martin, Nina Soto, Andrea Aguirre, Jimmy Olusakin, Joana Lourenço, Patricia Gaspar, Alberto Bacc. Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 45. issue 6. 2025-02-05. PMID:39909574. |
the prefrontal cortex (pfc) plays a key role in high-level cognitive functions and emotional behaviors, and pfc alterations correlate with different brain disorders including major depression and anxiety. |
2025-02-05 |
2025-02-08 |
mouse |
| Chun-Hung Chang, Wen-Chun Liu, Po-Han Cho. Near-infrared spectroscopy-guided personalized repetitive transcranial magnetic stimulation for bipolar depression: a case report. Frontiers in psychiatry. vol 15. 2025-02-04. PMID:39902251. |
high-frequency (10 hz), low-frequency (1 hz), or bilateral (left, high-frequency; right, low-frequency) stimulation of the dorsolateral prefrontal cortex (dlpfc) has been demonstrated to be effective in studies based on prefrontal asymmetry theory, which suggests that depression is associated with reduced left frontal function and increased right frontal function. |
2025-02-04 |
2025-02-06 |
Not clear |
| Darko Kastelan, Tina Duse. Do adrenal incidentalomas have an impact on mental health? A comprehensive review. European journal of endocrinology. 2025-02-01. PMID:39891589. |
it is well known that glucocorticoid excess affects the hippocampus and prefrontal cortex, brain structures involved in mood regulation and cognitive processes, leading to a wide range of psychiatric symptoms, including depression. |
2025-02-01 |
2025-02-04 |
Not clear |
| David H Sarrazin, Wilf Gardner, Tsvetan Sercho. [Importance of the prefrontal cortex circadian clock in neurobiology and treatment of depression]. Medecine sciences : M/S. vol 41. issue 1. 2025-01-31. PMID:39887095. |
[importance of the prefrontal cortex circadian clock in neurobiology and treatment of depression]. |
2025-01-31 |
2025-02-02 |
Not clear |
| Jialong Zhong, Huan Li, Kerun Cao, Liuchang Zhou, Lin An, Jinlan Zhao, Shasha Bai, Yafei Shi, Zhongqiu Liu, Qi Liang, Rong Zhang, Di Den. Glutamate-mediated antidepressant effects of Jieyu I Formula via modulation of PFC Journal of ethnopharmacology. 2025-01-27. PMID:39870335. |
glutamate-mediated antidepressant effects of jieyu i formula via modulation of pfc jieyu i formula (jy-i) is an improved version of the classic formula "sini san" documented in the books shanghan lun, which is known for regulating the liver and treating depression. |
2025-01-27 |
2025-01-30 |
Not clear |
| Baile Ning, Zhifang Wang, Jiangshan He, Qian Wu, Qiyue Deng, Qing Yang, Jing Gao, Wen Fu, Ying Deng, Bingxin Wu, Xichang Huang, Jilin Mei, Fan Jiang, Wenbin F. Corrigendum to "The rapid antidepressant effect of acupuncture on two animal models of depression by inhibiting M1-Ach receptors regulates synaptic plasticity in the prefrontal cortex" [Brain Res. 1822 (2024) 148609]. Brain research. vol 1851. 2025-01-23. PMID:39848023. |
corrigendum to "the rapid antidepressant effect of acupuncture on two animal models of depression by inhibiting m1-ach receptors regulates synaptic plasticity in the prefrontal cortex" [brain res. |
2025-01-23 |
2025-01-26 |
Not clear |
| Hengda He, Xiaoxiao Sun, Jayce Doose, Josef Faller, James R McIntosh, Golbarg T Saber, Sarah Huffman, Linbi Hong, Spiro P Pantazatos, Han Yuan, Lisa M McTeague, Robin I Goldman, Truman R Brown, Mark S George, Paul Sajd. TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study. medRxiv : the preprint server for health sciences. 2025-01-15. PMID:39763561. |
transcranial magnetic stimulation (tms) over the left dorsolateral prefrontal cortex (l-dlpfc) is an established intervention for treatment-resistant depression (trd), yet the underlying therapeutic mechanisms remain not fully understood. |
2025-01-15 |
2025-01-17 |
Not clear |
| Xiao Chen, Yeting Gan, Kaiqi Zhang, Yuhan Wu, Ye Li, Tian Lan, Xianghua Zhuang, Shihong Chen, Shuyan Y. MicroRNA-204-5p Deficiency within the vmPFC Region Contributes to Neuroinflammation and Behavioral Disorders via the JAK2/STAT3 Signaling Pathway in Rats. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025-01-10. PMID:39792918. |
here, it is found that mir-204-5p is markedly downregulated in the ventromedial prefrontal cortex (vmpfc) in a chronic unpredictable mild stress (cums) induce rat model of depression. |
2025-01-10 |
2025-01-13 |
rat |
| Waka Nakano, Satoshi Yokoyama, Hiroshi Sat. Brain Abnormalities During Self-Referential Task in Subthreshold Depression: A Near-Infrared Spectroscopy Study. Cureus. vol 16. issue 12. 2025-01-09. PMID:39781147. |
results our analysis revealed a positive correlation between hemodynamic changes in the right pfc during the srt and depression severity (srtl_coeff: 0.12), suggesting that increased activation in this region may be associated with higher levels of depressive severity. |
2025-01-09 |
2025-01-13 |
human |
| Waka Nakano, Satoshi Yokoyama, Hiroshi Sat. Brain Abnormalities During Self-Referential Task in Subthreshold Depression: A Near-Infrared Spectroscopy Study. Cureus. vol 16. issue 12. 2025-01-09. PMID:39781147. |
in contrast, hemodynamic changes in the left pfc during the srt did not significantly influence the severity of depression. |
2025-01-09 |
2025-01-13 |
human |