| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine Demery-Poulos, Sierra C Moore, Erica S Levitt, Jessica P Anand, John R Trayno. Xylazine Exacerbates Fentanyl-Induced Respiratory Depression and Bradycardia. bioRxiv : the preprint server for biology. 2024-09-04. PMID:39229079. |
xylazine exacerbates fentanyl-induced respiratory depression and bradycardia. |
2024-09-04 |
2024-09-06 |
mouse |
| Ping Dai, Yanqing Chen, Xianqin Luo, Zhiqiang Zhou, Mengdi Shi, Aerbusili Genjiafu, Xiangdong Jia. Fatal hyperpyrexia caused by xylazine: a case report. Frontiers in pharmacology. vol 15. 2024-08-01. PMID:39086384. |
xylazine poisoning is characterized by depression of the central nervous and cardiovascular systems. |
2024-08-01 |
2024-08-03 |
Not clear |
| Ping Dai, Yanqing Chen, Xianqin Luo, Zhiqiang Zhou, Mengdi Shi, Aerbusili Genjiafu, Xiangdong Jia. Fatal hyperpyrexia caused by xylazine: a case report. Frontiers in pharmacology. vol 15. 2024-08-01. PMID:39086384. |
herein, we present a case of a 41-year-old man who not only had severe depression of the central nervous and cardiovascular systems, but also developed hyperpyrexia during the treatment of xylazine poisoning, which led to his death 3 days after poisoning. |
2024-08-01 |
2024-08-03 |
Not clear |
| Paola Straticò, Giulia Guerri, Lorenza Bandera, Gianluca Celani, Laura Di Nunzio, Lucio Petrizzi, Vincenzo Varasan. Comparison of Xylazine and Lidocaine Infusion versus Medetomidine Continuous Rate Infusion during General Anesthesia with Isoflurane in Horses Undergoing Emergency Laparotomy. Veterinary sciences. vol 11. issue 5. 2024-05-26. PMID:38787168. |
minor respiratory depression was detected when xylazine was used, while recovery was longer with medetomidine. |
2024-05-26 |
2024-05-27 |
Not clear |
| James Morris, Dustin Hoan. The Management of Xylazine Overdose With Naloxone. Cureus. vol 16. issue 4. 2024-05-06. PMID:38707050. |
xylazine, typically used as a veterinary tranquilizer, acts as a potent α2 adrenergic agonist, leading to sedation, muscle relaxation, and potential respiratory depression. |
2024-05-06 |
2024-05-08 |
human |
| Mercy Ngosa Mumba, Johnny Tice, Whitnee Brow. Xylazine: The Drug Taking the World By Storm: What You Need to Know. Journal of psychosocial nursing and mental health services. vol 61. issue 12. 2023-12-05. PMID:38051681. |
adverse effects of xylazine are secondary to central nervous system (cns), cardiovascular, and respiratory function depression. |
2023-12-05 |
2023-12-10 |
Not clear |
| Shinbe Choi, Matthew R Irwin, Eugene A Kiyatki. Xylazine effects on opioid-induced brain hypoxia. Psychopharmacology. vol 240. issue 7. 2023-06-20. PMID:37340247. |
although its exact role in opioid-induced overdose deaths is largely unknown, xylazine is known to depress vital functions and cause hypotension, bradycardia, hypothermia, and respiratory depression. |
2023-06-20 |
2023-08-14 |
Not clear |
| Stephanie Anne Deutsch, Allan R De Jon. Xylazine Complicating Opioid Ingestions in Young Children. Pediatrics. 2022-12-22. PMID:36550066. |
the authors of this report present 3 cases of synthetic opioid intoxication complicated by the concomitant presence of the additive xylazine, a nonopioid sedative analgesic and muscle relaxant used in veterinary medicine that potentiates respiratory depression associated with the opioid toxidrome. |
2022-12-22 |
2023-08-14 |
Not clear |
| C G Donnelly, C T Quinn, S G Nielsen, S L Raida. Respiratory Support for Pharmacologically Induced Hypoxia in Neonatal Calves. Veterinary medicine international. vol 2016. 2016-03-21. PMID:26998379. |
ten calves were randomised to receive either nasal oxygen insufflation (group 1, n = 5) or cpap (group 2, n = 5) as a first treatment after induction of respiratory depression by intravenous administration of xylazine, fentanyl, and diazepam. |
2016-03-21 |
2023-08-13 |
cattle |
| Godwin Onyeamaechi Egwu, Gideon Dauda Mshelia, Saka Sanni, Patrick Azubuike Onyeyili, Gladys Taiwo Adeyanj. The effect of vitamin C at varying times on physiological parameters in rabbits after xylazine anaesthesia. Veterinaria italiana. vol 47. issue 1. 2011-03-25. PMID:21240855. |
the result of the study showed that vitamin c pre-medication prior to xylazine anaesthesia induced depression in respiratory and heart rates and a slight increase in rectal temperature. |
2011-03-25 |
2023-08-12 |
Not clear |
| b' Jana Mojzisov\\xc3\\xa1, R Hromada, I Valock\\xc3\\xbd, S Paul\\xc3\\xadk, Vlasta Hip\\xc3\\xadkov\\xc3\\xa1, Viera Bajov\\xc3\\xa1, Serena Posiv\\xc3\\xa1kov\\xc3\\xa1, A Bugarsk\\xc3\\xb. Effect of ovariohysterectomy on canine postsurgical leukocyte function. Acta veterinaria Hungarica. vol 51. issue 2. 2003-06-26. PMID:12737049.' |
simple ovariohysterectomy with anaesthesia induced by ketamine and xylazine or by ketamine, xylazine and halothane caused a short nonsignificant depression of phagocytic activity that persisted for four hours after surgery. |
2003-06-26 |
2023-08-12 |
Not clear |
| D G Mpanduji, M N Mgasa, S B Bittegeko, E K Batamuz. Comparison of xylazine and lidocaine effects for analgesia and cardiopulmonary functions following lumbosacral epidural injection in goats. Zentralblatt fur Veterinarmedizin. Reihe A. vol 46. issue 10. 2000-02-29. PMID:10638298. |
epidural injection of xylazine and lidocaine caused variable depression effects on the cardiopulmonary values but was not so low as to cause concern. |
2000-02-29 |
2023-08-12 |
Not clear |
| C E Short, A Bufalar. Propofol anesthesia. The Veterinary clinics of North America. Small animal practice. vol 29. issue 3. 1999-07-01. PMID:10332821. |
potent alpha 2 sedative/analgesics (e.g., xylazine, medetomidine) or opioids (e.g., oxymorphone, butorphanol) increase the probability of respiratory depression during anesthesia. |
1999-07-01 |
2023-08-12 |
dog |
| S Singh, S S Young, W N McDonell, M O'Grad. Modification of cardiopulmonary and intestinal motility effects of xylazine with glycopyrrolate in horses. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. vol 61. issue 2. 1997-08-07. PMID:9114960. |
xylazine (xyl) administration in horses is accompanied by significant cardiovascular depression characterized by a 25-35% decrease in cardiac output (co) which is likely to compromise tissue oxygen delivery (do2), and usually vagally mediated bradycardia is an important cause of this reduced cardiovascular performance. |
1997-08-07 |
2023-08-12 |
Not clear |
| B Y Aminkov, H D Hubeno. The effect of xylazine epidural anaesthesia on blood gas and acid-base parameters in rams. The British veterinary journal. vol 151. issue 5. 1996-02-27. PMID:8556317. |
xylazine at a dose of 0.4 mg kg-1 led to a metabolic alkalosis with a significant increase of ph, plasma bicarbonate and base excess and respiratory depression. |
1996-02-27 |
2023-08-12 |
Not clear |
| C A Kollias-Baker, M H Court, L L William. Influence of yohimbine and tolazoline on the cardiovascular, respiratory, and sedative effects of xylazine in the horse. Journal of veterinary pharmacology and therapeutics. vol 16. issue 3. 1993-12-17. PMID:8230406. |
in conclusion, both yohimbine and tolazoline successfully antagonized the cardiovascular and cns depression associated with xylazine administration. |
1993-12-17 |
2023-08-12 |
Not clear |
| E R Butelman, J H Wood. Effects of clonidine, dexmedetomidine and xylazine on thermal antinociception in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 264. issue 2. 1993-03-23. PMID:8094751. |
at dose ranges found to be effective in the antinociceptive assay, clonidine, dexmedetomidine and xylazine also dose-dependently caused sedation, muscle relaxation, bradycardia and moderate respiratory depression. |
1993-03-23 |
2023-08-12 |
monkey |
| T E Albertson, W F Walby, R M Jo. Modification of GABA-mediated inhibition by various injectable anesthetics. Anesthesiology. vol 77. issue 3. 1992-10-07. PMID:1519787. |
ketamine produced a small but significant depression in granule cell excitability during intervals of 10-200 ms. xylazine had no effect. |
1992-10-07 |
2023-08-11 |
rat |
| L G Harsing, J Kapocsi, E S Viz. Possible role of alpha-2 and alpha-1 adrenoceptors in the experimentally-induced depression of the central nervous system. Pharmacology, biochemistry, and behavior. vol 32. issue 4. 1989-11-07. PMID:2572006. |
the alpha-2 adrenoceptor agonists clonidine and xylazine were employed in chicks and rats to induce a loss of the righting reflex, a sign for depression of the central nervous system. |
1989-11-07 |
2023-08-11 |
rat |
| W H Hsu, C E Hanson, F B Hembrough, D D Schaffe. Effects of idazoxan, tolazoline, and yohimbine on xylazine-induced respiratory changes and central nervous system depression in ewes. American journal of veterinary research. vol 50. issue 9. 1989-11-06. PMID:2572191. |
we compared the ability of 3 alpha 2-adrenoreceptor antagonists, idazoxan (0.05 mg/kg), tolazoline (2 mg/kg), and yohimbine (0.2 mg/kg) to reverse xylazine (0.3 mg/kg)-induced respiratory changes and cns depression in 6 ewes. |
1989-11-06 |
2023-08-11 |
Not clear |