All Relations between Depression and Xylazine

Publication Sentence Publish Date Extraction Date Species
James Morris, Dustin Hoan. The Management of Xylazine Overdose With Naloxone. Cureus. vol 16. issue 4. 2024-05-06. PMID:38707050. xylazine, typically used as a veterinary tranquilizer, acts as a potent α2 adrenergic agonist, leading to sedation, muscle relaxation, and potential respiratory depression. 2024-05-06 2024-05-08 human
Mercy Ngosa Mumba, Johnny Tice, Whitnee Brow. Xylazine: The Drug Taking the World By Storm: What You Need to Know. Journal of psychosocial nursing and mental health services. vol 61. issue 12. 2023-12-05. PMID:38051681. adverse effects of xylazine are secondary to central nervous system (cns), cardiovascular, and respiratory function depression. 2023-12-05 2023-12-10 Not clear
Shinbe Choi, Matthew R Irwin, Eugene A Kiyatki. Xylazine effects on opioid-induced brain hypoxia. Psychopharmacology. vol 240. issue 7. 2023-06-20. PMID:37340247. although its exact role in opioid-induced overdose deaths is largely unknown, xylazine is known to depress vital functions and cause hypotension, bradycardia, hypothermia, and respiratory depression. 2023-06-20 2023-08-14 Not clear
Stephanie Anne Deutsch, Allan R De Jon. Xylazine Complicating Opioid Ingestions in Young Children. Pediatrics. 2022-12-22. PMID:36550066. the authors of this report present 3 cases of synthetic opioid intoxication complicated by the concomitant presence of the additive xylazine, a nonopioid sedative analgesic and muscle relaxant used in veterinary medicine that potentiates respiratory depression associated with the opioid toxidrome. 2022-12-22 2023-08-14 Not clear
C G Donnelly, C T Quinn, S G Nielsen, S L Raida. Respiratory Support for Pharmacologically Induced Hypoxia in Neonatal Calves. Veterinary medicine international. vol 2016. 2016-03-21. PMID:26998379. ten calves were randomised to receive either nasal oxygen insufflation (group 1, n = 5) or cpap (group 2, n = 5) as a first treatment after induction of respiratory depression by intravenous administration of xylazine, fentanyl, and diazepam. 2016-03-21 2023-08-13 cattle
Godwin Onyeamaechi Egwu, Gideon Dauda Mshelia, Saka Sanni, Patrick Azubuike Onyeyili, Gladys Taiwo Adeyanj. The effect of vitamin C at varying times on physiological parameters in rabbits after xylazine anaesthesia. Veterinaria italiana. vol 47. issue 1. 2011-03-25. PMID:21240855. the result of the study showed that vitamin c pre-medication prior to xylazine anaesthesia induced depression in respiratory and heart rates and a slight increase in rectal temperature. 2011-03-25 2023-08-12 Not clear
b' Jana Mojzisov\\xc3\\xa1, R Hromada, I Valock\\xc3\\xbd, S Paul\\xc3\\xadk, Vlasta Hip\\xc3\\xadkov\\xc3\\xa1, Viera Bajov\\xc3\\xa1, Serena Posiv\\xc3\\xa1kov\\xc3\\xa1, A Bugarsk\\xc3\\xb. Effect of ovariohysterectomy on canine postsurgical leukocyte function. Acta veterinaria Hungarica. vol 51. issue 2. 2003-06-26. PMID:12737049.' simple ovariohysterectomy with anaesthesia induced by ketamine and xylazine or by ketamine, xylazine and halothane caused a short nonsignificant depression of phagocytic activity that persisted for four hours after surgery. 2003-06-26 2023-08-12 Not clear
D G Mpanduji, M N Mgasa, S B Bittegeko, E K Batamuz. Comparison of xylazine and lidocaine effects for analgesia and cardiopulmonary functions following lumbosacral epidural injection in goats. Zentralblatt fur Veterinarmedizin. Reihe A. vol 46. issue 10. 2000-02-29. PMID:10638298. epidural injection of xylazine and lidocaine caused variable depression effects on the cardiopulmonary values but was not so low as to cause concern. 2000-02-29 2023-08-12 Not clear
C E Short, A Bufalar. Propofol anesthesia. The Veterinary clinics of North America. Small animal practice. vol 29. issue 3. 1999-07-01. PMID:10332821. potent alpha 2 sedative/analgesics (e.g., xylazine, medetomidine) or opioids (e.g., oxymorphone, butorphanol) increase the probability of respiratory depression during anesthesia. 1999-07-01 2023-08-12 dog
S Singh, S S Young, W N McDonell, M O'Grad. Modification of cardiopulmonary and intestinal motility effects of xylazine with glycopyrrolate in horses. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. vol 61. issue 2. 1997-08-07. PMID:9114960. xylazine (xyl) administration in horses is accompanied by significant cardiovascular depression characterized by a 25-35% decrease in cardiac output (co) which is likely to compromise tissue oxygen delivery (do2), and usually vagally mediated bradycardia is an important cause of this reduced cardiovascular performance. 1997-08-07 2023-08-12 Not clear
B Y Aminkov, H D Hubeno. The effect of xylazine epidural anaesthesia on blood gas and acid-base parameters in rams. The British veterinary journal. vol 151. issue 5. 1996-02-27. PMID:8556317. xylazine at a dose of 0.4 mg kg-1 led to a metabolic alkalosis with a significant increase of ph, plasma bicarbonate and base excess and respiratory depression. 1996-02-27 2023-08-12 Not clear
C A Kollias-Baker, M H Court, L L William. Influence of yohimbine and tolazoline on the cardiovascular, respiratory, and sedative effects of xylazine in the horse. Journal of veterinary pharmacology and therapeutics. vol 16. issue 3. 1993-12-17. PMID:8230406. in conclusion, both yohimbine and tolazoline successfully antagonized the cardiovascular and cns depression associated with xylazine administration. 1993-12-17 2023-08-12 Not clear
E R Butelman, J H Wood. Effects of clonidine, dexmedetomidine and xylazine on thermal antinociception in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 264. issue 2. 1993-03-23. PMID:8094751. at dose ranges found to be effective in the antinociceptive assay, clonidine, dexmedetomidine and xylazine also dose-dependently caused sedation, muscle relaxation, bradycardia and moderate respiratory depression. 1993-03-23 2023-08-12 monkey
T E Albertson, W F Walby, R M Jo. Modification of GABA-mediated inhibition by various injectable anesthetics. Anesthesiology. vol 77. issue 3. 1992-10-07. PMID:1519787. ketamine produced a small but significant depression in granule cell excitability during intervals of 10-200 ms. xylazine had no effect. 1992-10-07 2023-08-11 rat
L G Harsing, J Kapocsi, E S Viz. Possible role of alpha-2 and alpha-1 adrenoceptors in the experimentally-induced depression of the central nervous system. Pharmacology, biochemistry, and behavior. vol 32. issue 4. 1989-11-07. PMID:2572006. the alpha-2 adrenoceptor agonists clonidine and xylazine were employed in chicks and rats to induce a loss of the righting reflex, a sign for depression of the central nervous system. 1989-11-07 2023-08-11 rat
W H Hsu, C E Hanson, F B Hembrough, D D Schaffe. Effects of idazoxan, tolazoline, and yohimbine on xylazine-induced respiratory changes and central nervous system depression in ewes. American journal of veterinary research. vol 50. issue 9. 1989-11-06. PMID:2572191. we compared the ability of 3 alpha 2-adrenoreceptor antagonists, idazoxan (0.05 mg/kg), tolazoline (2 mg/kg), and yohimbine (0.2 mg/kg) to reverse xylazine (0.3 mg/kg)-induced respiratory changes and cns depression in 6 ewes. 1989-11-06 2023-08-11 Not clear
P C Pearce, R A Koc. Physiological effects of etorphine, acepromazine and xylazine in the scimitar horned oryx (Oryx dammah). Research in veterinary science. vol 47. issue 1. 1989-09-25. PMID:2772409. xylazine alone produced a dose dependent degree of sedation in semitame subadult animals kept in confinement, but only slight depression in their wild, unconfined counterparts. 1989-09-25 2023-08-11 Not clear
D Gavier, M D Kittleson, M E Fowler, L E Johnson, G Hall, D Nearenber. Evaluation of a combination of xylazine, ketamine, and halothane for anesthesia in llamas. American journal of veterinary research. vol 49. issue 12. 1989-05-02. PMID:3239840. the combination of xylazine, ketamine, and halothane in various doses and 2 ventilation procedures (spontaneous and controlled) provided a reliable method for general anesthesia in llamas, but marked cardiovascular depression developed during anesthesia maintenance with halothane. 1989-05-02 2023-08-11 Not clear
T C Moore, C H Spruck, L E Ledu. Depression of lymphocyte traffic in sheep by anaesthesia and associated changes in efferent-lymph PGE2 and antibody levels. Immunology. vol 63. issue 1. 1988-03-03. PMID:3422221. general anaesthesia of sheep with ketamine and xylazine has been found to produce a profound and prolonged depression in lymphocyte traffic through primary peripheral lymph nodes, as mirrored in the output of lymphocytes into efferent lymph. 1988-03-03 2023-08-11 Not clear
N S Lipman, P A Phillips, C E Newcome. Reversal of ketamine/xylazine anesthesia in the rabbit with yohimbine. Laboratory animal science. vol 37. issue 4. 1987-11-25. PMID:3669601. yohimbine, an alpha-2 adrenergic antagonist has been shown to reverse xylazine induced depression and partially antagonize ketamine in other species. 1987-11-25 2023-08-11 rabbit