| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P D Hrdina, D Bakish, J Chudzik, A Ravindran, Y D Lapierr. Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. Journal of psychiatry & neuroscience : JPN. vol 20. issue 1. 1995-03-27. PMID:7865496. |
the uptake of [3h]5-ht and the density (bmax) as well as affinity (kd) of 5-ht uptake sites labelled with [3h]paroxetine and of 5-ht2 receptors labelled by [3h]lsd were determined in platelets from 25 medication-free patients with major depression and 20 normal controls. |
1995-03-27 |
2023-08-12 |
human |
| D V Maurice, J E Jones, S F Lightsey, J F Rhoades, K T Hs. High dietary niacinamide and performance of male poults at 16 weeks of age. British poultry science. vol 31. issue 4. 1991-07-19. PMID:2151426. |
high dietary niacinamide (100 mg/kg alleviated the growth depression under hsd but decreased body weight gain under low stocking density (lsd). |
1991-07-19 |
2023-08-11 |
Not clear |
| G N Pandey, S C Pandey, P G Janicak, R C Marks, J M Davi. Platelet serotonin-2 receptor binding sites in depression and suicide. Biological psychiatry. vol 28. issue 3. 1990-09-12. PMID:2378926. |
in order to examine the role of serotonin-2 (5ht2) receptors in depression and suicide, we determined 5ht2 receptors using 125i-lysergic acid diethylamide (lsd) as the binding ligand in platelets obtained from 20 normal control and 23 drug-free depressed patients. |
1990-09-12 |
2023-08-11 |
human |
| S B Sparber, L P Dwoskin, M S Kleve. Studies on the specificity of neurochemical and behavioral effects of LSD-25. Pharmacology, biochemistry, and behavior. vol 24. issue 2. 1986-04-15. PMID:3952124. |
we suggest that behavioral effects of low doses of lsd are due to sympathetic arousal and may offer a model for agitated depression and/or anxiety and that drugs of the mianserin-type may prove useful for treating some forms of anxiety, as well as depression. |
1986-04-15 |
2023-08-11 |
rat |
| J Heym, K Rasmussen, B L Jacob. Some behavioral effects of hallucinogens are mediated by a postsynaptic serotonergic action: evidence from single unit studies in freely moving cats. European journal of pharmacology. vol 101. issue 1-2. 1984-09-04. PMID:6745319. |
pretreatment with 1.0 mg/kg of mianserin, which completely attenuated lsd's behavioral effect, failed to alter lsd-induced depression of mesencephalic serotonergic neuron discharge. |
1984-09-04 |
2023-08-12 |
cat |
| D M Wilkison, M J Hosk. Differential effects of lysergic acid diethylamide, methysergide, and cyproheptadine on modality-specific and nonspecific sensory evoked potentials. Experimental neurology. vol 82. issue 2. 1983-12-17. PMID:6628626. |
the depression of responses at heterosensory sites by lsd was blocked by cyproheptadine. |
1983-12-17 |
2023-08-12 |
Not clear |
| W E Foot. Electrophysiological studies of d-lysergic acid diethylamide in the visual system. Neuroscience and biobehavioral reviews. vol 6. issue 4. 1983-02-14. PMID:7177510. |
increasing the dose of lsd regardless of the manner in which it was applied tended to produce depression of both spontaneous and visually driven activity. |
1983-02-14 |
2023-08-12 |
Not clear |
| J C Strahlendorf, F J Goldstein, G V Rossi, R T Malsee. Differential effects of LSD serotonin and l-tryptophan on visually evoked responses. Pharmacology, biochemistry, and behavior. vol 16. issue 1. 1982-04-12. PMID:7058213. |
modification of raphe neuronal activity can significantly alter photically evoked responses, and may explain the perceptual disturbances associated with lsd, i.e., depression of an area (raphe) normally inhibiting forebrain areas of the visual system. |
1982-04-12 |
2023-08-12 |
Not clear |
| M Miśkiewicz, A Rokosz-Pelc, J Vetulan. The effect of quipazine and LSD on monoamines in the rat striatum. Polish journal of pharmacology and pharmacy. vol 31. issue 5. 1980-08-25. PMID:94944. |
lsd at the peak of its action depressed the level of 5-hiaa, and in the next period produced a significant depression of striatal levels of na, 5ht and 5-hiaa. |
1980-08-25 |
2023-08-11 |
rat |
| B Connors, A Dray, P Fox, M Hilmy, G Somje. LSD's effect on neuron populations in visual cortex gauged by transient responses of extracellular potassium evoked by optical stimuli. Neuroscience letters. vol 13. issue 2. 1980-04-26. PMID:530463. |
lsd most commonly produced a depression of [k+]o transients and a deterioration in their directional selectivity. |
1980-04-26 |
2023-08-11 |
Not clear |
| B Connors, A Dray, P Fox, M Hilmy, G Somje. LSD's effect on neuron populations in visual cortex gauged by transient responses of extracellular potassium evoked by optical stimuli. Neuroscience letters. vol 13. issue 2. 1980-04-26. PMID:530463. |
these observations suggest that the effect of lsd is to produce a net depression in visually evoked neuronal firing. |
1980-04-26 |
2023-08-11 |
Not clear |
| J Vetulani, B Byrska, K Reichenber. Head twitches produced by serotonergic drugs and opiates after lesion of the mesostriatal serotonergic system of the rat. Polish journal of pharmacology and pharmacy. vol 31. issue 4. 1980-03-17. PMID:316525. |
there was a good correlation between the extent of lesion, measured by the depression of the level of prosencephalic serotonin, and the depression of head twitch frequency produced by 5-hydroxytryptophan and quipazine, while the correlation was not significant for the action of lsd. |
1980-03-17 |
2023-08-11 |
rat |
| M E Trulson, B L Jacob. Dissociations between the effects of LSD on behavior and raphe unit activity in freely moving cats. Science (New York, N.Y.). vol 205. issue 4405. 1979-09-01. PMID:451617. |
the hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of d-lysergic acid diethylamide (lsd) while studying the activity of raphe neurons in freely moving cats. |
1979-09-01 |
2023-08-11 |
Not clear |
| M E Trulson, B L Jacob. Dissociations between the effects of LSD on behavior and raphe unit activity in freely moving cats. Science (New York, N.Y.). vol 205. issue 4405. 1979-09-01. PMID:451617. |
(i) low doses of lsd produced only small decreases in raphe unit activity but significant behavoiral changes; (ii) lsd-induced behavioral changes outlasted the depression of raphe unit activity; and (iii) raphe neurons were at least as responsive to lsd during tolerance as they were in the nontolerant condition. |
1979-09-01 |
2023-08-11 |
Not clear |
| J Maj, W Palider, A Rawłó. The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat. Journal of neural transmission. vol 43. issue 2. 1979-03-28. PMID:731232. |
haloperidol in doses which do not influence the action of lsd and fenfluramine produces a depression of the flexor reflex and antagonizes the action of clonidine. |
1979-03-28 |
2023-08-11 |
rat |
| G R Christoph, D M Kuhn, B L Jacob. Electrophysiological evidence for a dopaminergic action of LSD: depression of unit activity in the substantia nigra of the rat. Life sciences. vol 21. issue 11. 1978-03-10. PMID:202830. |
electrophysiological evidence for a dopaminergic action of lsd: depression of unit activity in the substantia nigra of the rat. |
1978-03-10 |
2023-08-11 |
rat |
| I D Hirschhorn, J A Rosecran. Generalization of morphine and lysergic acid diethylamide (LSD) stimulus properties to narcotic analgesics. Psychopharmacology. vol 47. issue 1. 1976-10-20. PMID:8812. |
depression of one lever in an operant chamber resulted in reinforcement following the administration of morphine or lsd and the opposite lever was reinforced after saline. |
1976-10-20 |
2023-08-11 |
rat |
| N Ambache, L P Dunk, J Verney, M A Za. An inhibition of post-ganglionic motor transmission in the mammalian vas deferens by D-lysergic acid diethylamide. The Journal of physiology. vol 231. issue 2. 1973-10-02. PMID:4352765. |
the lsd effect was not due to a non-specific smooth muscle depression because it was not associated with any reduction in motor responses to acetylcholine, atp or bradykinin.7. |
1973-10-02 |
2023-08-11 |
rat |