| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Li, Wei Wang, Li-Ming Zhang, Xiang-Yun Jiang, Shu-Zheng Sun, Li-Jun Sun, Ying Guo, Jie Gong, You-Zhi Zhang, Heng-Lin Wang, Yun-Feng L. Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects. Neuropharmacology. vol 125. 2018-06-12. PMID:28655607. |
however, the exact role that tspo plays in the pathophysiology of anxiety and depression and the involvement of the hippocampal dentate gyrus in regulating these behavioural effects remain elusive. |
2018-06-12 |
2023-08-13 |
mouse |
| Zhi-Kun Qiu, Jia-Li He, Xu Liu, Guan-Hua Zhang, Jia Zeng, Hong Nie, Yong-Gang Shen, Ji-Sheng Che. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. Scientific reports. vol 6. 2018-05-23. PMID:27886206. |
this study indicates that the antidepressant-like effects of ac-5216 on hfd-stz rats, suggesting that tspo may represent a novel therapeutic target for depression in t2dm. |
2018-05-23 |
2023-08-13 |
rat |
| Zhi-Kun Qiu, Jia-Li He, Xu Liu, Guan-Hua Zhang, Jia Zeng, Hong Nie, Yong-Gang Shen, Ji-Sheng Che. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. Scientific reports. vol 6. 2018-05-23. PMID:27886206. |
translocator protein (18kda) (tspo) and allopregnanolone play an important role in the depression treatment. |
2018-05-23 |
2023-08-13 |
rat |
| Zhi-Kun Qiu, Jia-Li He, Xu Liu, Guan-Hua Zhang, Jia Zeng, Hong Nie, Yong-Gang Shen, Ji-Sheng Che. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. Scientific reports. vol 6. 2018-05-23. PMID:27886206. |
however, few studies have evaluated tspo and allopregnanolone in the treatment of depression in t2dm. |
2018-05-23 |
2023-08-13 |
rat |
| Xiao-Ming Li, Jia Meng, Lin Tao Li, Ting Guo, Liu-Kun Yang, Qi-Xin Shi, Xu-Bo Li, Yong Chen, Qi Yang, Jian-Ning Zha. Effect of ZBD-2 on chronic pain, depressive-like behaviors, and recovery of motor function following spinal cord injury in mice. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28108322. |
recent studies have revealed that translocator protein (tspo) is involved in repairing neural cells as well as reducing anxiety and depression. |
2017-12-01 |
2023-08-13 |
mouse |
| Xiao-Ming Li, Jia Meng, Lin Tao Li, Ting Guo, Liu-Kun Yang, Qi-Xin Shi, Xu-Bo Li, Yong Chen, Qi Yang, Jian-Ning Zha. Effect of ZBD-2 on chronic pain, depressive-like behaviors, and recovery of motor function following spinal cord injury in mice. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28108322. |
however, the role of tspo in sci-pain and pain-induced depression remains unknown. |
2017-12-01 |
2023-08-13 |
mouse |
| Dongmei Li, Ji Zheng, Mingyang Wang, Lu Feng, Zhili Ren, Yanyong Liu, Nan Yang, Pingping Zu. Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice. Psychiatry research. vol 245. 2017-11-30. PMID:27543827. |
accumulated evidences strongly suggest that mitochondrial deficit is implicated in major depression and 18kda translocator protein (tspo) plays an important role in regulating mitochondrial function. |
2017-11-30 |
2023-08-13 |
mouse |
| Dongmei Li, Ji Zheng, Mingyang Wang, Lu Feng, Yanyong Liu, Nan Yang, Pingping Zu. Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy. Journal of ethnopharmacology. vol 186. 2017-02-22. PMID:27063986. |
in order to clarify the molecular mechanisms of the antidepressant effect of wuling powder, we established learned helplessness (lh) depression animal model and focused on 18kda translocator protein (tspo) mediated-mitophagy pathway. |
2017-02-22 |
2023-08-13 |
mouse |
| Zhi-Kun Qiu, Ming-Sheng Li, Jia-Li He, Xu Liu, Guan-Hua Zhang, Sha Lai, Jian-Chun Ma, Jia Zeng, Yan Li, Hong-Wei Wu, Yong Chen, Yong-Gang Shen, Ji-Sheng Che. Translocator protein mediates the anxiolytic and antidepressant effects of midazolam. Pharmacology, biochemistry, and behavior. vol 139. issue Pt A. 2016-09-22. PMID:26455280. |
the translocator protein (18 kda) (tspo) plays an important role in stress-related disorders, such as anxiety, depression and post-traumatic stress disorder (ptsd), caused by neurosteroids (e.g. |
2016-09-22 |
2023-08-13 |
Not clear |
| Jonas Hannestad, Nicole DellaGioia, Jean-Dominique Gallezot, Keunpoong Lim, Nabeel Nabulsi, Irina Esterlis, Brian Pittman, Jae-Yun Lee, Kevin C O'Connor, Daniel Pelletier, Richard E Carso. The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study. Brain, behavior, and immunity. vol 33. 2014-05-05. PMID:23850810. |
future studies are needed to determine whether individuals with mild-to-moderate depression have lower tspo levels and to assess whether individuals with severe depression and/or with elevated levels of systemic inflammation might have higher tspo levels than control subjects. |
2014-05-05 |
2023-08-12 |
human |
| Jonas Hannestad, Nicole DellaGioia, Jean-Dominique Gallezot, Keunpoong Lim, Nabeel Nabulsi, Irina Esterlis, Brian Pittman, Jae-Yun Lee, Kevin C O'Connor, Daniel Pelletier, Richard E Carso. The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study. Brain, behavior, and immunity. vol 33. 2014-05-05. PMID:23850810. |
the purpose of this study was to use positron emission tomography (pet) with [¹¹c]pbr28, which binds to the neuroinflammation marker translocator protein 18 kda (tspo), to compare the level of tspo between individuals with depression and control subjects. |
2014-05-05 |
2023-08-12 |
human |
| Jonas Hannestad, Nicole DellaGioia, Jean-Dominique Gallezot, Keunpoong Lim, Nabeel Nabulsi, Irina Esterlis, Brian Pittman, Jae-Yun Lee, Kevin C O'Connor, Daniel Pelletier, Richard E Carso. The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study. Brain, behavior, and immunity. vol 33. 2014-05-05. PMID:23850810. |
ten individuals who were in an acute episode of major depression and 10 control subjects matched for tspo genotype and other characteristics had a pet scan with arterial input function to quantify levels of tspo in brain regions of interest (rois). |
2014-05-05 |
2023-08-12 |
human |
| Marianna Abelli, Beatrice Chelli, Barbara Costa, Lisa Lari, Alessandra Cardini, Camilla Gesi, Matteo Muti, Antonio Lucacchini, Claudia Martini, Giovanni B Cassano, Stefano Pin. Reductions in platelet 18-kDa translocator protein density are associated with adult separation anxiety in patients with bipolar disorder. Neuropsychobiology. vol 62. issue 2. 2010-10-28. PMID:20523081. |
previously, we found a significant association between platelet expression of the 18-kda translocator protein (tspo) and adult separation anxiety in patients with panic disorder or major depression. |
2010-10-28 |
2023-08-12 |
Not clear |