| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin-Yu Cui, Jing-Yao Duan, Jiao-Zhao Yan, Jing-Ya Wang, Peng Ren, Li-Ming Zhang, Wen-Zhi Guo, Wei Dai, Yun-Feng L. The impact and mechanisms of YL-IPA08, a potent ligand for the translocator protein (18 kDa) on protection against LPS-induced depression and cognitive dysfunction in rodents. Metabolic brain disease. vol 40. issue 3. 2025-03-06. PMID:40047959. |
translocator protein (18 kda) (tspo) has been implicated in the development of depression and cognitive dysfunction. |
2025-03-06 |
2025-03-08 |
mouse |
| Brandi Eiff, Edward T Bullmore, Menna R Clatworthy, Tim D Fryer, Carmine M Pariante, Valeria Mondelli, Lucia Maccioni, Nouchine Hadjikhani, Marco L Loggia, Michael A Moskowitz, Emiliano Bruner, Mattia Veronese, Federico E Turkheimer, Julia J Schuber. Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression. Brain : a journal of neurology. 2024-12-10. PMID:39657983. |
this measure was correlated with brain tspo expression and peripheral cytokine concentrations in a cohort enriched for heightened peripheral and central immunity comprising 51 individuals with depression and 25 healthy controls. |
2024-12-10 |
2024-12-13 |
Not clear |
| Marco L Loggi. "Neuroinflammation": does it have a role in chronic pain? Evidence from human imaging. Pain. vol 165. issue 11S. 2024-11-19. PMID:39560416. |
overall, these studies suggest that brain tspo pet signal: (1) is elevated, compared to healthy volunteers, in individuals with chronic low back pain (with additional elevations in spinal cord and neuroforamina), fibromyalgia, migraine and other conditions characterized by persistent pain; (2) has a spatial distribution exhibiting a degree of disorder specificity; (3) is parametrically linked to pain characteristics or comorbid symptoms (eg, nociplastic pain, fatigue, depression), as well as measures of brain function (ie, functional connectivity), in a regionally-specific manner. |
2024-11-19 |
2024-11-22 |
human |
| Marco Riebel, Lisa-Marie Brunner, Caroline Nothdurfter, Simon Wein, Jens Schwarzbach, Philippe Liere, Michael Schumacher, Rainer Rupprech. Neurosteroids and translocator protein 18 kDa (TSPO) ligands as novel treatment options in depression. European archives of psychiatry and clinical neuroscience. 2024-07-08. PMID:38976049. |
neurosteroids and translocator protein 18 kda (tspo) ligands as novel treatment options in depression. |
2024-07-08 |
2024-07-11 |
Not clear |
| Simon Wein, Marco Riebel, Philipp Seidel, Lisa-Marie Brunner, Viola Wagner, Caroline Nothdurfter, Rainer Rupprecht, Jens V Schwarzbac. Local and global effects of sedation in resting-state fMRI: a randomized, placebo-controlled comparison between etifoxine and alprazolam. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-05-31. PMID:38822128. |
further, our results point towards the potential of tspo ligands in the treatment of anxiety and depression. |
2024-05-31 |
2024-06-02 |
human |
| Lisa-Marie Brunner, Marco Riebel, Simon Wein, Michael Koller, Florian Zeman, Gunnar Huppertz, Tanja Emmer, Yvonne Eberhardt, Jens Schwarzbach, Rainer Rupprecht, Caroline Nothdurfte. The translocator protein 18kDa ligand etifoxine in the treatment of depressive disorders-a double-blind, randomized, placebo-controlled proof-of-concept study. Trials. vol 25. issue 1. 2024-04-22. PMID:38650030. |
as such, neurosteroidogenesis mediated by the translocator protein 18 kda (tspo) might constitute a promising option for the treatment of depression. |
2024-04-22 |
2024-04-26 |
Not clear |
| Dong-Sheng Zhai, Xin-Shang Wang, Le Yang, Yong-Li Jiang, Yu-Chen Jin, Yu-Xuan Yan, Da-Ke Song, Kun Zhang, Zu-Kang Han, Ming-Ying Liu, Yu-Mei Wu, Xue Ma, Jing-Yu Qi, Fan Yang, Fei Tian, Xu-Bo Li, Shui-Bing Li. TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia. Journal of affective disorders. 2023-12-30. PMID:38159656. |
tom40 mediates the effect of tspo on postpartum depression partially through regulating calcium homeostasis in microglia. |
2023-12-30 |
2024-01-05 |
Not clear |
| Dong-Sheng Zhai, Xin-Shang Wang, Le Yang, Yong-Li Jiang, Yu-Chen Jin, Yu-Xuan Yan, Da-Ke Song, Kun Zhang, Zu-Kang Han, Ming-Ying Liu, Yu-Mei Wu, Xue Ma, Jing-Yu Qi, Fan Yang, Fei Tian, Xu-Bo Li, Shui-Bing Li. TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia. Journal of affective disorders. 2023-12-30. PMID:38159656. |
to assess the effect of the translocator protein 18 kda (tspo) on postpartum depression and explore its mechanism. |
2023-12-30 |
2024-01-05 |
Not clear |
| Lei Shi, Zhu Xia, Jiamei Guo, Lixia Wang, Zhiping Peng, Dachuan Qiu, Yi Zhou, Dongdong Zhou, Li Kuang, Tian Qi. Maresin-1 improves LPS-induced depressive-like behavior by inhibiting hippocampal microglial activation. Journal of affective disorders. 2023-02-22. PMID:36813041. |
); tspo petct scanning showed that maresin-1 reduced the standardized uptake value (suv) of [18 f] dpa-714 in brain regions associated with depression (e.g., hippocampus and pre-frontal cortex), while immunofluorescence of hippocampal and indicated that maresin-1 inhibited microglial activation reducing the expression of the pro-inflammatory cytokine il-1β and nlrp3. |
2023-02-22 |
2023-08-14 |
mouse |
| Ailin Luo, Zifeng Wu, Shan Li, Cindy B McReynolds, Di Wang, Hanyu Liu, Chaoli Huang, Teng He, Xinying Zhang, Yuanyuan Wang, Cunming Liu, Bruce D Hammock, Kenji Hashimoto, Chun Yan. The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. Journal of translational medicine. vol 21. issue 1. 2023-02-03. PMID:36732752. |
the soluble epoxide hydrolase inhibitor tppu improves comorbidity of chronic pain and depression via the ahr and tspo signaling. |
2023-02-03 |
2023-08-14 |
Not clear |
| Rainer Rupprecht, Arpit Kumar Pradhan, Marco Kufner, Lisa Marie Brunner, Caroline Nothdurfter, Simon Wein, Jens Schwarzbach, Xenia Puig, Christian Rupprecht, Gerhard Ramme. Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options. European archives of psychiatry and clinical neuroscience. 2022-12-27. PMID:36574032. |
neurosteroids and translocator protein 18 kda (tspo) in depression: implications for synaptic plasticity, cognition, and treatment options. |
2022-12-27 |
2023-08-14 |
Not clear |
| Jinhong Chen, Weiwei Zhu, Xianxiang Zeng, Kai Yang, Hongli Peng, Li H. Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways. Acta neurobiologiae experimentalis. vol 82. issue 3. 2022-10-10. PMID:36214717. |
paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the tspo and bdnf‑mtor pathways. |
2022-10-10 |
2023-08-14 |
human |
| Jiamei Guo, Tian Qiu, Lixia Wang, Lei Shi, Ming Ai, Zhu Xia, Zhiping Peng, Anhai Zheng, Xiao Li, Li Kuan. Microglia Loss and Astrocyte Activation Cause Dynamic Changes in Hippocampal [ Frontiers in cellular neuroscience. vol 16. 2022-03-07. PMID:35250485. |
thus, it is necessary to explore the relationships between tspo, microglia, and astrocytes in the context of depression. |
2022-03-07 |
2023-08-13 |
mouse |
| Yo-Han Joo, Min-Woo Lee, Young-Don Son, Keun-A Chang, Maqsood Yaqub, Hang-Keun Kim, Paul Cumming, Jong-Hoon Ki. In Vivo Cerebral Translocator Protein (TSPO) Binding and Its Relationship with Blood Adiponectin Levels in Treatment-Naïve Young Adults with Major Depression: A [ Biomedicines. vol 10. issue 1. 2022-01-21. PMID:35052718. |
in vivo cerebral translocator protein (tspo) binding and its relationship with blood adiponectin levels in treatment-naïve young adults with major depression: a [ adiponectin is an adipokine that mediates cellular cholesterol efflux and plays important roles in neuroinflammatory processes. |
2022-01-21 |
2023-08-13 |
Not clear |
| Peng Ren, Li Ma, Jing-Ya Wang, Hang Guo, Li Sun, Ming-Long Gao, Yong-Zhe Liu, Ya-Qun Ma, Yun-Feng Li, Wen-Zhi Gu. Anxiolytic and Anti-depressive Like Effects of Translocator Protein (18 kDa) Ligand YL-IPA08 in a Rat Model of Postpartum Depression. Neurochemical research. vol 45. issue 8. 2021-06-03. PMID:32383026. |
though the ligand of tspo has clinical value in the diagnosis and treatment of neuropsychiatric disorders, the pharmacological study of tspo for anti-postpartum depression has not been reported. |
2021-06-03 |
2023-08-13 |
rat |
| Federico E Turkheimer, Noha Althubaity, Julia Schubert, Maria A Nettis, Oliver Cousins, Danai Dima, Valeria Mondelli, Edward T Bullmore, Carmine Pariante, Mattia Verones. Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed patients: implications for inflammation and depression. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33160089. |
increased serum peripheral c-reactive protein is associated with reduced brain barriers permeability of tspo radioligands in healthy volunteers and depressed patients: implications for inflammation and depression. |
2021-05-27 |
2023-08-13 |
human |
| Federico E Turkheimer, Noha Althubaity, Julia Schubert, Maria A Nettis, Oliver Cousins, Danai Dima, Valeria Mondelli, Edward T Bullmore, Carmine Pariante, Mattia Verones. Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed patients: implications for inflammation and depression. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33160089. |
however, studies conducted so far using pet radioligands targeting the neuroinflammatory marker 18 kda translocator protein (tspo) in patient cohorts with depression have demonstrated mild inflammatory brain status but no correlation between central and peripheral immunity. |
2021-05-27 |
2023-08-13 |
human |
| Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Yosuke Yamawaki, Ezgi Hatice Sahin, Takashi Kitajima, Seishi Katsumata, Shigeto Yamawaki, Takahiro A Kato, Hidenori Aizaw. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress. Neuropharmacology. vol 162. 2021-01-06. PMID:31682855. |
thus, targeting tspo as a candidate for the development of antidepressants that reduce susceptibility to chronic stress could pave the way toward therapeutic interventions for relapse prophylaxis in depression. |
2021-01-06 |
2023-08-13 |
mouse |
| Tarik Dahoun, Marilia A Calcia, Mattia Veronese, Peter Bloomfield, Tiago Reis Marques, Federico Turkheimer, Oliver D Howe. The association of psychosocial risk factors for mental health with a brain marker altered by inflammation: A translocator protein (TSPO) PET imaging study. Brain, behavior, and immunity. vol 80. 2020-07-20. PMID:31112791. |
this study aimed at investigating whether psychosocial risk factors for depression and/or psychosis would be associated with alterations in a brain marker expressed by microglia, the translocator specific protein (tspo) in humans. |
2020-07-20 |
2023-08-13 |
Not clear |
| Adam M McNeela, Charles Bernick, Rochelle M Hines, Dustin J Hine. TSPO regulation in reactive gliotic diseases. Journal of neuroscience research. vol 96. issue 6. 2019-11-25. PMID:29315754. |
the changes in tspo expression levels both temporally and spatially relate to the pathogenesis of stroke, alzheimer's disease, traumatic brain injury, and depression. |
2019-11-25 |
2023-08-13 |
Not clear |