| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth S Wenzel, Tory Eisenlohr-Moul, Unnathi Nagelli, Beatriz Peñalver Bernabé, Pauline M Mak. Using self-report RDoC measures to identify transdiagnostic translational targets for perinatal affective disorders. Archives of women's mental health. 2021-11-29. PMID:34697660. |
potential threat may be a prominent, transdiagnostic feature of perinatal anxiety and depression, whereas reward valuation may be a non-transdiagnostic, weaker feature of perinatal depression. |
2021-11-29 |
2023-08-13 |
Not clear |
| Ram Kandasamy, Todd M Hillhouse, Kathryn E Livingston, Kelsey E Kochan, Claire Meurice, Shainnel O Eans, Ming-Hua Li, Andrew D White, Bernard P Roques, Jay P McLaughlin, Susan L Ingram, Neil T Burford, Andrew Alt, John R Trayno. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 16. 2021-11-23. PMID:33846240. |
because bms-986122 does not bind to the orthosteric site and has no inherent agonist action at endogenously expressed levels of mor, it produces a reduced level of morphine-like side effects of constipation, reward as measured by conditioned place preference, and respiratory depression. |
2021-11-23 |
2023-08-13 |
mouse |
| Vasileia Kotoula, Toby Webster, James Stone, Mitul A Meht. Resting-state connectivity studies as a marker of the acute and delayed effects of subanaesthetic ketamine administration in healthy and depressed individuals: A systematic review. Brain and neuroscience advances. vol 5. 2021-11-23. PMID:34805548. |
we conclude that brain areas that are important for emotional regulation and reward processing appear with altered connectivity in depression whereas the default mode network presents with increased connectivity in depressed individuals compared to healthy controls. |
2021-11-23 |
2023-08-13 |
human |
| Sheena Kristine Au-Yeung, James Griffiths, Sophie Roberts, Chloe Edwards, Ly-Mee Yu, Rafal Bogacz, Jennifer Rendell, Mary-Jane Attenburrow, Stuart Watson, Fiona Chan, Andrea Cipriani, Anthony Cleare, Catherine J Harmer, David Kessler, Jonathan Evans, Glyn Lewis, Ilina Singh, Judit Simon, Paul J Harrison, Phil Cowen, Milensu Shanyinde, John Geddes, Michael Brownin. PAX-D: study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression. Evidence-based mental health. 2021-11-23. PMID:34810175. |
previous small randomised controlled trials suggested that pramipexole, a dopamine d2/3 receptor agonist, may be effective for treating patients with unipolar and bipolar depression as it is known to influence motivational drive and reward processing. |
2021-11-23 |
2023-08-13 |
Not clear |
| Julia Klawohn, C J Brush, Greg Hajca. Neural responses to reward and pleasant pictures prospectively predict remission from depression. Journal of abnormal psychology. vol 130. issue 7. 2021-11-19. PMID:34516170. |
neural responses to reward and pleasant pictures prospectively predict remission from depression. |
2021-11-19 |
2023-08-13 |
human |
| Julia Klawohn, C J Brush, Greg Hajca. Neural responses to reward and pleasant pictures prospectively predict remission from depression. Journal of abnormal psychology. vol 130. issue 7. 2021-11-19. PMID:34516170. |
at initial assessment, participants performed both a guessing task to elicit the reward positivity (rewp) and a picture viewing paradigm with neutral and pleasant pictures to measure the late positive potential (lpp)-both event-related brain potentials (erps) independently related to diagnosis of depression. |
2021-11-19 |
2023-08-13 |
human |
| Julia Klawohn, C J Brush, Greg Hajca. Neural responses to reward and pleasant pictures prospectively predict remission from depression. Journal of abnormal psychology. vol 130. issue 7. 2021-11-19. PMID:34516170. |
these data provide initial evidence for the clinical utility of erps from reward and picture viewing tasks within depressed individuals to predict disease course prospectively, which could be further leveraged to improve intervention approaches and parse the heterogeneity of depression. |
2021-11-19 |
2023-08-13 |
human |
| Tomislav D Zbozinek, Toby Wise, Omar D Perez, Song Qi, Michael S Fanselow, Dean Mobb. Pavlovian occasion setting in human fear and appetitive conditioning: Effects of trait anxiety and trait depression. Behaviour research and therapy. vol 147. 2021-11-11. PMID:34740100. |
lastly, in fear conditioning, trait anxiety was associated with increases in fear of occasion setter/conditional stimulus compounds; in appetitive conditioning, trait depression was associated with lower expectations of monetary reward for the trained negative occasion setting compound and transfer of the negative occasion setter to the simple reinforced stimulus. |
2021-11-11 |
2023-08-13 |
human |
| Sara Costi, Laurel S Morris, Abigail Collins, Nicolas F Fernandez, Manishkumar Patel, Hui Xie, Seunghee Kim-Schulze, Emily R Stern, Katherine A Collins, Flurin Cathomas, Michael K Parides, Alexis E Whitton, Diego A Pizzagalli, Scott J Russo, James W Murroug. Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia. Translational psychiatry. vol 11. issue 1. 2021-11-10. PMID:34741019. |
peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia. |
2021-11-10 |
2023-08-13 |
human |
| Warren D Taylor, David H Zald, Jennifer C Felger, Seth Christman, Daniel O Claassen, Guillermo Horga, Jeffrey M Miller, Katherine Gifford, Baxter Rogers, Sarah M Szymkowicz, Bret R Rutherfor. Influences of dopaminergic system dysfunction on late-life depression. Molecular psychiatry. 2021-11-05. PMID:34404915. |
deficits in cognition, reward processing, and motor function are clinical features relevant to both aging and depression. |
2021-11-05 |
2023-08-13 |
Not clear |
| Rachel S Wightman, Jeanmarie Perrone, Rachel Scagos, Maxwell Krieger, Lewis S Nelson, Brandon D L Marshal. Opioid Overdose Deaths with Buprenorphine Detected in Postmortem Toxicology: a Retrospective Analysis. Journal of medical toxicology : official journal of the American College of Medical Toxicology. vol 17. issue 1. 2021-11-04. PMID:32648229. |
buprenorphine is a unique μ-opioid receptor partial agonist with avid receptor binding, nominal euphoric reward, and a ceiling effect on sedation and respiratory depression. |
2021-11-04 |
2023-08-13 |
Not clear |
| Shijing Wang, Francesco Leri, Sakina J Rizv. Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33631251. |
as well, serotonin, norepinephrine, opioids, glutamate, gamma aminobutyric acid (gaba), and acetylcholine are also involved in anhedonia, and medications targeting these systems may also potentially normalize reward processing in depression. |
2021-11-01 |
2023-08-13 |
Not clear |
| Nicholas J Santopetro, C J Brush, Kreshnik Burani, Alec Bruchnak, Greg Hajca. Doors P300 moderates the relationship between reward positivity and current depression status in adults. Journal of affective disorders. vol 294. 2021-10-29. PMID:34375202. |
doors p300 moderates the relationship between reward positivity and current depression status in adults. |
2021-10-29 |
2023-08-13 |
Not clear |
| Nicholas J Santopetro, C J Brush, Kreshnik Burani, Alec Bruchnak, Greg Hajca. Doors P300 moderates the relationship between reward positivity and current depression status in adults. Journal of affective disorders. vol 294. 2021-10-29. PMID:34375202. |
previous research has found deficits in both the reward positivity (rewp) and p300 components of the event-related potential (erp) in relation to depression. |
2021-10-29 |
2023-08-13 |
Not clear |
| Mόnika Gergelyfi, Ernesto J Sanz-Arigita, Oleg Solopchuk, Laurence Dricot, Benvenuto Jacob, Alexandre Zéno. Mental fatigue correlates with depression of task-related network and augmented DMN activity but spares the reward circuit. NeuroImage. vol 243. 2021-10-29. PMID:34496289. |
mental fatigue correlates with depression of task-related network and augmented dmn activity but spares the reward circuit. |
2021-10-29 |
2023-08-13 |
human |
| Rebecca Watson, Kate Harvey, Laura Pass, Ciara McCabe, Shirley Reynold. A qualitative study exploring adolescents' experience of brief behavioural activation for depression and its impact on the symptom of anhedonia. Psychology and psychotherapy. vol 94. issue 2. 2021-10-28. PMID:32918843. |
anhedonia, the loss of interest and pleasure, is a core symptom of depression and is associated with deficits in reward processing. |
2021-10-28 |
2023-08-13 |
Not clear |
| Vaibhav R Sapuram, Suzanne Vrshek-Schallhorn, Lori M Hilt, Catherine B Strou. Dopaminergic Genetic Variation in Young Adolescents: Associations with Sensation-Seeking. Research on child and adolescent psychopathology. vol 49. issue 10. 2021-10-28. PMID:33963956. |
deficient reward functioning, including reward-related personality, is implicated in depression's etiology. |
2021-10-28 |
2023-08-13 |
Not clear |
| Vaibhav R Sapuram, Suzanne Vrshek-Schallhorn, Lori M Hilt, Catherine B Strou. Dopaminergic Genetic Variation in Young Adolescents: Associations with Sensation-Seeking. Research on child and adolescent psychopathology. vol 49. issue 10. 2021-10-28. PMID:33963956. |
in sample 1, an exploratory mediation analysis intended to gauge effect size for future work tested a path between the mgps and depression through significant reward traits. in each independent sample, both mgps's showed significant associations with sensation-seeking but not social drive, a pattern that persisted following correction. |
2021-10-28 |
2023-08-13 |
Not clear |
| Maria Kryza-Lacombe, Nana Pearson, Sonja Lyubomirsky, Murray B Stein, Jillian Lee Wiggins, Charles T Taylo. Changes in neural reward processing following Amplification of Positivity treatment for depression and anxiety: Preliminary findings from a randomized waitlist controlled trial. Behaviour research and therapy. vol 142. 2021-10-25. PMID:33894554. |
changes in neural reward processing following amplification of positivity treatment for depression and anxiety: preliminary findings from a randomized waitlist controlled trial. |
2021-10-25 |
2023-08-13 |
human |
| Maria Kryza-Lacombe, Nana Pearson, Sonja Lyubomirsky, Murray B Stein, Jillian Lee Wiggins, Charles T Taylo. Changes in neural reward processing following Amplification of Positivity treatment for depression and anxiety: Preliminary findings from a randomized waitlist controlled trial. Behaviour research and therapy. vol 142. 2021-10-25. PMID:33894554. |
this preliminary study is the first to examine neural mechanisms of positive activity interventions in depression and anxiety and suggests that amp may strengthen brain connectivity in reward processing, attention, and emotion regulation networks. |
2021-10-25 |
2023-08-13 |
human |