| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Padmakar V Kulkarni, Celeste A Roney, Peter P Antich, Frederick J Bonte, Anjanapura V Raghu, Tejraj M Aminabhav. Quinoline-n-butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer's disease. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. vol 2. issue 1. 2010-03-11. PMID:20049829. |
a survey of research activity on nanoparticles (nps) based on polymeric devices that could cross the blood-brain barrier (bbb) is given along with the presentation of our own data on the development of nps of n-butyl-2-cyanoacrylate (bca) for brain delivery to aid the early diagnosis of alzheimer's disease (ad), a neurodegenerative disorder of the elderly people, the most prevalent form of dementia. |
2010-03-11 |
2023-08-12 |
mouse |
| Karan S Kverno, Betty S Black, Marie T Nolan, Peter V Rabin. Research on treating neuropsychiatric symptoms of advanced dementia with non-pharmacological strategies, 1998-2008: a systematic literature review. International psychogeriatrics. vol 21. issue 5. 2009-10-27. PMID:19586562. |
this review evaluates the published literature on non-pharmacological interventions for treating nps in advanced dementia. |
2009-10-27 |
2023-08-12 |
Not clear |
| Karan S Kverno, Peter V Rabins, David M Blass, Kathryn L Hicks, Betty S Blac. Prevalence and treatment of neuropsychiatric symptoms in advanced dementia. Journal of gerontological nursing. vol 34. issue 12. 2009-02-26. PMID:19112999. |
this study used a retrospective review of the medical records of 123 hospice-eligible nursing home residents with advanced dementia to investigate the prevalence of nps and nps-targeted pharmacological and non-pharmacological treatments. |
2009-02-26 |
2023-08-12 |
Not clear |
| Vahram Haroutunian, Michal Schnaider-Beeri, James Schmeidler, Michael Wysocki, Dushyant P Purohit, Daniel P Perl, Leslie S Libow, Gerson T Lesser, Maria Maroukian, Hillel T Grossma. Role of the neuropathology of Alzheimer disease in dementia in the oldest-old. Archives of neurology. vol 65. issue 9. 2008-09-29. PMID:18779425. |
neuritic plaques (nps) and neurofibrillary tangles (nfts) in the brain, especially in the hippocampus, entorhinal cortex, and isocortex, are hallmark lesions of alzheimer disease and dementia in the elderly. |
2008-09-29 |
2023-08-12 |
Not clear |
| Constantine G Lyketso. Neuropsychiatric symptoms (behavioral and psychological symptoms of dementia) and the development of dementia treatments. International psychogeriatrics. vol 19. issue 3. 2007-08-27. PMID:17346363. |
neuropsychiatric symptoms (nps) are central features of dementia and an important treatment target. |
2007-08-27 |
2023-08-12 |
Not clear |
| Constantine G Lyketso. Neuropsychiatric symptoms (behavioral and psychological symptoms of dementia) and the development of dementia treatments. International psychogeriatrics. vol 19. issue 3. 2007-08-27. PMID:17346363. |
empirical characterization of clinically meaningful change in nps--by examining their relationship with dementia care burden, disability, quality of life, caregiver distress, and resource utilization--would be an important advance. |
2007-08-27 |
2023-08-12 |
Not clear |
| Liat Ayalon, Amber M Gum, Leilani Feliciano, Patricia A Areá. Effectiveness of nonpharmacological interventions for the management of neuropsychiatric symptoms in patients with dementia: a systematic review. Archives of internal medicine. vol 166. issue 20. 2007-01-05. PMID:17101935. |
recent reports documenting limited evidence supporting the use of pharmacological interventions for neuropsychiatric symptoms (nps) and increased risk of death, the black box warnings against the use of atypical antipsychotic drugs in older adults, and omnibus budget reconciliation act regulations suggest the need to evaluate the usefulness of nonpharmacological interventions in the management of nps of dementia. |
2007-01-05 |
2023-08-12 |
Not clear |
| Kaycee M Sink, Kenneth E Covinsky, Deborah E Barnes, Robert J Newcomer, Kristine Yaff. Caregiver characteristics are associated with neuropsychiatric symptoms of dementia. Journal of the American Geriatrics Society. vol 54. issue 5. 2006-06-13. PMID:16696746. |
to determine whether caregiver characteristics are independently associated with neuropsychiatric symptoms of dementia (nps) after accounting for patient characteristics. |
2006-06-13 |
2023-08-12 |
Not clear |
| K R Peters, K Rockwood, S E Black, R Bouchard, S Gauthier, D Hogan, A Kertesz, I Loy-English, B L Beattie, A D Sadovnick, H H Feldma. Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics. Neurology. vol 66. issue 4. 2006-03-20. PMID:16505306. |
to characterize the neuropsychiatric symptoms (nps) of subjects classified as not cognitively impaired (nci), cognitively impaired-not demented (cind), and dementia. |
2006-03-20 |
2023-08-12 |
human |
| Zakiya J Wynn, Jeffrey L Cumming. Cholinesterase inhibitor therapies and neuropsychiatric manifestations of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 17. issue 1-2. 2004-02-27. PMID:14564129. |
evidence suggests that a cholinergic deficit resulting from a loss of cholinergic neurons is the biological basis of some nps in ad and related dementias. |
2004-02-27 |
2023-08-12 |
Not clear |
| S U Dani, J E Pittella, A Boehme, A Hori, B Schneide. Progressive formation of neuritic plaques and neurofibrillary tangles is exponentially related to age and neuronal size. A morphometric study of three geographically distinct series of aging people. Dementia and geriatric cognitive disorders. vol 8. issue 4. 1997-08-27. PMID:9213066. |
neuronal size and the incidence of neuritic plaques (nps) and neurofibrillary tangles (nfts) were morphometrically and quantitatively studied in the entorhinal cortex of 300 autopsied individuals without dementia in three geographically distinct series (brazil, germany and japan), and an additional series including 30 clinically diagnosed alzheimer's disease patients. |
1997-08-27 |
2023-08-12 |
Not clear |
| B Seltzer, J Fratkin, S Cleja. Diffuse Lewy body disease without amyloid plaques in a patient homozygous for apolipoprotein E allele epsilon 4: a case report. Journal of geriatric psychiatry and neurology. vol 9. issue 4. 1997-04-11. PMID:8970011. |
this case, the first explicitly reported patient homozygous for the epsilon 4 allele having dementia of the lewy body type (dlbt) without nps and nfts, reinforces the distinction between dlbt and dementia of the alzheimer type. |
1997-04-11 |
2023-08-12 |
Not clear |