| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoqiang Xing, Ming Ren, Ajay Verm. Divergent Induction of Branched-Chain Aminotransferases and Phosphorylation of Branched Chain Keto-Acid Dehydrogenase Is a Potential Mechanism Coupling Branched-Chain Keto-Acid-Mediated-Astrocyte Activation to Branched-Chain Amino Acid Depletion-Mediated Cognitive Deficit after Traumatic Brain Injury. Journal of neurotrauma. vol 35. issue 20. 2019-12-20. PMID:29764289. |
because increased pbckd would lead to increased bcka accumulation, bcka-mediated astrocyte activation, cell death, and cognitive dysfunction as found in maple syrup urine disease; thus, tbi may potentially induce cognitive deficit through diverting bcaa from glutamate production in neurons to bcka production in astrocytes through the pbckd-dependent mechanism. |
2019-12-20 |
2023-08-13 |
rat |
| Kazuo Takiguchi, Akihito Uezato, Michio Itasaka, Hidenori Atsuta, Kenji Narushima, Naoki Yamamoto, Akeo Kurumaji, Makoto Tomita, Kazunari Oshima, Kosaku Shoda, Mai Tamaru, Masahito Nakataki, Mitsutoshi Okazaki, Sayuri Ishiwata, Yasuyoshi Ishiwata, Masato Yasuhara, Kunimasa Arima, Tetsuro Ohmori, Toru Nishikaw. Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study. BMC psychiatry. vol 17. issue 1. 2018-02-20. PMID:28701225. |
it has been reported that drugs which promote the n-methyl-d-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs. |
2018-02-20 |
2023-08-13 |
Not clear |
| Darrick T Balu, Yan Li, Shunsuke Takagi, Kendall Taylor Presti, Teniel S Ramikie, Jerri M Rook, Carrie K Jones, Craig W Lindsley, P Jeffrey Conn, Vadim Y Bolshakov, Joseph T Coyl. An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 8. 2018-01-15. PMID:26741285. |
metabotropic glutamate receptor 5 (mglu5)-positive allosteric modulators (pams) are currently being developed to treat cognitive dysfunction. |
2018-01-15 |
2023-08-13 |
mouse |
| Chunhua Liu, Hongqiang Yin, Jing Gao, Xiaxia Xu, Tao Zhang, Zhuo Yan. Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 23. issue 13. 2017-06-05. PMID:27823628. |
leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy. |
2017-06-05 |
2023-08-13 |
Not clear |
| Jie Xiao, Yilong Huang, Xia Li, Longjun Li, Ting Yang, Lixuan Huang, Ling Yang, Hong Jiang, Hongchun Li, Fan L. TNP-ATP is Beneficial for Treatment of Neonatal Hypoxia-Induced Hypomyelination and Cognitive Decline. Neuroscience bulletin. vol 32. issue 1. 2016-11-03. PMID:26769489. |
our data indicated that activation of ionotropic atp receptors might be partially, if not fully, involved in glutamate deregulation, neuroinflammation, hypomyelination, and cognitive dysfunction after neonatal hypoxia. |
2016-11-03 |
2023-08-13 |
rat |
| Alan L Pehrson, Connie Sanche. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS spectrums. vol 19. issue 2. 2014-06-03. PMID:23903233. |
serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. |
2014-06-03 |
2023-08-12 |
Not clear |
| Alan L Pehrson, Connie Sanche. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS spectrums. vol 19. issue 2. 2014-06-03. PMID:23903233. |
the multimodal compounds vortioxetine and vilazodone are examples of this approach with diverse mechanisms, and their different clinical effects will provide valuable insights into serotonergic modulation of glutamate transmission for the potential treatment of depression and associated cognitive dysfunction. |
2014-06-03 |
2023-08-12 |
Not clear |
| Akihito Uezato, Toru Nishikaw. [Molecular pathology of schizophrenia]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 4. 2013-09-25. PMID:23678584. |
converging lines of evidence suggest altered regulation of other neurotransmitters including glutamate, gaba and acetylcholine, results in the dysregulation of dopaminergic neurons in schizophrenia, and is involved in the comprehensive symptoms such as positive, negative, and cognitive dysfunction. |
2013-09-25 |
2023-08-12 |
Not clear |
| Daniel C Javit. Twenty-five years of glutamate in schizophrenia: are we there yet? Schizophrenia bulletin. vol 38. issue 5. 2013-02-04. PMID:22987849. |
several classes of agent, including metabotropic glutamate agonists, glycine transport inhibitors, and d-serine-based compounds are currently in late-stage clinical development and may provide long-sought treatments for persistent positive and negative symptoms and cognitive dysfunction in schizophrenia. |
2013-02-04 |
2023-08-12 |
Not clear |
| Paul G Unschuld, Richard A E Edden, Aaron Carass, Xinyang Liu, Megan Shanahan, Xin Wang, Kenichi Oishi, Jason Brandt, Susan S Bassett, Graham W Redgrave, Russell L Margolis, Peter C M van Zijl, Peter B Barker, Christopher A Ros. Brain metabolite alterations and cognitive dysfunction in early Huntington's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 7. 2012-11-13. PMID:22649062. |
n-acetylaspartate and glutamate magnetic resonance spectroscopy signals of the posterior cingulate cortex region may serve as potential biomarkers of disease progression or treatment outcome in hd and other neurodegenerative disorders with early cognitive dysfunction, when structural brain changes are still minor. |
2012-11-13 |
2023-08-12 |
human |
| Marek Schwendt, Carmela M Reichel, Ronald E Se. Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats. PloS one. vol 7. issue 3. 2012-11-05. PMID:22479593. |
altered glutamate neurotransmission within the prefrontal cortex (pfc) and striatum has been linked to both persistent drug-seeking and cognitive dysfunction. |
2012-11-05 |
2023-08-12 |
rat |
| Marco Spangaro, Marta Bosia, Andrea Zanoletti, Margherita Bechi, Federica Cocchi, Adele Pirovano, Cristina Lorenzi, Placido Bramanti, Francesco Benedetti, Enrico Smeraldi, Roberto Cavallar. Cognitive dysfunction and glutamate reuptake: effect of EAAT2 polymorphism in schizophrenia. Neuroscience letters. vol 522. issue 2. 2012-11-05. PMID:22728822. |
cognitive dysfunction and glutamate reuptake: effect of eaat2 polymorphism in schizophrenia. |
2012-11-05 |
2023-08-12 |
human |
| Nurith Amitai, Ronald Kuczenski, M Margarita Behrens, Athina Marko. Repeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of rats. Neuropharmacology. vol 62. issue 3. 2012-09-27. PMID:21238466. |
a better understanding of glutamate and gaba dysregulation in schizophrenia may uncover new treatment targets for schizophrenia-related cognitive dysfunction. |
2012-09-27 |
2023-08-12 |
rat |
| Sylwia Owczarek, Jack Hou, Thomas Secher, Lars V Kristianse. Phencyclidine treatment increases NR2A and NR2B N-methyl-D-aspartate receptor subunit expression in rats. Neuroreport. vol 22. issue 17. 2012-08-08. PMID:22015741. |
these results indicate how behavioral changes in a developmental model for cognitive dysfunction involve changes to specific molecular subsets of the cortical glutamate system. |
2012-08-08 |
2023-08-12 |
rat |
| Graham M Pitcher, Lorraine V Kalia, David Ng, Nathalie M Goodfellow, Kathleen T Yee, Evelyn K Lambe, Michael W Salte. Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors. Nature medicine. vol 17. issue 4. 2011-06-02. PMID:21441918. |
hypofunction of the n-methyl d-aspartate subtype of glutamate receptor (nmdar) is hypothesized to be a mechanism underlying cognitive dysfunction in individuals with schizophrenia. |
2011-06-02 |
2023-08-12 |
Not clear |
| Nurith Amitai, Athina Marko. Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats. European journal of pharmacology. vol 639. issue 1-3. 2010-11-03. PMID:20371228. |
manipulation of glutamate signaling using drugs acting at metabotropic glutamate receptors has been suggested as a novel approach to treating schizophrenia-related cognitive dysfunction. |
2010-11-03 |
2023-08-12 |
rat |
| Akihiro Takan. The application of PET technique for the development and evaluation of novel antipsychotics. Current pharmaceutical design. vol 16. issue 3. 2010-04-02. PMID:20109145. |
to aim to treat the cognitive dysfunction and negative symptoms, various targets such as glutamate receptors, tachykinin receptors, cannabinoid receptors, and nicotinic acetylcholine receptors, have been investigated recently. |
2010-04-02 |
2023-08-12 |
human |
| Kafui Dzirasa, Amy J Ramsey, Daniel Yasumasa Takahashi, Jennifer Stapleton, Juan M Potes, Jamila K Williams, Raul R Gainetdinov, Koichi Sameshima, Marc G Caron, Miguel A L Nicoleli. Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 25. 2009-08-04. PMID:19553461. |
these results demonstrate that dopamine and nmda receptor dependent glutamate signaling play a critical role in coordinating neural phase signaling, and encourage further studies to investigate the role that deficits in phase signaling play in mediating cognitive dysfunction. |
2009-08-04 |
2023-08-12 |
mouse |
| Sunil K Hota, Kalpana Barhwal, Shashi B Singh, M Sairam, Govindasamy Ilavazhaga. NR1 and GluR2 expression mediates excitotoxicity in chronic hypobaric hypoxia. Journal of neuroscience research. vol 86. issue 5. 2008-04-23. PMID:17969105. |
this study also indicates the appropriate period for drug administration during exposure to hypobaric hypoxia and establishes ionotropic receptors of glutamate as potential therapeutic targets for ameliorating high-altitude-induced cognitive dysfunction. |
2008-04-23 |
2023-08-12 |
rat |
| Yanling Li, Wei Zhou, Xiangning Li, Shaoqun Zeng, Qingming Lu. Dynamics of learning in cultured neuronal networks with antagonists of glutamate receptors. Biophysical journal. vol 93. issue 12. 2008-01-16. PMID:17766359. |
cognitive dysfunction may result from abnormality of ionotropic glutamate receptors. |
2008-01-16 |
2023-08-12 |
Not clear |